基于FAHP-熵权法优选复方双花口服液醇沉工艺研究
|
摘要
目的优化复方双花口服液(FS)醇沉工艺的关键工艺参数,改善产品的澄明度,保证产品质量的安全有效、稳定可控。方法以(R,S)-告依春保留率(GY)、蛋白质清除率(DB)、多糖清除率(DT)、鞣质清除率(RZ)和出膏率(CG)为考察指标,采用模糊层次分析法(FAHP)、熵权法、FAHP-熵权法确定各指标的权重系数,优化FS醇沉工艺的关键工艺参数。结果 FAHP-熵权法较单一赋权法更加科学、合理、全面,根据所得权重系数进行综合评价,优化后的FS醇沉关键工艺参数为药液浓缩至相对密度1.00～1.05,加入乙醇使含醇量为80%,静置12 h。结论 FAHP法结合熵权法可用于FS醇沉工艺多指标权重的建立,优化后的醇沉工艺稳定可行,除去了水提液中较多的大分子物质,使该产品的澄明度得到了较大的改善,为其工业化大生产的适应性提供参考。
Objective To optimize the critical parameters of alcohol precipitation of Fufang Shuanghua oral liquid, and improve its clarity to ensure the safety and effectiveness of product quality and make it stable and controllable. Methods The(R, S)-goitrin retention rate, the precipitation rate of protein/polysaccharide/tannin and the solid content were chosen as indicators. Fuzzy analytic hierarchy process(FAHP), entropy method and FAHP-entropy method were used to determine the weight coefficients of each indicator, to optimize the critical process parameters of alcohol precipitation process. Results FAHP-entropy method was more scientific, reasonable and comprehensive than the single weighting method. According to the obtained weighting coefficients, comprehensive evaluation was conducted. Optimal alcohol precipitation critical technical parameters were as follows: the relative density of the drug concentration was 1.00-1.05; adding ethanol until treaching 80% and resting in cold storage for 12 h. Conclusion FAHP-entropy method can be used to establish the multi-index weights of alcohol precipitation process of Fufang Shuanghua oral liquid. The optimized alcohol precipitation process is stable and feasible. The clarity of the oral liquid is greatly improved after the macromolecules are removed in the extraction, providing a reference for the industrialized large-scale production.
Objective To optimize the critical parameters of alcohol precipitation of Fufang Shuanghua oral liquid, and improve its clarity to ensure the safety and effectiveness of product quality and make it stable and controllable. Methods The(R, S)-goitrin retention rate, the precipitation rate of protein/polysaccharide/tannin and the solid content were chosen as indicators. Fuzzy analytic hierarchy process(FAHP), entropy method and FAHP-entropy method were used to determine the weight coefficients of each indicator, to optimize the critical process parameters of alcohol precipitation process. Results FAHP-entropy method was more scientific, reasonable and comprehensive than the single weighting method. According to the obtained weighting coefficients, comprehensive evaluation was conducted. Optimal alcohol precipitation critical technical parameters were as follows: the relative density of the drug concentration was 1.00-1.05; adding ethanol until treaching 80% and resting in cold storage for 12 h. Conclusion FAHP-entropy method can be used to establish the multi-index weights of alcohol precipitation process of Fufang Shuanghua oral liquid. The optimized alcohol precipitation process is stable and feasible. The clarity of the oral liquid is greatly improved after the macromolecules are removed in the extraction, providing a reference for the industrialized large-scale production.
引文
[1]韦迎春,闫明,胡军华,等.六味地黄方醇沉工艺研究[J].中草药,2015,46(8):1161-1166.
[2]韩桂茹,徐韧柳,冯丽,等.水提醇沉对中药各类有效成分的影响[J].中国中药杂志,1993,18(5):286-287.
[3]白海生,张凤珍,张长海.中药复方制剂工艺中澄清技术对有效成分影响探讨[J].时珍国医国药,1999,10(1):69-71.
[4]李碧云,龚琼,张雄飞,等.中药口服液澄明度问题分析[J].中成药,2014,36(11):2384-2387.
[5]朱磊,刘婉莹,张宁,等.对中药口服液澄明度的研究[J].现代中药研究与实践,2015,29(1):86-88.
[6]张吉军.模糊层次分析法(FAHP)[J].模糊系统与数学,2010,14(2):80-88.
[7]田彦芳,万海同,朱紫烨,等.基于熵权法的多目标筛选甘草黄酮类成分纯化工艺[J].中草药,2016,47(7):1118-1125.
