补肾法辅治体外受精-胚胎移植的研究进展
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摘要
近年来,体外受精-胚胎移植(IVF-ET)因二胎政策的开放以及不孕症发生率的上升,发展迅速。肾为先天之本,主藏精,补肾中药在调经、治疗不孕症等方面有着广泛的应用。中医药基于补肾在协同干预IVF-ET方面有独特的优势,文章从IVF-ET常规过程及其并发症的病因病机、临床常用方剂及研究等方面进行归纳及分析,阐述补肾法在IVF-ET常规处理过程中的应用规律及研究概况,旨在为临床提供用药思路。
In recent years, in vitro fertilization and embryo transfer(IVF-ET) has developed rapidly due to the opening of the second child policy and the rising incidence of infertility. The kidney is congenital origin, storing the essence. Chinese materia medica of tonifying kidney is widely used in the treatment of infertility, menstrual disorders and other diseases. Based on tonifying kidney, traditional Chinese medicine has a unique advantage in the intervention of IVF-ET. This paper summarized and analyzed from the aspects of etiology and pathogenesis of IVF-ET, conventional process, complications, clinical prescriptions and research, etc. The application regularity and research situation of kidney-tonifying method in IVF-ET routine treatment were expounded, in order to provide ideas for clinical medication.
In recent years, in vitro fertilization and embryo transfer(IVF-ET) has developed rapidly due to the opening of the second child policy and the rising incidence of infertility. The kidney is congenital origin, storing the essence. Chinese materia medica of tonifying kidney is widely used in the treatment of infertility, menstrual disorders and other diseases. Based on tonifying kidney, traditional Chinese medicine has a unique advantage in the intervention of IVF-ET. This paper summarized and analyzed from the aspects of etiology and pathogenesis of IVF-ET, conventional process, complications, clinical prescriptions and research, etc. The application regularity and research situation of kidney-tonifying method in IVF-ET routine treatment were expounded, in order to provide ideas for clinical medication.
引文
[1]中华医学会.临床诊断指南-辅助生殖技术与精子库分册.北京:人民卫生出版社,2009:65-70
[2]Levi A J,Raynault M F,Bergh P A,et al.Reproductive outcome in patients with diminished ovarian reserve.Fertility and Sterility,2001,76(4):666
