白细胞介素家族基因多态性与慢性阻塞性肺疾病相关性
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摘要
<正>慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是常见的呼吸系统疾病,以不完全可逆和进行性发展的气流受限为主要特征。其发病机制目前尚未完全明了,目前有两个理论:蛋白酶-抗蛋白酶失衡理论和氧化应激增加理论。COPD的发病是外部环境和内在遗传共同作用的结果,外部环境包括烟草、烟雾、粉尘、化学物质等,而关于遗传因素,至今尚未形成统一观点。因此,想要有效预防COPD、指导临床个体化治疗,鉴定相关的遗传基因多态性显得尤为重要。白细胞介素(interleukin,IL)是由多种细胞产生并作用于多种细胞的一类细胞因子。目前被发现的IL共有
引文
[1]周舒,立普.炎症细胞因子与慢性阻塞性肺疾病[J].蛇志,2012,24(3):283-286.
[2]Nicklin MJ,Weith A,Duff GW.A physical map of the region encompassing the human interleukin-1 alpha,interleukin-1 beta,and interleukin-1 receptor antagonist genes[J].Genomics,1994,19(2):382-384.
[3]Adcock IM,Caramori G,Barnes PJ.Chronic obstructive pulmonary disease and lung cancer:new molecular insights[J].Respiration,2011,81(4):265-284.
[4]Shete AR,Joseph R,Vijayan NN,et al.Association of single nucleotide gene polymorphism at interleukin-1beta+3954,-511,and-31 in chronic periodontitis and aggressive periodontitis in Dravidian ethnicity[J].J Periodontol,2010,81(1):62-69.
[5]Baykara O,T?mek?e Ta?klran NB,Soyyi?it?,et al.IL-1βpolymorphism in COPD patients in Turkish population[J].Tuberk Toraks,2017,65(2):90-96.
[6]Wang YS,Liu L,Xu XY,et al.Association of interleukin-1β-511C/T promoter polymorphism with COPD risk:a metaanalysis[J].Genet Mol Res,14(2):4477-4484.
[7]Xie ZK,Huang QP,Huang J,et al.Association between the IL1β,IL1RN polymorphisms and COPD risk:a meta-analysis[J].Sci Rep,2014,4:6202.
[8]刘晓宇,刘运秋,李宏芬,等.慢性阻塞性肺疾病白介素1β基因多态性分析[J].现代预防医学,2013,40(1):130-133.
[9]Hegab AE,Sakamoto T,Saitoh W,et al.Polymorphisms of TNFalpha,IL1beta,and IL1RN genes in chronic obstructive pulmonary disease[J].Biochem Biophys Res Commun,2005,329(4):1246-1252.
[10]Jhun MA,Smith JA,Ware EB,et al.Modeling the causal role of DNA methylation in the association between cigarette smoking and inflammation in African Americans:A 2-Step Epigenetic Mendelian Randomization Study[J].Am J Epidemiol,2017,186(10):1149-1158.
[11]Wang J,Liu X,Xie J,et al.Association of interleukin-18promoter polymorphisms with chronic obstructive pulmonary disease in male smokers[J].Int J Immunogenet,2013,40(3):204-208.
[12]Oboki K,Ohno T,Kajiwara N,et al.IL-33 and IL-33 receptors in host defense and diseases[J].Allergol Int,2010,59(2):143-160.
[13]Xia J,Zhao J,Shang J,et al.Increased IL-33 expression in chronic obstructive pulmonary disease[J].Am J Physiol Lung Cell Mol Physiol,2015,308(7):619-627.
[14]Chen J,Zhang J,Hu H,et al.Polymorphisms of RAD50,IL33 and IL1RL1 are associated with atopic asthma in Chinese population[J].Tissue Antigens,2015,86(6):443-447.
[15]Angeles-Martinez J,Posadas-Sánchez R,Llorente L,et al.The rs7044343 polymorphism of the interleukin 33 gene is associated with decreased risk of developing premature coronary artery disease and central obesity,and could be involved in regulating the production of IL-33[J].PLoSOne,2017,12(1):e0168828.
