塑料包装材料中双酚A毒性及检测研究进展
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摘要
双酚A(BPA)主要用于生产聚碳酸酯、环氧树脂等高分子材料,广泛用于食品及生活品的包装。本文介绍了BPA的毒性、各国对BPA在食品包装上的管控情况及BPA的仪器分析技术进展,为相关食品包装材料中BPA研究提供参考。
Bisphenol A(BPA) is mainly used in the production of polycarbonate,epoxy resin and other polymer materials. It widely used in the packaging of food and daily life products. In this paper,the toxicity of BPA,the control of BPA in food packaging and the development of instrument analysis technology of BPA are introduced,which provides reference for BPA research in relevant food packaging materials.
Bisphenol A(BPA) is mainly used in the production of polycarbonate,epoxy resin and other polymer materials. It widely used in the packaging of food and daily life products. In this paper,the toxicity of BPA,the control of BPA in food packaging and the development of instrument analysis technology of BPA are introduced,which provides reference for BPA research in relevant food packaging materials.
引文
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[2]Kitamura S,Suzuki T,Sanoh S,et al.Comparative Study of the Endocrine-Disrupting Activity of Bisphenol Aand 19 Related Compounds.Toxicological Sciences,2005,84(2):249-259.
[3]王佳.双酚A对机体影响及其机制的研究进展[J].预防医学情报杂志,2005,21(5):541-544.
[4]Toyohira Y,Utsunomiya K,Ueno S,et al.Inhibition of the norepinephrine transporter function in cultured bovine adrenal medullary cells by bisphenol A.Biochemical Pharmacology,2003,65(12):2049-2054.
[5]Monje L,Varayoud J,Mu?oz-de-Toro M,et al.Neonatal exposure to bisphenol A alters estrogendependent mechanisms governing sexual behavior in the adult female rat.Reproductive Toxicology,2009,28(4):435-442.
[6]方超,宁博,范江霖,等.双酚A(BPA)暴露对WHHL家兔糖类和脂类代谢的影响[J].生态毒理学报,2015,10(1):252-262.
[7]刘红玲,刘晓华,王晓祎,等.双酚A和四溴双酚A对大型溞和斑马鱼的毒性[J].环境科学,2007,28(8):1784-1787.
[8]徐红梅,江云,谢庆效,等.双酚A对昆明小鼠免疫毒性的研究[J].环境科学学报,2015,35(9):3013-3019.
[9]Murray T J,Maffini M V,Ucci A A,et al.Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure[J].Reproductive Toxicology,2007,23(3):383-390.
[10]茅昌飞.双酚A介导GPR30诱导乳腺癌细胞增殖的机制研究[D].南京:南京医科大学,2015.
[11]张巍,谭岩,方艳秋.GPR30-EGFR信号通路在双酚A促乳腺癌细胞增殖中的作用[J].中国妇幼保健,2013,28(14):2286-2289.
[12]阴海鹏,张玲,李翠玲,等.双酚A对人卵巢癌3AO细胞、前列腺癌DU145细胞及子宫内膜癌HHUA细胞增殖活性的影响[J].环境与健康杂志,2011,28(1):29-32.
[13](EU)No 10/2011 On plastic materials and products in contact with food[M].2011.
[14]黄铃,谢明军,蒋燕.气相色谱法分析双酚A中的微量酚类杂质[J].石油化工,2002,31(6):476-478.
[15]马强,白桦,王超,等.高效液相色谱法对纺织品和食品包装材料中的壬基酚、辛基酚和双酚A的同时测定[J].分析测试学报,2009,28(10):1160-1164.
[16]高永刚,张艳艳,高建国,等.衍生化气相色谱-质谱法测定玩具和食品接触材料中双酚A[J].色谱,2012,30(10):1017-1020.
[17]黄少婵,杭义萍.液相色谱-质谱法同时测定塑料制品中的双酚A和四溴双酚A[J].色谱,2010,28(9):863-866.
[18]李璐.化妆品中抗氧化剂及化妆品塑料包装中双酚A的测定[D].长春:吉林大学,2014.
[19]余辉,何凤云,卞育蓉.塑料瓶中双酚A的电化学测定方法研究[J].化学分析计量,2012,21(3):48-51.
[20]贺彩梅,冯荣荣,李晓霞.石墨烯修饰电化学适配体传感器测定双酚A[J].分析试验室,2017,36(11):1306-1309.
[21]Mita D G,Attanasio A,Arduini F,et al.Enzymatic determination of BPA by means of tyrosinase immobilized on different carbon carriers[J].Biosensors and Bioelectronics,2007,23(1):60-65.
[22]蔡亚岐,江桂斌,周庆祥.胶束电动色谱法分离和测定双酚A、辛基酚和壬基酚[J].分析化学,2004,32,(9):1179-1181.
[23]卢丹,薛丰,薛勇,等.高效毛细管电泳-紫外检测法测定饮料等包装材料中的BPA[J].分析试验室,2011,30(9):112-115.
[24]石春红.酶联免疫法检测双酚A的研究[D].无锡:江南大学,2008.
[25]魏孔吉,赵美萍,李元宗,等.生物素-亲和素放大酶联免疫吸附法测定双酚A[J].分析化学,2005,33(8):1122-1124.
[26]Alexandrovich P R,Eugene S R.Situ determination of DPC and BPA in polycarbonate by Raman Spectroscopy[P].2003,US 6608678.
[27]Lee S N,Stolarski V,Letton A,et al.Studies of bisphenol-A-polycarbonateaging by Raman difference spectroscopy[J].Journal of Molecular Structure,2000,521(1/3):19-24.
