手术切除联合多磺酸粘多糖治疗耳廓瘢痕疙瘩疗效观察
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摘要
目的:探讨耳廓瘢痕疙瘩切除术联合多磺酸粘多糖对耳廓瘢痕疙瘩的治疗效果。方法:选择2007年3月-2017年11月笔者医院收治的114例耳廓瘢痕疙瘩患者作为研究对象,按照随机数字表法分为观察组和对照组,每组57例。两组均实施耳廓瘢痕疙瘩切除术,观察组在此基础上配合使用多磺酸粘多糖乳膏,2次/d。比较两组临床疗效、瘢痕病灶温哥华瘢痕量表(Vancouver scar scale,VSS)评分以及复发和感染发生情况。结果:观察组治疗有效率为87.71%,明显高于对照组的75.44%,差异有统计学意义(P<0.05)。两组患者治疗后1、6个月的VSS评分较治疗前明显下降,观察组优于对照组,差异有统计学意义(P<0.05)。两组患者的感染和复发率比较,差异无统计学意义(P>0.05)。结论:耳廓瘢痕疙瘩切除术配合多磺酸粘多糖可明显提高临床疗效,减少复发和感染率,值得临床推广应用。
Objective To observe and analyze the effect of auricle keloid resection combined with mucopolysaccharide polysulfate on auricular keloid. Methods A total of 114 patients with auricle keloids treated in our hospital from March 2007 to November 2017 were selected as study subjects and divided into the observation group and the control group according to random number table, 57 cases in each group. The patients underwent auricle keloid incision according to different conditions of auricle scar. The patients in the observation group were treated with mucopolysaccharide polysulfate cream after operation, twice daily. The clinical curative effect, scarring scars of vancouver scar scale(VSS) score, relapse and infection rate of the two groups were observed and analyzed. Results The effective rate of the observation group was 87.71%, significantly higher than that of the control group(75.44%), the difference was statistically significant(P<0.05). The VSS scores of the two groups at 1 and 6 months after treatment were significantly lower than those before treatment, the observation group was superior to the control group(P<0.05). There was no significant difference in the infection rate and recurrence rate between the two groups(P>0.05). Conclusion Auricular keloid resection combined with mucopolysaccharide polysulfate cream can significantly improve the clinical efficacy and reduce the recurrence and infection rate, it is worth promoting the use of the clinic.
Objective To observe and analyze the effect of auricle keloid resection combined with mucopolysaccharide polysulfate on auricular keloid. Methods A total of 114 patients with auricle keloids treated in our hospital from March 2007 to November 2017 were selected as study subjects and divided into the observation group and the control group according to random number table, 57 cases in each group. The patients underwent auricle keloid incision according to different conditions of auricle scar. The patients in the observation group were treated with mucopolysaccharide polysulfate cream after operation, twice daily. The clinical curative effect, scarring scars of vancouver scar scale(VSS) score, relapse and infection rate of the two groups were observed and analyzed. Results The effective rate of the observation group was 87.71%, significantly higher than that of the control group(75.44%), the difference was statistically significant(P<0.05). The VSS scores of the two groups at 1 and 6 months after treatment were significantly lower than those before treatment, the observation group was superior to the control group(P<0.05). There was no significant difference in the infection rate and recurrence rate between the two groups(P>0.05). Conclusion Auricular keloid resection combined with mucopolysaccharide polysulfate cream can significantly improve the clinical efficacy and reduce the recurrence and infection rate, it is worth promoting the use of the clinic.
引文
[1]黎柱杨,王春.耳廓瘢痕疙瘩的综合治疗[J].中国耳鼻咽喉颅底外科杂志,2014,20(2):146-148.
[2]姚明明.手术治疗耳廓瘢痕疙瘩的临床观察[J].中国医疗美容,2015,5(6):25-26.
[3]Liu K,Wu XL,Wang PH.Advances in therapy of auricular keloid[J].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2016,51(12):945-948.
[4]韩学杰,刘孟宇,连智华,等.《中医内科常见病诊疗指南》临床应用评价研究[J].中国中药杂志,2017,42(17):3257-3261.
[5]许华,鲍晓林,Xu Hua,等.耳廓瘢痕疙瘩研究进展[J].国际耳鼻咽喉头颈外科杂志,2016,40(3):151-153.
[6]任凯芳,付洋,傅全威.瘢痕疙瘩临床联合治疗研究进展[J].临床军医杂志,2017,45(10):1090-1092.
[7]吴泽勇,王绥江,黄海华,等.手术切除联合不同浓度曲安奈德注射治疗耳廓瘢痕疙瘩的临床观察[J].山东医药,2016,56(17):94-95.
[8]崔彦儒.手术切除辅助药物注射治疗耳廓瘢痕疙瘩的临床分析[J].系统医学,2016,1(12):23-25.
[9]郭文筠,汪国武,钟慧球,等.耳廓外伤的急诊处理与美容修复效果分析[J].中国美容医学,2015,24(15):5-7.
[10]闫艺之,姜佳霖,张国林,等.瘢痕疙瘩的临床治疗最新探索[J].中国美容医学,2016,25(6):34-37.
[11]黄玉成,李天举,李雅琼,等.585nm脉冲染料激光联合多磺酸粘多糖乳膏治疗瘢痕疙瘩临床观察[J].河南医学研究,2016,25(5):860-861.
