桂滇黔交界地区不同胎龄早产儿宫内宫外生长发育迟缓发生状况分析
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摘要
目的评价桂滇黔交界地区不同胎龄早产儿出生时宫内生长发育迟缓(IUGR)和出院时宫外生长发育迟缓(EUGR)的发生情况。方法对2014年1月-2015年12月在右江民族医学院附属医院新生儿科住院早产儿的病例资料进行回顾性分析,将入选早产儿按胎龄分3组,即28～31~(+6)周、32～33~(+6)周、34～36~(+6)周,以出生时、出院时体质量小于同胎龄儿生长曲线的第10百分位(住院早产儿,出生时IUGR发生率为27. 30%,出院时EUGR发生率为59. 64%,其中出生时IUGR早产儿出院时EUGR发生率达98. 75%。胎龄28～31~(+6)周、32～33~(+6)周、34～36~(+6)周早产儿出生时IUGR发生率分别为6. 67%、25. 37%、35. 41%,组间比较差异有统计学意义(P<0. 05),随着胎龄的增加,IUGR的发生率逐步升高,差异有统计学意义(P<0. 05)。结论桂滇黔交界地区住院早产儿IUGR、EUGR的发生率仍较高,IUGR发生率随着胎龄增大而升高,EUGR发生率随着胎龄、出生体质量百分位数的降低而升高。
Objective To evaluate the prevalence of intrauterine growth restriction (IUGR) and extrauterine growth restriction (EUGR) among premature infants of different gestational age in the border area of Yunnan,Guizhou,and Guangxi. Methods The medical data of premature infants from Department of Neonatology,Affiliated Hospital of Youjiang Medical College for Nationalities from January 2014 to December 2015 were analyzed retrospectively,all the premature infants were divided into 28-31~(+6) week group,32-33~(+6) week group,and 34-36~(+6) week group. IUGR and EUGR were defined as weight below the 10th percentile for gestational age (
Objective To evaluate the prevalence of intrauterine growth restriction (IUGR) and extrauterine growth restriction (EUGR) among premature infants of different gestational age in the border area of Yunnan,Guizhou,and Guangxi. Methods The medical data of premature infants from Department of Neonatology,Affiliated Hospital of Youjiang Medical College for Nationalities from January 2014 to December 2015 were analyzed retrospectively,all the premature infants were divided into 28-31~(+6) week group,32-33~(+6) week group,and 34-36~(+6) week group. IUGR and EUGR were defined as weight below the 10th percentile for gestational age (
引文
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[18]Radmacher PG,Looney SW,Rafail ST,et al.Prediction of extrauterine growth retardation(EUGR)in VVLBW infants[J].J Perinatol,2003,23(5):392.
[19]谭小华,崔其亮,吴繁,等.广州和佛山地区早产低出生体重儿出院时宫外生长迟缓发生情况调查[J].中国新生儿科杂志,2012,27(2):73.
[20]庄思齐.中国新生儿营养支持临床应用指南(2013年更新版)解读[J].临床儿科杂志,2014,32(9):801-803.
[21]赵小朋,周伟,梁红,等.极低出生体重儿早期营养状况对神经发育的影响[J].中国儿童保健杂志,2015,23(8):837-839.
[2]Hack M,Fanaroff AA.Outcomes of children of extremely lowbirth weight and gestational age in the 1990's[J].Early Hum Dev,1999,53(3):193-218.
[3]Dusick AM,Poindexter BB,Ehrenkranz RA,et al.Growth failure in the preterm infant,can we catch up?[J].Semin Perinatol,2003,27(4):302-310.
[4]Ehrenkranz RA,Das A,Wrage LA,et al.Early nutrition mediates the influence of severity of illness on extremely LBW infants[J].Pediatr Res,2011,69(6):522-529.
[5]Barker DJ.The developmental origins of well-being[J].PhilosTrans R Soc Lond B Biol Sci,2004,359(1449):1359-1366.
[6]De Curtis M,Rigo J.Extrauterine growth restriction in very-low-birth weight infants[J].Acta Paediatr,2004,93(12):1563-1568.
[7]婓启越,李丛,刘盼盼,等.极低出生体重儿宫外生长发育迟缓的危险因素分析[J].中国新生儿科杂志,2016,31(4):289-293.
[8]李晓,俞生林,高沙沙,等.26例早产儿住院期间宫外生长情况评估[J].中国儿童保健杂志,2014,22(5):511-514.
[9]张小华,李双双,周金君.极低出生体重儿住院期间生长速度及相关影响因素分析[J].中国儿童保健杂志,2016,24(4):419-422.
[10]郭明明,庄思齐,李易娟.早产儿宫外生长发育迟缓及相关因素分析[J].中国妇幼保健,2010,25(12):1644.
[11]赖春华,何淑华,杨冰岩,等.中山地区早产儿出院时宫外生长迟缓调查[J].中国妇幼保健,2013,28(21):3486-3491.
[12]乐杰主编.妇产科学[M].第7版,北京:人民卫生出版社,2008:130-132.
[13]中华医学会儿科学分会新生儿学组.我国小于胎龄儿现状分析[J].中国实用儿科杂志,2009,24(3):177-180.
[14]茹喜芳,冯琪,王颖,等.早产儿体重增长的动态评估及其意义[J].中华儿科杂志,2010,48(9):661-667.
[15]Adamkin DH.Two key strategies in the nutritional management of the extremely low birth weight infant[J].Przegl Lek,2002,59(Suppl 1):14.
[16]曹玮,张永红,赵冬莹,等.34周以下早产儿宫外生长发育迟缓发生的影响因素[J].中国当代儿科杂志,2015,17(5):453-458.
[17]Clark RH,Thomas P,Peabody J.Extrauterine growth restriction remains a serious problem in prematurely born neonates[J].Pediatrics,2003,111(5):986.
[18]Radmacher PG,Looney SW,Rafail ST,et al.Prediction of extrauterine growth retardation(EUGR)in VVLBW infants[J].J Perinatol,2003,23(5):392.
[19]谭小华,崔其亮,吴繁,等.广州和佛山地区早产低出生体重儿出院时宫外生长迟缓发生情况调查[J].中国新生儿科杂志,2012,27(2):73.
[20]庄思齐.中国新生儿营养支持临床应用指南(2013年更新版)解读[J].临床儿科杂志,2014,32(9):801-803.
[21]赵小朋,周伟,梁红,等.极低出生体重儿早期营养状况对神经发育的影响[J].中国儿童保健杂志,2015,23(8):837-839.