鱼类肠道应激及其损伤防护研究进展
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摘要
"应激"是动物机体在外界环境或身体内部产生异常刺激时做出的各种生理应答反应的总和,它直接影响着鱼类的代谢、生长和免疫等多方面。肠道是鱼类消化吸收营养物质的重要场所,是"最大的免疫器官",也是鱼类与外界环境联系最紧密的部位之一。肠道的结构与功能正常与否直接关系到鱼类个体的健康。本文综述了应激对鱼类肠道组织形态及肠道菌群的影响,以及热应激蛋白、益生菌和益生元等在鱼类肠道损伤防护作用方面的研究进展,以期为深入研究鱼类肠道应激损伤防护机制提供参考。
Stress response is the collective physiological responses of animals to both external and internal abnormal stimulations. It has direct effects on the metabolism, growth and immunity of fish. The intestine is an important place for fish to digest and absorb nutrients. It is also the largest immune organ, and one of important sites where fish cooperate with the external environment. The structure and function of the intestine tract are directly related to the health of fish. This article reviewed the effects of stress on fish intestinal structure and intestinal flora at different stages of growth and development, and the research progresses in heat shock protein, probiotics and prebiotics and the protection of intestinal injury. The review provided also some references for further studies on the protection mechanism of intestinal stress injury in fish.
Stress response is the collective physiological responses of animals to both external and internal abnormal stimulations. It has direct effects on the metabolism, growth and immunity of fish. The intestine is an important place for fish to digest and absorb nutrients. It is also the largest immune organ, and one of important sites where fish cooperate with the external environment. The structure and function of the intestine tract are directly related to the health of fish. This article reviewed the effects of stress on fish intestinal structure and intestinal flora at different stages of growth and development, and the research progresses in heat shock protein, probiotics and prebiotics and the protection of intestinal injury. The review provided also some references for further studies on the protection mechanism of intestinal stress injury in fish.
引文
[1] Tort L.Stress and immune modulation in fish[J].Developmental & Comparative Immunology,United States,2011,35(12):1366-1375.
[2] Ley R E,Hamady M,Lozupone C,et al.Evolution of mammals and their gut microbes[J].Science,United States,2008,320(5883):1647-1651.
[3] Sugiharto S,Yudiarti T,Isroli I,et al.Dietary supplementation of probiotics in poultry exposed to heat stress - a review[J].Annals of Animal Science,Poland,2016,17(3):591-604.
[4] Pickering A D.Growth and stress in fish production[J].Aquaculture,Netherlands,1993,111(1-4):51-63.
[5] Bonga S E W.Stress response in fish[J].Physiological Reviews,United States,1997,77(3):591-625.
[6] Barton B A,Iwama G K.Physiological changes in fish from stress in aquaculture with emphasis on the response and effects of corticosteroids[J].Annual review of fish diseases,United Kingdom,1991,1(1):3-26.
[7] 刘波.高温应激与大黄蒽醌提取物对团头鲂生理反应及相关应激蛋白表达的影响[D].南京农业大学,南京,2012.
[8] 沈凡,樊启学,杨凯,等.不同溶氧条件下黄颡鱼免疫机能及抗病力的研究[J].淡水渔业,武汉,2010,40(4):44-49.
[9] KOMMALY ONXAYVIENG.不同养殖密度对黄颡鱼组份和抗氧化系统产生的相关影响[D].华中农业大学,武汉,2016.
[10] Selye H.Stress and the general adaptation syndrome[J].British medical journal,United Kingdom,1950,1(4667):1383.
[11] 汪开毓,耿毅,钟妮娜.鱼类应激性出血症的病理学研究[J].淡水渔业,武汉,2000,30(11):28-31.
[12] 姚金水,陈家祥,祁保民.欧洲鳗的不适应性反应与"狂游病"的关系初探[J].动物医学进展,杨陵,1999(3) :144-146.
[13] 母丹利,袁思平,薛聪顺,等.马口鱼消化道的形态及组织学结构特征[J].宁波大学学报(理工版),宁波,2016,29(3):39-44.
[14] 关海红,徐伟,匡友谊,等.哲罗鱼与2种有胃鱼消化系统比较解剖的观察[J].水产学杂志,黑龙江,2008,21(2):42-46.
[15] 傅丽容,陈学光,黎学春,等.奥尼罗非鱼消化系统的组织学研究[J].水产养殖,南京,2008,29(05):1-3.
[16] 阮国良,杨代勤,王卫民.草鱼、鳡和翘嘴鲌消化道组织的早期发育[J].水生生物学报,武汉,2012,36(6):1164-1170.
[17] 谢木娇,区又君,李加儿,等.不同发育阶段的四指马鲅消化道组织学比较研究[J].南方水产科学,广州,2016,12(2):51-58.
[18] 陈慕雁,张秀梅.大菱鲆仔稚幼鱼消化系统发育的组织学研究[J].水生生物学报,2006,30(2):236-240.
[19] 区又君,李加儿,勾效伟,等.黄斑篮子鱼消化道组织学和组织化学研究[J].南方水产科学,广州,2013,9(5):51-57.
[20] Alvarez-González C A,Cervantes-Trujano M,Tovar-Ramírez D,et al.Development of digestive enzymes in California halibut Paralichthys californicus larvae[J].Fish Physiology and Biochemistry,Netherlands,2005,31(1):83-93.
