益气和血方联合恩替卡韦治疗乙肝肝硬化脾功能亢进的临床价值研究
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摘要
目的探讨益气和血方联合恩替卡韦治疗乙肝肝硬化脾功能亢进疗效。方法将116例乙肝肝硬化脾功能亢进患者分成2组,对照组58例实施恩替卡韦等西药治疗,观察组58例加用益气和血方治疗,观察治疗后相关指标变化情况。结果 2组治疗后在胁痛、腹胀、纳差、恶心、身倦乏力、抑郁烦闷、便溏上较治疗前均显著下降(P<0.05),治疗后观察组以上指标观察组显著低于对照组(P<0.05);2组治疗后白细胞计数(WBC)、血小板(PLT)均显著升高,脾长径、脾厚、门静脉主干(MPV)、脾静脉内径(SPV)较治疗前均显著下降(P<0.05),治疗后以上指标观察组显著优于对照组(P<0.05);观察组临床痊愈率、总有效率高于对照组(P<0.05)。结论益气和血方联合恩替卡韦治疗乙肝肝硬化脾功能亢进临床效果显著。
Objective To investigate the effect of Reinforcing Qi and Blood Decoction combined with entecavir in treatment of hepatitis B cirrhosis and hypersplenism. Methods A total of 116 liver cirrhosis and hypersplenism patients were divided into two groups,the control group( n = 58)was given entecavir treatment,and the observation group( n = 58) applied Reinforcing Qi and Blood Decoction treatment,the changes of relevant indicators were observed after the treatment. Results Hypochondriac pain,abdominal distension,nausea,anorexia,lassitude,depression,loose stools were significantly improved( P < 0. 05),and the above indexes of the observation group was significantly lower than that in the control group( P < 0. 05). After treatment,white blood count( WBC)and platelets( PLT) were significantly increased,spleen length,thickness of spleen,main portal vein( MPV) and splenic vein diameter( SPV) were significantly lower than treatment before( P <0. 05),and above indicators of the observation group was significantly better than that in the control group( P < 0. 05). The curative effect,and total efficiency of the observation group were significantly higher than that in the control group( P < 0. 05). Conclusion Reinforcing Qi and Blood Decoction combined with entecavir has obvious clinical outcomes in the treatment of hepatitis B cirrhosis and hypersplenism.
Objective To investigate the effect of Reinforcing Qi and Blood Decoction combined with entecavir in treatment of hepatitis B cirrhosis and hypersplenism. Methods A total of 116 liver cirrhosis and hypersplenism patients were divided into two groups,the control group( n = 58)was given entecavir treatment,and the observation group( n = 58) applied Reinforcing Qi and Blood Decoction treatment,the changes of relevant indicators were observed after the treatment. Results Hypochondriac pain,abdominal distension,nausea,anorexia,lassitude,depression,loose stools were significantly improved( P < 0. 05),and the above indexes of the observation group was significantly lower than that in the control group( P < 0. 05). After treatment,white blood count( WBC)and platelets( PLT) were significantly increased,spleen length,thickness of spleen,main portal vein( MPV) and splenic vein diameter( SPV) were significantly lower than treatment before( P <0. 05),and above indicators of the observation group was significantly better than that in the control group( P < 0. 05). The curative effect,and total efficiency of the observation group were significantly higher than that in the control group( P < 0. 05). Conclusion Reinforcing Qi and Blood Decoction combined with entecavir has obvious clinical outcomes in the treatment of hepatitis B cirrhosis and hypersplenism.
引文
[1]黄微.活血软坚汤治疗乙肝肝硬化脾功能亢进30例疗效观察[J].内蒙古中医药,2014,33(23):32-32.
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[3]张朝阳,路霞,闫文杰,等.解郁软坚活血方治疗代偿期肝硬化106例[J].河北中医,2014,4(6):823-824.
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[6]萧焕明,池晓玲,陈培琼,等.中医药对35例肝硬化脾功能亢进症患者部分脾栓塞术后影响的临床观察[J].江苏中医药,2011,40(4):45-46.
[7]佘世锋,常少琼,樊冬梅,等.中医综合疗法防治肝硬化部分脾栓塞术后并发症临床观察[J].海南医学,2010,21(13):67-68.
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[9]罗在容,吴艳丽.中医药对35例肝硬化脾功能亢进症患者部分脾栓塞术后影响的临床观察[J].世界临床医学,2015(10):181-181.
[10]廖文城,陈兰玲.肝硬化脾大及脾功能亢进的中医药治疗概况[J].湖南中医杂志,2014,30(4):169-171.
[11]顾学云.乙肝肝硬化合并脾亢脾切除术后应用恩替卡韦的疗效分析[J].中国卫生产业,2014,1(4):127-128.
[2]余杨桦.扶正软肝缩脾方联合抗病毒药物治疗乙肝肝硬化脾亢的临床疗效观察[D].广州中医药大学,2015.
[3]张朝阳,路霞,闫文杰,等.解郁软坚活血方治疗代偿期肝硬化106例[J].河北中医,2014,4(6):823-824.
[4]宋朝阳.丹参注射液对肝硬化脾亢脾切除术后血液流变学的影响[J].吉林中医药,2013,33(11):1127-1128.
[5]江一平,李娅娅.滋补肝肾法治疗肝肾阴虚型肝硬化脾功能亢进症30例[J].江西中医药,2011,42(5):26-27.
[6]萧焕明,池晓玲,陈培琼,等.中医药对35例肝硬化脾功能亢进症患者部分脾栓塞术后影响的临床观察[J].江苏中医药,2011,40(4):45-46.
[7]佘世锋,常少琼,樊冬梅,等.中医综合疗法防治肝硬化部分脾栓塞术后并发症临床观察[J].海南医学,2010,21(13):67-68.
[8]江一平,马峥.益气健脾法治疗肝硬化脾功能亢进症的临床观察[C].江西省中医药学会2011年学术年会论文集,2011:273-278.
[9]罗在容,吴艳丽.中医药对35例肝硬化脾功能亢进症患者部分脾栓塞术后影响的临床观察[J].世界临床医学,2015(10):181-181.
[10]廖文城,陈兰玲.肝硬化脾大及脾功能亢进的中医药治疗概况[J].湖南中医杂志,2014,30(4):169-171.
[11]顾学云.乙肝肝硬化合并脾亢脾切除术后应用恩替卡韦的疗效分析[J].中国卫生产业,2014,1(4):127-128.