针对中枢神经系统的核酸递送策略及其诊疗应用
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摘要
近年来,基于核酸分子的探针与药物在针对中枢系统的诊疗应用中展现出强大的潜力。但是,复杂的中枢神经系统以及生理屏障使得核酸分子的递送成为一大难题。因此,开发更加高效而安全的中枢神经递送载体仍是一项迫切需求。本文综述了目前针对中枢神经系统的多种核酸递送方式,包括利用病毒载体、非病毒载体以及无载体递送等方法。这些方法在一定程度上提高了核酸药物递送的效率以及在机体内的稳定性,获得了较好的诊断与治疗效果。本文讨论了这些递送方式的优势和局限性,并对新型核酸递送载体的发展进行了展望。
[Background] The use of nucleic acid in the diagnosis and treatment of diseases and injuries of the central nervous system(CNS) has shown great promise in recent years. However, transporting nucleic acids to CNS with highly complex structure and barriers remains challenging. [Purpose] This study aims to give a comprehensive review of efficient and low-toxic delivery strategies of nucleic acids towards central nervous system for theranostic applications.[Methods] By means of literature review, the progress in developing nucleic acid delivery strategies for applications in CNS in recent years are analyzed. These strategies can be categorized into viral vector-based, nonviral carrier-based, and carrier-free. We also discussed their advantages and limitations, and provided suggestions for the future development of novel strategies. [Results & Conclusion] These strategies have been shown to enhance the structural stability and cell uptake of the nucleic acids, thus improving the theranostic performance.
[Background] The use of nucleic acid in the diagnosis and treatment of diseases and injuries of the central nervous system(CNS) has shown great promise in recent years. However, transporting nucleic acids to CNS with highly complex structure and barriers remains challenging. [Purpose] This study aims to give a comprehensive review of efficient and low-toxic delivery strategies of nucleic acids towards central nervous system for theranostic applications.[Methods] By means of literature review, the progress in developing nucleic acid delivery strategies for applications in CNS in recent years are analyzed. These strategies can be categorized into viral vector-based, nonviral carrier-based, and carrier-free. We also discussed their advantages and limitations, and provided suggestions for the future development of novel strategies. [Results & Conclusion] These strategies have been shown to enhance the structural stability and cell uptake of the nucleic acids, thus improving the theranostic performance.
引文
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