ADRB2基因多态性在疾病中的研究进展
|
摘要
ADRB2在多种组织细胞中广泛表达,且ADRB2基因多态性会影响基因表达、受体功能和对配体的应答。因此,近年来,ADRB2不同位点基因多态性在不同疾病中的研究越来越多。本文重点概述了ADRB2基因多态性在哮喘、慢性阻塞性肺病、肥胖、创伤后应激障碍、心血管疾病等疾病中的关键作用。
The ADRB2 gene polymorphism,widely expressed in a variety of tissue cells,affects gene expression,receptor function,and response to ligands. Therefore,in recent years,ADRB2 polymorphisms in different loci have been increasingly studied in different diseases. This article focuses on the key role of ADRB2 gene polymorphisms in some disease such as asthma,chronic obstructive pulmonary disease(COPD),obesity,post-traumatic stress disorder(PTSD),and cardiovascular disease.
The ADRB2 gene polymorphism,widely expressed in a variety of tissue cells,affects gene expression,receptor function,and response to ligands. Therefore,in recent years,ADRB2 polymorphisms in different loci have been increasingly studied in different diseases. This article focuses on the key role of ADRB2 gene polymorphisms in some disease such as asthma,chronic obstructive pulmonary disease(COPD),obesity,post-traumatic stress disorder(PTSD),and cardiovascular disease.
引文
[1] Litonjua AA,Gong L,Duan QL,et al. Very important pharmacogene summary ADRB2[J]. Pharmacogenet Genomics,2010,20(1):64-69.
[2] Guo X,Zheng H,Mao C,et al. An association and meta-analysis study of 4 SNPs from beta-2 adrenergic receptor(ADRB2)gene with risk of asthma in children[J]. Asian Pac J Allergy Immunol,2016,34(1):11-20.
[3] Chung JE,Choi SA,Hwang HS,et al. Association between?2-adrenergic receptor gene polymorphisms and adverse events of ritodrine in the treatment of preterm labor:a prospective observational study[J]. BMC Genet,2017,18(1):96.
[4] Liberzon I,King AP,Ressler KJ,et al. Interaction of the ADRB2gene polymorphism with childhood trauma in predicting adult symptoms of posttraumatic stress disorder[J]. JAMA Psychiatry,2014,71(10):1174-1182.
[5] Anthony EG,Richard E,Lipkowitz MS,et al. Association of the ADRB2(rs2053044)polymorphism and angiotensin-converting enzyme-inhibitor blood pressure response in the African American Study of Kidney Disease and Hypertension[J]. Pharmacogenet Genomics,2015,25(9):444-449.
[6] Saadi AV,Gupta H,Angural A,et al. Single nucleotide polymorphisms of ADRB2 gene and their association with susceptibility for Plasmodium falciparum malaria and asthma in an Indian population[J]. Infect Genet Evol,2013,20:140-147.
[7] Naka I,Ohashi J,Kimura R,et al. Association of ADRB2 polymorphism with triglyceride levels in Tongans[J]. Lipids Health Dis,2013,12:110.
[8] Li JX,Fu WP,Zhang J,et al. A functional SNP upstream of the ADRB2 gene is associated with COPD[J]. Int J Chron Obstruct Pulmon Dis,2018,13:917-925.
[9] Kushnir VM,Cassell B,Gyawali CP,et al. Genetic variation in the beta-2 adrenergic receptor(ADRB2)predicts functional gastrointestinal diagnoses and poorer health-related quality of life[J]. Aliment Pharmacol Ther,2013,38(3):313-323.
[10] Tian M,Liang H,Qin QZ,et al. ADRB2 polymorphisms in allergic asthma in Han Chinese children[J]. Int Forum Allergy Rhinol,2016,6(4):367-372.
[11] Liang SQ,Chen XL,Deng JM,et al. Beta-2 adrenergic receptor(ADRB2)gene polymorphisms and the risk of asthma:a metaanalysis of case-control studies[J]. PLoS One,2014,9(8):e104488.
[12] Petrovic-Stanojevic N,Topic A,Nikolic A,et al. Polymorphisms of beta2-adrenergic receptor gene in Serbian asthmatic adults:effects on response to beta-agonists[J]. Mol Diagn Ther,2014,18(6):639-646.
[13] de Paiva AC,Marson FA,Ribeiro JD,et al. Asthma:Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors[J]. Allergy Asthma Clin Immunol,2014,10(1):8.
[14] Hua L,Zuo XB,Bao YX,et al. Four-locus gene interaction between IL13,IL4,FCER1B,and ADRB2 for asthma in Chinese Han children[J]. Pediatr Pulmonol,2016,51(4):364-371.
