参芪降糖颗粒辅助治疗2型糖尿病性膝关节炎的临床观察
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摘要
目的:观察参芪降糖颗粒辅助治疗2型糖尿病性膝关节炎的疗效和安全性。方法:62例2型糖尿病性膝关节炎患者随机分为对照组(31例)和观察组(31例)。对照组患者均给予降糖、针对关节炎的基础治疗,包括饮食控制、运动疗法及健康教育,同时口服盐酸二甲双胍片0.25g,每日3次,餐中服用+阿卡波糖片50mg,每日3次,餐中嚼服;关节炎疼痛患者服用阿司匹林肠溶片100mg,每日1次,饭后口服(不可嚼碎或掰开服用)。观察组患者在对照组治疗的基础上给予参芪降糖颗粒3g,每日3次,餐前半小时用50ml温水冲服。两组疗程均为6个月。观察两组患者的临床疗效,治疗前后的空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、白细胞介素(IL)-1β、IL-6及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者FPG、2hPG、HbA_1c、IL-1β、IL-6水平比较,差异均无统计学意义(P>0.05)。治疗后,两组患者FPG、2hPG、HbA1c、IL-1β、IL-6水平均显著低于同组治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗的基础上,参芪降糖颗粒辅助治疗2型糖尿病性膝关节炎的疗效显著,可降低血糖及炎症因子水平,且不良反应症状轻微。
OBJECTIVE:To observe the efficacy and safety of Shenqi jiangtang granule in the adjuvant treatment of type 2 diabetes knee arthritis. METHODS:62 patients with type 2 diabetes knee arthritis were randomly divided into control group(31 cases) and observation group(31 cases). Control group received hypoglycemic and basic treatment for arthritis,including diet control,exercise therapy and health education,as well as 0.25 g Metformin hydrochloride tablet with a meal,3 times a day + 50 mg Acarbose tablet with a meal,3 times a day,chewing;patients with arthritis pain 100 mg Aspirin enteric-coated tablet after a meal,once a day(chewing or breaking apart was prohibited). Observation group additionally received 3 g Shenqi jiangtang granule half an hour before a meal with 50 ml warm water,3 times a day. The treatment course for both groups was 6 months. Clinical efficacy,and fasting plasma glucose(FPG),2 h postprandial blood glucose(2 h PG),glycated hemoglobin(Hb A1c),interleukin-1β(IL-1β),IL-6 before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observation group was significantly higher than control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the FPG,2 h PG,Hb A1 c,IL-1β and IL-6 between 2 groups(P>0.05).After treatment,FPG,2 h PG,Hb A1 c,IL-1 β and IL-6 in 2 groups were significantly lower than before,and observation group was lower than control group,the differences were statistically significant(P<0.05). And there was no significant in the incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Based on conventional treatment,Shenqi jiangtang granule shows obvious efficacy in the adjuvant treatment of type 2 diabetes knee arthritis.,it can reduce blood glucose and inflammation cytokine levels,mild symptoms of adverse reactions.
OBJECTIVE:To observe the efficacy and safety of Shenqi jiangtang granule in the adjuvant treatment of type 2 diabetes knee arthritis. METHODS:62 patients with type 2 diabetes knee arthritis were randomly divided into control group(31 cases) and observation group(31 cases). Control group received hypoglycemic and basic treatment for arthritis,including diet control,exercise therapy and health education,as well as 0.25 g Metformin hydrochloride tablet with a meal,3 times a day + 50 mg Acarbose tablet with a meal,3 times a day,chewing;patients with arthritis pain 100 mg Aspirin enteric-coated tablet after a meal,once a day(chewing or breaking apart was prohibited). Observation group additionally received 3 g Shenqi jiangtang granule half an hour before a meal with 50 ml warm water,3 times a day. The treatment course for both groups was 6 months. Clinical efficacy,and fasting plasma glucose(FPG),2 h postprandial blood glucose(2 h PG),glycated hemoglobin(Hb A1c),interleukin-1β(IL-1β),IL-6 before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observation group was significantly higher than control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the FPG,2 h PG,Hb A1 c,IL-1β and IL-6 between 2 groups(P>0.05).After treatment,FPG,2 h PG,Hb A1 c,IL-1 β and IL-6 in 2 groups were significantly lower than before,and observation group was lower than control group,the differences were statistically significant(P<0.05). And there was no significant in the incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Based on conventional treatment,Shenqi jiangtang granule shows obvious efficacy in the adjuvant treatment of type 2 diabetes knee arthritis.,it can reduce blood glucose and inflammation cytokine levels,mild symptoms of adverse reactions.
