干细胞移植治疗创伤性脑外伤的研究进展
摘要
<正>创伤性脑外伤(traumatic brain injury,TBI)是临床上常发生的一种因头部被撞击、突然加速或者突然减速等机械力造成的脑部损伤疾病。TBI主要表现为平衡能力和协调能力差,此外TBI患者多出现学习认知能力、记忆能力和情感障碍。近年来,神经外科学的飞速发展极大地提高了颅脑损伤患者术后成活率。但是大部分脑损伤幸存者都会存在严
引文
[1]周静,杨磊,赵瑞,等.双重任务在脑外伤康复中应用的研究进展[J].中国康复医学杂志,2017,32(11):95-98.
[2]郑磊,朱建国,袁栋才.脑卒中后内源性神经修复的研究进展[J].中国康复医学杂志,2014,29(1):95-98.
[3]Algattas H,Huang JH.Traumatic Brain Injury pathophysiology and treatments:early,intermediate,and late phases postinjury[J].Int J Mol Sci,2014,15(1):309-341.
[4]Benge JF,Phenis RA,Bernett A,et al.Neurobehavioral Effects of Levetiracetam in Patients with Traumatic Brain Injury[J].Front Neurol,2013,4:195.
[5]Andrews PJ,Sinclair HL,Rodríguez A,et al.Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury:the Eurotherm3235 RCT[J].Health Technol Assess,2018,22(45):1-134.
[6]Fu XM,Liu SJ,Dan QQ,et al.Combined Bone Mesenchymal Stem Cells and Olfactory Ensheathing Cells Transplantation Promote Neural Repair Associated with CNTF Expression in Traumatic Brain-Injured Rats[J].Cell Transplant,2015,24(8):1533-44.
[7]Shear DA,Tate MC,Archer DR,et al.Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury[J].Brain Res,2004,1026:11-22.
[8]Englund U,Bjorklund A,Wictorin K,et al.Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry[J].Proc Natl Acad Sci USA,2002,99:17089-17094.
[9]Haus DL,López-Velázquez L,Gold EM,et al.Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury[J].Exp Neurol,2016,281:1-16.
[10]Becker A,Peleg K,Olsha O,et al.Analysis of incidence of traumatic brain injury in blunt trauma patients with Glasgow Coma Scale of 12 or less[J].Chin J Traumatol,2018,21(3):152-155.
[11]Nudi ET,Jacqmain J,DubbsK,et al.Combining enriched environment,progesterone,and embryonic neural stem celltherapy improves recovery after brain injury[J].J Neurotrauma,2015,32:1117-1129.
[12]Yu P,Li S,Zhang Z,et al.Progesterone-mediated angiogenic activity of endothelial progenitor cell andangiogenesis in traumatic brain injury rats were antagonized by progesterone receptorantagonis[J].Cell Prolif,2017,50(5):.doi:10.1111/cpr.12362.
[13]Duan H,Li X,Wang C,et al.Functional hyaluronate collagen scaffolds induce NSCs differentiation into functionalneurons in repairing the traumatic brain injury[J].Acta Biomater,2016,45:182-195.
[14]Weston NM,Sun D.The Potential of Stem Cells in Treatment of Traumatic Brain Injury[J].Curr Neurol Neurosci Rep,2018,18(1):1.doi:10.1007/S11910-018-0812-2
[15]Zhu J,Zhou L,XingWu F.Tracking neural stem cells in patients with brain trauma[J].N Engl J Med,2006,355:2376-2378.
[16]Jeong CH,Kim SM,Lim JY,et al.Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model[J].Biomed Res Int,2014,2014(4):129145.
[17]Lee ST,Chu K,Jung KH,et al.Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke[J].Brain,2008,131(Pt 3):616-629.
[18]Liu SJ,Zou Y,Belegu V,et al.Co-grafting of neural stem cells with olfactory en sheathing cells promotes neuronal restoration in traumatic brain injury with an anti-inflammatory mechanism[J].J Neuroinflamm,2014,11(1):66.
[19]Sullivan GM,Armstrong RC.Transplanted Adult Neural Stem Cells Express Sonic Hedgehog In Vivo and Suppress White Matter Neuroinflammation after Experimental Traumatic Brain Injury[J].Stem Cells Int,2017,2017:9342534.
[20]Yang Y,Wei H,Zhou X,et al.Hyperbaric oxygen promotes neural stem cell proliferation by activating vascular endothelial growth factor/extracellular signal-regulated kinase signaling after traumatic brain injury[J].Neuroreport,2017,28(18):1232-1238.
[21]Shin MS,Park HK,Kim TW,et al.Neuroprotective effects of bone marrow stromal cell transplantation in combination with treadmill exercise following traumatic brain injury[J].Int Neurourol J,2016,20(Suppl 1):S49-56.
[22]Anbari F,Khalili MA,Bahrami AR,et al.Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury[J].Neural Regen Res,2014,9(9):919-23.