[3]李俊敏,尤昭玲.“安胎前移法”在体外受精胚胎移植技术中的应用.中医杂志,2015,56(9):737-739
[4]郭燕京.卫爱武教授将中药运用于体外受精-胚胎移植的经验.中医学报,2015,30(204):716-718
[5]巫海旺,郜洁,高飞霞,等.罗颂平辨证辅助体外受精-胚胎移植临床研究.中医学报,2017,23(5):657-658,677
[6]辛喜艳,李东,李赛,等.杨“辨体-辨病-辨证诊疗模式”在辅助生殖技术中的应用.中华中医药杂志,2017,32(9):3942-3945
[7]连方,王瑞霞,马凤梅,等.补肾方药对肾阴虚不孕患者IVF-ET结局及着床期子宫内膜DNMT1表达的影响.厦门:中华医学会第十次全国妇产科学术会议妇科内分泌会场论文汇编,2012:177
[8]王铮,帅文,滕晓明.益气养血补肾活血中药在体外受精-胚胎移植患者中的应用.生殖与避孕,2014,34(2):160-165
[9]张媛.补肾通脉法对体外受精-胚胎移植患者妊娠结局的影响.哈尔滨:黑龙江中医药学,2017
[10]连方,辛明蔚.体外授精-胚胎移植患者降调节后肾虚本质探讨.山东中医药大学学报,2008,32(8):109-110
[11]陆葳,卢苏.傅友丰教授治疗卵泡发育不良经验指导.长春中医药大学学报,2012,28(5):807-809
[12]常秀峰,杜惠兰,高星,等.中药补肾调经方对体外受精-胚胎移植超排卵周期妊娠结局及骨形成蛋白(BMP)-15的影响.生殖与避孕,2011,31(3):170-173
[13]琚文娟.补肾调周法对排卵障碍性不孕症刺激周期黄体功能干预的临床研究.南京:南京中医药大学,2012
[14]刘建国,金保方,杨晓玉,等.补肾调周法对IVF-ET的干预及其结局的影响.南京中医药大学学报,2012,28(6):513-516
[15]刘丽琴,于婷儿,陈莉,等.养精种玉汤辅以体外受精-胚胎移植对子宫内膜容受性的影响.中医学报,2017,32(4):623-626
[16]李婷婷,连方,孙振高.补肾益天癸对肾气虚不孕患者长方案促排卵效果的影响.时珍国医国药,2017,28(1):18-19
[17]顾淑英,田麒,胡越吉,等.以中医补肾调冲针法辅助体外受精-胚胎移植治疗不孕症的临床疗效观察.天津中医药,2012,29(5):440-442
[18]张明敏,何新芳,张锦金.补肾安胎方及其不同组分对胚泡着床障碍小鼠雌、孕激素及其受体的影响.中国中西医结合杂志,2010,30(3):291-294
[19]连方,梁静雅.体外受精-胚胎移植中控制性超排卵后的中医证候分布.中医杂志,2012,53(6):485-487
[20]胡欣欣,孙云,马大正,等.移植后应用补胞汤及着床后应用温肾安胎对体外受精-胚胎移植妊娠结局的研究.浙江中医药大学学报,2014,38(8):970-972,975
[21]吴丽敏,韩辉,胡美红,等.黄体期添加滋肾育胎丸对体外受精-胚胎移植周期胚胎着床和妊娠结局的影响.中医药临床杂志,2016,28(2):209-212
[22]卢越,龙晓林.体外受精-胚胎移植术后辅助固肾安胎丸联合黄体酮治疗的临床疗效.中国妇幼保健,2017,32(9):1980-1982
[23]Delvigne A,Rozenberg S.Epidemiology and prevention of ovarian hyperstimulation syndrome(OHSS):A review.Human Reproduction Update,2002,8(6):559-577
[24]滕依丽.体外受精-胚胎移植过程中卵巢过度刺激综合征的中医病机治法探讨.中华中医药学刊,2011,29(11):2586-2588
[25]Whelan J G,Vlahos N F.The ovarian hyperstimulation syndrome.Fertil,2000,73(5):883-896
[26]葛明晓,张金玉,邓伟民,等.补肾健脾利湿中药在体外受精-胚胎移植周期中防治卵巢过度刺激综合征的临床研究.广州中医药大学学报,2012,29(3):257-260
[27]连方,孙振高,张建伟,等.中药联合体外受精-胚胎移植治疗多囊卵巢综合征临床研究.中国中西医结合杂志,2008,28(11):977-980
[28]闫歆.基于“已病防变”思想补肾预防卵巢过度刺激综合征的实验与临床研究.哈尔滨:黑龙江中医药大学,2014
[29]刘凤云,吴先哲,张敏,等.益肾利水方对卵巢过度刺激综合征患者血管通透性的影响.中医杂志,2007,48(11):989-991
[30]孙振高,连方,张建伟,等.补肾中药在多胎妊娠早期选择性减胎术后的应用.中华中医药杂志,2012,27(9):2293-2295
[2]Levi A J,Raynault M F,Bergh P A,et al.Reproductive outcome in patients with diminished ovarian reserve.Fertility and Sterility,2001,76(4):666