[21] MLA 蒋朱明,于康.肠黏膜屏障损害与肠外和肠内营养[J].外科理论与实践,上海,2000,5(1):54-56.
[22] Abreu-Martin M T,Targan S R.Regulation of immune responses of the intestinal mucosa[J].Critical Reviews in Immunology,United States,1996,16(3):277-309.
[23] 张杏波.食性对草鱼消化道发育及三种消化酶活性的影响[D].暨南大学,广州,2012.
[24] Sugita H,Oshima K,Tamura M,et al.Bacterial flora in the gastrointestine of freshwater fishes in the river[J].Nihon-suisan-gakkai-shi,Japan,1983,49(49):1387-1395.
[25] Sugita H,Enomoto A,Deguchi Y.Intestinal microflora in the fry of Tilapia mossambica.[J].Bulletin of the Japanese Society of Scientific Fisheries,Japan,1982,48(6):875-875.
[26] 吴小峰,赵庆新.关于草鱼肠炎微生态调节的研究[J].微生物学杂志,朝阳,2003,23(04):23-24.
[27] 葛莉莉.鱼类肠道菌群的研究概况[J].水生态学杂志,武汉,2006,26(04):17-20.
[28] Ray A K,Ghosh K,Ringo E.Enzyme-producing bacteria isolated from fish gut:a review[J].Aquaculture Nutrition,United Kingdom,2012,18(5):465-492.
[29] Swank G M,Deitch E A.Role of the gut in multiple organ failure:bacterial translocation and permeability changes[J].World journal of surgery,Germany,1996,20(4):411-417.
[30] Van D H,Doolgindachbaporn S,Suksri A.Effects of low molecular weight agar and Lactobacillus plantarum on growth performance,immunity,and disease resistance of basa fish (Pangasius bocourti,Sauvage 1880)[J].Fish & Shellfish Immunology,United States,2014,41(2):340-345.
[31] Lopetuso L R,Petito V,Graziani C,et al.Gut microbiota in health,diverticular disease,irritable bowel syndrome,and inflammatory bowel diseases:time for microbial marker of gastrointestinal disorders[J].Digestive Diseases,Switzerland,2017,36(1):56-65.
[32] McKenzie C,Tan J,Macia L,et al.The nutrition-gut microbiome-physiology axis and allergic diseases[J].Immunological reviews,United Kingdom,2017,278(1):277-295.
[33] Postler T S,Ghosh S.Understanding the holobiont:how microbial metabolites affect human health and shape the immune system[J].Cell Metabolism,United States,2017,26(1):110-130.
[34] van de Wouw M,Schellekens H,Dinan T G,et al.Microbiota-gut-brain axis:modulator of host metabolism and appetite[J].Journal of Nutrition,United States,2017,147(5):727-745.
[35] Bairagi A,Ghosh K S,Sen S K,et al.Enzyme producing bacterial flora isolated from fish digestive tracts[J].Aquaculture International,Netherlands,2002,10(2):109-121.
[36] 迟骋.鲤肠道优势菌对其免疫功能的影响[D].西北农林科技大学,杨陵,2014.
[37] Sugita H,Miyajima C,Deguchi Y.The vitamin B 12 -producing ability of the intestinal microflora of freshwater fish[J].Aquaculture,Netherlands,1991,92(2-3):267-276.
[38] 李英英,陈曦,宋铁英.不同生长速度的大黄鱼肠道菌群结构的差异[J].大连海洋大学学报,大连,2017,32(5):509-513.
[39] Uni Z,Gal-Garber O,Geyra A,et al.Changes in growth and function of chick small intestine epithelium due to early thermal conditioning[J].Poultry Science,United States,2001,80(4):438-445.
[40] Yamauchi K,Kamisoyama H,Isshiki Y.Effects of fasting and refeeding on structures of the intestinal villi and epithelial cells in White Leghorn hens[J].British poultry science,United Kingdom,1996,37(5):909-921.
[41] 刘晓琳.H9N2AIV对肉鸡肠道菌群和肠道组织紧密连接的影响[D].华南农业大学,广州,2016.
[42] 翁幼竹,方永强.饥饿对斜带石斑鱼稚鱼胃肠道内分泌细胞的形态、定位和分布密度的影响[J].应用海洋学学报,厦门,2011,30(01):10-16.
[43] 宋海霞,翁幼竹,方琼珊,等.斜带石斑鱼幼鱼饥饿前后胃肠道的组织学研究[J].应用海洋学学报,厦门,2008,27(01):74-78.
[44] 齐国山.饥饿对星突江鲽幼鱼影响的初步研究[D].中国海洋大学,青岛,2009.
[45] 谢骏,王广军,邓岳松,等.耐高温酶制剂对奥尼罗非鱼免疫和肠道结构的影响[J].渔业现代化,上海,2008,35(3):27-30.
[46] 陈科全,叶元土,蔡春芳,等.饲料氧化鱼油引起草鱼肠道结构损伤、通透性增加[J].水生生物学报,武汉,2016,40(04):804-813.
[47] 夏永娟,黄威权,姜国良.鳗弧菌感染牙鲆的组织学和免疫组织化学观察[J].海洋科学,青岛,2000,24(10):41-44.
