伏立康唑注射剂临床应用情况及合理性分析
|
摘要
目的:了解某医院伏立康唑注射剂的临床应用情况,分析药物使用的合理性。方法:根据伏立康唑注射剂药品说明书,真菌感染治疗相关指南及参考文献制定合理性评价标准。利用医院HIS系统随机抽取某医院2016年1-12月份住院患者使用伏立康唑注射剂的病历,查阅病程记录及住院医嘱,进行合理性评价分析。结果:本研究纳入的50份病历在伏立康唑注射剂给药途径、溶媒选用及溶媒用量方面均合理,但在用药指征、给药剂量、给药频次和给药疗程等方面存在不规范现象。结论:该医院伏立康唑注射剂存在不合理使用现象,应进一步加强处方点评制度的实施,提高伏立康唑注射剂在临床的安全、合理使用。
AIM:To investigate the clinical application of voriconazole injection in a hospital and to analyze the rationality of drug use.METHODS:Rationality evaluation criteria were formulated according to voliconazole injection drug instructions,fungal infection treatment guidelines and references.The hospital HIS system was used to randomly select the medical records of the hospitalized patients with voriconazole from Jan.2016 to Dec.2016,and the history of the hospital and the medical advice of the hospital were consulted,and the rationality of the hospital was analyzed.RESULTS:The 50 medical records included in this study are reasonable in the way of the administration of voriconazole injection,the selection of solvent and the amount of solvent,but there are some nonstandard phenomena in the indication of drug use,the dosage,the frequency of administration and the treatment course.CONCLUSION:The irrational use of voriconazole injection in this hospital should be corrected and the implementation of the prescription review system should be further strengthened to promote the safety and rational use of voriconazole injection in clinical practice.
AIM:To investigate the clinical application of voriconazole injection in a hospital and to analyze the rationality of drug use.METHODS:Rationality evaluation criteria were formulated according to voliconazole injection drug instructions,fungal infection treatment guidelines and references.The hospital HIS system was used to randomly select the medical records of the hospitalized patients with voriconazole from Jan.2016 to Dec.2016,and the history of the hospital and the medical advice of the hospital were consulted,and the rationality of the hospital was analyzed.RESULTS:The 50 medical records included in this study are reasonable in the way of the administration of voriconazole injection,the selection of solvent and the amount of solvent,but there are some nonstandard phenomena in the indication of drug use,the dosage,the frequency of administration and the treatment course.CONCLUSION:The irrational use of voriconazole injection in this hospital should be corrected and the implementation of the prescription review system should be further strengthened to promote the safety and rational use of voriconazole injection in clinical practice.
引文
[1]张弨.伏立康唑的药效学研究评价[J].中国临床药理学与治疗学,2018,23(1):116-120.
[2]《抗菌药物临床应用指导原则》修订工作组.抗菌药物临床应用指导原则(2015年版)[M].北京:人民卫生出版社,201:44.
[3]陈恳,陈耀龙,张相林,等.伏立康唑个体化用药指南计划书[J].药物流行病学杂志,2017,26(4):289-293.
[4]匡扶,钱妍,余娴,等.注射用伏立康唑临床合理使用评价标准的制定[J].川北医学院学报,2015,30(3):283-286.
[5]中华内科杂志编辑委员会.侵袭性肺部真菌感染的诊断标准与治疗原则(草案)[J].中华内科杂志,2006,45(8):697-700.
[6]中国侵袭性真菌感染工作组.血液病恶性肿瘤患者侵袭性真菌病的诊断标准与治疗原则(第四次修订版)[J].中华内科杂志,2013,52(8):704-709.
[7]中华医学会重症医学分会.重症患者侵袭性真菌感染诊断与治疗指南[J].中华内科杂志,2007,46(11):960-966.
[8]赵晶,周颖,崔一民.29例伏立康唑致精神症状不良反应分析[J].临床药物治疗杂志,2016,14(4):67-71.
[9]汪向海,金艺凤,邢敏.伏立康唑引起精神症状的影响因素分析[J].皖南医学院学报,2016,35(1):44-47.
[10]冯飞飞,张晓云,任秋霞.伏立康唑致精神、视觉障碍和肝功能异常1例[J].中国药物应用与监测,2017,14(2):128-129.
[11]王陶陶,陈思颖,尤海生,等.侵袭性真菌感染患者伏立康唑肝毒性的研究[J].中国药学杂志,2018,53(4):290-294.
[12]刘亮,郭美华,陈岩.高效液相色谱法测定人血浆中伏立康唑浓度及其应用[J].中国药物应用与监测,2017,14(4):205-208.
[13]张娟,廖银根.伏立康唑的抗真菌机制与治疗药物监测进展[J].中国药房,2012,23(14):1322-1324.
[14]戴婷婷,胡林,李逃明,等.伏立康唑所致精神异常与其血浆谷浓度的相关性探讨[J].中国药学杂志,2018,53(5):375-378.
[2]《抗菌药物临床应用指导原则》修订工作组.抗菌药物临床应用指导原则(2015年版)[M].北京:人民卫生出版社,201:44.
[3]陈恳,陈耀龙,张相林,等.伏立康唑个体化用药指南计划书[J].药物流行病学杂志,2017,26(4):289-293.
[4]匡扶,钱妍,余娴,等.注射用伏立康唑临床合理使用评价标准的制定[J].川北医学院学报,2015,30(3):283-286.
[5]中华内科杂志编辑委员会.侵袭性肺部真菌感染的诊断标准与治疗原则(草案)[J].中华内科杂志,2006,45(8):697-700.
[6]中国侵袭性真菌感染工作组.血液病恶性肿瘤患者侵袭性真菌病的诊断标准与治疗原则(第四次修订版)[J].中华内科杂志,2013,52(8):704-709.
[7]中华医学会重症医学分会.重症患者侵袭性真菌感染诊断与治疗指南[J].中华内科杂志,2007,46(11):960-966.
[8]赵晶,周颖,崔一民.29例伏立康唑致精神症状不良反应分析[J].临床药物治疗杂志,2016,14(4):67-71.
[9]汪向海,金艺凤,邢敏.伏立康唑引起精神症状的影响因素分析[J].皖南医学院学报,2016,35(1):44-47.
[10]冯飞飞,张晓云,任秋霞.伏立康唑致精神、视觉障碍和肝功能异常1例[J].中国药物应用与监测,2017,14(2):128-129.
[11]王陶陶,陈思颖,尤海生,等.侵袭性真菌感染患者伏立康唑肝毒性的研究[J].中国药学杂志,2018,53(4):290-294.
[12]刘亮,郭美华,陈岩.高效液相色谱法测定人血浆中伏立康唑浓度及其应用[J].中国药物应用与监测,2017,14(4):205-208.
[13]张娟,廖银根.伏立康唑的抗真菌机制与治疗药物监测进展[J].中国药房,2012,23(14):1322-1324.
[14]戴婷婷,胡林,李逃明,等.伏立康唑所致精神异常与其血浆谷浓度的相关性探讨[J].中国药学杂志,2018,53(5):375-378.