[16]Guo J,Xiang Y,Peng YF,et al.The association of novel IL-33 polymorphisms with sIL-33 and risk of systemic lupus erythematosus[J].Mol Immunol,2016,77:1-7.
[17]Talei M,Abdi A,Shanebandi D,et al.Interleukin-33 gene expression and rs1342326 polymorphism in Beh?et.s disease[J].Immunol Lett,2018,11.
[18]郭静,向阳,黄华佗,等.广西人群中白介素-33基因rs1891385A/C、rs10975519C/T多态性的分布特点[J].南方医科大学学报,2016,36(7):964-968.
[19]Murasko DM,Weiner P,Kaye D.Decline in mitogen induced proliferation of lymphocytes with increasing age[J].Clin Exp Immunol,2005,70(2):440-448.
[20]杨光,赵跃萍,朱红霞,等.中心静脉导管胸腔闭式引流联合IL-2胸内注射治疗慢性阻塞性肺疾病合并气胸的临床分析[J].重庆医学,2018,47(16):2223-2225.
[21]Dente FL,Bacci E,Vagaggini B,et al.Cytokines in induced sputum:a role for the ratio of IL-6/IL-13 in the differentiation of asthma and chronic obstructive pulmonary disease[J].Respiration,2012,84(2):98-100.135
[22]Miotto D,Ruggieri MP,Boschetto P,et al.Interleukin-13and-4 expression in the central airways of smokers with chronic bronchitis[J].Eur Respir J,2003,22(4):602-608.
[23]Hegab AE,Sakamoto T,Saitoh W,et al.Polymorphisms of IL4,IL13,and ADRB2 genes in COPD[J].Chest,2004,126(6):1832-1839.
[24]van der Pouw Kraan TC,Kucukaycan M,Bakker AM,et al.Chronic obstructive pulmonary disease is associated with the-1055 IL-13 promoter polymorphism[J].Genes Immun,2002,3(7):436-439.
[25]曹霞,李清泉,陈国忠,等.慢性阻塞性肺病患者IL-4、IL-13以及ADRβ2基因多态性的检测[J].武汉大学学报:医学版,2009,30(2):219-223.
[26]汤兵,康丽,陈敏.IL-4基因-589C/T多态性与慢性阻塞性肺疾病发病风险相关性的Meta分析[J].中国循证医学杂志,2016,16(6):663-667.
[27]Huang AX,Lu LW,Liu WJ,et al.Plasma inflammatory cytokine IL-4,IL-8,IL-10,and TNF-αlevels correlate with pulmonary function in patients with asthma-chronic obstructive pulmonary disease(COPD)overlap syndrome[J].Med Sci Monit,2016,22:2800-2808.
[28]Liu HC,Lu MC,Lin YC,et al.Differences in IL-8 in serum and exhaled breath condensate from patients with exacerbated COPD or asthma attacks[J].J Formos Med Assoc,2014,113(12):908-914.
[29]岳文香,陈愉生,谢宝松,等.血清白介素-8、白介素-18与慢性阻塞性肺疾病、支气管哮喘及支气管扩张的相关性研究[J].黑龙江医学,2018,42(9):853-855.
[30]Arinir U,Klein W,Rohde G,et al.Polymorphisms in the interleukin-8 gene in patients with chronic obstructive pulmonary disease[J].Electrophoresis,2005,26(15):2888-2891.
[31]张雄如,蔡仁豪,陈日坚.白细胞介素6/8联合诊断在不同诱因引起慢性阻塞性肺疾病急性加重的应用价值[J].中国医学创新,2018,15(18):62-65.
[32]Moy ML,Teylan M,Weston NA,et al.Daily step count is associated with plasma C-reactive protein and IL-6 in a US cohort with COPD[J].Chest,2014,145(3):542-550.
[33]孙丽蓉,王海龙,高扬,等.IL-1、IL-6基因多态性与慢性阻塞性肺疾病肺动脉高压相关性研究[J].医学研究杂志,2013,42(11):80-84.
[34]郭秋野,张霞,王娟.白细胞介素-6572C/G基因多态性与COPD患者气道炎症反应及重塑的相关性[J].海南医学院学报,2018,24(13):1238-1241.
