紫草油膏的制备工艺筛选
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摘要
对紫草油膏的制备工艺进行研究和筛选,得出最佳制备工艺.以煎炸法制备,通过紫草油膏不同煎炸温度、不同煎炸时间、不同油量与药量比三个制备工艺.采用正交实验,以紫草油膏中的左旋紫草素含量为考察指标,优化紫草油膏的制备工艺.结果表明,最佳提取工艺为提取温度110℃,保温时间1. 5 min,药量与油量比为1∶8时,紫草油膏的质量最好.该提取工艺可以有效地提高紫草油膏中左旋紫草素的含量,提取工艺合理、高效、经济.
This paper studied on the prepare process of Arnebiae ointment and get the best preparation technology. The preparation process of different frying temperature,different frying time,and different oil quantity and dosage ratio were prepared by frying method. The orthogonal method was used in this paper. The content of Arnebiae in Arnebiae ointment was used as the research factor,and the preparation process of Arnebiae ointment was optimized by this method. The experimental results showed that the optimum extraction process was the extraction temperature of 110 ℃. The holding time was 1. 5 min,and when the ratio of oil to oil was 1:8,the quality of Arnebiae ointment was the best. The extraction process can effectively improve the Arnebiae content in the Arnebiae ointment,and the extraction process was reasonable,efficient and economical.
This paper studied on the prepare process of Arnebiae ointment and get the best preparation technology. The preparation process of different frying temperature,different frying time,and different oil quantity and dosage ratio were prepared by frying method. The orthogonal method was used in this paper. The content of Arnebiae in Arnebiae ointment was used as the research factor,and the preparation process of Arnebiae ointment was optimized by this method. The experimental results showed that the optimum extraction process was the extraction temperature of 110 ℃. The holding time was 1. 5 min,and when the ratio of oil to oil was 1:8,the quality of Arnebiae ointment was the best. The extraction process can effectively improve the Arnebiae content in the Arnebiae ointment,and the extraction process was reasonable,efficient and economical.
引文
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[14]WANG X,HAYASHI S,UMEZAKI M,et al.Shikonin,a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells[J].Chemico-biological interactions,2014,224:117-127.
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[2]WIEDENFELD H,PIETROSIUK A,FURMANOWA M,et al.Pyrrolizidine alkaloids from Lithospermum canescens Lehm.[J].Zeitschrift für Naturforschung C A Journal of Biosciences,2003,58(3-4):173.
[3]邓丽华,肖飞,王玲,等.复方紫草油治疗婴幼儿湿疹的临床疗效观察[J].世界中医药,2017,12(6):1358-1360.
[4]谢微,陈秋娟,何星存,等.超声波辅助消解-紫外可见分光光度法测定大肉姜中的硒[J].中国调味品,2017,42(6):122-127.
[5]ZHANG Q,MA X,DZAKPASU M.Evaluation of ecotoxicological effects of benzophenone UV filters:Luminescent bacteria toxicity,genotoxicity and hormonal activity[J].Ecotoxicology and Environmental Safety,2017,142:338.
[6]KURAMOCHI H,FUJISAWA T,TAKEUCHI S,et al.Broadband stimulated Raman spectroscopy in the deep ultraviolet region[J].Chemical Physics Letters,2017,683:543-546.
[7]詹志来,胡峻,刘谈,等.紫草化学成分与药理活性研究进展[J].中国中药杂志,2015,40(21):4127-4135.
[8]张火儒,黄远圳,叶永浓.正交试验优选岭南炒薏苡仁炮制工艺[J].亚太传统医药,2017,13(13):25-26.
[9]蒲忠慧,苏海国,王力,等.正交试验法优选川芎总生物碱的提取工艺[J].成都中医药大学学报,2017,40(2):20-24.
[10]DENG Z Z,ZHAO M.The Optimization of agent formula by orthogonal experiment[J].Procedia Engineering,2016,135:649-654.
[11]郑立红,李淑莉.中药凝胶膏剂研究进展[J].中国中医药信息杂志,2017,24(4):134-136.
[12]许伟英,黄春香,吴田珠.紫草联合虎杖泡制油防治PVC所致静脉炎的疗效观察[J].中国当代医药,2017,24(15):108-110.
[13]CHOI S B,BAE G S,JO I J,et al.Protective effects of Lithospermum erythrorhizon against cerulein-induced acute pancreatitis[J].Pancreas,2015,44(1):31-40.
[14]WANG X,HAYASHI S,UMEZAKI M,et al.Shikonin,a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells[J].Chemico-biological interactions,2014,224:117-127.
[15]KO H,KIM S J,SHIM S H,et al.Shikonin induces apoptotic cell death via regulation of p53 and Nrf2 in AGS human stomach carcinoma cells[J].Biomolecules&,therapeutics,2016,24(5):501-509.