高压氧治疗中老年急性脑梗死的临床疗效及对患者巨噬细胞集落刺激因子、氧化修饰低密度脂蛋白、可溶性细胞黏附因子-1的影响
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摘要
目的分析高压氧治疗中老年急性脑梗死的临床疗效及对患者巨噬细胞集落刺激因子(M-CSF)、氧化修饰低密度脂蛋白(ox-LDL)、可溶性细胞黏附因子-1(s ICAM-1)的影响。方法选取本院接受诊治的100例中老年人急性脑梗死患者作为研究对象,根据随机数表法分为对照组、研究组,各50例。对照组患者采用常规治疗方法,研究组患者采用高压氧治疗方法。比较2组患者治疗前后血清指标、神经缺损功能及脑血流量(CBF)、脑血容量(CBV)情况。结果治疗后,2组患者M-CSF、ox-LDL、s ICAM-1水平均低于治疗前,且研究组低于对照组(P<0.05);研究组患者治疗总有效率高于对照组(P<0.05);治疗后2组患者CBF、CBV水平均高于治疗前,且研究组高于对照组(P<0.05)。结论采用高压氧治疗中老年急性脑梗死效果显著,能有效降低M-CSF、ox-LDL、s ICAM-1的表达,减少患者脑血管损伤,抑制血栓的形成,改善患者神经缺损功能,缓解脑组织血氧供应不足,值得临床推广。
Objective To study the clinical efficacy of hyperbaric oxygen therapy in the treatment of middle-aged and elderly patients with acute cerebral infarction and their effects on M-CSF,ox-LDL and s ICAM-1. Methods A total of 100 elderly patients with acute cerebral infarction who were treated in our hospital were divided into control group and study group according to the random number table method,with 50 cases in each group. The patients in the control group were treated with conventional therapy,and the patients in the study group were treated with hyperbaric oxygen therapy.The levels of serum markers,nerve defect function and cerebral cerebral blood flow( CBF),cerebral blood volume( CBV) were observed and compared between the two groups before and after treatment.Results After treatment,the levels of M-CSF,ox-LDL and s ICAM-1 in the two groups were lower than treatment before,and study group was lower than the control group( P < 0. 05); The total clinical outcomes was higher in the study group than that in the control group( P < 0. 05). After treatment,the CBF and CBV levels of the two groups were higher than treatment before,and the study group was higher than the control group( P < 0. 05). Conclusion Hyperbaric oxygen therapy in the treatment of the elderly with acute cerebral infarction can effectively reduce the expression of M-CSF,ox-LDL,s ICAM-1,reduce cerebral vascular injury,inhibit the formation of thrombosis,improve the function of nerve deficit,relieve the insufficient of oxygen supply,so it is worthy of clinical promotion.
Objective To study the clinical efficacy of hyperbaric oxygen therapy in the treatment of middle-aged and elderly patients with acute cerebral infarction and their effects on M-CSF,ox-LDL and s ICAM-1. Methods A total of 100 elderly patients with acute cerebral infarction who were treated in our hospital were divided into control group and study group according to the random number table method,with 50 cases in each group. The patients in the control group were treated with conventional therapy,and the patients in the study group were treated with hyperbaric oxygen therapy.The levels of serum markers,nerve defect function and cerebral cerebral blood flow( CBF),cerebral blood volume( CBV) were observed and compared between the two groups before and after treatment.Results After treatment,the levels of M-CSF,ox-LDL and s ICAM-1 in the two groups were lower than treatment before,and study group was lower than the control group( P < 0. 05); The total clinical outcomes was higher in the study group than that in the control group( P < 0. 05). After treatment,the CBF and CBV levels of the two groups were higher than treatment before,and the study group was higher than the control group( P < 0. 05). Conclusion Hyperbaric oxygen therapy in the treatment of the elderly with acute cerebral infarction can effectively reduce the expression of M-CSF,ox-LDL,s ICAM-1,reduce cerebral vascular injury,inhibit the formation of thrombosis,improve the function of nerve deficit,relieve the insufficient of oxygen supply,so it is worthy of clinical promotion.
引文
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[10]孙茜,常淑美,吕宪民,等.阿加曲班联合高压氧治疗老年急性缺血性脑卒中的疗效及安全性[J].中国老年学杂志,2014,34(07):1938-1939.
[11]寇雪莲,陈琳迪,何松彬,等.高同型半胱氨酸血症对急性脑梗死患者预后的影响[J].中国全科医学,2015,13(05):697-699.
