基于“绿色设计”理念的中药制药膜分离工艺选择原则与方法
|
摘要
面向绿色制造的中药制药工艺路线设计,亦称"绿色设计",其目的是极小化产品全生命周期过程的资源消耗和环境影响,协调优化经济效益和环境效益。以膜技术为核心的制药分离工艺技术与药物绿色制造息息相关,"环境、性能和成本"三大要求和成熟度、分离技术原理是制药分离工艺绿色设计的基本要素,"清洁工艺"可降低原料及能源耗损,切合"预防优于治理"的理念,也可提高企业的经济效益,对生态保护和经济建设的和谐发展具有重要保障作用。以构建膜与树脂技术系统集成为例,介绍中药制药工艺绿色设计具体实施方案,对中药制药分离工艺设计的技术经济问题开展分析和讨论。
The Chinese materia medica pharmaceutical process route designed for green manufacturing, also known as "green design", aims to minimize the resource consumption and environmental effect of the life cycle of products process, coordinate and optimize economic and environmental efficiency. With membrane technology at the core of the pharmaceutical separation process technology closely related to green manufacturing of drugs. The three major requirements and maturity of "environment, performance, and cost" and separation technology principle are the basic elements of the pharmaceutical separation process green design. The development and adoption of clean technology not only conforms to the "principle of precautionary superior to governance", but also reduces the consumption of raw materials and energy, and at the same time improves the economic efficiency of the enterprises. It is the best way to protect the coordinated development of the ecological environment and economic construction. In this paper, taking the construction of "membrane and resin technology system integration" as an example, the specific implementation plan for the green design of Chinese materia medica pharmaceutical process is introduced, and the technical economical problems in the design of pharmaceutical separation process are analyzed and discussed.
The Chinese materia medica pharmaceutical process route designed for green manufacturing, also known as "green design", aims to minimize the resource consumption and environmental effect of the life cycle of products process, coordinate and optimize economic and environmental efficiency. With membrane technology at the core of the pharmaceutical separation process technology closely related to green manufacturing of drugs. The three major requirements and maturity of "environment, performance, and cost" and separation technology principle are the basic elements of the pharmaceutical separation process green design. The development and adoption of clean technology not only conforms to the "principle of precautionary superior to governance", but also reduces the consumption of raw materials and energy, and at the same time improves the economic efficiency of the enterprises. It is the best way to protect the coordinated development of the ecological environment and economic construction. In this paper, taking the construction of "membrane and resin technology system integration" as an example, the specific implementation plan for the green design of Chinese materia medica pharmaceutical process is introduced, and the technical economical problems in the design of pharmaceutical separation process are analyzed and discussed.
引文
[1]王北婴,王跃生,王焕魁.我国中药制药工业中亟需推广的高新技术[J].世界科学技术,2001,2(2):18-24.
[2]韩立炜,王昌恩,刘屏,等.国家自然科学基金中药制剂学5年来受理与资助情况分析[J].中国中药杂志,2004,29(1):4-6.
[3]郭立玮.中药分离原理与技术[M].北京:人民卫生出版社,2010.
[4]刘飞,曾华军,张华,等.绿色制造的理论与技术[M].北京:科学出版社,2007.
[5]吴燕生.技术成熟度及其评价方法[M].北京:国防工业出版社,2012.
[6]耿信笃.现代分离科学理论导引[M].北京:高等教育出版社,2001.
[7]Wang M,Lamers R A,Korthout H A,et al.Metabolomics in thecontext of systems biology:Bridging traditional Chinese medicine and molecular pharmacology[J].Phytother Res,2005,19(3):173-182.
[8]宗杰.不同精制工艺条件对骨痹颗粒喷干粉吸湿性能的影响及吸湿性物质基础的初步研究[D].南京:南京中医药大学,2014.
[9]宗杰,朱华旭,龙观洪,等.陶瓷膜与醇沉等方法精制骨痹颗粒的药效学比较及其作用[J].膜科学与技术,2016,36(4):110-118.
[10]Garcia A A.生物分离过程科学[M].刘铮,詹劲,译.北京:清华大学出版社,2004.
[11]韩鲁佳,阎巧娟,江正强,等.黄芪多糖及皂苷提取工艺研究[J].农业工程学报,2000,16(增刊):116-118.
