母体叶酸水平与子代生长发育状况相关性的研究进展
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摘要
叶酸是一种重要的人体必需营养素。研究表明,孕期补充叶酸可以预防多种出生缺陷的发生,已有多个国家全面推行了叶酸强化政策。但有证据指出,过量补充叶酸不仅无法预防疾病,还会适得其反。目前研究聚焦在母体叶酸补充剂量与子代健康的相关性上,特别是孕期过量补充叶酸是否会对子代造成副作用。本文拟从叶酸的代谢、人群叶酸营养水平、临床常见的叶酸检测方法、应用以及母体叶酸摄入异常对后代生长发育的影响4个方面进行综述。
Folic acid, as one of the essential nutrients, plays a crucial role in human body. Recent researches showed that the supplementation of folic acid during pregnancy could prevent various birth defects, and many countries around the world having implemented policies of folic acid fortification. However, there are epidemiological evidences that excess folic acid supplement may not only fail to exert preventive effects on diseases, but may also be counter productive. Therefore, recent researches are focusing on the correlation of maternal folic acid level and the growth and development of offspring, in particular, whether the excess folic acid supplementation during pregnancy will cause detrimental side effects on offspring. In this article, the metabolism of folic acid, the crowd nutrient level of folic acid,the common detection methods used clinically and their application, and the effects of abnormal maternal intake of folic acid on the growth and development of offspring are reviewed.
Folic acid, as one of the essential nutrients, plays a crucial role in human body. Recent researches showed that the supplementation of folic acid during pregnancy could prevent various birth defects, and many countries around the world having implemented policies of folic acid fortification. However, there are epidemiological evidences that excess folic acid supplement may not only fail to exert preventive effects on diseases, but may also be counter productive. Therefore, recent researches are focusing on the correlation of maternal folic acid level and the growth and development of offspring, in particular, whether the excess folic acid supplementation during pregnancy will cause detrimental side effects on offspring. In this article, the metabolism of folic acid, the crowd nutrient level of folic acid,the common detection methods used clinically and their application, and the effects of abnormal maternal intake of folic acid on the growth and development of offspring are reviewed.
引文
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[13]杨晓光,翟凤英,朴建华,等.中国居民营养状况调查[J].中国预防医学杂志,2010,11(1):5-7.DOI:10.3772/j.issn.1009-5659.2010.01.025.
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[16]Stamm RA,Houghton LA.Nutrient intake values for folate during pregnancy and lactation vary widely around the world[J].Nutrients,2013,5(10):3920-3947.DOI:10.3390/nu5103920.
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[18]Rycyna KJ,Bacich DJ,O’Keefe DS.Divergence between dietary folate intake and concentrations in the serum and red blood cells of aging males in the United States[J].Clin Nutr,2015,35(4):928-934.DOI:10.1016/j.clnu.2015.07.002.
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[23]孙红,王留娣.124例孕妇妊娠期血清叶酸水平动态观察[J].上海预防医学杂志,2002,14(2):60-61.DOI:10.3969/j.issn.1004-9231.2002.02.004.
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[25]沈国平,沈国松,毕丹,等.妊娠20周内血清叶酸及同型半胱氨酸水平检测分析[J].浙江预防医学,2016,28(6):631-633.
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