[48] Olsen R E,Sundell K,Hansen T,et al.Acute stress alters the intestinal lining of Atlantic salmon,Salmo salar L.:an electron microscopical study[J].Fish physiology and biochemistry,Netherlands,2002,26(3):211-221.
[49] Handeland S O,Imsland A K,Stefansson S O.The effect of temperature and fish size on growth,feed intake,food conversion efficiency and stomach evacuation rate of Atlantic salmon post-smolts[J].Aquaculture,Netherlands,2008,283(1):36-42.
[50] Bayne B L.The Effects of stress and pollution on marine animals[M].Praeger,United States,1985,384-394.
[51] Tzeng T D,Pao Y Y,Chen P C,et al.Effects of host phylogeny and habitats on gut microbiomes of oriental river prawn (Macrobrachium nipponense)[J].Plos One,United States,2015,10(7):e0132860.
[52] Turnbaugh P J,Backhed F,Fulton L,et al.Marked alterations in the distal gut microbiome linked to diet-induced obesity[J].Cell host & microbe,United States,2008,3(4):213-223.
[53] Yang L,Liu S,Ding J,et al.Gut microbiota co-microevolution with selection for host humoral immunity[J].Frontiers in microbiology,Switzerland,2017,8:1243.
[54] Jia W,Li H,Zhao L,et al.Gut microbiota:a potential new territory for drug targeting[J].Nature reviews Drug discovery,United Kingdom,2008,7(2):123-129.
[55] Givens C E.A fish tale:comparison of the gut microbiome of 15 fish species and the influence of diet and temperature on its composition[D].University of Georgia,United States,2012.
[56] 陈孝煊,吴志新,周文豪.鱼类消化道菌群的作用与影响因素研究进展[J].养殖与饲料,武汉,2005,24(5):523-528.
[57] 李东亮.感染嗜水气单胞菌草鱼肠道菌群结构研究[D].西北农林科技大学,杨陵,2016.
[58] Margolis L.The effect of fasting on the bacterial flora of the intestine of fish[J].Journal of the Fisheries Board of Canada,Canada,1953,10(2):62-63.
[59] 李星浩,颜庆云,胡红娟,等.异育银鲫消化道微生物群落对恢复投喂的响应[J].水生生物学报,武汉,2014,38(5):854-859.
[60] 郁二蒙,毕香梅,谢骏,等.摄食不同饵料草鱼肠道菌群PCR-DGGE指纹图谱构建及分子鉴定[J].生物技术通报,北京,2012(9):179-184.
[61] 周文豪,陈孝煊,张冬晓,等.摄食不同饵料对草鱼肠道菌群影响的研究[J].华中农业大学学报,武汉,1998(3):252-256.
[62] 陈成,耿毅,汪开毓,等.拟态弧菌感染黄颡鱼的动态病理损伤及病原分布研究[J].南方水产科学,广州,2017,13(1):10-18.
[63] 高会会,侯立婷,李槿年,等.拟态弧菌的绿色荧光蛋白标记及其在感染草鱼体内的动态分布[J].水产学报,上海,2015,39(4):557-565.
[64] Yang Y,Liu Z,Lu S,et al.Molecular cloning,expression and characterization of programmed cell death 10 from sheep (Ovis aries)[J].Gene,Netherlands,2015,558(1):65.
[65] 李铁,张席锦.氧自由基在应激性胃溃疡中的发病学意义[J].生理学报,北京,1993(3):286-291.
[66] 周建华,丛国正,高闪电,等.细胞凋亡的研究进展[J].生物技术通讯,北京,2008,19(2):274-276.
[67] Danial N N,Korsmeyer S J.Cell death:critical control points[J].Cell,United States,2004,116(2):205-219.
[68] Nayak S K,Swain P,Nanda P K,et al.Immunomodulating potency of lipopolysaccharides (LPS) derived from smooth type of bacterial pathogens in Indian major carp[J].Veterinary Microbiology,Netherlands,2011,151(3-4):413-417.
[69] Kakuta I,Ogata T,Igarashi K,et al.Effect of orally administrated bovine lactoferrin on the survival rate of juvenile ayu,Plecoglossus altivelis,held under deteriorating environmental conditions[J].Suisanzoshoku,Japan,1998,46:93-96.
[70] 潘孝毅,张琴,李俊,等.饲料中添加甘氨酸可提高大黄鱼(Larimichthys crocea)的抗氧化和抗应激能力[J].渔业科学进展,青岛,2017,38(2):91-98.
[71] Khalil A A,Kabapy N F,Deraz S F,et al.Heat shock proteins in oncology:Diagnostic biomarkers or therapeutic targets[J].Biochimica Et Biophysica Acta,Netherlands,2011,1816(2):89-104.
[72] Robert R E.Biological indicators of stress in fish[J].Transactions of the American Fisheries Society,United States,1992,121(2):274-276.
[73] Bakthisaran R,Tangirala R,Rao C.Small heat shock proteins:Role in cellular functions and pathology[J].Biochimica Et Biophysica Acta,Netherlands,2015,1854(4):291.
[74] 刘玮丽.热休克蛋白HSP70在萎缩性胃炎的表达及其作用机制研究[D].浙江大学,杭州,2007.
[75] Zhang M,Lv Y,Yue Z,et al.Effects of transportation on expression of Hsp90,Hsp70,Hsp27 and αB-crystallin in the pig stomach[J].Veterinary Record,United Kingdom,2011,169(12):312.
