纳米孔单分子传感器电导特性有限元分析
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摘要
主要从纳米孔结构角度,考虑生物分子在纳米孔内的位阻效应影响。运用有限元模拟方法分别模拟了3类常见纳米孔的电导,并比较了3种不同纳米孔在检测纳米杆通过纳米孔时的相对堵塞电流值大小。研究了纳米杆上带有亚结构时,在3种纳米孔内的电流堵塞效应的差异。研究方法有助于进一步理解纳米孔结构对检测生物分子的影响。
Mainly consider influence of steric effect of biomolecule inside the nanopore from the perspective of nanopore structure.Finite element simulation method is used to simulate conductance of three common types of nanopore.The relative blockade current value of three nanopores while the testing nanorod is passing through the nanpores are compared.In the meantime,the difference of current blockade effect of nanorod with substructure in three nanopores is also researched. This work is helpful to understand the influence of nanopore structure on detecting biomolecules.
Mainly consider influence of steric effect of biomolecule inside the nanopore from the perspective of nanopore structure.Finite element simulation method is used to simulate conductance of three common types of nanopore.The relative blockade current value of three nanopores while the testing nanorod is passing through the nanpores are compared.In the meantime,the difference of current blockade effect of nanorod with substructure in three nanopores is also researched. This work is helpful to understand the influence of nanopore structure on detecting biomolecules.
引文
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[2]Merchant C A,Healy K,Wanunu M,et al.DNA translocation through graphene nanopores[J].Nano Letters,2010,10(8):2915-2921.
[3]Schneider G F,Kowalczyk S W,Calado V E,et al.DNA translocation through graphene nanopores[J].Nano Letters,2010,10(8):3163-3167.
[4]Garaj S,Hubbard W,Reina A,et al.Graphene as a subnanometre trans-electrode membrane[J].Nature,2010,467(7312):190-193.
[5]Liu K,Feng J,Kis A,et al.Atomically thin molybdenum disulfide nanopores with high sensitivity for DNA translocation[J].ACS Nano,2014,8(3):2504-2511.
[6]Liu S,Lu B,Zhao Q,et al.Boron nitride nanopores:Highly sensitive DNA single-molecule detectors[J].Advanced Materials,2013,25(33):4549-4554.
[7]Li J,Zhang Y,Yang J,et al.Molecular dynamics study of DNA translocation through graphene nanopores[J].Physical Review E,2013,87(6):062707—1-062707—6.
[8]Borsenberger V,Mitchell N,Howorka S.Chemically labeled nucleotides and oligonucleotides encode DNA for sensing with nanopores[J].Journal of the American Chemical Society,2009,131(22):7530-7531.
[9]Clarke J,Wu H,Jayasinghe L,et al.Continuous base identification for single-molecule nanopore DNA sequencing[J].Nature Nanotechnology,2009,4(4):265-270.
[10]Derrington I M,Butler T Z,Collins M D,et al.Nanopore DNA sequencing with Msp A[C]∥Proceedings of the National Academy of Sciences,2010:16060-16065.
[11]Hall J E.Access resistance of a small circular pore[J].The Journal of General Physiology,1975,66(4):531-532.
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[13]Kowalczyk S W,Grosberg A Y,Rabin Y,et al.Modeling the conductance and DNA blockade of solid-state nanopores[J].Nanotechnology,2011,22(31):315101—1-315101—5.
[14]Smeets R M,Keyser U F,Krapf D,et al.Salt dependence of ion transport and DNA translocation through solid-state nanopores[J].Nano Letters,2006,6(1):89-95.
[15]Zhang Y,Wu G,Si W,et al.Ionic current modulation from DNA translocation through nanopores under high ionic strength and concentration gradients[J].Nanoscale,2017,9(2):930-939.