川乌生物碱类成分及药理作用研究进展
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摘要
川乌性味为辛、苦、热;有大毒;归心、肝、肾、脾经;主治祛风除湿,温经止痛。笔者结合近年来的资料对川乌的化学成分及药理作用进行综述,旨在为临床用药提供一定的借鉴。
The flavor of radix aconite is symphonic,bitter,hot and extremely poisonous; The meridians of the heart,liver,kidney and spleen; Main treatment dispel wind dehumidification,warm through pain. In this paper,the chemical composition and pharmacological action of radix aconite were reviewed based on the data of recent years.In order to provide some reference for clinical medication.
The flavor of radix aconite is symphonic,bitter,hot and extremely poisonous; The meridians of the heart,liver,kidney and spleen; Main treatment dispel wind dehumidification,warm through pain. In this paper,the chemical composition and pharmacological action of radix aconite were reviewed based on the data of recent years.In order to provide some reference for clinical medication.
引文
[1]杨茗,万丽,陈斌,等.川乌氯仿部位的化学成分研究[J].现代药物与临床,2014,29(3):223-226.
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[5]马玲,朱涛,岳显可,等.HPLC分析不同蒸制温度下川乌化学成分的变化[J].中国中医药科技,2017,24(6):743-747.
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[8]ZHANG Y B,SHU Z H,YIN L,et al.Anti-inflammatory and antinociceptive activities of non-alkaloids fractions from Aconitum flavum in vivo[J].Rev Bras Farmac,2015,25(1):47-52
[9]李敏,李晓强,焦海胜,等.松潘乌头总碱的抗炎机制研究[J].中国药房,2012,23(23):2130-2131.
[10]LI X,JIANG J,SHI S,et al.A RG-II type polysaccharide purified from Aconitum coreanum alleviates lipopolysaccharide-induced inflammation by inhibiting the NF-κB signal pathway[J].PLoS One,2014,9(6):36-40.
[11]刘铭佩.松潘乌头总碱的镇痛作用[J].中药药理与临床,2007,23(1):36-37.
[12]张政,邓月婷,王小芳,等.松潘乌头总碱的镇痛作用研究[J].中药药理与临床,2014,30(6):62-65.
[13]方堃,李志会,李国辉,等.次乌头碱对H2O2致大鼠心肌细胞凋亡的保护作用[J].中国中医药科技,2010,17(4):315-317,280.
[14]李志勇,谭鹏,孙建宁,等.次乌头碱对乳大鼠原代培养心肌细胞Ca2+及Cx43表达的影响[J].时珍国医国药,2011,22(11):2689-2691.
[15]李志勇,谭鹏,赵晖,等.次乌头碱对心肌细胞Ca2+调控蛋白mRNA表达的影响[J].重庆医学,2011,40(25):2546-2548.
[16]GAO F,LI Y Y,WANG D,et al.Diterpenoid alkaloids from the Chinese traditional herbal“Fuzi”and their cytotoxic activity[J].Molecules,2012,17(5):5187.
[17]WADA K J,OHKOSHI E,ZHAO Y,et al.Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents[J].Bioor Med Chem Lett,2015,25(7):1525-1531.
[18]ZHANG Q,CHEN X,LUO Y.Fuzi enhances anti-tumor efficacy of radiotherapy on lung cancer[J].J Cancer,2017,8(19):3945-3951.
[19]SHI Y B,LIU L,SHAO W,et al.Microcalorimetry studies of the antimicrobial actions of Aconitum alkaloids[J].JZhejiang Univ Sci,2015,16(8).690-695.
[20]YUAN C L,WANG X L.Isolation of actives substances and bioactivity of Aconitum sinomontanum Na Kai[J].Nat Prod Res,2012,26(22):2099-2102.
[21]刘太华,刘德芳,汪晓军,等.乌头碱与新乌头碱对巨噬细胞RAW 264.7的作用研究[J].西南国防医药,2009,19(12):1168-1171,1350.
[22]韦祎,唐汉庆,李晓华,等.附子理中汤对脾阳虚证大鼠免疫细胞因子的影响[J].中国实验方剂学杂志,2013,19(21):179-182.
[23]LUI L,LI B J,WANG L,et al.Antidepressant-like effect of fuzi total alkaloid on ovariectomized mice[J].J Pharm Scien,2012,120(4):280-287.
[24]龙亚秋,谢文源,李华,等.附子多糖对抑郁大鼠模型的影响[J].河北医学,2017,23(6):1029-1031.
[25]LI B,MENG X J,SUN L W,et al.Isolation,chemical characterization and in vitro antioxidant activities of polysaccharides from Aconitum coreanum[J].J Med Plan Res,2012,6(5):876-883.
[26]LI B J,TANG F,WANG L,et al.Anticonvulsant effects of fuzi total alkaloid on pentylenetetrazole-induced seizure in mice[J].J Pharm Scien,2013,123(2):195-198.
[27]阚东方,季旭明,陈倩,等.附子含药血清对大鼠原代肝细胞能量代谢的影响[J].辽宁中医杂志,2018,45(3):645-647.
[28]孙启慧,付业佩,李灿,等.基于代谢组学方法研究麻黄细辛附子汤治疗肾阳虚外感小鼠的作用机制[J].中华中医药杂志,2018,33(5):1752-1757.