[15] Bandaru S,Akka J,Marri VK,et al. Analysis of ADRB2(Arg-16Gly)gene variant with susceptibility,pharmacogenetic response and disease severity in south Indian asthmatics[J]. Inflammation,2015,38(6):2146-2155.
[16] Scichilone N,Caponetto C,Fagone E,et al. The Arg/Arg polymorphism of the ADRB2 is associated with the severity of allergic asthma[J]. J Allergy Clin Immunol Pract,2016,4(6):1251-1252.
[17] Turner S,Francis B,Vijverberg S,et al. Childhood asthma exacerbations and the Arg16β2-receptor polymorphism:a metaanalysis stratified by treatment[J]. J Allergy Clin Immunol,2016,138(1):107-113,e5.
[18] Zuurhout MJ,Vijverberg SJ,Raaijmakers JA,et al. Arg16 ADRB2genotype increases the risk of asthma exacerbation in children with a reported use of long-actingβ2-agonists:results of the PACMAN cohort[J]. Pharmacogenomics,2013,14(16):1965-1971.
[19] Bandaru S,Tarigopula P,Akka J,et al. Association of Beta 2adrenergic receptor(Thr164Ile)polymorphism with Salbutamol refractoriness in severe asthmatics from Indian population[J].Gene,2016,592(1):15-22.
[20] Lipworth BJ,Basu K,Donald HP,et al. Tailored second-line therapy in asthmatic children with the Arg(16)genotype[J].Clin Sci(Lond),2013,124(8):521-528.
[21] Zhao H,Wu X,Dong CL,et al. Association between ADRB2genetic polymorphisms and the risk of chronic obstructive pulmonary disease:a case-control study in a chinese population[J]. Genet Test Mol Biomarkers,2017,21(8):491-496.
[22] Nojiri M,Mizuno S,Nishiki K,et al. ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema[J]. Pulm Pharmacol Ther,2018,48:80-87.
[23] Ramos-Lopez O,Riezu-Boj JI,Milagro FI,et al. Differential lipid metabolism outcomes associated with ADRB2 gene polymorphisms in response to two dietary interventions in overweight/obese subjects[J]. Nutr Metab Cardiovasc Dis,2018,28(2):165-172.
[24] Rauhio A,Uusi-Rasi K,Nikkari ST,et al. Association of the FTO and ADRB2 genes with body composition and fat distribution in obese women[J]. Maturitas,2013,76(2):165-171.
[25] Naka I,Hikami K,Nakayama K,et al. A functional SNP upstream of the beta-2 adrenergic receptor gene(ADRB2)is associated with obesity in Oceanic populations[J]. Int J Obes(Lond),2013,37(9):1204-1210.
[26] Hauser MA,Garrett ME,Liu Y,et al. Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder[J]. J Psychiatr Res,2017,84:59-61.
[27] Wang DW,Liu M,Wang P,et al. ADRB2 polymorphisms predict the risk of myocardial infarction and coronary artery disease[J]. Genet Mol Biol,2015,38(4):433-443.
[28] Ferreira-Santos L,Martinez DG,Nicolau JC,et al. Neurovascular control during exercise in acute coronary syndrome patients with Gln27Glu polymorphism ofβ2-adrenergic receptor[J]. PLoS One,2017,12(2):e0173061.
[29] Staals?JM,Rokamp KZ,Olesen ND,et al. ADRB2 gly16gly genotype,cardiac output,and cerebral oxygenation in patients undergoing anesthesia for abdominal aortic aneurysm surgery[J]. Anesth Analg,2016,123(6):1408-1415.
[30] Reitman E,Conell-Price J,Evansmith J,et al.β2-adrenergic receptor genotype and other variables that contribute to labor pain and progress[J]. Anesthesiology,2011,114(4):927-939.
[31] Terkawi AS,Jackson WM,Hansoti S,et al. Polymorphism in the ADRB2 gene explains a small portion of intersubject variability in pain relative to cervical dilation in the first stage of labor[J]. Anesthesiology,2014,121(1):140-148.
[32] Marson FA,Bertuzzo CS,Ribeiro AF,et al. Polymorphisms in ADRB2 gene can modulate the response to bronchodilators and the severity of cystic fibrosis[J]. BMC Pulm Med,2012,12:50.
[33] Connor A,Baumgartner RN,Kerber RA,et al. ADRB2 G-G haplotype associated with breast cancer risk among Hispanic and non-Hispanic white women:interaction with type 2 diabetes and obesity[J]. Cancer Causes Control,2012,23(10):1653-1663.
