芦笋对高脂饮食小鼠体质量的影响
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摘要
目的探究芦笋对高脂饮食小鼠体质量的影响。方法将实验动物随机分为正常组、高脂饮食组、高脂饮食低剂量芦笋组、高脂饮食中剂量芦笋组、高脂饮食高剂量芦笋组、高脂饮食阳性对照组。其中正常组喂食正常饲料,其余组喂食高脂饲料。分别灌胃蒸馏水(正常组、高脂饮食组)、芦笋1.05g/(kg·d)(高脂饮食低剂量芦笋组)、芦笋2.10g/(kg·d)(高脂饮食中剂量芦笋组)、芦笋4.20g/(kg·d)(高脂饮食高剂量芦笋组)、降脂理肝汤1.19g/(kg·d)(高脂饮食阳性对照组),每天2次,每次0.35mL。比较分析各组小鼠的体质量变化,同时对各组之间的雌性小鼠和雄性小鼠体质量变化进行对比。结果随饲养时间的增加,服用芦笋后的三组小鼠体质量均低于高脂饮食组,但与高脂饮食组相比差异无统计学意义(P>0.05)。高脂饮食低剂量芦笋组、高脂饮食中剂量芦笋组、高脂饮食高剂量芦笋组小鼠的体质量变化率低于高脂饮食组,差异无统计学意义(P>0.05)。对各组之间的雌性小鼠和雄性小鼠体质量变化进行对比可以发现雄性小鼠的体质量变化大于雌性小鼠的,差异有统计学意义(P<0.05)。结论芦笋能降低高脂饮食小鼠的体质量,雄性小鼠和雌性小鼠的体质量变化存在差异。
Objective To explore the effect of asparagus on the weights of mice on high-fat diet.Methods The animals were randomly divided into normal group,high-fat diet group,high-fat diet/low-dose asparagus group,high-fat diet/medium-dose asparagus group,high-fat diet/high-dose asparagus group,or high-fat diet positive control group.The normal group was fed normal feed,while all the other groups were fed highfat feed.Distilled water(normal group,high-fat diet group),asparagus 1.05 g/(kg·d)(high-fat diet/low-dose asparagus group),asparagus 2.10 g/(kg·d)(high-fat diet/medium-dose asparagus group),asparagus 4.20 g/(kg·d)(high-fat diet/high-dose asparagus group),Jiangzhi Ligan Decoction 1.19 g/(kg·d)(high-fat diet positive control group)were given by gavage,0.35 mLbid.The weights of mice in each group were compared and analyzed,and the changes in weights of female mice and male mice in each group were compared respectively.Results With the increase of feeding time,the weights of mice in the three groups given asparagus were lower than those in the high-fat diet groups,but with no significant differences(Ps>0.05);The same result was seen in the rates of weight change(Ps>0.05).The weight changes of male mice were greater than those of female mice,with significant differences(Ps<0.05).Conclusion Asparagus can reduce the weights of mice on high-fat diet.There are differences in the energy metabolism between male mice and female mice.
Objective To explore the effect of asparagus on the weights of mice on high-fat diet.Methods The animals were randomly divided into normal group,high-fat diet group,high-fat diet/low-dose asparagus group,high-fat diet/medium-dose asparagus group,high-fat diet/high-dose asparagus group,or high-fat diet positive control group.The normal group was fed normal feed,while all the other groups were fed highfat feed.Distilled water(normal group,high-fat diet group),asparagus 1.05 g/(kg·d)(high-fat diet/low-dose asparagus group),asparagus 2.10 g/(kg·d)(high-fat diet/medium-dose asparagus group),asparagus 4.20 g/(kg·d)(high-fat diet/high-dose asparagus group),Jiangzhi Ligan Decoction 1.19 g/(kg·d)(high-fat diet positive control group)were given by gavage,0.35 mLbid.The weights of mice in each group were compared and analyzed,and the changes in weights of female mice and male mice in each group were compared respectively.Results With the increase of feeding time,the weights of mice in the three groups given asparagus were lower than those in the high-fat diet groups,but with no significant differences(Ps>0.05);The same result was seen in the rates of weight change(Ps>0.05).The weight changes of male mice were greater than those of female mice,with significant differences(Ps<0.05).Conclusion Asparagus can reduce the weights of mice on high-fat diet.There are differences in the energy metabolism between male mice and female mice.
引文
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[7]Rodríguez AM,Palou A.Uncoupling proteins:Gender dependence and their relation to body weight control[J].Int J Obesity,2004,28(2):500-502.
[8]王先科,史莹华,王成章,等.不同高脂饲料建立高脂血症大鼠模型的对比研究[J].江苏农业科学,2012,40(1):182-184.
