脑转移瘤伽马刀治疗进展
摘要
脑转移瘤是常见的恶性肿瘤神经系统并发症,随着治疗水平的提高与对肿瘤治疗认识的加深,脑转移瘤患者的生存时间得到了有效的延长。目前脑转移瘤的治疗方案主要包括两种手段:全脑放疗与立体定向放射外科治疗。但治疗手段的选择是临床医生在工作中始终面临的问题。本文对脑转移瘤的特点、脑转移瘤治疗的推荐方案进行回顾,并对不同治疗方案所致并发症进行了比较,这对于脑转移瘤治疗方式的选择,具有十分重要的指导意义,为临床工作提供了可靠的参考依据。
引文
[1]Pickren JW,Lopez G,Tzuduka Y. Brain Metastases. An autopsy study[J]. Cancer Treat Symp,1982,2:295-313.
[2]Posner J. Management of central nervous system metastases[J].Semin Oncol,1977,4(1):81-91.
[3]Andrews DW,Scott CB,Sperduto PW,et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases:phaseⅢresults of the RTOG 9508 randomised trial[J]. Lancet,2004,363(9422):1665-1672.
[4]Borgelt B,Gelber R,Kramer S,et al. The palliation of brain metastases. The final results of the first two studies by the radiation therapy oncology group[J]. Int J Radiat Oncol Biol Phys,1980,6(1):1-9.
[5]Kihlstrohm L,Karlsson B,Lindquist C. Gamma Knife surgery for cerebral metastases:implications for survival based on 16 years experience[J]. Stereotact Funct Neurosurg,1993,61 Suppl 1:45-50.
[6]Fuller BG,Kaplan ID,Adler JR,et al. Stereotaxic radiosurgery for brain metastases:the importance of adjuvant whole brain radiation[J]. Int J Radiat Oncol Biol Phys,1992,23(2):413-418.
[7]Kim CH,Im YS,Nam DH,et al. Gamma knife radiosurgery for ten or more brain metastases[J]. J Korean Neurosurg Soc,2008,44(6):358-363.
[8]Patil CG,Pricola K,Sarmiento JM,et al. Whole brain radiation therapy(WBRT)alone versus WBRT and radiosurgery for the treatment of brain metastases[J]. Cochrane Database Syst Rev,2017,9:CD006121.
[9]Jawahar A,Willis BK,Smith DR,et al. Gamma knife radiosurgery for brain metastases:do patients benefit from adjuvant external-beam radiotherapy? An 18-month comparative analysis[J].Stereotact Funct Neurosurg,2002,79(3/4):262-271.
[10]Radbill AE,Fiveash JF,Falkenberg ET,et al. Initial treatment of melanoma brain metastases using gamma knife radiosurgery:an evaluation of efficacy and toxicity[J]. Cancer,2004,101(4):825-833.
[11]Hazard LJ,Jensen RL,Shrieve SC. Role of stereotactic radiosurgery in the treatment of brain metastases[J]. J Clin Oncol,2005,28(4):403-410.
[12]Tsao MN,Lloyd N,Wong RK,et al. Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases[J].Cochrane Database Syst Rev,2012(4):CD003869.
[13]Shehata MK,Young B,Reid B,et al. Stereotatic radiosurgery of468 brain metastases [14]Majhail NS,Chander S,Mehta VS,et al. Factors influencing early complications following Gamma Knife surgery:a prospective study[J]. Stereotact Funct Neurosurge,2001,76(1):36-46.
[15]Chang EL,Wefel JS,Maor MH,et al. Neurocognition in patients with brain metastases treated with radiosurgery for radiosurgery plus whole-brain irradiation:a randomised controlled trial[J]. Lancet Oncol,2009,10(11):1037-1044.
[16]Amendola BE,Wolf AL,Coy SR,et al. Gamma knife radiosurgery in the treatment of patients with single and multiple brain metastases from carcinoma of the breast[J]. Cancer J,2000,6(2):88-92.
[17]Lorenzoni JG,Devriendt D,Massager N,et al. Brain stem metastases treated with radiosurgery:prognostic factors of survival and life expectancy estimation[J]. Surg Neurol,2008,71(2):188-195.
[18]Shaw E,Scott C,Souhami L,et al. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases:final report of RTOG protocol 90-05[J].Int J Radiat Oncol Biol Phys,2000,47(2):291-298.
[19]Aoyama H,Shirato H,Tago M,et al. Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases[J]. JAMA,2006,295(21):2483-2491.
[20]Chao ST,De Salles A,Hayashi M,et al. Stereotactic Radiosurgery in the Management of Limited(1-4)Brain Metasteses:Systematic Review and International Stereotactic Radiosurgery Society Practice Guideline[J]. Neurosurgery,2018,83(3):345-353.