[34] Zeng Y,Cheng L,Zhao L,et al. Interactions between social/behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China[J]. BMC Geriatr,2013,13:91.
[35] Han J,Zuo J,Zhu D,et al. The correlation between SNPs within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo[J]. J Clin Lab Anal,2018,32(5):e22366.
[36]王莉莉,张运,贺茂林.β2肾上腺素能受体基因多态性与伴发胸腺异常的重症肌无力的关系[J].中华医学杂志,2015,95(19):1518-1521.
[37] Kong DR,Wang JG,Sun B,et al.β-2 Adrenergic receptor gene polymorphism and response to propranolol in cirrhosis[J].World J Gastroenterol,2015,21(23):7191-7196.
[2] Guo X,Zheng H,Mao C,et al. An association and meta-analysis study of 4 SNPs from beta-2 adrenergic receptor(ADRB2)gene with risk of asthma in children[J]. Asian Pac J Allergy Immunol,2016,34(1):11-20.
[3] Chung JE,Choi SA,Hwang HS,et al. Association between?2-adrenergic receptor gene polymorphisms and adverse events of ritodrine in the treatment of preterm labor:a prospective observational study[J]. BMC Genet,2017,18(1):96.
[4] Liberzon I,King AP,Ressler KJ,et al. Interaction of the ADRB2gene polymorphism with childhood trauma in predicting adult symptoms of posttraumatic stress disorder[J]. JAMA Psychiatry,2014,71(10):1174-1182.
[5] Anthony EG,Richard E,Lipkowitz MS,et al. Association of the ADRB2(rs2053044)polymorphism and angiotensin-converting enzyme-inhibitor blood pressure response in the African American Study of Kidney Disease and Hypertension[J]. Pharmacogenet Genomics,2015,25(9):444-449.
[6] Saadi AV,Gupta H,Angural A,et al. Single nucleotide polymorphisms of ADRB2 gene and their association with susceptibility for Plasmodium falciparum malaria and asthma in an Indian population[J]. Infect Genet Evol,2013,20:140-147.
[7] Naka I,Ohashi J,Kimura R,et al. Association of ADRB2 polymorphism with triglyceride levels in Tongans[J]. Lipids Health Dis,2013,12:110.
[8] Li JX,Fu WP,Zhang J,et al. A functional SNP upstream of the ADRB2 gene is associated with COPD[J]. Int J Chron Obstruct Pulmon Dis,2018,13:917-925.
[9] Kushnir VM,Cassell B,Gyawali CP,et al. Genetic variation in the beta-2 adrenergic receptor(ADRB2)predicts functional gastrointestinal diagnoses and poorer health-related quality of life[J]. Aliment Pharmacol Ther,2013,38(3):313-323.
[10] Tian M,Liang H,Qin QZ,et al. ADRB2 polymorphisms in allergic asthma in Han Chinese children[J]. Int Forum Allergy Rhinol,2016,6(4):367-372.
[11] Liang SQ,Chen XL,Deng JM,et al. Beta-2 adrenergic receptor(ADRB2)gene polymorphisms and the risk of asthma:a metaanalysis of case-control studies[J]. PLoS One,2014,9(8):e104488.
[12] Petrovic-Stanojevic N,Topic A,Nikolic A,et al. Polymorphisms of beta2-adrenergic receptor gene in Serbian asthmatic adults:effects on response to beta-agonists[J]. Mol Diagn Ther,2014,18(6):639-646.
[13] de Paiva AC,Marson FA,Ribeiro JD,et al. Asthma:Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors[J]. Allergy Asthma Clin Immunol,2014,10(1):8.
[14] Hua L,Zuo XB,Bao YX,et al. Four-locus gene interaction between IL13,IL4,FCER1B,and ADRB2 for asthma in Chinese Han children[J]. Pediatr Pulmonol,2016,51(4):364-371.
[15] Bandaru S,Akka J,Marri VK,et al. Analysis of ADRB2(Arg-16Gly)gene variant with susceptibility,pharmacogenetic response and disease severity in south Indian asthmatics[J]. Inflammation,2015,38(6):2146-2155.
[16] Scichilone N,Caponetto C,Fagone E,et al. The Arg/Arg polymorphism of the ADRB2 is associated with the severity of allergic asthma[J]. J Allergy Clin Immunol Pract,2016,4(6):1251-1252.
[17] Turner S,Francis B,Vijverberg S,et al. Childhood asthma exacerbations and the Arg16β2-receptor polymorphism:a metaanalysis stratified by treatment[J]. J Allergy Clin Immunol,2016,138(1):107-113,e5.
