药品不良反应报告147例的回顾性分析
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摘要
目的掌握南京鼓楼医院集团安庆市石化医院药品不良反应(ADR)发生的特点和规律。方法利用Excel,回顾性分析2011年1月至2013年12月上报的147例药品不良反应报告。结果 147例ADR报告中,A型不良反应有140例,占95.24%,B型不良反应有7例,占4.76%,无C型不良反应。60岁以上老年病人所占比例最高,为41.50%;给药途径中,静脉给药所占比例最高,为81.63%;涉及药品种类中,抗感染药物所占比例最高,为49.66%;临床表现以皮肤及其附件损害最多,为42.18%;上报科室以呼吸内科最多,为38.78%;上报人以临床医师最多,为75.51%。结论 ADR的发生不可完全避免,但是在临床实践中,因不合理用药导致的A型不良反应(有140例,占95.24%)却占有重要比例。要提升药师的药学服务能力,促进药学监测工作的开展,才能确保病人用药安全,做到合理用药。
Objective To master the characteristics and regularity of adverse drug reactions(ADR) in Nanjing Gulou Hospital Group Anqing Petrochemical Hospital.Methods One hundred and forty-seven adverse drug reactions reported from January 2011 to December 2013 was retrospectively analyzed using Excel.Results Among the 147 cases of ADR,there were 140 cases of type A adverse reactions,accounting for 95.24%,there were 7 cases of B type adverse reactions,accounting for 4.76%,and there was no C type adverse reaction.Patients older than 60 years accounted for the highest proportion of 41.50%;the route of administration,the proportion of intravenous administration was the highest(81.63%);involving the types of drugs,anti-infective drugs accounted for the highest proportion of 49.66%;the clinical manifestations of the damage of skin and its appendages were most,accounting for 42.18%;Department of Respiratory Medicine was the most frequently reported department(38.78%),clinicians was the most reported people(75.51%).Conclusions The occurrence of ADR cannot be completely avoided,but in clinical practice,the A type adverse reactions caused by irrational use of drugs occupy an important proportion(140 cases,accounting for 95.24%).To improve the pharmaceutical service ability of pharmacists and promote the development of pharmaceutical monitoring,it is necessary to ensure the safety of patients' medication and rational use of drugs.
Objective To master the characteristics and regularity of adverse drug reactions(ADR) in Nanjing Gulou Hospital Group Anqing Petrochemical Hospital.Methods One hundred and forty-seven adverse drug reactions reported from January 2011 to December 2013 was retrospectively analyzed using Excel.Results Among the 147 cases of ADR,there were 140 cases of type A adverse reactions,accounting for 95.24%,there were 7 cases of B type adverse reactions,accounting for 4.76%,and there was no C type adverse reaction.Patients older than 60 years accounted for the highest proportion of 41.50%;the route of administration,the proportion of intravenous administration was the highest(81.63%);involving the types of drugs,anti-infective drugs accounted for the highest proportion of 49.66%;the clinical manifestations of the damage of skin and its appendages were most,accounting for 42.18%;Department of Respiratory Medicine was the most frequently reported department(38.78%),clinicians was the most reported people(75.51%).Conclusions The occurrence of ADR cannot be completely avoided,but in clinical practice,the A type adverse reactions caused by irrational use of drugs occupy an important proportion(140 cases,accounting for 95.24%).To improve the pharmaceutical service ability of pharmacists and promote the development of pharmaceutical monitoring,it is necessary to ensure the safety of patients' medication and rational use of drugs.
引文
[1] 张艳,李苑雅,沈爱宗.某三甲医院1603例药品不良反应报告分析[J].安徽医药,2017,21(1):183-186.
[2] 张锃亮,高萍,赵丽,等.中国药品不良反应信息通报15年回顾分析[J].药物流行病学杂志,2016,25(11):698-703.
[3] 贾宏军,郑晓辉,赵振营.新版《抗菌药物临床应用指导原则》(2015)的解读[J].天津药学,2016,28(5):46-48.
[4] 桑滨生.《中医药发展战略规划纲要(2016—2030年)》解读[J].世界科学技术-中医药现代化,2016,18(7):1088-1092.
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[6] 尹航,郭鑫,李忻.915例药品不良事件用药分析[J].中国药物应用与监测,2017,14(5):289-292,316.
[7] 吴迪,王真.某院2013—2015年813例ADR报告分析[J].中国药房,2017,28(17):2359-2362.
[8] 黄翠丽,郭代红,朱曼,等.军队医院9819例喹诺酮类药物药品不良反应/事件报告分析[J].中国药物应用与监测,2017,14(5):293-296.
[9] 田春华.促进医疗机构药品不良反应监测工作的思考[J].中国药物警戒,2016,13(5):272-274.
[10] 杨悦.近年我国药品不良反应报告与监测总体情况分析[J].西北药学杂志,2016,31(3):323-326.
[11] 杜成凤,钱妍,邓丹.医院临床药师药学服务能力及影响因素研究[J].中国药房,2017,28(17):2436-2440.
[12] 袁芳,黄瑾,王建,等.上海市浦东新区人民医院196例新的和严重的药品不良反应报告分析[J].中国医院用药评价与分析,2016,16(1):92-94.
[13] 王晓骏,路长飞,赵玉娟,等.我国药品不良反应公众报告途径和报告内容调研和思考[J].中国药物警戒,2017,14(7):413-418.
[14] 张鑫,金永新,杨丽宁,等.临床药物治疗中用药错误的风险识别研究[J].中国药事,2017,31(4):423-429.
[2] 张锃亮,高萍,赵丽,等.中国药品不良反应信息通报15年回顾分析[J].药物流行病学杂志,2016,25(11):698-703.
[3] 贾宏军,郑晓辉,赵振营.新版《抗菌药物临床应用指导原则》(2015)的解读[J].天津药学,2016,28(5):46-48.
[4] 桑滨生.《中医药发展战略规划纲要(2016—2030年)》解读[J].世界科学技术-中医药现代化,2016,18(7):1088-1092.
[5] 叶思款,袁进,凌丽,等.2009年度我院药品不良反应监测工作总结[J].实用药物与临床,2011,14(3):247-249.
[6] 尹航,郭鑫,李忻.915例药品不良事件用药分析[J].中国药物应用与监测,2017,14(5):289-292,316.
[7] 吴迪,王真.某院2013—2015年813例ADR报告分析[J].中国药房,2017,28(17):2359-2362.
[8] 黄翠丽,郭代红,朱曼,等.军队医院9819例喹诺酮类药物药品不良反应/事件报告分析[J].中国药物应用与监测,2017,14(5):293-296.
[9] 田春华.促进医疗机构药品不良反应监测工作的思考[J].中国药物警戒,2016,13(5):272-274.
[10] 杨悦.近年我国药品不良反应报告与监测总体情况分析[J].西北药学杂志,2016,31(3):323-326.
[11] 杜成凤,钱妍,邓丹.医院临床药师药学服务能力及影响因素研究[J].中国药房,2017,28(17):2436-2440.
[12] 袁芳,黄瑾,王建,等.上海市浦东新区人民医院196例新的和严重的药品不良反应报告分析[J].中国医院用药评价与分析,2016,16(1):92-94.
[13] 王晓骏,路长飞,赵玉娟,等.我国药品不良反应公众报告途径和报告内容调研和思考[J].中国药物警戒,2017,14(7):413-418.
[14] 张鑫,金永新,杨丽宁,等.临床药物治疗中用药错误的风险识别研究[J].中国药事,2017,31(4):423-429.