[9]FENG Mengjun,XIE Jianan,ZHANG Yixin,et al.Influence of lipid-lowering decoction on hepatic morphology and pathological changes in rats with nonalcoholic fatty liver disease[J].World Chin J Digestol,2015,23(16):2532-2538.(in Chinese)冯梦君,谢佳楠,张怡歆,等.降脂理肝汤对非酒精性脂肪肝大鼠肝组织病理的影响[J].世界华人消化杂志,2015,23(16):2532-2538.
[10]李学奇,曹晓培.高脂饮食到底多伤身[J].农产品市场周刊,2017,(21):54-54.
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[12]Kautzky-Willer A,Handisurya A.Metabolic diseases and associated complications:Sex and gender matter[J].Eur J Clin Invest,2009,39(8):631-648.
[13]Lee HJ,Yang SJ.Aging-related correlation between serum sirtuin 1activities and basal metabolic rate in women,but not in men[J].Clin Nutr Res,2017,6(1):18-26.
[14]Allan CA,Strauss BJG,Burger HG,et al.Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men[J].J Clin Endocrinol&Metabol,2008,93(1):139-146.
[15]Cheung OK,Cheng AS.Gender differences in adipocyte metabolism and liver cancer progression[J].Front Genet,2016,7:168.
[16]Wang GJ,Volkow ND,Telang F,et al.Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation[J].Proc Natl Acad Sci U S A,2009,106(4):1249-1254.
[17]CUI Ju,CHEN Aiqun,PANG Jing,et al.Difference of energy metabolism between male and female mice exposed to high fat diet[J].J Shanxi Med Univ,2007,48(7):658-664.(in Chinese)崔菊,陈爱群,庞婧,等.高脂饮食影响小鼠体内能量代谢的性别差异[J].山西医科大学学报,2017,48(7):658-664.
[18]ZHANg Yong.The gender differences in energy expenditure and substrate metabolism in college students during cycling[J].Chin J Sports Med,2009,28(5):491-494.(in Chinese)张勇.普通大学生骑车运动中机体能量消耗和底物代谢的性别差异研究[J].中国运动医学杂志,2009,28(5):491-494.
[19]Tarnopolsky MA.Gender differences in substrate metabolism during endurance exercise[J].Can J Appl Physiol,2000,25(4):312-327.
[20]Frontera WR,Suh D,Krivickas LS,et al.Skeletal muscle fiber quality in older men and women[J].Am J Physiol:Cell Physiol(Print),2000,279(3):611-618.
[21]Suh SH,Casazza GA,Horning MA,et al.Effects of oral contraceptives on glucose flux and substrate oxidation rates during rest and exercise[J].J Appl Physiol,2003,94(1):285-294.
[22]Cross TL,Kasahara K,Rey FE.Sexual dimorphism of cardiometabolic dysfunction:Gut microbiome in the play?[J].Mol Metabol,2018,15:70-81.
[23]JIANG Dan,TAO Fengyun,LI Yaqiu,et al.The development of flavonoids in Asparagus officinalis L[J].Food Industry Technol,2014,35(3):357-362.(in Chinese)蒋丹,陶凤云,李亚秋,等.芦笋中黄酮类化合物的研究进展[J].食品工业科技,2014,35(3):357-362.
[24]方诩.芦笋的综台利用与开发[J].四川省食品工业科技,1997(4):50-52.
[25]刘林丽,杨茂才.芦笋的综合加工利用[J].陕西农业科学,1998(3):46-47.
[26]卜春文.保健型芦笋酸奶的研制[J].冷饮与速冻食品工业,2003,9(2):11.
[27]左春旭,李风琴,仲英,等.芦笋茎皮综合利用新途径---具抗癌活性的芦笋茎皮浸膏及其制法[J].中外技术情报,1995(2):18-20.
[28]石传林.利用芦笋加工下脚料饲喂泌乳牛的效果[J].饲料博览,2001(2):22-23.
[2]高言诚.体重、体脂和去脂体重[J].北京体育学院学报,1980(3):66-70.
[3]Legato MJ.Gender-specific aspects of obesity[J].Int J Fertil Womens Med,1997,42(3):184-197.
[4]Hong JN,Stubbins RE,Smith RR,et al.Differential susceptibility to obesity between male,female and ovariectomized female mice[J].Nutr J,2009,8:11.
[5]Rodriguez-Cuenca S,Pujol E,Justo R,et al.Sex-dependent thermogenesis,differences in mitochondrial morphology and function,and adrenergic response in brown adipose tissue[J].J Biolog Chem,2002,277(45):42958-42963.