[76] 张红艳,吕农华,谢勇,等.严重烫伤大鼠胃黏膜一氧化氮合酶和环氧合酶-2表达变化及其与热休克蛋白70的关系[J].中华消化杂志,上海,2008,28(2):117-119.
[77] Hwang I Y,Quan J H,Ahn M H,et al.Toxoplasma gondii,infection inhibits the mitochondrial apoptosis through induction of Bcl-2 and HSP70[J].Parasitology Research,Germany,2010,107(6):1313-1321.
[78] Yuan Z Q,Zhang Y,Li X L,et al.HSP70 protects intestinal epithelial cells from hypoxia/reoxygenation injury via a mechanism that involves the mitochondrial pathways[J].European Journal of Pharmacology,Netherlands,2010,643(3):282-288.
[79] 高焕云.替普瑞酮对斜带石斑鱼消化道HSPs诱导效应及其应激保护作用初步研究[D].河南农业大学,郑州,2015.
[80] Suemasu S,Tanaka K,Namba T,et al.A role for HSP70 in protecting against indomethacin-induced gastric lesions[J].Journal of Biological Chemistry,United States,2009,284(29):19705-19715.
[81] Wischmeyer P E,Musch M W,Madonna M B,et al.Glutamine protects intestinal epithelial cells:role of inducible HSP70[J].American Journal of Physiology,United States,1997,272(1):879-884.
[82] Odashima M,Otaka M,Jin M,et al.Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine[J].Digestive diseases and sciences,United States,2002,47(12):2799-2804.
[83] Termen S,Tollin M,Rodriguez E,et al.PU.1 and bacterial metabolites regulate the human gene CAMP,encoding antimicrobial peptide LL-37 in colon epithelial cells[J].Molecular Immunology,United Kingdom,2008,45(15):3947-3955.
[84] 涂宗,庞娟娟,王辉,等.水环境中重金属铜对异育银鲫肠道微生物的影响[J].微生物学报,北京,2017,57(7):1060-1068.
[85] Narrowe A B,Albuthilantz M,Smith E P,et al.Perturbation and restoration of the fathead minnow gut microbiome after low-level triclosan exposure[J].Microbiome,United Kingdom,2015,3(1):6.
[86] Kan H,Zhao F,Zhang X X,et al.Correlations of gut microbial community shift with hepatic damage and growth inhibition of Carassius auratus induced by pentachlorophenol exposure.[J].Environmental Science & Technology,United States,2015,49(19):11894-11902.
[87] Hai N V.The use of probiotics in aquaculture[J].Journal of Applied Microbiology,United Kingdom,2015,119:917-935.
[88] De B C,Meena D K,Behera B K,et al.Probiotics in fish and shellfish culture:immunomodulatory and ecophysiological responses[J].Fish physiology and biochemistry,Netherlands,2014,40(3):921-971.
[89] Kozasa M.Toyocerin (Bacillus toyoi) as growth promotor for animal feeding[J].Microbiology Aliment Nutrition,United States,1986,4(1):121-135.
[90] 陈营,王福强,邵占涛,等.乳酸菌对牙鲆稚鱼养殖水体和肠道菌群的影响[J].渔业科学进展,青岛,2006,27(3):37-41.
[91] Sugita H,Hirose Y,Matsuo N,et al.Production of the antibacterial substance by Bacillus sp.strain NM 12,an intestinal bacterium of Japanese coastal fish[J].Aquaculture,Netherlands,1998,165(3-4):269-280.
[92] 刘波,刘文斌,王恬.地衣芽孢杆菌对异育银鲫消化机能和生长的影响[J].南京农业大学学报,南京,2005,28(4):80-84.
[93] 黄路.酿酒酵母在鱼类中的益生效应研究[D].华中农业大学,武汉,2015.
[94] 刘淮德.应用微生物分子生态学方法研究对虾肠道细菌组成及其变化规律[D].中国科学院研究生院(海洋研究所),青岛,2010.
[95] 潘康成,冯轼.微生态制剂在绿色养殖中的作用[J].中国家禽,扬州,2008,30(14):39-41.
[96] O'Toole P W,Marchesi J R,Hill C.Next-generation probiotics:the spectrum from probiotics to live biotherapeutics[J].Nature Microbiology,United Kingdom,2017,2(5):17057.
[97] Villena J,Kitazawa H.Immunobiotics-interactions of beneficial microbes with the immune System[J].Frontiers in Immunology,Switzerland,2017,8(2):1580.
[98] Villena J,Vizoso-Pinto M G,Kitazawa H.Intestinal innate antiviral immunity and immunobiotics:beneficial effects against rotavirus infection[J].Frontiers in Immunology,Switzerland,2016,7(9478).
[99] Albarracin L,Kobayashi H,Iida H,et al.Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells:influence of immunobiotic Lactobacilli[J].Frontiers in Immunology,Switzerland,2017,8(2):57.
[100] Gibson G R,Hutkins R,Sanders M E,et al.Expert consensus document:the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics[J].Nature Reviews Gastroenterology & Hepatology,United Kingdom,2017,14:491-502.
[101] Boehm G,Lidestri M,Casetta P,et al.Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants[J].Archives of Disease in Childhood-Fetal and Neonatal Edition,United Kingdom,2002,86(3):F178-F181.