[21]Dequesada IM,Quisling RG,Yachnis A,et al. Can standard magnetic resonance imaging reliably distinguish recurrent tumor from radiation necrosis after radiosurgery for brain metastases? A radiographic-pathological study[J]. Neurosurgery,2008,63(5):898-903.
[22]Wang B,Zhao B,Zhang Y,et al. Absolute CBV for the differentiation of recurrence and radionecrosis of brain metastases after gamma knife radiotherapy:a comparison with relative CBV[J].Clin Radiol,2018,73(8):758. e1-758,e7.
[2]Posner J. Management of central nervous system metastases[J].Semin Oncol,1977,4(1):81-91.
[3]Andrews DW,Scott CB,Sperduto PW,et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases:phaseⅢresults of the RTOG 9508 randomised trial[J]. Lancet,2004,363(9422):1665-1672.
[4]Borgelt B,Gelber R,Kramer S,et al. The palliation of brain metastases. The final results of the first two studies by the radiation therapy oncology group[J]. Int J Radiat Oncol Biol Phys,1980,6(1):1-9.
[5]Kihlstrohm L,Karlsson B,Lindquist C. Gamma Knife surgery for cerebral metastases:implications for survival based on 16 years experience[J]. Stereotact Funct Neurosurg,1993,61 Suppl 1:45-50.
[6]Fuller BG,Kaplan ID,Adler JR,et al. Stereotaxic radiosurgery for brain metastases:the importance of adjuvant whole brain radiation[J]. Int J Radiat Oncol Biol Phys,1992,23(2):413-418.
[7]Kim CH,Im YS,Nam DH,et al. Gamma knife radiosurgery for ten or more brain metastases[J]. J Korean Neurosurg Soc,2008,44(6):358-363.
[8]Patil CG,Pricola K,Sarmiento JM,et al. Whole brain radiation therapy(WBRT)alone versus WBRT and radiosurgery for the treatment of brain metastases[J]. Cochrane Database Syst Rev,2017,9:CD006121.
[9]Jawahar A,Willis BK,Smith DR,et al. Gamma knife radiosurgery for brain metastases:do patients benefit from adjuvant external-beam radiotherapy? An 18-month comparative analysis[J].Stereotact Funct Neurosurg,2002,79(3/4):262-271.
[10]Radbill AE,Fiveash JF,Falkenberg ET,et al. Initial treatment of melanoma brain metastases using gamma knife radiosurgery:an evaluation of efficacy and toxicity[J]. Cancer,2004,101(4):825-833.
[11]Hazard LJ,Jensen RL,Shrieve SC. Role of stereotactic radiosurgery in the treatment of brain metastases[J]. J Clin Oncol,2005,28(4):403-410.
[12]Tsao MN,Lloyd N,Wong RK,et al. Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases[J].Cochrane Database Syst Rev,2012(4):CD003869.
[13]Shehata MK,Young B,Reid B,et al. Stereotatic radiosurgery of468 brain metastases
[15]Chang EL,Wefel JS,Maor MH,et al. Neurocognition in patients with brain metastases treated with radiosurgery for radiosurgery plus whole-brain irradiation:a randomised controlled trial[J]. Lancet Oncol,2009,10(11):1037-1044.
[16]Amendola BE,Wolf AL,Coy SR,et al. Gamma knife radiosurgery in the treatment of patients with single and multiple brain metastases from carcinoma of the breast[J]. Cancer J,2000,6(2):88-92.
[17]Lorenzoni JG,Devriendt D,Massager N,et al. Brain stem metastases treated with radiosurgery:prognostic factors of survival and life expectancy estimation[J]. Surg Neurol,2008,71(2):188-195.
[18]Shaw E,Scott C,Souhami L,et al. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases:final report of RTOG protocol 90-05[J].Int J Radiat Oncol Biol Phys,2000,47(2):291-298.
[19]Aoyama H,Shirato H,Tago M,et al. Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases[J]. JAMA,2006,295(21):2483-2491.
[20]Chao ST,De Salles A,Hayashi M,et al. Stereotactic Radiosurgery in the Management of Limited(1-4)Brain Metasteses:Systematic Review and International Stereotactic Radiosurgery Society Practice Guideline[J]. Neurosurgery,2018,83(3):345-353.
[21]Dequesada IM,Quisling RG,Yachnis A,et al. Can standard magnetic resonance imaging reliably distinguish recurrent tumor from radiation necrosis after radiosurgery for brain metastases? A radiographic-pathological study[J]. Neurosurgery,2008,63(5):898-903.
[22]Wang B,Zhao B,Zhang Y,et al. Absolute CBV for the differentiation of recurrence and radionecrosis of brain metastases after gamma knife radiotherapy:a comparison with relative CBV[J].Clin Radiol,2018,73(8):758. e1-758,e7.