[18] Zuurhout MJ,Vijverberg SJ,Raaijmakers JA,et al. Arg16 ADRB2genotype increases the risk of asthma exacerbation in children with a reported use of long-actingβ2-agonists:results of the PACMAN cohort[J]. Pharmacogenomics,2013,14(16):1965-1971.
[19] Bandaru S,Tarigopula P,Akka J,et al. Association of Beta 2adrenergic receptor(Thr164Ile)polymorphism with Salbutamol refractoriness in severe asthmatics from Indian population[J].Gene,2016,592(1):15-22.
[20] Lipworth BJ,Basu K,Donald HP,et al. Tailored second-line therapy in asthmatic children with the Arg(16)genotype[J].Clin Sci(Lond),2013,124(8):521-528.
[21] Zhao H,Wu X,Dong CL,et al. Association between ADRB2genetic polymorphisms and the risk of chronic obstructive pulmonary disease:a case-control study in a chinese population[J]. Genet Test Mol Biomarkers,2017,21(8):491-496.
[22] Nojiri M,Mizuno S,Nishiki K,et al. ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema[J]. Pulm Pharmacol Ther,2018,48:80-87.
[23] Ramos-Lopez O,Riezu-Boj JI,Milagro FI,et al. Differential lipid metabolism outcomes associated with ADRB2 gene polymorphisms in response to two dietary interventions in overweight/obese subjects[J]. Nutr Metab Cardiovasc Dis,2018,28(2):165-172.
[24] Rauhio A,Uusi-Rasi K,Nikkari ST,et al. Association of the FTO and ADRB2 genes with body composition and fat distribution in obese women[J]. Maturitas,2013,76(2):165-171.
[25] Naka I,Hikami K,Nakayama K,et al. A functional SNP upstream of the beta-2 adrenergic receptor gene(ADRB2)is associated with obesity in Oceanic populations[J]. Int J Obes(Lond),2013,37(9):1204-1210.
[26] Hauser MA,Garrett ME,Liu Y,et al. Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder[J]. J Psychiatr Res,2017,84:59-61.
[27] Wang DW,Liu M,Wang P,et al. ADRB2 polymorphisms predict the risk of myocardial infarction and coronary artery disease[J]. Genet Mol Biol,2015,38(4):433-443.
[28] Ferreira-Santos L,Martinez DG,Nicolau JC,et al. Neurovascular control during exercise in acute coronary syndrome patients with Gln27Glu polymorphism ofβ2-adrenergic receptor[J]. PLoS One,2017,12(2):e0173061.
[29] Staals?JM,Rokamp KZ,Olesen ND,et al. ADRB2 gly16gly genotype,cardiac output,and cerebral oxygenation in patients undergoing anesthesia for abdominal aortic aneurysm surgery[J]. Anesth Analg,2016,123(6):1408-1415.
[30] Reitman E,Conell-Price J,Evansmith J,et al.β2-adrenergic receptor genotype and other variables that contribute to labor pain and progress[J]. Anesthesiology,2011,114(4):927-939.
[31] Terkawi AS,Jackson WM,Hansoti S,et al. Polymorphism in the ADRB2 gene explains a small portion of intersubject variability in pain relative to cervical dilation in the first stage of labor[J]. Anesthesiology,2014,121(1):140-148.
[32] Marson FA,Bertuzzo CS,Ribeiro AF,et al. Polymorphisms in ADRB2 gene can modulate the response to bronchodilators and the severity of cystic fibrosis[J]. BMC Pulm Med,2012,12:50.
[33] Connor A,Baumgartner RN,Kerber RA,et al. ADRB2 G-G haplotype associated with breast cancer risk among Hispanic and non-Hispanic white women:interaction with type 2 diabetes and obesity[J]. Cancer Causes Control,2012,23(10):1653-1663.
[34] Zeng Y,Cheng L,Zhao L,et al. Interactions between social/behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China[J]. BMC Geriatr,2013,13:91.
[35] Han J,Zuo J,Zhu D,et al. The correlation between SNPs within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo[J]. J Clin Lab Anal,2018,32(5):e22366.
[36]王莉莉,张运,贺茂林.β2肾上腺素能受体基因多态性与伴发胸腺异常的重症肌无力的关系[J].中华医学杂志,2015,95(19):1518-1521.
[37] Kong DR,Wang JG,Sun B,et al.β-2 Adrenergic receptor gene polymorphism and response to propranolol in cirrhosis[J].World J Gastroenterol,2015,21(23):7191-7196.