简述疫苗研发动物模型
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摘要
在过去的100年里,动物模型的研究已在人类疫苗的发展中起到至关重要的作用。动物模型的使用不仅有助于疫苗从基本研究转到临床应用,而且动物模型通常能够预测疫苗实用的潜能,从而帮助疫苗的生产商预测财政风险。由于每种动物模型都有其自身的优缺点,选择一种合适的动物模型可促进疫苗研发的顺利进行。
In the past 100 years,the animal models have played a crucial role in the development of human vaccines. Animal models help to make the translation from basic research to clinical application,and they often allow prediction of the vaccine potential in application,which helps in predicting the financial risks for vaccine manufacturers. Since each animal model has its own advantages and disadvantages,choosing a suitable animal model could promote the research and development process of vaccine.
In the past 100 years,the animal models have played a crucial role in the development of human vaccines. Animal models help to make the translation from basic research to clinical application,and they often allow prediction of the vaccine potential in application,which helps in predicting the financial risks for vaccine manufacturers. Since each animal model has its own advantages and disadvantages,choosing a suitable animal model could promote the research and development process of vaccine.
引文
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[2]McGonigle P,Ruggeri B.Animal models of human disease:challenges in enabling translation[J].Biocheml Pharmacol,2014,87(1):162-171.
[3]Fedele M,Gualillo O,Vecchione A.Animal models of human pathology 2013[J].Biomed Res Int,2014,2014:1-2.
[4]Ruggeri BA,Camp F,Miknyoczki S.Animal models of disease:Pre-clinical animal models of cancer and their applications and utility in drug discovery[J].Biochem Pharmacol,2014,87(1):150-161.
[5]Falzarano D,Bente DA.Animal models for viral hemorrhagic fever[J].Clin Microbiol Infect,2014,Apr,1.
[6]Plummer E,Shresta S.Animal models in dengue[J].Methods Mol Biol,2014,1138:377-390.
[7]McShane H,Williams A.A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data[J].Tuberculosis,2014,94(2):105-110.
[8]Izadjoo MJ,Mense MG,Bhattacharjee AK,et al.A study on the use of male animal models for developing a live vaccine for brucellosis[J].Transbound Emerg Dis,2008,55(3/4):145-151.
[9]Kiros TG,Levast B,Auray G,et al.The Importance of Animal Models in the Development of Vaccines[M]//Laura Serino.Innovation in Vaccinology,Selene Baschieri:2012:251-264.
[10]Torosantucci R,Brinks V,Kijanka G,et al.Development of a transgenic mouse model to study the immunogenicity of recombinant human insulin[J].J pharm Sci,2014,103(5):1367-1374.
[11]Calderon VE,Valbuena G,Goez Y,et al.A humanized mouse model of tuberculosis[J].PLoS One,2013,8(5):e63331.
[12]Osiceanu AM,Murao LE,Kollanur D,et al.In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks[J].Antiviral Res,2014,105:59-63.
[13]Keckler MS,Reynolds MG,Damon IK,et al.The effects of postexposure smallpox vaccination on clinical disease presentation:addressing the data gaps between historical epidemiology and modern surrogate model data[J].Vaccine,2013,31(45):5192-5201.
[14]Warfel J,Zimmerman L,Merkel T.Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model[J].Proc Natl Acad Sci USA,2014,111(2):782-792.
[15]Ploemen IH,Hirschberg HJ,Kraan H,et al.Minipigs as an animal model for dermal vaccine delivery[J].Comp Med,2014,64(1):50-54.
[16]Nordin JD,Kharbanda EO,Vazquez Benitez G,et al.Maternal influenza vaccine and risks for preterm or small for gestational age birth[J].J Pediatr,2014,165(5):1051-1057.
[17]Warfel JM,Papin JF,Wolf RF,et al.Maternal and neonatal vaccination protects newborn baboons from pertussis infection[J].J Iinfect Dis,2014,February 12.
[18]Cepeda M,Salas M,Folwarczny J,et al.Establishment of a neonatal rhesus macaque model to study Mycobacterium tuberculosis infection[J].Tuberculosis,2013,93(Suppl 1):S51-S59.
[19]Eichelberger MC,Green MD.Animal models to assess the toxicity,immunogenicity and effectiveness of candidate influenza vaccines[J].Expert Opin Drug Metab Toxicol,2011,7(9):1117-1127.
[20]Fuentes D,Chacon L,Casaco A,et al.Effects of an epidermal growth factor receptor-based cancer vaccine on wound healing and inflammation processes in murine experimental models[J].Int Wound J,2014,11(1):98-103.
[21]南大航,潘宁,张建琼.乙型肝炎动物模型研究进展[J].东南大学学报:医学版,2012,31:4.