[12]徐萍.基于膜集成技术的中药挥发性小分子物质的富集研究--基于工业化生产的中药挥发油提取过程[D].南京:南京中医院大学,2009.
[13]田晓然.全蝎湿法超微粉碎-超滤法提取分离与凝胶耦合纯化抗凝血、抗血栓活性物质的研究[D].南京:南京中医院大学,2013.
[14]郭立玮,邢卫红,高从堦,等.中药膜技术的“绿色制造”特征、国家战略需求及其关键科学问题与应对策略[J].中草药,2017,48(16):3267-3279.
[15]郭立玮.制药分离工程[M].北京:人民卫生出版社,2014.
[16]潘林梅,郭立玮,黄敏燕,等.陶瓷膜清洗剂及其制备方法和应用:中国,ZL200910027181.6[P].2009-05-22.
[17]郭维图.膜分离技术在中药提取液浓缩中的应用[J].机电信息,2007(23):8-15.
[18]杨祖金,袁雨婕,葛发欢,等.纳滤技术在中药浓缩中的应用[J].中药材,2008,31(6):910-912.
[19]李全宏,蔡同一,倪元颍.膜分离技术在果蔬汁浓缩中应用研究进展[J].莱阳农学院学报,2002,19(1):44-48.
[20]Nabetani H.Development of a membrane system for highly concentrated fruit juice[J].Membrane,1996,21(2):102-108.
[21]Cassano A,Jiao B,Drioli E,et al.Production of concentrated kiwifruit juice by integrated membrane process[J].Food Res Int,2004,37(2):139-148.
[22]Casson A,Drioli E,Galaverna G.Clarification and concentration of citrus and carrot juices by integrated membrane processes[J].J Food Eng,2003,57(2):153-163.
[23]Lagana F,Barbieri G,Drioli E.Direct contact membrane distillation:Modeling and concentration experiments[J].J Membrane Sci,2000,166(1):1-11.
[24]Kelly S T,Zydney A L.Protein fouling during microfiltration:Camparative behavior of different model proteins[J].Bio Eng,1997,55(1):91-100.
[25]Blancom M,Ba?óR G,Bertran E.Monitoring powder blending in pharmaceutical processes by use of near infrared spectroscopy[J].Talanta,2002,56(1):203-212.
[26]Jiao B,Cassano A,Drioli E.Recent advances on membrane processes forthe concentration of fruit juices:A review[J].J Food Eng,2004,63(3):303-324.
[27]Tomaszewska M,Gryta M,Morawski A W.Mass transfer of HCl and H2O across the hydrophobic membrane during membrane distillation[J].J Membrane Sci,2000,166(2):149-157.
[28]Tan P N,Steinbach M,Kumar V.数据挖掘导论[M].范明,范宏建,译.北京:人民邮电出版社,2006.
[29]徐南平.面向应用过程的陶瓷膜设计、制造与应用[M].北京:科学出版社,2005.
[30]Dal-Cin M M,McLellan F,Striez C N,et al.Membrane performance with a pulp mill effluent:Relative contributions of fouling mechanisms[J].J Membrane Sci,1996,120(2):273-285.
[31]纪晓声,楼永通,高从堦.膜分离技术在中药制备中的应用[J].水处理技术,2006,32(3):11-14.
[32]谭显春,刘华飞,曹华军.绿色制造的一种工艺路线决策模型及其求解算法[J].机械工程学报,2004,40(4):154-159.
[2]韩立炜,王昌恩,刘屏,等.国家自然科学基金中药制剂学5年来受理与资助情况分析[J].中国中药杂志,2004,29(1):4-6.
[3]郭立玮.中药分离原理与技术[M].北京:人民卫生出版社,2010.
[4]刘飞,曾华军,张华,等.绿色制造的理论与技术[M].北京:科学出版社,2007.
[5]吴燕生.技术成熟度及其评价方法[M].北京:国防工业出版社,2012.
[6]耿信笃.现代分离科学理论导引[M].北京:高等教育出版社,2001.
[7]Wang M,Lamers R A,Korthout H A,et al.Metabolomics in thecontext of systems biology:Bridging traditional Chinese medicine and molecular pharmacology[J].Phytother Res,2005,19(3):173-182.