[12]俞宁,李通,陈琼珍.早期高压氧治疗对急性脑梗死患者脑能量代谢及疗效的影响[J].卒中与神经疾病,2014,21(01):48-50.
[13]沙瑞娟,陈洁,张书刚,等.阿加曲班注射液联合依达拉奉治疗急性缺血性脑梗死的临床疗效[J].现代药物与临床,2014,29(08):923-926.
[14]葛长江,吕树铮,柳弘,等.脉血康胶囊对经皮冠状动脉介入治疗急性冠脉综合征患者血小板聚集率及其长期预后的影响[J].中国中西医结合杂志,2012,32(07):906-909.
[15]吕朋飞.高压氧疗法联合音乐疗法治疗急性脑梗死的疗效分析[J].中国医药指南,2015,13(13):120-121.
[16]韩扬,王敏,谢荭.高压氧综合治疗对脑梗死患者血脂及血液流变学的影响[J].中华航海医学与高气压医学杂志,2014,21(02):127-128.
[17]De Lorenzo R J,Sun D A,Blair R E,et al.An in vitro model of stroke-induced epilepsy:elucidation of the roles of glutamate and calcium in the induction and maintenance of strokeinduced epileptogenesis[J].Int Rev Neurobiol,2014,81(26):59-84.
[2]杨晓榆.不同时间窗高压氧治疗急性脑梗死的效果对比观察[J].心理医生,2015,21(08):24-25.
[3]徐军鹏,程超婵,潘君枝.急诊高压氧治疗对脑梗死患者血清细胞因子及脑血流灌注的影响[J].中国老年学杂志,2016,36(11):2635-2637.
[4]张悦,荣阳,荣根满.脑卒中继发性癫痫的临床疗治疗分析与前瞻性研究[J].中国医药指南,2017,15(5):66-67.
[5]Fisher R S,van Emde B W,Blume W,et al.Epileptic seizures and epilepsy:definitions proposed by the International League Against Epilepsy(ILAE)and the International Bureau for Epilepsy(IBE)[J].Epilepsia,2015,46(4):470-472.
[6]白永杰.高压氧对急性脑梗死作用机制研究进展[J].西南国防医药,2014,24(12):1394-1396.
[7]梁伟,刘光金,杨红兵.急性脑梗死患者血清同型半胱氨酸、高敏C反应蛋白及D-二聚体水平检测的临床分析[J].医学综述,2014,20(3):544-546.
[8]薛芳芳,赵婷婷.同型半胱氨酸、高敏C反应蛋白及D-二聚体在急性脑梗死患者中的变化及意义[J].中国实用神经疾病杂志,2015,18(7):80-81.
[9]王以翠,常焕显,孔令胜.阿加曲班对急性脑梗死患者血管内皮功能及炎症因子的影响[J].中山大学学报:医学科学版,2015,36(6):870-876.
[10]孙茜,常淑美,吕宪民,等.阿加曲班联合高压氧治疗老年急性缺血性脑卒中的疗效及安全性[J].中国老年学杂志,2014,34(07):1938-1939.
[11]寇雪莲,陈琳迪,何松彬,等.高同型半胱氨酸血症对急性脑梗死患者预后的影响[J].中国全科医学,2015,13(05):697-699.
[12]俞宁,李通,陈琼珍.早期高压氧治疗对急性脑梗死患者脑能量代谢及疗效的影响[J].卒中与神经疾病,2014,21(01):48-50.
[13]沙瑞娟,陈洁,张书刚,等.阿加曲班注射液联合依达拉奉治疗急性缺血性脑梗死的临床疗效[J].现代药物与临床,2014,29(08):923-926.
[14]葛长江,吕树铮,柳弘,等.脉血康胶囊对经皮冠状动脉介入治疗急性冠脉综合征患者血小板聚集率及其长期预后的影响[J].中国中西医结合杂志,2012,32(07):906-909.
[15]吕朋飞.高压氧疗法联合音乐疗法治疗急性脑梗死的疗效分析[J].中国医药指南,2015,13(13):120-121.
[16]韩扬,王敏,谢荭.高压氧综合治疗对脑梗死患者血脂及血液流变学的影响[J].中华航海医学与高气压医学杂志,2014,21(02):127-128.
[17]De Lorenzo R J,Sun D A,Blair R E,et al.An in vitro model of stroke-induced epilepsy:elucidation of the roles of glutamate and calcium in the induction and maintenance of strokeinduced epileptogenesis[J].Int Rev Neurobiol,2014,81(26):59-84.