[102] Salze G,Mclean E,Schwarz M H,et al.Dietary mannan oligosaccharide enhances salinity tolerance and gut development of larval cobia[J].Aquaculture,Netherlands,2008,274(1):148-152.
[103] Torrecillas S,Makol A,Caballero M J,et al.Immune stimulation and improved infection resistance in European sea bass (Dicentrarchus labrax) fed mannan oligosaccharides[J].Fish & Shellfish Immunology,United States,2007,23(5):969-981.
[104] Cook M T,Hayball P J,Hutchinson W,et al.Administration of a commercial immunostimulant preparation,EcoActiva as a feed supplement enhances macrophage respiratory burst and the growth rate of snapper (Pagrus auratus,Sparidae (Bloch and Schneider)) in winter[J].Fish & Shellfish Immunology,United States,2003,14(4):333-345.
[105] Claussen J C,Skiecevi?ienè J,Wang J,et al.Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome[J].Plos Computational Biology,United States,2017,13(6):e1005361.
[2] Ley R E,Hamady M,Lozupone C,et al.Evolution of mammals and their gut microbes[J].Science,United States,2008,320(5883):1647-1651.
[3] Sugiharto S,Yudiarti T,Isroli I,et al.Dietary supplementation of probiotics in poultry exposed to heat stress - a review[J].Annals of Animal Science,Poland,2016,17(3):591-604.
[4] Pickering A D.Growth and stress in fish production[J].Aquaculture,Netherlands,1993,111(1-4):51-63.
[5] Bonga S E W.Stress response in fish[J].Physiological Reviews,United States,1997,77(3):591-625.
[6] Barton B A,Iwama G K.Physiological changes in fish from stress in aquaculture with emphasis on the response and effects of corticosteroids[J].Annual review of fish diseases,United Kingdom,1991,1(1):3-26.
[7] 刘波.高温应激与大黄蒽醌提取物对团头鲂生理反应及相关应激蛋白表达的影响[D].南京农业大学,南京,2012.
[8] 沈凡,樊启学,杨凯,等.不同溶氧条件下黄颡鱼免疫机能及抗病力的研究[J].淡水渔业,武汉,2010,40(4):44-49.
[9] KOMMALY ONXAYVIENG.不同养殖密度对黄颡鱼组份和抗氧化系统产生的相关影响[D].华中农业大学,武汉,2016.
[10] Selye H.Stress and the general adaptation syndrome[J].British medical journal,United Kingdom,1950,1(4667):1383.
[11] 汪开毓,耿毅,钟妮娜.鱼类应激性出血症的病理学研究[J].淡水渔业,武汉,2000,30(11):28-31.
[12] 姚金水,陈家祥,祁保民.欧洲鳗的不适应性反应与"狂游病"的关系初探[J].动物医学进展,杨陵,1999(3) :144-146.
[13] 母丹利,袁思平,薛聪顺,等.马口鱼消化道的形态及组织学结构特征[J].宁波大学学报(理工版),宁波,2016,29(3):39-44.
[14] 关海红,徐伟,匡友谊,等.哲罗鱼与2种有胃鱼消化系统比较解剖的观察[J].水产学杂志,黑龙江,2008,21(2):42-46.
[15] 傅丽容,陈学光,黎学春,等.奥尼罗非鱼消化系统的组织学研究[J].水产养殖,南京,2008,29(05):1-3.
[16] 阮国良,杨代勤,王卫民.草鱼、鳡和翘嘴鲌消化道组织的早期发育[J].水生生物学报,武汉,2012,36(6):1164-1170.
[17] 谢木娇,区又君,李加儿,等.不同发育阶段的四指马鲅消化道组织学比较研究[J].南方水产科学,广州,2016,12(2):51-58.
[18] 陈慕雁,张秀梅.大菱鲆仔稚幼鱼消化系统发育的组织学研究[J].水生生物学报,2006,30(2):236-240.
[19] 区又君,李加儿,勾效伟,等.黄斑篮子鱼消化道组织学和组织化学研究[J].南方水产科学,广州,2013,9(5):51-57.
[20] Alvarez-González C A,Cervantes-Trujano M,Tovar-Ramírez D,et al.Development of digestive enzymes in California halibut Paralichthys californicus larvae[J].Fish Physiology and Biochemistry,Netherlands,2005,31(1):83-93.
[21] MLA 蒋朱明,于康.肠黏膜屏障损害与肠外和肠内营养[J].外科理论与实践,上海,2000,5(1):54-56.
[22] Abreu-Martin M T,Targan S R.Regulation of immune responses of the intestinal mucosa[J].Critical Reviews in Immunology,United States,1996,16(3):277-309.
[23] 张杏波.食性对草鱼消化道发育及三种消化酶活性的影响[D].暨南大学,广州,2012.
[24] Sugita H,Oshima K,Tamura M,et al.Bacterial flora in the gastrointestine of freshwater fishes in the river[J].Nihon-suisan-gakkai-shi,Japan,1983,49(49):1387-1395.
[25] Sugita H,Enomoto A,Deguchi Y.Intestinal microflora in the fry of Tilapia mossambica.[J].Bulletin of the Japanese Society of Scientific Fisheries,Japan,1982,48(6):875-875.