[28]汪仕韬.表面增强拉曼光谱法检测双酚A的研究[D].无锡:江南大学,2010.
[29]食品接触材料及制品2,2-二(4-羟基苯基)丙烷(双酚A)迁移量的测定[S]:GB 31604.10-2016.北京:中国标准出版社,2016.
[30]食品接触材料高分子材料食品模拟物中2,2-二(4-羟基苯基)丙烷(双酚A)的测定高效液相色谱法[S]:GB/T 23296.16-2009.北京:中国标准出版社,2009.
[2]Kitamura S,Suzuki T,Sanoh S,et al.Comparative Study of the Endocrine-Disrupting Activity of Bisphenol Aand 19 Related Compounds.Toxicological Sciences,2005,84(2):249-259.
[3]王佳.双酚A对机体影响及其机制的研究进展[J].预防医学情报杂志,2005,21(5):541-544.
[4]Toyohira Y,Utsunomiya K,Ueno S,et al.Inhibition of the norepinephrine transporter function in cultured bovine adrenal medullary cells by bisphenol A.Biochemical Pharmacology,2003,65(12):2049-2054.
[5]Monje L,Varayoud J,Mu?oz-de-Toro M,et al.Neonatal exposure to bisphenol A alters estrogendependent mechanisms governing sexual behavior in the adult female rat.Reproductive Toxicology,2009,28(4):435-442.
[6]方超,宁博,范江霖,等.双酚A(BPA)暴露对WHHL家兔糖类和脂类代谢的影响[J].生态毒理学报,2015,10(1):252-262.
[7]刘红玲,刘晓华,王晓祎,等.双酚A和四溴双酚A对大型溞和斑马鱼的毒性[J].环境科学,2007,28(8):1784-1787.
[8]徐红梅,江云,谢庆效,等.双酚A对昆明小鼠免疫毒性的研究[J].环境科学学报,2015,35(9):3013-3019.
[9]Murray T J,Maffini M V,Ucci A A,et al.Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure[J].Reproductive Toxicology,2007,23(3):383-390.
[10]茅昌飞.双酚A介导GPR30诱导乳腺癌细胞增殖的机制研究[D].南京:南京医科大学,2015.
[11]张巍,谭岩,方艳秋.GPR30-EGFR信号通路在双酚A促乳腺癌细胞增殖中的作用[J].中国妇幼保健,2013,28(14):2286-2289.
[12]阴海鹏,张玲,李翠玲,等.双酚A对人卵巢癌3AO细胞、前列腺癌DU145细胞及子宫内膜癌HHUA细胞增殖活性的影响[J].环境与健康杂志,2011,28(1):29-32.
[13](EU)No 10/2011 On plastic materials and products in contact with food[M].2011.
[14]黄铃,谢明军,蒋燕.气相色谱法分析双酚A中的微量酚类杂质[J].石油化工,2002,31(6):476-478.
[15]马强,白桦,王超,等.高效液相色谱法对纺织品和食品包装材料中的壬基酚、辛基酚和双酚A的同时测定[J].分析测试学报,2009,28(10):1160-1164.
[16]高永刚,张艳艳,高建国,等.衍生化气相色谱-质谱法测定玩具和食品接触材料中双酚A[J].色谱,2012,30(10):1017-1020.
[17]黄少婵,杭义萍.液相色谱-质谱法同时测定塑料制品中的双酚A和四溴双酚A[J].色谱,2010,28(9):863-866.
[18]李璐.化妆品中抗氧化剂及化妆品塑料包装中双酚A的测定[D].长春:吉林大学,2014.
[19]余辉,何凤云,卞育蓉.塑料瓶中双酚A的电化学测定方法研究[J].化学分析计量,2012,21(3):48-51.
[20]贺彩梅,冯荣荣,李晓霞.石墨烯修饰电化学适配体传感器测定双酚A[J].分析试验室,2017,36(11):1306-1309.
[21]Mita D G,Attanasio A,Arduini F,et al.Enzymatic determination of BPA by means of tyrosinase immobilized on different carbon carriers[J].Biosensors and Bioelectronics,2007,23(1):60-65.
[22]蔡亚岐,江桂斌,周庆祥.胶束电动色谱法分离和测定双酚A、辛基酚和壬基酚[J].分析化学,2004,32,(9):1179-1181.
[23]卢丹,薛丰,薛勇,等.高效毛细管电泳-紫外检测法测定饮料等包装材料中的BPA[J].分析试验室,2011,30(9):112-115.
[24]石春红.酶联免疫法检测双酚A的研究[D].无锡:江南大学,2008.
[25]魏孔吉,赵美萍,李元宗,等.生物素-亲和素放大酶联免疫吸附法测定双酚A[J].分析化学,2005,33(8):1122-1124.
[26]Alexandrovich P R,Eugene S R.Situ determination of DPC and BPA in polycarbonate by Raman Spectroscopy[P].2003,US 6608678.
[27]Lee S N,Stolarski V,Letton A,et al.Studies of bisphenol-A-polycarbonateaging by Raman difference spectroscopy[J].Journal of Molecular Structure,2000,521(1/3):19-24.
[28]汪仕韬.表面增强拉曼光谱法检测双酚A的研究[D].无锡:江南大学,2010.
[29]食品接触材料及制品2,2-二(4-羟基苯基)丙烷(双酚A)迁移量的测定[S]:GB 31604.10-2016.北京:中国标准出版社,2016.
[30]食品接触材料高分子材料食品模拟物中2,2-二(4-羟基苯基)丙烷(双酚A)的测定高效液相色谱法[S]:GB/T 23296.16-2009.北京:中国标准出版社,2009.