化斑通络方治疗颈动脉粥样硬化斑块临床研究
|
摘要
目的:观察化斑通络方治疗颈动脉粥样硬化斑块的临床疗效。方法:选取2014年1月至2017年1月在邯郸市中医院脑病科门诊及住院治疗的颈动脉粥样硬化斑块患者394例,随机分为治疗组200例和对照组194例。对照组给予肠溶阿司匹林、阿托伐他汀钙片口服治疗,治疗组在对照组治疗的基础上给予高社光教授经验方化斑通络方口服治疗,两组均以6个月为1个疗程。观察两组患者治疗前后斑块面积、颈动脉内膜中层厚度、C反应蛋白等指标的变化情况。结果:治疗组有效率93.5%,对照组有效率65.2%,治疗组疗效优于对照组(P<0.05);治疗组治疗后斑块面积优于对照组,差异有统计学意义(P<0.05);治疗组治疗后血清总胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白水平优于对照组,差异有统计学意义(P<0.05);治疗组治疗后C反应蛋白水平优于对照组,差异有统计学意义(P<0.05)。结论:化斑通络方治疗颈动脉粥样硬化斑块疗效显著。
Objective:To observe the clinical curative effect of Decoction for Removing Plagues and Dredging Meridians on carotid atherosclerotic plaques. Methods:Three hundred and ninety-four patients with carotid atherosclerotic plaques who were treated in the clinic of encephalopathy and hospitalized in Handan TCM Hospital from January 2014 to January 2017,were randomly divided into the treatment group and the control group,with 200 cases and 194 cases respectively in each group. The control group was given enteric aspirin and Atorvastatin Calcium Tablets for oral treatment. On the basis of the treatment of the control group,the treatment group was given professor Gao Sheguang's Decoction for Removing Plagues and Dredging Meridians. Both groups regarded 6 months as one course,then the changes of plaque area,carotid artery intima media thickness and C reactive protein in two groups before and after the treatment were observed. Results:The effective rate of the treatment group was 93. 5%,while that of the control group was 65. 2%,the curative effect of the treatment group was superior to that of the control group( P < 0. 05). And the plaque area in the treatment group was better than that of the control group( P < 0. 05). The level of serum total cholesterol,three acylglycerol,low density lipoprotein and high-density lipoprotein in the treatment group after the treatment were better than those of the control group. And all the differences were statistically significant( P < 0. 05). The C reactive protein level in the treatment group was better than that in the control group after the treatment( P < 0. 05),and the difference was statistically significant( P < 0. 05). Conclusion:Decoction for Removing Plagues and Dredging Meridians has a remarkable clinical curative effect on carotid atherosclerotic plaques.
Objective:To observe the clinical curative effect of Decoction for Removing Plagues and Dredging Meridians on carotid atherosclerotic plaques. Methods:Three hundred and ninety-four patients with carotid atherosclerotic plaques who were treated in the clinic of encephalopathy and hospitalized in Handan TCM Hospital from January 2014 to January 2017,were randomly divided into the treatment group and the control group,with 200 cases and 194 cases respectively in each group. The control group was given enteric aspirin and Atorvastatin Calcium Tablets for oral treatment. On the basis of the treatment of the control group,the treatment group was given professor Gao Sheguang's Decoction for Removing Plagues and Dredging Meridians. Both groups regarded 6 months as one course,then the changes of plaque area,carotid artery intima media thickness and C reactive protein in two groups before and after the treatment were observed. Results:The effective rate of the treatment group was 93. 5%,while that of the control group was 65. 2%,the curative effect of the treatment group was superior to that of the control group( P < 0. 05). And the plaque area in the treatment group was better than that of the control group( P < 0. 05). The level of serum total cholesterol,three acylglycerol,low density lipoprotein and high-density lipoprotein in the treatment group after the treatment were better than those of the control group. And all the differences were statistically significant( P < 0. 05). The C reactive protein level in the treatment group was better than that in the control group after the treatment( P < 0. 05),and the difference was statistically significant( P < 0. 05). Conclusion:Decoction for Removing Plagues and Dredging Meridians has a remarkable clinical curative effect on carotid atherosclerotic plaques.
引文
[1]刘建设,高社光,王玲玲,等.益气活血、解毒化浊法治疗颈动脉斑块216例临床研究[J].中医杂志,2013,54(3):225.
[2]HOLLANDER M,BOTS M L,DEL SOL A I,et al.Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly the Rotterdam study[J].Circulation,2002,105(24):2872-2877.
[3]LISPIS C D,KAKISIS J K,KOSTSKIS A G.Carotid stenosis:factors affecting symptoenatology[J].Stroke,2001,32(12):782-786.
[4]贺平.超敏C-反应蛋白在心血管疾病的研究进展[J].华夏医学,2006,19(6):1293-1295.
[5]周永昌,郭万学.超声医学[M].北京:科学技术文献出版社,2003:799-800.
[6]MICHAEL M,ARNANE M,CAROTI D,et al.Carotid Plaque Inflammation on18F-Fluorodeoxyglucose Positron Emission Tomography Predicts Early Stroke Recurrence[J].American Neurological Association,2012,71(5):706-716.