[26] 吴小峰,赵庆新.关于草鱼肠炎微生态调节的研究[J].微生物学杂志,朝阳,2003,23(04):23-24.
[27] 葛莉莉.鱼类肠道菌群的研究概况[J].水生态学杂志,武汉,2006,26(04):17-20.
[28] Ray A K,Ghosh K,Ringo E.Enzyme-producing bacteria isolated from fish gut:a review[J].Aquaculture Nutrition,United Kingdom,2012,18(5):465-492.
[29] Swank G M,Deitch E A.Role of the gut in multiple organ failure:bacterial translocation and permeability changes[J].World journal of surgery,Germany,1996,20(4):411-417.
[30] Van D H,Doolgindachbaporn S,Suksri A.Effects of low molecular weight agar and Lactobacillus plantarum on growth performance,immunity,and disease resistance of basa fish (Pangasius bocourti,Sauvage 1880)[J].Fish & Shellfish Immunology,United States,2014,41(2):340-345.
[31] Lopetuso L R,Petito V,Graziani C,et al.Gut microbiota in health,diverticular disease,irritable bowel syndrome,and inflammatory bowel diseases:time for microbial marker of gastrointestinal disorders[J].Digestive Diseases,Switzerland,2017,36(1):56-65.
[32] McKenzie C,Tan J,Macia L,et al.The nutrition-gut microbiome-physiology axis and allergic diseases[J].Immunological reviews,United Kingdom,2017,278(1):277-295.
[33] Postler T S,Ghosh S.Understanding the holobiont:how microbial metabolites affect human health and shape the immune system[J].Cell Metabolism,United States,2017,26(1):110-130.
[34] van de Wouw M,Schellekens H,Dinan T G,et al.Microbiota-gut-brain axis:modulator of host metabolism and appetite[J].Journal of Nutrition,United States,2017,147(5):727-745.
[35] Bairagi A,Ghosh K S,Sen S K,et al.Enzyme producing bacterial flora isolated from fish digestive tracts[J].Aquaculture International,Netherlands,2002,10(2):109-121.
[36] 迟骋.鲤肠道优势菌对其免疫功能的影响[D].西北农林科技大学,杨陵,2014.
[37] Sugita H,Miyajima C,Deguchi Y.The vitamin B 12 -producing ability of the intestinal microflora of freshwater fish[J].Aquaculture,Netherlands,1991,92(2-3):267-276.
[38] 李英英,陈曦,宋铁英.不同生长速度的大黄鱼肠道菌群结构的差异[J].大连海洋大学学报,大连,2017,32(5):509-513.
[39] Uni Z,Gal-Garber O,Geyra A,et al.Changes in growth and function of chick small intestine epithelium due to early thermal conditioning[J].Poultry Science,United States,2001,80(4):438-445.
[40] Yamauchi K,Kamisoyama H,Isshiki Y.Effects of fasting and refeeding on structures of the intestinal villi and epithelial cells in White Leghorn hens[J].British poultry science,United Kingdom,1996,37(5):909-921.
[41] 刘晓琳.H9N2AIV对肉鸡肠道菌群和肠道组织紧密连接的影响[D].华南农业大学,广州,2016.
[42] 翁幼竹,方永强.饥饿对斜带石斑鱼稚鱼胃肠道内分泌细胞的形态、定位和分布密度的影响[J].应用海洋学学报,厦门,2011,30(01):10-16.
[43] 宋海霞,翁幼竹,方琼珊,等.斜带石斑鱼幼鱼饥饿前后胃肠道的组织学研究[J].应用海洋学学报,厦门,2008,27(01):74-78.
[44] 齐国山.饥饿对星突江鲽幼鱼影响的初步研究[D].中国海洋大学,青岛,2009.
[45] 谢骏,王广军,邓岳松,等.耐高温酶制剂对奥尼罗非鱼免疫和肠道结构的影响[J].渔业现代化,上海,2008,35(3):27-30.
[46] 陈科全,叶元土,蔡春芳,等.饲料氧化鱼油引起草鱼肠道结构损伤、通透性增加[J].水生生物学报,武汉,2016,40(04):804-813.
[47] 夏永娟,黄威权,姜国良.鳗弧菌感染牙鲆的组织学和免疫组织化学观察[J].海洋科学,青岛,2000,24(10):41-44.
[48] Olsen R E,Sundell K,Hansen T,et al.Acute stress alters the intestinal lining of Atlantic salmon,Salmo salar L.:an electron microscopical study[J].Fish physiology and biochemistry,Netherlands,2002,26(3):211-221.
[49] Handeland S O,Imsland A K,Stefansson S O.The effect of temperature and fish size on growth,feed intake,food conversion efficiency and stomach evacuation rate of Atlantic salmon post-smolts[J].Aquaculture,Netherlands,2008,283(1):36-42.
[50] Bayne B L.The Effects of stress and pollution on marine animals[M].Praeger,United States,1985,384-394.
[51] Tzeng T D,Pao Y Y,Chen P C,et al.Effects of host phylogeny and habitats on gut microbiomes of oriental river prawn (Macrobrachium nipponense)[J].Plos One,United States,2015,10(7):e0132860.
[52] Turnbaugh P J,Backhed F,Fulton L,et al.Marked alterations in the distal gut microbiome linked to diet-induced obesity[J].Cell host & microbe,United States,2008,3(4):213-223.
