眠安合剂治疗32例失眠症临床疗效研究
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摘要
目的 :观察眠安合剂治疗失眠症的临床疗效。方法 :将64例患者随机分成治疗组和对照组各32例,治疗组给予眠安合剂口服,每次10 ml,3次/d;对照组给予右佐匹克隆片3 mg口服,每晚1次,连续服用4周。观察两组患者有效率及匹兹堡睡眠质量指数评分变化。结果 :两组患者睡眠改善有效率的差异无显著意义;治疗4周后两组间匹兹堡评分具有显著性差异(P<0.05)。结论 :眠安合剂治疗失眠症疗效肯定,且能够显著提高患者的睡眠质量及生活质量。
Objective: To observe the effect of Mian'an Heji on insomnia. Methods: Sixty-four cases were randomly divided into a treatment group and a control group with 32 cases each. The treatment group was treated with 10 ml of Mian'an Heji, three times a day while the control group was treated with oral 3 mg of dexzopiclone, once a night for 4 consecutive weeks. The therapeutic effect and the change of Pittsburgh sleep quality index(PSQI) score were observed. Results: There were no significant differences between the two groups in the efficiency of sleep improvement. However, there were significant differences between the two groups in PSQI scores after 4 weeks of treatment(P<0.05). Conclusion: Mian'an Heji for the treatment of insomniac is effective and can significantly improve the sleep and life quality of the patients.
Objective: To observe the effect of Mian'an Heji on insomnia. Methods: Sixty-four cases were randomly divided into a treatment group and a control group with 32 cases each. The treatment group was treated with 10 ml of Mian'an Heji, three times a day while the control group was treated with oral 3 mg of dexzopiclone, once a night for 4 consecutive weeks. The therapeutic effect and the change of Pittsburgh sleep quality index(PSQI) score were observed. Results: There were no significant differences between the two groups in the efficiency of sleep improvement. However, there were significant differences between the two groups in PSQI scores after 4 weeks of treatment(P<0.05). Conclusion: Mian'an Heji for the treatment of insomniac is effective and can significantly improve the sleep and life quality of the patients.
引文
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[11]刘侗,康馨元,任伯颖,等.珍珠母超微粉蛋白及寡肽对小鼠镇静安眠作用比较[J].吉林中医药,2014,34(2):172-173,176.
[12]冯波.合欢皮对小鼠的抗焦虑作用研究[D].郑州:河南中医学院,2014.
[13]唐锴,叶庆红,陈志斌,等.右佐匹克隆治疗失眠症患者的疗效[J].临床精神医学杂志,2012,22(3):197-198.
[2]Ong JC,Manber R,Segal Z,et al.A randomized controlled trial of mindfulness meditation for chronic insomnia[J].Sleep,2014,37(9):1553-1563.
[3]Wang L,Song Y,Li F,et al.Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin[J].Neural Regen Res,2014,9(2):205-212.
[4]张东,于逢春,罗斌,等.百乐眠胶囊治疗失眠症85例[J].南京中医药大学学报,2015,31(5):488-490.
[5]中华医学会神经病学分会睡眠障碍学组.中国成人失眠诊断与治疗指南[J].中华神经科杂志,2012,45(7):534-540.
[6]杨翠花,魏琴,何林熹,等.从心神治疗失眠症探讨[J].时珍国医国药,2015,24(9):2211-2212.
[7]王翘楚,徐建,施明,等.落花生枝叶制剂治疗失眠症疗效观察[J].上海中医药杂志,2001,35(5):8-10.
[8]施明,许红,张晓峰,等.落花生枝叶治疗失眠症临床观察和有关药理研究[J].江苏中医药,2003,24(7):48-50.
[9]张舜波,王平,田代志,等.酸枣仁总皂苷对失眠老年大鼠脑氨基酸类神经递质及受体表达的影响[J].中国实验方剂学杂志,2014,20(4):124-127.
[10]李家娣,范桂红,吴迪,等.酸枣仁汤对虚劳不眠小鼠脑内NO、SOD和Glu含量及学习记忆能力的影响[J].中国老年学杂志,2014,34(20):5778-5779.
[11]刘侗,康馨元,任伯颖,等.珍珠母超微粉蛋白及寡肽对小鼠镇静安眠作用比较[J].吉林中医药,2014,34(2):172-173,176.
[12]冯波.合欢皮对小鼠的抗焦虑作用研究[D].郑州:河南中医学院,2014.
[13]唐锴,叶庆红,陈志斌,等.右佐匹克隆治疗失眠症患者的疗效[J].临床精神医学杂志,2012,22(3):197-198.