氟喹诺酮类抗生素不良反应临床分析
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摘要
目的对氟喹诺酮类抗生素(FQNS)的临床使用不良反应情况进行探讨分析。方法选取2014年7月~2015年7月我院的1 000例接受氟喹诺酮类抗生素治疗感染性疾病患者进行分析,对患者的不良反应情况进行统计总结和归纳。结果共出现80例不良反应病例,占总数的8%,以诺氟沙星的不良反应率最高,依次是环丙沙星、培氟沙星、莫西沙星、左氧氟沙星。这些出现不良反应的比例中有18例胃肠道反应,比例22.5%;40例变态反应,比例是50.0%;4例肝胆系统反应,比例是5.0%;12例神经系统反应,占15.0%;4例肾脏系统反应,占5.0%;2例内分泌系统反应,占2.5%。结论感染性疾病患者接受氟喹诺酮类药物治疗的效果比较好,氟喹诺酮是对该类感染的一线抗生素药物,使用时需要对药物剂量进行把控,降低患者的不良反应发生率,确保患者接受治疗的安全性。
Objective To fluoroquinolones(FQNS) analysis of adverse reactions in clinical use. Methods Selected 1 000 cases July 2014 to July 2015 in our hospital accept fluoroquinolone antibiotics in treatment of patients with infectious diseases were analyzed in patients with adverse reactions for statistical summary. Results All patients were 80 cases of adverse reaction cases, accounted for 8% to the adverse reaction of norfloxacin was the highest, followed by ciprofloxacin, culture of levofloxacin, moxifloxacin, levofloxacin. The proportion of adverse reactions of 18 cases of gastrointestinal reaction, the proportion was 22.5%, 40 cases of allergic reaction, the ratio was 50.0%, 4 cases of hepatobiliary system reaction, the ratio was 5.0%, 12 cases of nervous system reaction was 15.0%, 4 cases of renal system reaction was 5.0%, 2 cases response of endocrine system, accounting for 2.5%. Conclusion Patients with infectious diseases received fluoroquinolone therapy effect is good, he is the infection of the first-line antibiotics, the incidence rate of adverse reactions of the use of drug dose is to control, reduce patient, to ensure that patients receive treatment safety.
Objective To fluoroquinolones(FQNS) analysis of adverse reactions in clinical use. Methods Selected 1 000 cases July 2014 to July 2015 in our hospital accept fluoroquinolone antibiotics in treatment of patients with infectious diseases were analyzed in patients with adverse reactions for statistical summary. Results All patients were 80 cases of adverse reaction cases, accounted for 8% to the adverse reaction of norfloxacin was the highest, followed by ciprofloxacin, culture of levofloxacin, moxifloxacin, levofloxacin. The proportion of adverse reactions of 18 cases of gastrointestinal reaction, the proportion was 22.5%, 40 cases of allergic reaction, the ratio was 50.0%, 4 cases of hepatobiliary system reaction, the ratio was 5.0%, 12 cases of nervous system reaction was 15.0%, 4 cases of renal system reaction was 5.0%, 2 cases response of endocrine system, accounting for 2.5%. Conclusion Patients with infectious diseases received fluoroquinolone therapy effect is good, he is the infection of the first-line antibiotics, the incidence rate of adverse reactions of the use of drug dose is to control, reduce patient, to ensure that patients receive treatment safety.
引文
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[6]黎微微.喹诺酮类抗生素耐药情况及其耐药机制研究[J].中国疗养医学,2013,12(3):1090-1093.
[2]何佩莹.氟喹诺酮类抗生素不良反应65例临床分析[J].中外医疗,2012,31(11):109-111.
[3]古力努尔·多送别克,闫海风.氟喹诺酮类抗生素的不良反应分析[J].中国伤残医学,2013,21(9):430-431.
[4]段红珍.氟喹诺酮类抗生素不良反应分析[J].内蒙古中医药,2013,32(24):75.
[5]李星如,毕凤兰.浅析氟喹诺酮类药物的安全性现状[J].中国药物警戒,2013,1(19):44-46.
[6]黎微微.喹诺酮类抗生素耐药情况及其耐药机制研究[J].中国疗养医学,2013,12(3):1090-1093.