[35]Chaouat A,Savale L,Chouaid C,et al.Role for interleukin-6 in COPD-related pulmonary hypertension[J].Chest,2009,136(3):678-687.
[36]Lin JS,Lee LH,Liu HM,et al.Association of IL-6C-572Ggene polymorphism with anti-E production[J].Transfus Med Hemother,2018,45(1):48-52.
[37]Lu QK,Zhang JT,Zhao N,et al.Association of IL-6 gene(-174 and-572 G/C)polymorphisms with proliferative diabetic retinopathy of type 2 diabetes in a Chinese population[J].Ophthalmic Res,2017,58(3):162-167.
[38]黄洁媛,刘文明.IL-17A、CRP、ESR、IL-10水平的变化与重症肺部感染发生发展的关系研究[J].中国地方病防治杂志,2018,33(5):585.
[39]王雷,王晓梅.肿瘤坏死因子-α和白细胞介素-10在重症肺炎中的变化和意义[J].中国老年学杂志,2018,38(17):4174-4176.
[40]Seifart C,Dempfle A,Plagens A,et al.TNF-α,TNF-β,IL-6-,and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary disease[J].Tissue Antigens,2005,65(1):93-100.
[41]胡瑞成,徐永健,张珍祥,等.白细胞介素-10基因启动子多态性与慢性阻塞性疾病易感性的关系[J].中华医学遗传学杂志,2003,20(6):504-507.
[42]Demeo DL,Campbell EJ,Barker AF,et al.IL10 polymorphisms are associated with airflow obstruction in severeα1-antitrypsin deficiency[J].Am J Respir Cell Mol Biol,2008,38(1):114-120.
[43]Chang Y,Al-Alwan L,Risse PA,et al.TH17 cytokines induce human airway smooth muscle cell migration[J].J Allergy Clin Immunol,2011,127(4):1046-1053.
[44]Fujisawa T,Chang MM,Velichko S,et al.NF-κB mediates IL-1β-and IL-17A-induced MUC5B expression in airway epithelial cells[J].Am J Respir Cell Mol Biol,2011,45(2):246-252.
[45]李小波.白细胞介素-17对慢性阻塞性肺疾病患者病情和生存状况的影响[J].检验医学与临床,2017,14(16):2416-2418.
[46]徐丹,李风森,龚理,等.IL-17基因多态性位点与新疆地区慢性阻塞性肺病的风险关系[J].临床检验杂志,2017,35(5):341-345.(:2019-05-08)
[2]Nicklin MJ,Weith A,Duff GW.A physical map of the region encompassing the human interleukin-1 alpha,interleukin-1 beta,and interleukin-1 receptor antagonist genes[J].Genomics,1994,19(2):382-384.
[3]Adcock IM,Caramori G,Barnes PJ.Chronic obstructive pulmonary disease and lung cancer:new molecular insights[J].Respiration,2011,81(4):265-284.
[4]Shete AR,Joseph R,Vijayan NN,et al.Association of single nucleotide gene polymorphism at interleukin-1beta+3954,-511,and-31 in chronic periodontitis and aggressive periodontitis in Dravidian ethnicity[J].J Periodontol,2010,81(1):62-69.
[5]Baykara O,T?mek?e Ta?klran NB,Soyyi?it?,et al.IL-1βpolymorphism in COPD patients in Turkish population[J].Tuberk Toraks,2017,65(2):90-96.
[6]Wang YS,Liu L,Xu XY,et al.Association of interleukin-1β-511C/T promoter polymorphism with COPD risk:a metaanalysis[J].Genet Mol Res,14(2):4477-4484.
[7]Xie ZK,Huang QP,Huang J,et al.Association between the IL1β,IL1RN polymorphisms and COPD risk:a meta-analysis[J].Sci Rep,2014,4:6202.
[8]刘晓宇,刘运秋,李宏芬,等.慢性阻塞性肺疾病白介素1β基因多态性分析[J].现代预防医学,2013,40(1):130-133.