[8]中国药典2015年版.四部[S]. 2015:203.
[9]谢松,卞晓岚,陈敬贤,等.葛芪颗粒水提醇沉工艺的优化[J].中成药,2017,39(8):1723-1726.
[10]陈恒文,张翠英,任伟光,等.多指标综合评分法优化宣痹安痛方的水提醇沉工艺[J].中国中药杂志,2016,41(1):70-74.
[11]侯林中,张熙洁,王玉,等.正交试验优选宽心口服液醇沉工艺[J].中国实验方剂学杂志,2011,17(2):32-34.
[12]原素敏,倪健,朱盈.正交实验优选威灵仙总皂苷提取工艺[J].中南药学,2009,7(1):4-6.
[13]孙铭忆,李冰韶,王永洁,等.基于模糊层次分析法优选复方黄芪水浸膏提取工艺路线[J].中草药,2018,49(2):325-329.
[14]刘艳,邓博,邱玥,等.基于模糊层次分析法优选红花通络方最佳提取工艺路线[J].中草药,2016,47(17):3009-3015.
[15]朱紫烨,田彦芳,张迁,等. BP神经网络结合熵权法优化甘草皂苷提取工艺[J].中成药,2017,39(9):1830-1834.
[16]王继龙,魏舒畅,刘永琦,等.基于G1-熵权法和正交设计优选黄芪百合颗粒的提取纯化工艺[J].中草药,2018,49(3):596-603.
[17]田彦芳,万海同,朱紫烨,等.基于熵权法的多目标筛选甘草黄酮类成分纯化工艺[J].中草药,2016,47(7):1118-1125.
[18]陈述云.综合评价中指标的客观赋权方法[J].江苏统计,1995,6(11):16-18.
[2]韩桂茹,徐韧柳,冯丽,等.水提醇沉对中药各类有效成分的影响[J].中国中药杂志,1993,18(5):286-287.
[3]白海生,张凤珍,张长海.中药复方制剂工艺中澄清技术对有效成分影响探讨[J].时珍国医国药,1999,10(1):69-71.
[4]李碧云,龚琼,张雄飞,等.中药口服液澄明度问题分析[J].中成药,2014,36(11):2384-2387.
[5]朱磊,刘婉莹,张宁,等.对中药口服液澄明度的研究[J].现代中药研究与实践,2015,29(1):86-88.
[6]张吉军.模糊层次分析法(FAHP)[J].模糊系统与数学,2010,14(2):80-88.
[7]田彦芳,万海同,朱紫烨,等.基于熵权法的多目标筛选甘草黄酮类成分纯化工艺[J].中草药,2016,47(7):1118-1125.
[8]中国药典2015年版.四部[S]. 2015:203.
[9]谢松,卞晓岚,陈敬贤,等.葛芪颗粒水提醇沉工艺的优化[J].中成药,2017,39(8):1723-1726.
[10]陈恒文,张翠英,任伟光,等.多指标综合评分法优化宣痹安痛方的水提醇沉工艺[J].中国中药杂志,2016,41(1):70-74.
[11]侯林中,张熙洁,王玉,等.正交试验优选宽心口服液醇沉工艺[J].中国实验方剂学杂志,2011,17(2):32-34.
[12]原素敏,倪健,朱盈.正交实验优选威灵仙总皂苷提取工艺[J].中南药学,2009,7(1):4-6.
[13]孙铭忆,李冰韶,王永洁,等.基于模糊层次分析法优选复方黄芪水浸膏提取工艺路线[J].中草药,2018,49(2):325-329.
[14]刘艳,邓博,邱玥,等.基于模糊层次分析法优选红花通络方最佳提取工艺路线[J].中草药,2016,47(17):3009-3015.
[15]朱紫烨,田彦芳,张迁,等. BP神经网络结合熵权法优化甘草皂苷提取工艺[J].中成药,2017,39(9):1830-1834.
[16]王继龙,魏舒畅,刘永琦,等.基于G1-熵权法和正交设计优选黄芪百合颗粒的提取纯化工艺[J].中草药,2018,49(3):596-603.
[17]田彦芳,万海同,朱紫烨,等.基于熵权法的多目标筛选甘草黄酮类成分纯化工艺[J].中草药,2016,47(7):1118-1125.
[18]陈述云.综合评价中指标的客观赋权方法[J].江苏统计,1995,6(11):16-18.