[23]Freyman T,Polin G,Osman H,et al.A quantitative,randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction[J].Eur Heart J,2006,27(9):1114-1122.
[24]Shen Q,Yin Y,Xia QJ,et al.Bone Marrow Stromal Cells Promote Neuronal Restoration in Rats with Traumatic Brain Injury:Involvement of GDNF Regulating BAD and BAX Signaling[J].Cell Physiol Biochem,2016,38(2):748-62.
[25]Zhang R,Liu Y,Yan K,et al.Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury[J].J Neuroinflamm,2013,10:106.doi:10.1186/1742-2094-10-106
[26]Feng Y,Ju Y,Cui J,et al.Bone marrow stromal cells promote neuromotor functional recovery,via upregulation of neurotrophic factors and synapse proteins following traumatic brain injury in rats[J].Mol Med Rep,2017,16(1):654-660.
[27]Reis C,Gospodarev V,Reis H,et al.Traumatic brain injury and stem cell:pathophysiology and update on recent treatment modalities.stem cells int,2017;2017:6392592.doi:10.1155/2017/6392592.
[28]Hasan A,Deeb G,Rahal R,et al.Mesenchymal stem cells in the treatment of traumatic brain injury[J].Front Neurol,2017,8:28.doi:10.3389/fneur.
[29]Shi X,Bai Y,Zhang G,et al.Effects of over-expression of SOD2 in bone marrow-derived mesenchymal stem cells on traumatic brain injury[J].Cell Tissue Res,2018,372(1):67-75.
[30]de Munter JP,Wolters E.70th Birthday symposium of Prof.Dr.Riederer:autologous adult stem cells in ischemic and traumatic CNS disorders[J].J Neural Transm,2013,120(1):91-102.
[31]Guo X,Liu L,Zhang M,et al.Correlation of CD34+cells with tissue angiogenesis after traumatic brain injury in a rat model[J].J Neurotrauma,2009,26(8):1337-1344.
[32]Ghanjati F,Santourlidis S.Effect on multipotency and phenotypic transition of unrestricted somatic stem cells from human umbilical cord blood after treatment with epigenetic agents[J].Stem Cells Int,2016,2016:7643218.
[33]Tajiri N,Acosta S,Glover LE,et al.Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats[J].PLoS One,2012,7(8):e43779.
[34]Wang S,Cheng H,Dai G,et al.Umbilical cord mesenchymal stem cell transplantation significantly improves neurological function in patients with sequelae of traumatic brain injury[J].Brain Res,2013,26:76-84.
[35]Zibara K,Ballout N,Mondello S,et al.Combination of drug and stem cells neurotherapy:Potential interventions inneurotrauma and traumatic brain injury[J].Neuropharmacology,2018;pii:S0028-3908(18):30694-4.
[2]郑磊,朱建国,袁栋才.脑卒中后内源性神经修复的研究进展[J].中国康复医学杂志,2014,29(1):95-98.
[3]Algattas H,Huang JH.Traumatic Brain Injury pathophysiology and treatments:early,intermediate,and late phases postinjury[J].Int J Mol Sci,2014,15(1):309-341.
[4]Benge JF,Phenis RA,Bernett A,et al.Neurobehavioral Effects of Levetiracetam in Patients with Traumatic Brain Injury[J].Front Neurol,2013,4:195.
[5]Andrews PJ,Sinclair HL,Rodríguez A,et al.Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury:the Eurotherm3235 RCT[J].Health Technol Assess,2018,22(45):1-134.
[6]Fu XM,Liu SJ,Dan QQ,et al.Combined Bone Mesenchymal Stem Cells and Olfactory Ensheathing Cells Transplantation Promote Neural Repair Associated with CNTF Expression in Traumatic Brain-Injured Rats[J].Cell Transplant,2015,24(8):1533-44.
[7]Shear DA,Tate MC,Archer DR,et al.Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury[J].Brain Res,2004,1026:11-22.
[8]Englund U,Bjorklund A,Wictorin K,et al.Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry[J].Proc Natl Acad Sci USA,2002,99:17089-17094.
[9]Haus DL,López-Velázquez L,Gold EM,et al.Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury[J].Exp Neurol,2016,281:1-16.
[10]Becker A,Peleg K,Olsha O,et al.Analysis of incidence of traumatic brain injury in blunt trauma patients with Glasgow Coma Scale of 12 or less[J].Chin J Traumatol,2018,21(3):152-155.
[11]Nudi ET,Jacqmain J,DubbsK,et al.Combining enriched environment,progesterone,and embryonic neural stem celltherapy improves recovery after brain injury[J].J Neurotrauma,2015,32:1117-1129.
[12]Yu P,Li S,Zhang Z,et al.Progesterone-mediated angiogenic activity of endothelial progenitor cell andangiogenesis in traumatic brain injury rats were antagonized by progesterone receptorantagonis[J].Cell Prolif,2017,50(5):.doi:10.1111/cpr.12362.
