摘要
以2-氯代三苯甲基氯树脂为载体,采用Fmoc/t-Bu/Dmab正交保护策略,在微波辅助下合成了环肽c(fKRGD),收率22.5%,纯度94.5%,其结构经MS(ESI), MS(MALDI-TOF)和HPLC确证。
A cyclic RGD peptide c(fKRGD) was synthesized by microwave assisted Fmoc/t-Bu/Dmab orthogonal protection strategy using 2-CTC resin as supporter, with yield of 22.5% and purity of 94.5%. The structure was confirmed by MS(ESI), MS(MALDI-TOF) and HPLC.
引文
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