[9]Hegab AE,Sakamoto T,Saitoh W,et al.Polymorphisms of TNFalpha,IL1beta,and IL1RN genes in chronic obstructive pulmonary disease[J].Biochem Biophys Res Commun,2005,329(4):1246-1252.
[10]Jhun MA,Smith JA,Ware EB,et al.Modeling the causal role of DNA methylation in the association between cigarette smoking and inflammation in African Americans:A 2-Step Epigenetic Mendelian Randomization Study[J].Am J Epidemiol,2017,186(10):1149-1158.
[11]Wang J,Liu X,Xie J,et al.Association of interleukin-18promoter polymorphisms with chronic obstructive pulmonary disease in male smokers[J].Int J Immunogenet,2013,40(3):204-208.
[12]Oboki K,Ohno T,Kajiwara N,et al.IL-33 and IL-33 receptors in host defense and diseases[J].Allergol Int,2010,59(2):143-160.
[13]Xia J,Zhao J,Shang J,et al.Increased IL-33 expression in chronic obstructive pulmonary disease[J].Am J Physiol Lung Cell Mol Physiol,2015,308(7):619-627.
[14]Chen J,Zhang J,Hu H,et al.Polymorphisms of RAD50,IL33 and IL1RL1 are associated with atopic asthma in Chinese population[J].Tissue Antigens,2015,86(6):443-447.
[15]Angeles-Martinez J,Posadas-Sánchez R,Llorente L,et al.The rs7044343 polymorphism of the interleukin 33 gene is associated with decreased risk of developing premature coronary artery disease and central obesity,and could be involved in regulating the production of IL-33[J].PLoSOne,2017,12(1):e0168828.
[16]Guo J,Xiang Y,Peng YF,et al.The association of novel IL-33 polymorphisms with sIL-33 and risk of systemic lupus erythematosus[J].Mol Immunol,2016,77:1-7.
[17]Talei M,Abdi A,Shanebandi D,et al.Interleukin-33 gene expression and rs1342326 polymorphism in Beh?et.s disease[J].Immunol Lett,2018,11.
[18]郭静,向阳,黄华佗,等.广西人群中白介素-33基因rs1891385A/C、rs10975519C/T多态性的分布特点[J].南方医科大学学报,2016,36(7):964-968.
[19]Murasko DM,Weiner P,Kaye D.Decline in mitogen induced proliferation of lymphocytes with increasing age[J].Clin Exp Immunol,2005,70(2):440-448.
[20]杨光,赵跃萍,朱红霞,等.中心静脉导管胸腔闭式引流联合IL-2胸内注射治疗慢性阻塞性肺疾病合并气胸的临床分析[J].重庆医学,2018,47(16):2223-2225.
[21]Dente FL,Bacci E,Vagaggini B,et al.Cytokines in induced sputum:a role for the ratio of IL-6/IL-13 in the differentiation of asthma and chronic obstructive pulmonary disease[J].Respiration,2012,84(2):98-100.135
[22]Miotto D,Ruggieri MP,Boschetto P,et al.Interleukin-13and-4 expression in the central airways of smokers with chronic bronchitis[J].Eur Respir J,2003,22(4):602-608.
[23]Hegab AE,Sakamoto T,Saitoh W,et al.Polymorphisms of IL4,IL13,and ADRB2 genes in COPD[J].Chest,2004,126(6):1832-1839.
[24]van der Pouw Kraan TC,Kucukaycan M,Bakker AM,et al.Chronic obstructive pulmonary disease is associated with the-1055 IL-13 promoter polymorphism[J].Genes Immun,2002,3(7):436-439.
[25]曹霞,李清泉,陈国忠,等.慢性阻塞性肺病患者IL-4、IL-13以及ADRβ2基因多态性的检测[J].武汉大学学报:医学版,2009,30(2):219-223.
[26]汤兵,康丽,陈敏.IL-4基因-589C/T多态性与慢性阻塞性肺疾病发病风险相关性的Meta分析[J].中国循证医学杂志,2016,16(6):663-667.
[27]Huang AX,Lu LW,Liu WJ,et al.Plasma inflammatory cytokine IL-4,IL-8,IL-10,and TNF-αlevels correlate with pulmonary function in patients with asthma-chronic obstructive pulmonary disease(COPD)overlap syndrome[J].Med Sci Monit,2016,22:2800-2808.