[53] Yang L,Liu S,Ding J,et al.Gut microbiota co-microevolution with selection for host humoral immunity[J].Frontiers in microbiology,Switzerland,2017,8:1243.
[54] Jia W,Li H,Zhao L,et al.Gut microbiota:a potential new territory for drug targeting[J].Nature reviews Drug discovery,United Kingdom,2008,7(2):123-129.
[55] Givens C E.A fish tale:comparison of the gut microbiome of 15 fish species and the influence of diet and temperature on its composition[D].University of Georgia,United States,2012.
[56] 陈孝煊,吴志新,周文豪.鱼类消化道菌群的作用与影响因素研究进展[J].养殖与饲料,武汉,2005,24(5):523-528.
[57] 李东亮.感染嗜水气单胞菌草鱼肠道菌群结构研究[D].西北农林科技大学,杨陵,2016.
[58] Margolis L.The effect of fasting on the bacterial flora of the intestine of fish[J].Journal of the Fisheries Board of Canada,Canada,1953,10(2):62-63.
[59] 李星浩,颜庆云,胡红娟,等.异育银鲫消化道微生物群落对恢复投喂的响应[J].水生生物学报,武汉,2014,38(5):854-859.
[60] 郁二蒙,毕香梅,谢骏,等.摄食不同饵料草鱼肠道菌群PCR-DGGE指纹图谱构建及分子鉴定[J].生物技术通报,北京,2012(9):179-184.
[61] 周文豪,陈孝煊,张冬晓,等.摄食不同饵料对草鱼肠道菌群影响的研究[J].华中农业大学学报,武汉,1998(3):252-256.
[62] 陈成,耿毅,汪开毓,等.拟态弧菌感染黄颡鱼的动态病理损伤及病原分布研究[J].南方水产科学,广州,2017,13(1):10-18.
[63] 高会会,侯立婷,李槿年,等.拟态弧菌的绿色荧光蛋白标记及其在感染草鱼体内的动态分布[J].水产学报,上海,2015,39(4):557-565.
[64] Yang Y,Liu Z,Lu S,et al.Molecular cloning,expression and characterization of programmed cell death 10 from sheep (Ovis aries)[J].Gene,Netherlands,2015,558(1):65.
[65] 李铁,张席锦.氧自由基在应激性胃溃疡中的发病学意义[J].生理学报,北京,1993(3):286-291.
[66] 周建华,丛国正,高闪电,等.细胞凋亡的研究进展[J].生物技术通讯,北京,2008,19(2):274-276.
[67] Danial N N,Korsmeyer S J.Cell death:critical control points[J].Cell,United States,2004,116(2):205-219.
[68] Nayak S K,Swain P,Nanda P K,et al.Immunomodulating potency of lipopolysaccharides (LPS) derived from smooth type of bacterial pathogens in Indian major carp[J].Veterinary Microbiology,Netherlands,2011,151(3-4):413-417.
[69] Kakuta I,Ogata T,Igarashi K,et al.Effect of orally administrated bovine lactoferrin on the survival rate of juvenile ayu,Plecoglossus altivelis,held under deteriorating environmental conditions[J].Suisanzoshoku,Japan,1998,46:93-96.
[70] 潘孝毅,张琴,李俊,等.饲料中添加甘氨酸可提高大黄鱼(Larimichthys crocea)的抗氧化和抗应激能力[J].渔业科学进展,青岛,2017,38(2):91-98.
[71] Khalil A A,Kabapy N F,Deraz S F,et al.Heat shock proteins in oncology:Diagnostic biomarkers or therapeutic targets[J].Biochimica Et Biophysica Acta,Netherlands,2011,1816(2):89-104.
[72] Robert R E.Biological indicators of stress in fish[J].Transactions of the American Fisheries Society,United States,1992,121(2):274-276.
[73] Bakthisaran R,Tangirala R,Rao C.Small heat shock proteins:Role in cellular functions and pathology[J].Biochimica Et Biophysica Acta,Netherlands,2015,1854(4):291.
[74] 刘玮丽.热休克蛋白HSP70在萎缩性胃炎的表达及其作用机制研究[D].浙江大学,杭州,2007.
[75] Zhang M,Lv Y,Yue Z,et al.Effects of transportation on expression of Hsp90,Hsp70,Hsp27 and αB-crystallin in the pig stomach[J].Veterinary Record,United Kingdom,2011,169(12):312.
[76] 张红艳,吕农华,谢勇,等.严重烫伤大鼠胃黏膜一氧化氮合酶和环氧合酶-2表达变化及其与热休克蛋白70的关系[J].中华消化杂志,上海,2008,28(2):117-119.
[77] Hwang I Y,Quan J H,Ahn M H,et al.Toxoplasma gondii,infection inhibits the mitochondrial apoptosis through induction of Bcl-2 and HSP70[J].Parasitology Research,Germany,2010,107(6):1313-1321.
[78] Yuan Z Q,Zhang Y,Li X L,et al.HSP70 protects intestinal epithelial cells from hypoxia/reoxygenation injury via a mechanism that involves the mitochondrial pathways[J].European Journal of Pharmacology,Netherlands,2010,643(3):282-288.
[79] 高焕云.替普瑞酮对斜带石斑鱼消化道HSPs诱导效应及其应激保护作用初步研究[D].河南农业大学,郑州,2015.
