阿加曲班治疗急性脑梗死的疗效及对血清和肽素(CPP)、N末端脑钠肽前体的影响
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摘要
目的:分析阿加曲班治疗急性脑梗死疗效以及对患者血清和肽素(CPP)、N末端脑钠肽前体(NT-pro BNP)指标的影响。方法:选择90例急性脑梗死患者,随机分为两组。45例为对照组,应用吸氧、卧床以及肠内营养等治疗;45例为观察组,在对照组基础上给予阿加曲班治疗。比较患者治疗效果及相关临床指标。结果:治疗后,患者血清中CPP与NT-pro BNP水平明显降低,且观察组比对照组更低,差异有统计学意义(P<0.05);治疗后,患者汉密顿抑郁量表(HAMD)、神经功能缺损程度量表(CSS)评分及日常生活能力(Barthel)指数改善显著,且观察组优于对照组,差异有统计学意义(P<0.05);观察组疗效高于对照组,差异有统计学意义(P<0.05)。结论:阿加曲班可以降低急性脑梗死患者血清中CPP、NT-pro BNP水平,改善神经功能,疗效显著。
Objective The analysis of influence of CPP and NT-pro BNP and the treatment effect of acute cerebral infarction treated by argatroban. Method 90 cases of patients with acute cerebral infarction were selected,they were randomly divided into two groups. The 45 cases as the control group,they were treated by oxygen uptake,lie in bed and enteral nutrition. The 45 cases as the treatment group,they treated by argatroban based on the control. To compare the treatment effect and other clinical tar-gets. Results After treatment,the level of CPP and NT-proB NP in the serum was significantly decreased,and the treatment group was lower than the control,the difference was statistically significante( P < 0. 05). After treatment,the grade of HAMD and CSS,and level of Barthel was significantly improved,the treatment group was better than the control,the difference was statistically significant( P < 0. 05). Conclusion The argatroban able to reduce the level of CPP and NT-proB NP in the serum of the patients,improve the neurological function,and effective in treatment.
Objective The analysis of influence of CPP and NT-pro BNP and the treatment effect of acute cerebral infarction treated by argatroban. Method 90 cases of patients with acute cerebral infarction were selected,they were randomly divided into two groups. The 45 cases as the control group,they were treated by oxygen uptake,lie in bed and enteral nutrition. The 45 cases as the treatment group,they treated by argatroban based on the control. To compare the treatment effect and other clinical tar-gets. Results After treatment,the level of CPP and NT-proB NP in the serum was significantly decreased,and the treatment group was lower than the control,the difference was statistically significante( P < 0. 05). After treatment,the grade of HAMD and CSS,and level of Barthel was significantly improved,the treatment group was better than the control,the difference was statistically significant( P < 0. 05). Conclusion The argatroban able to reduce the level of CPP and NT-proB NP in the serum of the patients,improve the neurological function,and effective in treatment.
引文
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[9]陈磊,张婧.奥扎格雷钠联合阿加曲班治疗短暂性脑缺血发作的疗效观察[J].中国医院药学杂志,2014,34(9):749.
[10]沙瑞娟,陈洁,张书刚,等.阿加曲班注射液联合依达拉奉治疗急性缺血性脑梗死的临床疗效[J].现代药物与临床,2014,29(8):923.
[2]罗世炜,林楚生,翁建东.阿加曲班治疗急性脑梗死疗效及对血清和肽素、N末端脑钠肽前体的影响[J].疑难病杂志,2015,14(10):1017.
[3]楼文胜,顾建平,苏浩波,等.阿加曲班联合置管溶栓治疗肝素诱导的血小板减少症及继发血栓[J].中国介入影响与治疗学,2016,13(1):16.
[4]盛晓华,李军辉,崔勇平,等.阿加曲班抗凝法在伴有血小板减少的脓毒血症患者行连续性肾脏替代治疗中的应用[J].中国临床医师杂志(电子版),2015,9(23):4272.
[5]戴文卓,孔岳南,胡晶晶.阿加曲班联合长春西汀注射液对急性脑梗死患者的LPA、超敏CRP影响及临床效果观察[J].黑龙江医学,2014,38(11):1255.
[6]王以翠,常焕显,孔令胜.阿加曲班对急性脑梗死患者血管内皮功能及炎症因子的影响[J].中山大学学报(医学科学版),2015,36(6):870.
[7]孙茜,常淑美,吕宪民,等.阿加曲班联合高压氧治疗老年急性缺血性脑卒中的疗效及安全性[J].中国老年学杂志,2014,34(7):1938.
[8]付洪伟,李嫚.阿加曲班治疗急性缺血性脑卒中疗效观察及对血小板功能的影响[J].海南医学院学报,2014,20(8):1129.
[9]陈磊,张婧.奥扎格雷钠联合阿加曲班治疗短暂性脑缺血发作的疗效观察[J].中国医院药学杂志,2014,34(9):749.
[10]沙瑞娟,陈洁,张书刚,等.阿加曲班注射液联合依达拉奉治疗急性缺血性脑梗死的临床疗效[J].现代药物与临床,2014,29(8):923.