摘要
ADRB2在多种组织细胞中广泛表达,且ADRB2基因多态性会影响基因表达、受体功能和对配体的应答。因此,近年来,ADRB2不同位点基因多态性在不同疾病中的研究越来越多。本文重点概述了ADRB2基因多态性在哮喘、慢性阻塞性肺病、肥胖、创伤后应激障碍、心血管疾病等疾病中的关键作用。
The ADRB2 gene polymorphism,widely expressed in a variety of tissue cells,affects gene expression,receptor function,and response to ligands. Therefore,in recent years,ADRB2 polymorphisms in different loci have been increasingly studied in different diseases. This article focuses on the key role of ADRB2 gene polymorphisms in some disease such as asthma,chronic obstructive pulmonary disease(COPD),obesity,post-traumatic stress disorder(PTSD),and cardiovascular disease.
引文
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