何氏化痰平肝汤治疗眩晕疗效观察
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摘要
目的:观察何氏化痰平肝汤治疗眩晕临床疗效。方法:选取眩晕患者100例,随机分为两组,每组50例,治疗组予何氏化痰平肝汤加减治疗,对照组给予常规西医治疗,均连续治疗2周。观察两组患者治疗前后临床疗效、DHI评分、中医证候评分及HAD评分的变化。结果:治疗组与对照组总有效率分别为94.0%、82.0%,疗效比较差异有统计学意义(P<0.05)。治疗前两组DHI评分、中医证候评分、HAD分布、HAD、HAD-A和HAD-D总积分比较,差异无统计学意义(P>0.05),具有可比性。治疗后,两组DHI评分均有不同程度的下降,与同组治疗前比较,差异有显著性意义(P<0.01);治疗组与对照组DHI评分差异有统计学意义(P<0.05)。治疗后,两组中医证候评分积分均有不同程度的下降,与同组治疗前比较,差异有显著性意义(P<0.01);治疗组与对照组中医证候评分比较,差异有统计学意义(P<0.01)。治疗后两组间HAD分布差异有统计学意义(P<0.05);治疗后两组HAD分布分别与治疗前比较,差异有统计学意义(P<0.05)。治疗后两组间HAD、HAD-A和HAD-D总积分差异均有统计学意义(P<0.05);治疗后两组HAD、HAD-A和HAD-D总积分分别与治疗前比较,差异有统计学意义(P<0.05)。结论:何氏化痰平肝汤加减治疗眩晕疗效确切,并能有效减轻眩晕患者焦虑/抑郁状态,有临床应用价值。
Objective: To observe the clinical efficacy of the Heshi Huatan Pinggan decoction(何氏化痰平肝汤) on vertigo. Methods:100 patients were randomly divided into two groups, 50 cases in each. The treatment group was treated with the Heshi Huatan Pinggan decoction. The control group was given conventional western medicine. The clinical effect, DHI score, TCM syndrome score and HAD score were observed. Results: The total effective rate in treatment group and control group was 94.0% and 82.0% respectively, with a statistically significant difference(P<0.05). After treatment, DHI score was decreased in both groups, and the difference was significant between before and after treatment(P<0.01). The difference of DHI score was statistically significant between two groups(P<0.05). After treatment, the scores of TCM syndromes was decreased in two groups(P<0.01). The difference of TCM syndromes was significant between two groups(P<0.01). There was a statistically significant difference of the distribution of HAD between two groups(P<0.05). The HAD distribution showed a statistically significant difference in two groups between before and after treatment(P<0.05). The total scores of HAD, HAD-A and HAD-D in two groups showed statistically significant differences(P<0.05). The total scores of HAD, HAD-A and HAD-D in two groups showed statistically significant differences between before and after treatment(P<0.05). Conclusion: The Heshi Huatan Pinggan decoction is effective, can effectively reduce the anxiety and depression, with clinical application value.
Objective: To observe the clinical efficacy of the Heshi Huatan Pinggan decoction(何氏化痰平肝汤) on vertigo. Methods:100 patients were randomly divided into two groups, 50 cases in each. The treatment group was treated with the Heshi Huatan Pinggan decoction. The control group was given conventional western medicine. The clinical effect, DHI score, TCM syndrome score and HAD score were observed. Results: The total effective rate in treatment group and control group was 94.0% and 82.0% respectively, with a statistically significant difference(P<0.05). After treatment, DHI score was decreased in both groups, and the difference was significant between before and after treatment(P<0.01). The difference of DHI score was statistically significant between two groups(P<0.05). After treatment, the scores of TCM syndromes was decreased in two groups(P<0.01). The difference of TCM syndromes was significant between two groups(P<0.01). There was a statistically significant difference of the distribution of HAD between two groups(P<0.05). The HAD distribution showed a statistically significant difference in two groups between before and after treatment(P<0.05). The total scores of HAD, HAD-A and HAD-D in two groups showed statistically significant differences(P<0.05). The total scores of HAD, HAD-A and HAD-D in two groups showed statistically significant differences between before and after treatment(P<0.05). Conclusion: The Heshi Huatan Pinggan decoction is effective, can effectively reduce the anxiety and depression, with clinical application value.
引文
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[2]Yardley L,Owen N,Nazareth I,et al.Prevalence and presentation of dizziness in a general practice community sample of working age people[J].Br J Gen Praot,1998(48):1131-1135.
[3]Hannaford PC,Simpson JA,Bisset AF,et al.The prevalence of ear,nose and throat problems in the community:results from a national crosssectional postal survey in Scotland[J].Fam Pract,2005(22):227-233.
[4]Newman-Toker DE,Hsieh YH,Camargo CA,et al.Spectrum of dizziness visits to US emergency departments:cross-sectional analysis from a nationally representative sample[J].Mayo Clin Proc,2008(83):765-775.
[5]粟秀初,黄如训.眩晕[M].2版.西安:第四军医大学出版社,2008.
[6]王永炎,鲁兆麟.中医内科学[M].2版.北京:人民卫生出版社,2011:45.
[7]郑筱萸.中药新药临床研究指导原则[M].2版.北京:中国医药科技出版社,2002:105.
[8]Silverstone PH.Poor efficacy of the Hospital Anxiety and Depression Scale in the diagnosis of major depressive disorder in both medical and psychiatric patients[J].Psychosom Res,1994,38(5):441-450.
[9]汪向东.医院焦虑抑郁自评量表[J].北京:中国心理卫生杂志,1999:223-226.
[10]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:23.
[11]Nagaratnam N,Ip J,Bou-Haidar P.The vestibular dysfunction and anxiety disorder interface:a descriptive study with special reference to the elderly[J].Arch Gerontol Geriatr,2005,40(3):253-264.
[12]Kalueff AV,Ishikawa K,Griffith AJ.Anxiety and otovestibular disorders:linking behavioral phenotypes in men and mice[J].Behav Brain Res,2008,186(1):1-11.
[13]Eckhardt-henna A,Breuer P,Thomalske C,et al.Anxiety disorders and other psychiatric subgroups in patients complaining of dizziness[J].Anxiety Disorders,2003,17(4):369-388.
[14]Jacob RG,Whitney SL,Detweiler-Shostak G,et al.Vestibular rehabilitation for patients with agoraphobia and vestibular dysfunction:a pilot study[J].J Anxiety Disord,2001,15(1-2):131-146.
[15]Staab JP,Ruckenstein MJ,Solomon D,et al.Serotonin reuptake inhibitors for dizziness with psychiatric symptoms[J].Arch Otolaryngol Head Neck Surg,2002,128(5):554-560.