[29]程丽丽,许妍妍,张艳军.中药川乌多成分同时检测及药动学评价研究进展[J].天津中医药大学学报,2014,33(1):56-60.
[2]肖培根,王锋鹏,高峰,等.中国乌头属植物药用亲缘学研究[J].植物分类学报,2006(1):1-46.
[3]国家药典委员会.中华人民共和国药典(一部)[M].北京:中国医药科技出版社,2015:39-40.
[4]林宏英,苏畅,段天璇,等.基于HPLC/ESI-MS技术的川乌加热前后化学成分变化[J].中国现代中药,2015,17(3):208-211.
[5]马玲,朱涛,岳显可,等.HPLC分析不同蒸制温度下川乌化学成分的变化[J].中国中医药科技,2017,24(6):743-747.
[6]王桂玲,徐雅娟,房建强.附子非生物碱类成分的研究[J].泰山医学院学报,2007,28(3):179-181.
[7]陈信义,李峨,侯丽,等.乌头类生物碱研究进展与应用前景评述[J].中国中医药信息杂志,2004,11(10):922-923.
[8]ZHANG Y B,SHU Z H,YIN L,et al.Anti-inflammatory and antinociceptive activities of non-alkaloids fractions from Aconitum flavum in vivo[J].Rev Bras Farmac,2015,25(1):47-52
[9]李敏,李晓强,焦海胜,等.松潘乌头总碱的抗炎机制研究[J].中国药房,2012,23(23):2130-2131.
[10]LI X,JIANG J,SHI S,et al.A RG-II type polysaccharide purified from Aconitum coreanum alleviates lipopolysaccharide-induced inflammation by inhibiting the NF-κB signal pathway[J].PLoS One,2014,9(6):36-40.
[11]刘铭佩.松潘乌头总碱的镇痛作用[J].中药药理与临床,2007,23(1):36-37.
[12]张政,邓月婷,王小芳,等.松潘乌头总碱的镇痛作用研究[J].中药药理与临床,2014,30(6):62-65.
[13]方堃,李志会,李国辉,等.次乌头碱对H2O2致大鼠心肌细胞凋亡的保护作用[J].中国中医药科技,2010,17(4):315-317,280.
[14]李志勇,谭鹏,孙建宁,等.次乌头碱对乳大鼠原代培养心肌细胞Ca2+及Cx43表达的影响[J].时珍国医国药,2011,22(11):2689-2691.
[15]李志勇,谭鹏,赵晖,等.次乌头碱对心肌细胞Ca2+调控蛋白mRNA表达的影响[J].重庆医学,2011,40(25):2546-2548.
[16]GAO F,LI Y Y,WANG D,et al.Diterpenoid alkaloids from the Chinese traditional herbal“Fuzi”and their cytotoxic activity[J].Molecules,2012,17(5):5187.
[17]WADA K J,OHKOSHI E,ZHAO Y,et al.Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents[J].Bioor Med Chem Lett,2015,25(7):1525-1531.
[18]ZHANG Q,CHEN X,LUO Y.Fuzi enhances anti-tumor efficacy of radiotherapy on lung cancer[J].J Cancer,2017,8(19):3945-3951.
[19]SHI Y B,LIU L,SHAO W,et al.Microcalorimetry studies of the antimicrobial actions of Aconitum alkaloids[J].JZhejiang Univ Sci,2015,16(8).690-695.
[20]YUAN C L,WANG X L.Isolation of actives substances and bioactivity of Aconitum sinomontanum Na Kai[J].Nat Prod Res,2012,26(22):2099-2102.
[21]刘太华,刘德芳,汪晓军,等.乌头碱与新乌头碱对巨噬细胞RAW 264.7的作用研究[J].西南国防医药,2009,19(12):1168-1171,1350.
[22]韦祎,唐汉庆,李晓华,等.附子理中汤对脾阳虚证大鼠免疫细胞因子的影响[J].中国实验方剂学杂志,2013,19(21):179-182.
[23]LUI L,LI B J,WANG L,et al.Antidepressant-like effect of fuzi total alkaloid on ovariectomized mice[J].J Pharm Scien,2012,120(4):280-287.
[24]龙亚秋,谢文源,李华,等.附子多糖对抑郁大鼠模型的影响[J].河北医学,2017,23(6):1029-1031.
[25]LI B,MENG X J,SUN L W,et al.Isolation,chemical characterization and in vitro antioxidant activities of polysaccharides from Aconitum coreanum[J].J Med Plan Res,2012,6(5):876-883.
[26]LI B J,TANG F,WANG L,et al.Anticonvulsant effects of fuzi total alkaloid on pentylenetetrazole-induced seizure in mice[J].J Pharm Scien,2013,123(2):195-198.
[27]阚东方,季旭明,陈倩,等.附子含药血清对大鼠原代肝细胞能量代谢的影响[J].辽宁中医杂志,2018,45(3):645-647.
[28]孙启慧,付业佩,李灿,等.基于代谢组学方法研究麻黄细辛附子汤治疗肾阳虚外感小鼠的作用机制[J].中华中医药杂志,2018,33(5):1752-1757.
[29]程丽丽,许妍妍,张艳军.中药川乌多成分同时检测及药动学评价研究进展[J].天津中医药大学学报,2014,33(1):56-60.