血清泌乳素水平与育龄期女性系统性红斑狼疮病情活动性的相关性
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摘要
目的探讨血清泌乳素水平与育龄期女性系统性红斑狼疮病情活动性的相关性。方法选取2014年1月~2015年8月佛山市顺德区第一人民医院收治的90例育龄期女性系统性红斑狼疮(SLE)患者,其中活动期52例为A组,非活动期38例为B组,同时选取同期健康女性50例为对照(C组)。对三组进行清晨空腹抽血及SLEDAI评分,比较三组患者血清泌乳素(PRL)、补体C3、C4,抗ds-DNA抗体水平及SLEDAI评分。结果 A组和B组的血清PRL、抗ds-DNA抗体水平均明显高于C组,补体C3、C4水平则明显低于C组(P<0.01)。SLE患者中A组的血清PRL、抗ds-DNA抗体水平、SLEDAI评分又明显高于B组(P<0.01),补体C3水平明显低于B组(P<0.01);Pearson相关分析结果显示:血清PRL、抗ds-DNA抗体水平与SLEDAI评分呈正相关(r=0.656、0.786,P<0.01),补体C3水平与SLEDAI评分呈负相关(r=-0.529,P<0.01);抗ds-DNA抗体水平与血清PRL水平呈正相关(r=0.603,P<0.01),补体C3水平与血清PRL水平呈负相关(r=-0.472,P<0.01)。结论育龄期女性SLE患者的血清PRL水平相对于健康育龄期女性有明显上升,血清PRL水平和SLE疾病活动性呈明显正相关,血清PRL参与了SLE的发病过程。
Objective To discuss the correlation between serum prolactin level and childbearing age women with systemic lupus erythematosus(SLE) disease activity. Methods From January 2014 to August 2015, in the First People's Hospital of Shunde District, 90 childbearing age women with systemic lupus erythematosus were selected, 52 patients in activity period were as group A, 38 patients in non-activity period were as group B; at the same time, 50 healthy women were selected as control(group C). Three groups were given fasting blood in the morning and SLEDAI assessment, serum PRL, C3, C4, anti ds-DNA antibody and SLEDAI scores were compared between three groups. Results Serum PRL and anti ds-DNA antibody levels of group A and group B were significantly higher than those of group C(P <0.01), complement C3, C4 levels of group A and group B were significantly lower than those of group C(P < 0.01). The serum levels of PRL, anti ds-DNA antibody and SLEDAI score of group A were significantly higher than those of group B(P <0.01), the level of complement C3 of group A was significantly lower than that of group B(P < 0.0.1). Pearson related analysis showed: serum PRL, anti ds-DNA antibody level were positively correlated with SLEDAI score(r = 0.656, 0.786,P < 0.01), the level of complement C3 was negatively correlated with SLEDAI score(r =-0.529, P < 0.01); anti dsDNA antibody level was positively correlated with serum PRL level(r = 0.603, P < 0.01), the level of complement C3 was negatively correlated with serum PRL(r =-0.472, P < 0.01). Conclusion The serum level of PRL of childbearing age women with SLE is significantly higher than that of the healthy childbearing age women, serum PRL levels and SLE disease activity are significantly positively correlated, serum PRL is involved in the pathogenesis of SLE.
Objective To discuss the correlation between serum prolactin level and childbearing age women with systemic lupus erythematosus(SLE) disease activity. Methods From January 2014 to August 2015, in the First People's Hospital of Shunde District, 90 childbearing age women with systemic lupus erythematosus were selected, 52 patients in activity period were as group A, 38 patients in non-activity period were as group B; at the same time, 50 healthy women were selected as control(group C). Three groups were given fasting blood in the morning and SLEDAI assessment, serum PRL, C3, C4, anti ds-DNA antibody and SLEDAI scores were compared between three groups. Results Serum PRL and anti ds-DNA antibody levels of group A and group B were significantly higher than those of group C(P <0.01), complement C3, C4 levels of group A and group B were significantly lower than those of group C(P < 0.01). The serum levels of PRL, anti ds-DNA antibody and SLEDAI score of group A were significantly higher than those of group B(P <0.01), the level of complement C3 of group A was significantly lower than that of group B(P < 0.0.1). Pearson related analysis showed: serum PRL, anti ds-DNA antibody level were positively correlated with SLEDAI score(r = 0.656, 0.786,P < 0.01), the level of complement C3 was negatively correlated with SLEDAI score(r =-0.529, P < 0.01); anti dsDNA antibody level was positively correlated with serum PRL level(r = 0.603, P < 0.01), the level of complement C3 was negatively correlated with serum PRL(r =-0.472, P < 0.01). Conclusion The serum level of PRL of childbearing age women with SLE is significantly higher than that of the healthy childbearing age women, serum PRL levels and SLE disease activity are significantly positively correlated, serum PRL is involved in the pathogenesis of SLE.
引文
[1]王许娜,尹光辉,田浩,等.自身抗体和补体C3、C4联合检测在SLE诊断中的意义[J].中国卫生检验杂志,2014,24(19):2807-2808,2811.
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[4]陈燕文,王超,王旭光,等.系统性红斑狼疮患者外周血T、B细胞自噬水平及其临床意义[J].中国免疫学杂志,2015,31(10):1380-1384,1388.