[13]Duan H,Li X,Wang C,et al.Functional hyaluronate collagen scaffolds induce NSCs differentiation into functionalneurons in repairing the traumatic brain injury[J].Acta Biomater,2016,45:182-195.
[14]Weston NM,Sun D.The Potential of Stem Cells in Treatment of Traumatic Brain Injury[J].Curr Neurol Neurosci Rep,2018,18(1):1.doi:10.1007/S11910-018-0812-2
[15]Zhu J,Zhou L,XingWu F.Tracking neural stem cells in patients with brain trauma[J].N Engl J Med,2006,355:2376-2378.
[16]Jeong CH,Kim SM,Lim JY,et al.Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model[J].Biomed Res Int,2014,2014(4):129145.
[17]Lee ST,Chu K,Jung KH,et al.Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke[J].Brain,2008,131(Pt 3):616-629.
[18]Liu SJ,Zou Y,Belegu V,et al.Co-grafting of neural stem cells with olfactory en sheathing cells promotes neuronal restoration in traumatic brain injury with an anti-inflammatory mechanism[J].J Neuroinflamm,2014,11(1):66.
[19]Sullivan GM,Armstrong RC.Transplanted Adult Neural Stem Cells Express Sonic Hedgehog In Vivo and Suppress White Matter Neuroinflammation after Experimental Traumatic Brain Injury[J].Stem Cells Int,2017,2017:9342534.
[20]Yang Y,Wei H,Zhou X,et al.Hyperbaric oxygen promotes neural stem cell proliferation by activating vascular endothelial growth factor/extracellular signal-regulated kinase signaling after traumatic brain injury[J].Neuroreport,2017,28(18):1232-1238.
[21]Shin MS,Park HK,Kim TW,et al.Neuroprotective effects of bone marrow stromal cell transplantation in combination with treadmill exercise following traumatic brain injury[J].Int Neurourol J,2016,20(Suppl 1):S49-56.
[22]Anbari F,Khalili MA,Bahrami AR,et al.Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury[J].Neural Regen Res,2014,9(9):919-23.
[23]Freyman T,Polin G,Osman H,et al.A quantitative,randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction[J].Eur Heart J,2006,27(9):1114-1122.
[24]Shen Q,Yin Y,Xia QJ,et al.Bone Marrow Stromal Cells Promote Neuronal Restoration in Rats with Traumatic Brain Injury:Involvement of GDNF Regulating BAD and BAX Signaling[J].Cell Physiol Biochem,2016,38(2):748-62.
[25]Zhang R,Liu Y,Yan K,et al.Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury[J].J Neuroinflamm,2013,10:106.doi:10.1186/1742-2094-10-106
[26]Feng Y,Ju Y,Cui J,et al.Bone marrow stromal cells promote neuromotor functional recovery,via upregulation of neurotrophic factors and synapse proteins following traumatic brain injury in rats[J].Mol Med Rep,2017,16(1):654-660.
[27]Reis C,Gospodarev V,Reis H,et al.Traumatic brain injury and stem cell:pathophysiology and update on recent treatment modalities.stem cells int,2017;2017:6392592.doi:10.1155/2017/6392592.
[28]Hasan A,Deeb G,Rahal R,et al.Mesenchymal stem cells in the treatment of traumatic brain injury[J].Front Neurol,2017,8:28.doi:10.3389/fneur.
[29]Shi X,Bai Y,Zhang G,et al.Effects of over-expression of SOD2 in bone marrow-derived mesenchymal stem cells on traumatic brain injury[J].Cell Tissue Res,2018,372(1):67-75.
[30]de Munter JP,Wolters E.70th Birthday symposium of Prof.Dr.Riederer:autologous adult stem cells in ischemic and traumatic CNS disorders[J].J Neural Transm,2013,120(1):91-102.
[31]Guo X,Liu L,Zhang M,et al.Correlation of CD34+cells with tissue angiogenesis after traumatic brain injury in a rat model[J].J Neurotrauma,2009,26(8):1337-1344.
[32]Ghanjati F,Santourlidis S.Effect on multipotency and phenotypic transition of unrestricted somatic stem cells from human umbilical cord blood after treatment with epigenetic agents[J].Stem Cells Int,2016,2016:7643218.
[33]Tajiri N,Acosta S,Glover LE,et al.Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats[J].PLoS One,2012,7(8):e43779.
[34]Wang S,Cheng H,Dai G,et al.Umbilical cord mesenchymal stem cell transplantation significantly improves neurological function in patients with sequelae of traumatic brain injury[J].Brain Res,2013,26:76-84.
[35]Zibara K,Ballout N,Mondello S,et al.Combination of drug and stem cells neurotherapy:Potential interventions inneurotrauma and traumatic brain injury[J].Neuropharmacology,2018;pii:S0028-3908(18):30694-4.