[12]Masoodi Z,Ahmad I,Khurram MF,et al.Excision,skin grafting,corticosteroids,adjuvant radiotherapy,pressure therapy,and emancipation:the ESCAPE model for successful taming of giant auricular keloids[J].Adv Skin Wound Care,2014,27(9):404-412.
[13]吕操,白忠,钮燕,等.多功能电离子手术联合药物治疗耳廓瘢痕疙瘩的临床疗效观察[J].中国现代医学杂志,2016,26(7):93-95.
[14]孟繁俊.硅胶与多磺酸粘多糖联合曲安奈德治疗瘢痕156例分析[J].中国中医药咨讯,2012,4(1):33-34.
[15]卢斌珠,李健民,潘延斌.曲尼司特联合多磺酸黏多糖乳膏治疗瘢痕疙瘩和增生性瘢痕[J].广西医学,2010,32(3):339-341.
[16]许俊.手术治疗耳廓瘢痕疙瘩的临床效果观察[J].世界最新医学信息文摘,2016,27(16):95-96.
[17]Park SY,Lee GH,Park JM,et al.Clinical characteristics of auricular keloids treated with surgical excision[J].Korean J Audiol,2012,16(3):134-137.
[18]吴有位,白忠.耳廓瘢痕疙瘩综合治疗的研究进展[J].实用临床医学,2016,10(17):105-107.
[19]Recalcati S,Caccialanza M,Piccinno R,et al.Postoperative radiotherapy of auricular keloids:A 26-year experience[J].J Dermatolog Treat,2011,22(1):38-42.
[20]Park TH,Lee B,Park JH,et al.Do histopathologic parameters affect the rate of recurrence in auricular keloid patients?[J].J Craniofac Surg,2015,26(7):e571-573.
[21]Zhu Z,Shan Y,Ying L,et al.Complete earlobe keloid resection with fistulectomy[J].Dermatol Surg,2015,41(1):83-86.
[2]姚明明.手术治疗耳廓瘢痕疙瘩的临床观察[J].中国医疗美容,2015,5(6):25-26.
[3]Liu K,Wu XL,Wang PH.Advances in therapy of auricular keloid[J].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2016,51(12):945-948.
[4]韩学杰,刘孟宇,连智华,等.《中医内科常见病诊疗指南》临床应用评价研究[J].中国中药杂志,2017,42(17):3257-3261.
[5]许华,鲍晓林,Xu Hua,等.耳廓瘢痕疙瘩研究进展[J].国际耳鼻咽喉头颈外科杂志,2016,40(3):151-153.
[6]任凯芳,付洋,傅全威.瘢痕疙瘩临床联合治疗研究进展[J].临床军医杂志,2017,45(10):1090-1092.
[7]吴泽勇,王绥江,黄海华,等.手术切除联合不同浓度曲安奈德注射治疗耳廓瘢痕疙瘩的临床观察[J].山东医药,2016,56(17):94-95.
[8]崔彦儒.手术切除辅助药物注射治疗耳廓瘢痕疙瘩的临床分析[J].系统医学,2016,1(12):23-25.
[9]郭文筠,汪国武,钟慧球,等.耳廓外伤的急诊处理与美容修复效果分析[J].中国美容医学,2015,24(15):5-7.
[10]闫艺之,姜佳霖,张国林,等.瘢痕疙瘩的临床治疗最新探索[J].中国美容医学,2016,25(6):34-37.
[11]黄玉成,李天举,李雅琼,等.585nm脉冲染料激光联合多磺酸粘多糖乳膏治疗瘢痕疙瘩临床观察[J].河南医学研究,2016,25(5):860-861.
[12]Masoodi Z,Ahmad I,Khurram MF,et al.Excision,skin grafting,corticosteroids,adjuvant radiotherapy,pressure therapy,and emancipation:the ESCAPE model for successful taming of giant auricular keloids[J].Adv Skin Wound Care,2014,27(9):404-412.
[13]吕操,白忠,钮燕,等.多功能电离子手术联合药物治疗耳廓瘢痕疙瘩的临床疗效观察[J].中国现代医学杂志,2016,26(7):93-95.
[14]孟繁俊.硅胶与多磺酸粘多糖联合曲安奈德治疗瘢痕156例分析[J].中国中医药咨讯,2012,4(1):33-34.
[15]卢斌珠,李健民,潘延斌.曲尼司特联合多磺酸黏多糖乳膏治疗瘢痕疙瘩和增生性瘢痕[J].广西医学,2010,32(3):339-341.
[16]许俊.手术治疗耳廓瘢痕疙瘩的临床效果观察[J].世界最新医学信息文摘,2016,27(16):95-96.
[17]Park SY,Lee GH,Park JM,et al.Clinical characteristics of auricular keloids treated with surgical excision[J].Korean J Audiol,2012,16(3):134-137.
[18]吴有位,白忠.耳廓瘢痕疙瘩综合治疗的研究进展[J].实用临床医学,2016,10(17):105-107.
[19]Recalcati S,Caccialanza M,Piccinno R,et al.Postoperative radiotherapy of auricular keloids:A 26-year experience[J].J Dermatolog Treat,2011,22(1):38-42.
[20]Park TH,Lee B,Park JH,et al.Do histopathologic parameters affect the rate of recurrence in auricular keloid patients?[J].J Craniofac Surg,2015,26(7):e571-573.
[21]Zhu Z,Shan Y,Ying L,et al.Complete earlobe keloid resection with fistulectomy[J].Dermatol Surg,2015,41(1):83-86.