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[13]Sun Z,Zhang R,Wang H,et al.Serum IL-10 from systemic lupus erythematosus patients suppresses the differentiation and function of monocyte-derived dendritic cells[J].J Biomed Mater Res,2012,26(6):456-466.
[14]Correa F,Hernangómez-Herrero M,Mestre L,et al.The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis:evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells[J].Brain Behav Immun,2011,25(4):736-749.
[15]Alexandru A,Zurac S,Salavastru CM.Direct immunofluorescence on hair follicles-present and future perspectives[J].Am J Dermatopathol,2013,35(4):472-476.
[16]阎雨,方莲花,杜冠华等.系统性红斑狼疮动物模型研究进展[J].中国实验动物学报,2015,25(4):428-433.
[17]Mohammad H,Saberi H,Najatizadeh SR,et al.Evaluation of brain and cervical MRI abnormality rates in patients with systemic lupus erythematosus with or without neurological manifestations[J].Iran J Radiol,2011,8(3):157-160.
[18]文韵诗,秦海红,徐金华.系统性红斑狼疮患者CD4+T细胞中mi R-17和mi R-20a的表达及与病情活动的相关性研究[J].中华皮肤科杂志,2014,47(3):172-175.
[19]王海婷,叶霜.中性粒细胞胞外网络线粒体DNA及其抗体与系统性红斑狼疮病情活动性的关系[J].中华风湿病学杂志,2014,18(11):738-742.
[20]杨斌,刘湘茹,董维.系统性红斑狼疮患者C反应蛋白测定的临床意义[J].中国医药导报,2015,12(11):117-120.
[2]张朝鸣,余杨桦.近十年肿瘤坏死因子与系统性红斑狼疮的相关研究[J].中国医药导报,2012,9(21):10-12.
[3]穆银玉,王爱珍,吴淑燕.82例系统性红斑狼疮5种自身抗体及补体结果分析[J].医学研究杂志,2012,41(11):184-185.
[4]陈燕文,王超,王旭光,等.系统性红斑狼疮患者外周血T、B细胞自噬水平及其临床意义[J].中国免疫学杂志,2015,31(10):1380-1384,1388.
[5]Kalaivani V,Appukuttan PS.Circulating Lp(a):LDL complexes contain LDL molecules proportionate to Lp(a)size and bind to galectin-1:a possible route for LDL entry into cells[J].Lipids,2014,49(11):1101-1113.
[6]宋冰冰,陈沐,黄涛祥,等.雌激素诱导泌乳素瘤动物模型的建立及稳定性的观察[J].中山大学学报:医学科学版,2014,35(2):224-229.
[7]孔艳华,任安.泌乳素与免疫调节[J].广东医学,2012,33(16):2517-2519.
[8]曹华,万朋杰,李卫平,等.高亲和力抗双链DNA抗体检测在系统性红斑狼疮诊断中的意义[J].中华风湿病学杂志,2014,18(4):244-247.
[9]张淑娟,谭国珍,朱妮娅.系统性红斑狼疮患者皮损中C3沉积与病情活动的关系[J].中国皮肤性病学杂志,2012,26(5):389-390.
[10]邱文娟,张绍峰,徐春.溴隐亭对大鼠泌乳素瘤表达Pit-1的影响[J].中国药学杂志,2013,48(7):527-530.
[11]Takada K,Suzuki K,Matsumoto M,et al.Negative correlation of anti-U1RNP antibody titers and the amount of salivary secretion with age correction[J].Intern Med,2008,47(5):385-390.
[12]Anyfantakis D,Symvoulakis EK,Barbounakis E,et al.A fatal case of seronegative,late-onset systemic lupus erythematosus presenting with motor sensory axonal polyneuropathy[J].Mod Rheumatol,2014,24(5):858-861.
[13]Sun Z,Zhang R,Wang H,et al.Serum IL-10 from systemic lupus erythematosus patients suppresses the differentiation and function of monocyte-derived dendritic cells[J].J Biomed Mater Res,2012,26(6):456-466.
[14]Correa F,Hernangómez-Herrero M,Mestre L,et al.The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis:evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells[J].Brain Behav Immun,2011,25(4):736-749.
[15]Alexandru A,Zurac S,Salavastru CM.Direct immunofluorescence on hair follicles-present and future perspectives[J].Am J Dermatopathol,2013,35(4):472-476.
[16]阎雨,方莲花,杜冠华等.系统性红斑狼疮动物模型研究进展[J].中国实验动物学报,2015,25(4):428-433.
[17]Mohammad H,Saberi H,Najatizadeh SR,et al.Evaluation of brain and cervical MRI abnormality rates in patients with systemic lupus erythematosus with or without neurological manifestations[J].Iran J Radiol,2011,8(3):157-160.
[18]文韵诗,秦海红,徐金华.系统性红斑狼疮患者CD4+T细胞中mi R-17和mi R-20a的表达及与病情活动的相关性研究[J].中华皮肤科杂志,2014,47(3):172-175.
[19]王海婷,叶霜.中性粒细胞胞外网络线粒体DNA及其抗体与系统性红斑狼疮病情活动性的关系[J].中华风湿病学杂志,2014,18(11):738-742.
[20]杨斌,刘湘茹,董维.系统性红斑狼疮患者C反应蛋白测定的临床意义[J].中国医药导报,2015,12(11):117-120.