[28]Liu HC,Lu MC,Lin YC,et al.Differences in IL-8 in serum and exhaled breath condensate from patients with exacerbated COPD or asthma attacks[J].J Formos Med Assoc,2014,113(12):908-914.
[29]岳文香,陈愉生,谢宝松,等.血清白介素-8、白介素-18与慢性阻塞性肺疾病、支气管哮喘及支气管扩张的相关性研究[J].黑龙江医学,2018,42(9):853-855.
[30]Arinir U,Klein W,Rohde G,et al.Polymorphisms in the interleukin-8 gene in patients with chronic obstructive pulmonary disease[J].Electrophoresis,2005,26(15):2888-2891.
[31]张雄如,蔡仁豪,陈日坚.白细胞介素6/8联合诊断在不同诱因引起慢性阻塞性肺疾病急性加重的应用价值[J].中国医学创新,2018,15(18):62-65.
[32]Moy ML,Teylan M,Weston NA,et al.Daily step count is associated with plasma C-reactive protein and IL-6 in a US cohort with COPD[J].Chest,2014,145(3):542-550.
[33]孙丽蓉,王海龙,高扬,等.IL-1、IL-6基因多态性与慢性阻塞性肺疾病肺动脉高压相关性研究[J].医学研究杂志,2013,42(11):80-84.
[34]郭秋野,张霞,王娟.白细胞介素-6572C/G基因多态性与COPD患者气道炎症反应及重塑的相关性[J].海南医学院学报,2018,24(13):1238-1241.
[35]Chaouat A,Savale L,Chouaid C,et al.Role for interleukin-6 in COPD-related pulmonary hypertension[J].Chest,2009,136(3):678-687.
[36]Lin JS,Lee LH,Liu HM,et al.Association of IL-6C-572Ggene polymorphism with anti-E production[J].Transfus Med Hemother,2018,45(1):48-52.
[37]Lu QK,Zhang JT,Zhao N,et al.Association of IL-6 gene(-174 and-572 G/C)polymorphisms with proliferative diabetic retinopathy of type 2 diabetes in a Chinese population[J].Ophthalmic Res,2017,58(3):162-167.
[38]黄洁媛,刘文明.IL-17A、CRP、ESR、IL-10水平的变化与重症肺部感染发生发展的关系研究[J].中国地方病防治杂志,2018,33(5):585.
[39]王雷,王晓梅.肿瘤坏死因子-α和白细胞介素-10在重症肺炎中的变化和意义[J].中国老年学杂志,2018,38(17):4174-4176.
[40]Seifart C,Dempfle A,Plagens A,et al.TNF-α,TNF-β,IL-6-,and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary disease[J].Tissue Antigens,2005,65(1):93-100.
[41]胡瑞成,徐永健,张珍祥,等.白细胞介素-10基因启动子多态性与慢性阻塞性疾病易感性的关系[J].中华医学遗传学杂志,2003,20(6):504-507.
[42]Demeo DL,Campbell EJ,Barker AF,et al.IL10 polymorphisms are associated with airflow obstruction in severeα1-antitrypsin deficiency[J].Am J Respir Cell Mol Biol,2008,38(1):114-120.
[43]Chang Y,Al-Alwan L,Risse PA,et al.TH17 cytokines induce human airway smooth muscle cell migration[J].J Allergy Clin Immunol,2011,127(4):1046-1053.
[44]Fujisawa T,Chang MM,Velichko S,et al.NF-κB mediates IL-1β-and IL-17A-induced MUC5B expression in airway epithelial cells[J].Am J Respir Cell Mol Biol,2011,45(2):246-252.
[45]李小波.白细胞介素-17对慢性阻塞性肺疾病患者病情和生存状况的影响[J].检验医学与临床,2017,14(16):2416-2418.
[46]徐丹,李风森,龚理,等.IL-17基因多态性位点与新疆地区慢性阻塞性肺病的风险关系[J].临床检验杂志,2017,35(5):341-345.(:2019-05-08)