[80] Suemasu S,Tanaka K,Namba T,et al.A role for HSP70 in protecting against indomethacin-induced gastric lesions[J].Journal of Biological Chemistry,United States,2009,284(29):19705-19715.
[81] Wischmeyer P E,Musch M W,Madonna M B,et al.Glutamine protects intestinal epithelial cells:role of inducible HSP70[J].American Journal of Physiology,United States,1997,272(1):879-884.
[82] Odashima M,Otaka M,Jin M,et al.Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine[J].Digestive diseases and sciences,United States,2002,47(12):2799-2804.
[83] Termen S,Tollin M,Rodriguez E,et al.PU.1 and bacterial metabolites regulate the human gene CAMP,encoding antimicrobial peptide LL-37 in colon epithelial cells[J].Molecular Immunology,United Kingdom,2008,45(15):3947-3955.
[84] 涂宗,庞娟娟,王辉,等.水环境中重金属铜对异育银鲫肠道微生物的影响[J].微生物学报,北京,2017,57(7):1060-1068.
[85] Narrowe A B,Albuthilantz M,Smith E P,et al.Perturbation and restoration of the fathead minnow gut microbiome after low-level triclosan exposure[J].Microbiome,United Kingdom,2015,3(1):6.
[86] Kan H,Zhao F,Zhang X X,et al.Correlations of gut microbial community shift with hepatic damage and growth inhibition of Carassius auratus induced by pentachlorophenol exposure.[J].Environmental Science & Technology,United States,2015,49(19):11894-11902.
[87] Hai N V.The use of probiotics in aquaculture[J].Journal of Applied Microbiology,United Kingdom,2015,119:917-935.
[88] De B C,Meena D K,Behera B K,et al.Probiotics in fish and shellfish culture:immunomodulatory and ecophysiological responses[J].Fish physiology and biochemistry,Netherlands,2014,40(3):921-971.
[89] Kozasa M.Toyocerin (Bacillus toyoi) as growth promotor for animal feeding[J].Microbiology Aliment Nutrition,United States,1986,4(1):121-135.
[90] 陈营,王福强,邵占涛,等.乳酸菌对牙鲆稚鱼养殖水体和肠道菌群的影响[J].渔业科学进展,青岛,2006,27(3):37-41.
[91] Sugita H,Hirose Y,Matsuo N,et al.Production of the antibacterial substance by Bacillus sp.strain NM 12,an intestinal bacterium of Japanese coastal fish[J].Aquaculture,Netherlands,1998,165(3-4):269-280.
[92] 刘波,刘文斌,王恬.地衣芽孢杆菌对异育银鲫消化机能和生长的影响[J].南京农业大学学报,南京,2005,28(4):80-84.
[93] 黄路.酿酒酵母在鱼类中的益生效应研究[D].华中农业大学,武汉,2015.
[94] 刘淮德.应用微生物分子生态学方法研究对虾肠道细菌组成及其变化规律[D].中国科学院研究生院(海洋研究所),青岛,2010.
[95] 潘康成,冯轼.微生态制剂在绿色养殖中的作用[J].中国家禽,扬州,2008,30(14):39-41.
[96] O'Toole P W,Marchesi J R,Hill C.Next-generation probiotics:the spectrum from probiotics to live biotherapeutics[J].Nature Microbiology,United Kingdom,2017,2(5):17057.
[97] Villena J,Kitazawa H.Immunobiotics-interactions of beneficial microbes with the immune System[J].Frontiers in Immunology,Switzerland,2017,8(2):1580.
[98] Villena J,Vizoso-Pinto M G,Kitazawa H.Intestinal innate antiviral immunity and immunobiotics:beneficial effects against rotavirus infection[J].Frontiers in Immunology,Switzerland,2016,7(9478).
[99] Albarracin L,Kobayashi H,Iida H,et al.Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells:influence of immunobiotic Lactobacilli[J].Frontiers in Immunology,Switzerland,2017,8(2):57.
[100] Gibson G R,Hutkins R,Sanders M E,et al.Expert consensus document:the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics[J].Nature Reviews Gastroenterology & Hepatology,United Kingdom,2017,14:491-502.
[101] Boehm G,Lidestri M,Casetta P,et al.Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants[J].Archives of Disease in Childhood-Fetal and Neonatal Edition,United Kingdom,2002,86(3):F178-F181.
[102] Salze G,Mclean E,Schwarz M H,et al.Dietary mannan oligosaccharide enhances salinity tolerance and gut development of larval cobia[J].Aquaculture,Netherlands,2008,274(1):148-152.
[103] Torrecillas S,Makol A,Caballero M J,et al.Immune stimulation and improved infection resistance in European sea bass (Dicentrarchus labrax) fed mannan oligosaccharides[J].Fish & Shellfish Immunology,United States,2007,23(5):969-981.
[104] Cook M T,Hayball P J,Hutchinson W,et al.Administration of a commercial immunostimulant preparation,EcoActiva as a feed supplement enhances macrophage respiratory burst and the growth rate of snapper (Pagrus auratus,Sparidae (Bloch and Schneider)) in winter[J].Fish & Shellfish Immunology,United States,2003,14(4):333-345.
[105] Claussen J C,Skiecevi?ienè J,Wang J,et al.Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome[J].Plos Computational Biology,United States,2017,13(6):e1005361.