[6]Kim SN,Jung YS,Kwon HJ,et al.Sex differences in sympathetic innervation and browning of white adipose tissue of mice[J].Biol Sex Differ,2016,7:67.
[7]Rodríguez AM,Palou A.Uncoupling proteins:Gender dependence and their relation to body weight control[J].Int J Obesity,2004,28(2):500-502.
[8]王先科,史莹华,王成章,等.不同高脂饲料建立高脂血症大鼠模型的对比研究[J].江苏农业科学,2012,40(1):182-184.
[9]FENG Mengjun,XIE Jianan,ZHANG Yixin,et al.Influence of lipid-lowering decoction on hepatic morphology and pathological changes in rats with nonalcoholic fatty liver disease[J].World Chin J Digestol,2015,23(16):2532-2538.(in Chinese)冯梦君,谢佳楠,张怡歆,等.降脂理肝汤对非酒精性脂肪肝大鼠肝组织病理的影响[J].世界华人消化杂志,2015,23(16):2532-2538.
[10]李学奇,曹晓培.高脂饮食到底多伤身[J].农产品市场周刊,2017,(21):54-54.
[11]Zillikens MC,Yazdanpanah M,Pardo LM,et al.Sex-specific genetic effects influence variation in body composition[J].Diabetologia,2008,51(12):2233-2241.
[12]Kautzky-Willer A,Handisurya A.Metabolic diseases and associated complications:Sex and gender matter[J].Eur J Clin Invest,2009,39(8):631-648.
[13]Lee HJ,Yang SJ.Aging-related correlation between serum sirtuin 1activities and basal metabolic rate in women,but not in men[J].Clin Nutr Res,2017,6(1):18-26.
[14]Allan CA,Strauss BJG,Burger HG,et al.Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men[J].J Clin Endocrinol&Metabol,2008,93(1):139-146.
[15]Cheung OK,Cheng AS.Gender differences in adipocyte metabolism and liver cancer progression[J].Front Genet,2016,7:168.
[16]Wang GJ,Volkow ND,Telang F,et al.Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation[J].Proc Natl Acad Sci U S A,2009,106(4):1249-1254.
[17]CUI Ju,CHEN Aiqun,PANG Jing,et al.Difference of energy metabolism between male and female mice exposed to high fat diet[J].J Shanxi Med Univ,2007,48(7):658-664.(in Chinese)崔菊,陈爱群,庞婧,等.高脂饮食影响小鼠体内能量代谢的性别差异[J].山西医科大学学报,2017,48(7):658-664.
[18]ZHANg Yong.The gender differences in energy expenditure and substrate metabolism in college students during cycling[J].Chin J Sports Med,2009,28(5):491-494.(in Chinese)张勇.普通大学生骑车运动中机体能量消耗和底物代谢的性别差异研究[J].中国运动医学杂志,2009,28(5):491-494.
[19]Tarnopolsky MA.Gender differences in substrate metabolism during endurance exercise[J].Can J Appl Physiol,2000,25(4):312-327.
[20]Frontera WR,Suh D,Krivickas LS,et al.Skeletal muscle fiber quality in older men and women[J].Am J Physiol:Cell Physiol(Print),2000,279(3):611-618.
[21]Suh SH,Casazza GA,Horning MA,et al.Effects of oral contraceptives on glucose flux and substrate oxidation rates during rest and exercise[J].J Appl Physiol,2003,94(1):285-294.
[22]Cross TL,Kasahara K,Rey FE.Sexual dimorphism of cardiometabolic dysfunction:Gut microbiome in the play?[J].Mol Metabol,2018,15:70-81.
[23]JIANG Dan,TAO Fengyun,LI Yaqiu,et al.The development of flavonoids in Asparagus officinalis L[J].Food Industry Technol,2014,35(3):357-362.(in Chinese)蒋丹,陶凤云,李亚秋,等.芦笋中黄酮类化合物的研究进展[J].食品工业科技,2014,35(3):357-362.
[24]方诩.芦笋的综台利用与开发[J].四川省食品工业科技,1997(4):50-52.
[25]刘林丽,杨茂才.芦笋的综合加工利用[J].陕西农业科学,1998(3):46-47.
[26]卜春文.保健型芦笋酸奶的研制[J].冷饮与速冻食品工业,2003,9(2):11.
[27]左春旭,李风琴,仲英,等.芦笋茎皮综合利用新途径---具抗癌活性的芦笋茎皮浸膏及其制法[J].中外技术情报,1995(2):18-20.
[28]石传林.利用芦笋加工下脚料饲喂泌乳牛的效果[J].饲料博览,2001(2):22-23.