阿托西班联合盐酸利托君治疗高龄晚期流产及先兆早产患者疗效分析
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摘要
目的观察阿托西班联合盐酸利托君治疗高龄晚期先兆流产及先兆早产患者疗效。方法研究收集佛山市禅城区中心医院妇产科2018年1—12月高龄晚期先兆流产及先兆早产者100例,随机分为观察组50例及对照组50例,对照组给予盐酸利托君静脉,观察组在对照组之上,联合醋酸阿托西班给药,比较治疗后两组疗效、利托君平均药量及总药量、新生儿结局,并观察不良反应。结果治疗后,观察组48 h有效率88.00%,显著高于对照组的64.00%(P<0.05);观察组7 d有效率78.00%,显著高于对照组的54.00%;观察组平均妊娠延长(4.35±1.24)周,显著高于对照组的(3.12±0.89)周;治疗期间,观察组利托君平均用量及总用量均显著低于对照组(P<0.05);治疗后,观察组新生儿窒息发生率、极低体重及低体重儿发生率、胎儿丢失率均显著低于对照组(P<0.05);治疗期间,观察组不良反应总发生率22.00%,显著低于对照组的56.00%(P<0.05)。结论阿托西班与盐酸利托君联合用于高龄晚期先兆流产及先兆早产患者,可提高治疗效果,延长妊娠时间,降低利托君用药量,改善新生儿结局,降低胎儿丢失率,且有效减少临床不良反应。
ObjectiveTo observe the efficacy of atroxiban combined with ritodrine hydrochloride in the treatment of advanced threatened abortion and premature delivery in elderly patients.Methods100 cases of advanced threatened abortion and premature delivery in Department of Obstetrics and Gynecology from Januaryto December,2018 were randomly divided into observation group(50 cases)and control group(50 cases). Clinical efficiency,total dose and neonatal outcome of two groups were compared,and the adverse reactions were observed.ResultsAfter treatment,the 48-hour effective rate of observation group was 88.00%,which was significantly higher than 64.00% of the control group;the 7-day effective rate of observation group was 78.00%,which was significantly higher than 54.00% of the control group;the average pregnancy prolongation of observation group was(4.35±1.24)weeks,which was significantly higher than that of control group(3.12±0.89)weeks(P< 0.05);during treatment,the observation group was significantly higher than that of control group(3.12±0.89)weeks(P<0.05). After treatment,the incidence of neonatal asphyxia,the incidence of very low birth weight and low birth weight infants,and the rate of fetal loss in the observation group were significantly lower than those in the control group(P< 0.05);during the treatment,the total incidence of adverse reactions in the observation group was 22.00%,which was significantly lower than that in the control group(56.00%)(P<0.05).ConclusionAtoxiban combined with ritodrine hydrochloride can improve the therapeutic effect,prolong the pregnancy time,reduce the dosage of ritodrine,improve the neonatal outcome,reduce the rate of fetal loss,and effectively reduce the clinical adverse reactions.
ObjectiveTo observe the efficacy of atroxiban combined with ritodrine hydrochloride in the treatment of advanced threatened abortion and premature delivery in elderly patients.Methods100 cases of advanced threatened abortion and premature delivery in Department of Obstetrics and Gynecology from Januaryto December,2018 were randomly divided into observation group(50 cases)and control group(50 cases). Clinical efficiency,total dose and neonatal outcome of two groups were compared,and the adverse reactions were observed.ResultsAfter treatment,the 48-hour effective rate of observation group was 88.00%,which was significantly higher than 64.00% of the control group;the 7-day effective rate of observation group was 78.00%,which was significantly higher than 54.00% of the control group;the average pregnancy prolongation of observation group was(4.35±1.24)weeks,which was significantly higher than that of control group(3.12±0.89)weeks(P< 0.05);during treatment,the observation group was significantly higher than that of control group(3.12±0.89)weeks(P<0.05). After treatment,the incidence of neonatal asphyxia,the incidence of very low birth weight and low birth weight infants,and the rate of fetal loss in the observation group were significantly lower than those in the control group(P< 0.05);during the treatment,the total incidence of adverse reactions in the observation group was 22.00%,which was significantly lower than that in the control group(56.00%)(P<0.05).ConclusionAtoxiban combined with ritodrine hydrochloride can improve the therapeutic effect,prolong the pregnancy time,reduce the dosage of ritodrine,improve the neonatal outcome,reduce the rate of fetal loss,and effectively reduce the clinical adverse reactions.
引文
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[4]罗晓华,冉利敏,张莹莹,等.阿托西班与利托君治疗双胎妊娠晚期流产及早产的临床疗效分析[J].现代妇产科进展,2016,25(6):455-457.
[5]谢幸,苟文丽.妇产科学[M]. 8版.北京:人民卫生出版社,2013.
[6]刘月华.阿托西班与利托君联合用药与单一用药治疗早产的临床效果比较[J].实用医院临床杂志,2017,14(2):64-66.
[7]叶小丽,吴志军,许园姣.不同宫缩抑制剂在先兆早产治疗中临床疗效与安全性的研究[J].中国妇幼健康研究,2017,28(8):957-960.
[8]许雅娟,任利单,翟闪闪,等.盐酸利托君联合烯丙雌醇治疗先兆早产的效果评价[J].现代妇产科进展,2016,25(11):849-851.
[9]张慧.阿托西班与β受体激动剂治疗早产效果和安全性meta分析[J].临床误诊误治,2016,29(3):81-89.