引文
[1]张念荣,朱惠娟,李乃适.重构高密度脂蛋白对2型糖尿病患者的代谢影响及机制研究进展[J].中国新药与临床杂志,2013,32(9):679.
[2]于建红,刘海霞,刘晓丹,等.中药湿敷治疗糖尿病性关节炎的临床研究[J].实用医学杂志,2012,28(24):4 174.
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[5]中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中华糖尿病杂志,2004,12(3):156.
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[8]刘永贵,解学星,吴疆,等.治疗2型糖尿病的新靶点药物研究进展[J].现代药物与临床,2015,30(2):222.
[9]刘锋,蒋生云,杨鸿珠,等.中医健康教育对糖尿病性膝骨关节炎患者生存质量的影响[J].上海医药,2013,34(2):49.
[10]刘海蔚.2型糖尿病合并双膝骨性关节炎38例临床分析[J].中国热带医学,2010,10(2):220.
[11]刘芳洁,张国梁,刘海英,等.参芪降糖颗粒辅助治疗早期糖尿病肾病临床观察[J].中国中医急症,2013,22(11):1 945.
[12]中华中医药学会糖尿病分会.糖尿病中医诊疗标准[J].世界中西医结合杂志,2011,6(6):540.
[13]孙艳霞,何腾龙.正交试验法优选六味地黄微丸的制丸工艺[J].中国药业,2011,20(12):45.
[14]方朝晖,赵进东,舒仪琼,等.参芪降糖颗粒对2型糖尿病患者临床有效性的系统评价[J].江西中医药大学学报,2014,26(5):32.
[15]曾誌復,季美霞.参芪降糖颗粒联合胰岛素对磺脲类降糖药物继发性失效的2型糖尿病患者糖脂代谢及低血糖发作的影响[J].中国药房,2015,26(15):2 065.
[2]于建红,刘海霞,刘晓丹,等.中药湿敷治疗糖尿病性关节炎的临床研究[J].实用医学杂志,2012,28(24):4 174.
[3]彭伟.参芪降糖颗粒治疗2型糖尿病气阴两虚证的临床研究[D].北京:北京中医药大学,2012.
[4]张涛会.参芪降糖颗粒治疗早期糖尿病肾病的临床疗效观察[D].广州:广州中医药大学,2012.
[5]中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中华糖尿病杂志,2004,12(3):156.
[6]中华医学会风湿病学分会.骨关节炎诊断及治疗指南[J].中华风湿病学杂志,2010,14(6):416.
[7]尹德海,梁晓春,朴元林,等.2型糖尿病患者中医证型分析及其与糖尿病慢性并发症关系的探讨[J].中国中西医结合杂志,2009,29(6):506.
[8]刘永贵,解学星,吴疆,等.治疗2型糖尿病的新靶点药物研究进展[J].现代药物与临床,2015,30(2):222.
[9]刘锋,蒋生云,杨鸿珠,等.中医健康教育对糖尿病性膝骨关节炎患者生存质量的影响[J].上海医药,2013,34(2):49.
[10]刘海蔚.2型糖尿病合并双膝骨性关节炎38例临床分析[J].中国热带医学,2010,10(2):220.
[11]刘芳洁,张国梁,刘海英,等.参芪降糖颗粒辅助治疗早期糖尿病肾病临床观察[J].中国中医急症,2013,22(11):1 945.
[12]中华中医药学会糖尿病分会.糖尿病中医诊疗标准[J].世界中西医结合杂志,2011,6(6):540.
[13]孙艳霞,何腾龙.正交试验法优选六味地黄微丸的制丸工艺[J].中国药业,2011,20(12):45.
[14]方朝晖,赵进东,舒仪琼,等.参芪降糖颗粒对2型糖尿病患者临床有效性的系统评价[J].江西中医药大学学报,2014,26(5):32.
[15]曾誌復,季美霞.参芪降糖颗粒联合胰岛素对磺脲类降糖药物继发性失效的2型糖尿病患者糖脂代谢及低血糖发作的影响[J].中国药房,2015,26(15):2 065.