[8]宗杰.不同精制工艺条件对骨痹颗粒喷干粉吸湿性能的影响及吸湿性物质基础的初步研究[D].南京:南京中医药大学,2014.
[9]宗杰,朱华旭,龙观洪,等.陶瓷膜与醇沉等方法精制骨痹颗粒的药效学比较及其作用[J].膜科学与技术,2016,36(4):110-118.
[10]Garcia A A.生物分离过程科学[M].刘铮,詹劲,译.北京:清华大学出版社,2004.
[11]韩鲁佳,阎巧娟,江正强,等.黄芪多糖及皂苷提取工艺研究[J].农业工程学报,2000,16(增刊):116-118.
[12]徐萍.基于膜集成技术的中药挥发性小分子物质的富集研究--基于工业化生产的中药挥发油提取过程[D].南京:南京中医院大学,2009.
[13]田晓然.全蝎湿法超微粉碎-超滤法提取分离与凝胶耦合纯化抗凝血、抗血栓活性物质的研究[D].南京:南京中医院大学,2013.
[14]郭立玮,邢卫红,高从堦,等.中药膜技术的“绿色制造”特征、国家战略需求及其关键科学问题与应对策略[J].中草药,2017,48(16):3267-3279.
[15]郭立玮.制药分离工程[M].北京:人民卫生出版社,2014.
[16]潘林梅,郭立玮,黄敏燕,等.陶瓷膜清洗剂及其制备方法和应用:中国,ZL200910027181.6[P].2009-05-22.
[17]郭维图.膜分离技术在中药提取液浓缩中的应用[J].机电信息,2007(23):8-15.
[18]杨祖金,袁雨婕,葛发欢,等.纳滤技术在中药浓缩中的应用[J].中药材,2008,31(6):910-912.
[19]李全宏,蔡同一,倪元颍.膜分离技术在果蔬汁浓缩中应用研究进展[J].莱阳农学院学报,2002,19(1):44-48.
[20]Nabetani H.Development of a membrane system for highly concentrated fruit juice[J].Membrane,1996,21(2):102-108.
[21]Cassano A,Jiao B,Drioli E,et al.Production of concentrated kiwifruit juice by integrated membrane process[J].Food Res Int,2004,37(2):139-148.
[22]Casson A,Drioli E,Galaverna G.Clarification and concentration of citrus and carrot juices by integrated membrane processes[J].J Food Eng,2003,57(2):153-163.
[23]Lagana F,Barbieri G,Drioli E.Direct contact membrane distillation:Modeling and concentration experiments[J].J Membrane Sci,2000,166(1):1-11.
[24]Kelly S T,Zydney A L.Protein fouling during microfiltration:Camparative behavior of different model proteins[J].Bio Eng,1997,55(1):91-100.
[25]Blancom M,Ba?óR G,Bertran E.Monitoring powder blending in pharmaceutical processes by use of near infrared spectroscopy[J].Talanta,2002,56(1):203-212.
[26]Jiao B,Cassano A,Drioli E.Recent advances on membrane processes forthe concentration of fruit juices:A review[J].J Food Eng,2004,63(3):303-324.
[27]Tomaszewska M,Gryta M,Morawski A W.Mass transfer of HCl and H2O across the hydrophobic membrane during membrane distillation[J].J Membrane Sci,2000,166(2):149-157.
[28]Tan P N,Steinbach M,Kumar V.数据挖掘导论[M].范明,范宏建,译.北京:人民邮电出版社,2006.
[29]徐南平.面向应用过程的陶瓷膜设计、制造与应用[M].北京:科学出版社,2005.
[30]Dal-Cin M M,McLellan F,Striez C N,et al.Membrane performance with a pulp mill effluent:Relative contributions of fouling mechanisms[J].J Membrane Sci,1996,120(2):273-285.
[31]纪晓声,楼永通,高从堦.膜分离技术在中药制备中的应用[J].水处理技术,2006,32(3):11-14.
[32]谭显春,刘华飞,曹华军.绿色制造的一种工艺路线决策模型及其求解算法[J].机械工程学报,2004,40(4):154-159.