[3]李俊敏,尤昭玲.“安胎前移法”在体外受精胚胎移植技术中的应用.中医杂志,2015,56(9):737-739
[4]郭燕京.卫爱武教授将中药运用于体外受精-胚胎移植的经验.中医学报,2015,30(204):716-718
[5]巫海旺,郜洁,高飞霞,等.罗颂平辨证辅助体外受精-胚胎移植临床研究.中医学报,2017,23(5):657-658,677
[6]辛喜艳,李东,李赛,等.杨“辨体-辨病-辨证诊疗模式”在辅助生殖技术中的应用.中华中医药杂志,2017,32(9):3942-3945
[7]连方,王瑞霞,马凤梅,等.补肾方药对肾阴虚不孕患者IVF-ET结局及着床期子宫内膜DNMT1表达的影响.厦门:中华医学会第十次全国妇产科学术会议妇科内分泌会场论文汇编,2012:177
[8]王铮,帅文,滕晓明.益气养血补肾活血中药在体外受精-胚胎移植患者中的应用.生殖与避孕,2014,34(2):160-165
[9]张媛.补肾通脉法对体外受精-胚胎移植患者妊娠结局的影响.哈尔滨:黑龙江中医药学,2017
[10]连方,辛明蔚.体外授精-胚胎移植患者降调节后肾虚本质探讨.山东中医药大学学报,2008,32(8):109-110
[11]陆葳,卢苏.傅友丰教授治疗卵泡发育不良经验指导.长春中医药大学学报,2012,28(5):807-809
[12]常秀峰,杜惠兰,高星,等.中药补肾调经方对体外受精-胚胎移植超排卵周期妊娠结局及骨形成蛋白(BMP)-15的影响.生殖与避孕,2011,31(3):170-173
[13]琚文娟.补肾调周法对排卵障碍性不孕症刺激周期黄体功能干预的临床研究.南京:南京中医药大学,2012
[14]刘建国,金保方,杨晓玉,等.补肾调周法对IVF-ET的干预及其结局的影响.南京中医药大学学报,2012,28(6):513-516
[15]刘丽琴,于婷儿,陈莉,等.养精种玉汤辅以体外受精-胚胎移植对子宫内膜容受性的影响.中医学报,2017,32(4):623-626
[16]李婷婷,连方,孙振高.补肾益天癸对肾气虚不孕患者长方案促排卵效果的影响.时珍国医国药,2017,28(1):18-19
[17]顾淑英,田麒,胡越吉,等.以中医补肾调冲针法辅助体外受精-胚胎移植治疗不孕症的临床疗效观察.天津中医药,2012,29(5):440-442
[18]张明敏,何新芳,张锦金.补肾安胎方及其不同组分对胚泡着床障碍小鼠雌、孕激素及其受体的影响.中国中西医结合杂志,2010,30(3):291-294
[19]连方,梁静雅.体外受精-胚胎移植中控制性超排卵后的中医证候分布.中医杂志,2012,53(6):485-487
[20]胡欣欣,孙云,马大正,等.移植后应用补胞汤及着床后应用温肾安胎对体外受精-胚胎移植妊娠结局的研究.浙江中医药大学学报,2014,38(8):970-972,975
[21]吴丽敏,韩辉,胡美红,等.黄体期添加滋肾育胎丸对体外受精-胚胎移植周期胚胎着床和妊娠结局的影响.中医药临床杂志,2016,28(2):209-212
[22]卢越,龙晓林.体外受精-胚胎移植术后辅助固肾安胎丸联合黄体酮治疗的临床疗效.中国妇幼保健,2017,32(9):1980-1982
[23]Delvigne A,Rozenberg S.Epidemiology and prevention of ovarian hyperstimulation syndrome(OHSS):A review.Human Reproduction Update,2002,8(6):559-577
[24]滕依丽.体外受精-胚胎移植过程中卵巢过度刺激综合征的中医病机治法探讨.中华中医药学刊,2011,29(11):2586-2588
[25]Whelan J G,Vlahos N F.The ovarian hyperstimulation syndrome.Fertil,2000,73(5):883-896
[26]葛明晓,张金玉,邓伟民,等.补肾健脾利湿中药在体外受精-胚胎移植周期中防治卵巢过度刺激综合征的临床研究.广州中医药大学学报,2012,29(3):257-260
[27]连方,孙振高,张建伟,等.中药联合体外受精-胚胎移植治疗多囊卵巢综合征临床研究.中国中西医结合杂志,2008,28(11):977-980
[28]闫歆.基于“已病防变”思想补肾预防卵巢过度刺激综合征的实验与临床研究.哈尔滨:黑龙江中医药大学,2014
[29]刘凤云,吴先哲,张敏,等.益肾利水方对卵巢过度刺激综合征患者血管通透性的影响.中医杂志,2007,48(11):989-991
[30]孙振高,连方,张建伟,等.补肾中药在多胎妊娠早期选择性减胎术后的应用.中华中医药杂志,2012,27(9):2293-2295