[7]贾玉勤,郑文玲,冯乐燕,等.化痰活血法治疗颈动脉斑块临床观察[J].中国中医急症,2006,15(9):940.
[8]于俊生,陈兆昌.动脉粥样硬化从痰瘀毒论治探讨[J].山东中医杂志,2002,21(8):451-453.
[9]姜建昌,曹雷,姚瑜洁,等.冰片的临床应用研究概况[J].现代中西医结合杂志,2013,22(2):221.
[10]陈秋月,黄米武,柯绍发,等.水蛭胶囊对颈动脉斑块稳定性及血小板膜糖蛋白分子表达的影响[J].中华中医药杂志,1989,24(12):1643-1645.
[11]王楠,万建波,李铭源,等.三七治疗动脉粥样硬化的研究进展[J].中草药,2008,39(5):787-790.
[12]袁志兵,李晓辉,李淑慧,等.三七总皂苷对动脉粥样硬化斑块稳定性的影响[J].中国天然药物,2006,4(1):62-64.
[13]侯家玉.中药药理学[M].北京:中国中医院药出版社,2002:190.
[14]王宁.颈动脉不稳定斑块及中医药干预治疗研究进展[J].中国中医药信息杂志,2010,9(17):108-109.
[15]ZHOU Z G,JIANG Y.Effect ofmain inflammatory cell factors in the atherosclerosis[J].Guoji Jianyan Yixue Zazhi,2006,27(10):919-920,923.
[16]PASCERI V,CHANG J,WILLERSON J T,et al.Modulation of C-reactive protein mediated monocyte chemoattractant protein induction in human endothelial cells by anti-atherosclerosis drugs[J].Circulation,2001,103:2531-2534.
[17]钱怡宁,张拙,勇强,等.进展性脑卒中与颈动脉斑块性质及高敏C反应蛋白水平关系[J].中华老年心脑血管杂志,2008,10(5):358-360.
[18]CURB J D,ABVOTT R D,RODRIGUEZ B L,et al.C-reactive protein and the future risk of thromboembolic stroke in health men[J].Circulation,2003,(107):2016.
[2]HOLLANDER M,BOTS M L,DEL SOL A I,et al.Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly the Rotterdam study[J].Circulation,2002,105(24):2872-2877.
[3]LISPIS C D,KAKISIS J K,KOSTSKIS A G.Carotid stenosis:factors affecting symptoenatology[J].Stroke,2001,32(12):782-786.
[4]贺平.超敏C-反应蛋白在心血管疾病的研究进展[J].华夏医学,2006,19(6):1293-1295.
[5]周永昌,郭万学.超声医学[M].北京:科学技术文献出版社,2003:799-800.
[6]MICHAEL M,ARNANE M,CAROTI D,et al.Carotid Plaque Inflammation on18F-Fluorodeoxyglucose Positron Emission Tomography Predicts Early Stroke Recurrence[J].American Neurological Association,2012,71(5):706-716.
[7]贾玉勤,郑文玲,冯乐燕,等.化痰活血法治疗颈动脉斑块临床观察[J].中国中医急症,2006,15(9):940.
[8]于俊生,陈兆昌.动脉粥样硬化从痰瘀毒论治探讨[J].山东中医杂志,2002,21(8):451-453.
[9]姜建昌,曹雷,姚瑜洁,等.冰片的临床应用研究概况[J].现代中西医结合杂志,2013,22(2):221.
[10]陈秋月,黄米武,柯绍发,等.水蛭胶囊对颈动脉斑块稳定性及血小板膜糖蛋白分子表达的影响[J].中华中医药杂志,1989,24(12):1643-1645.
[11]王楠,万建波,李铭源,等.三七治疗动脉粥样硬化的研究进展[J].中草药,2008,39(5):787-790.
[12]袁志兵,李晓辉,李淑慧,等.三七总皂苷对动脉粥样硬化斑块稳定性的影响[J].中国天然药物,2006,4(1):62-64.
[13]侯家玉.中药药理学[M].北京:中国中医院药出版社,2002:190.
[14]王宁.颈动脉不稳定斑块及中医药干预治疗研究进展[J].中国中医药信息杂志,2010,9(17):108-109.
[15]ZHOU Z G,JIANG Y.Effect ofmain inflammatory cell factors in the atherosclerosis[J].Guoji Jianyan Yixue Zazhi,2006,27(10):919-920,923.
[16]PASCERI V,CHANG J,WILLERSON J T,et al.Modulation of C-reactive protein mediated monocyte chemoattractant protein induction in human endothelial cells by anti-atherosclerosis drugs[J].Circulation,2001,103:2531-2534.
[17]钱怡宁,张拙,勇强,等.进展性脑卒中与颈动脉斑块性质及高敏C反应蛋白水平关系[J].中华老年心脑血管杂志,2008,10(5):358-360.
[18]CURB J D,ABVOTT R D,RODRIGUEZ B L,et al.C-reactive protein and the future risk of thromboembolic stroke in health men[J].Circulation,2003,(107):2016.