三角坐标图法在优化高效氟氯氰菊酯纳米乳液配方上的应用
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摘要
[目的]建立一种简便、高效筛选高效氟氯氰菊酯纳米乳液最佳配方的方法。[方法]采用单因素及三角坐标图法,以乳液粒径、多分散系数、热贮稳定性和表面张力为评价指标,对2.5%高效氟氯氰菊酯的纳米乳液配方进行优化。[结果]通过单因素法筛选出亲水亲油平衡值为11.0的复合配方表面活性剂(Span80∶Tween80)。通过三角坐标图法筛选出2.5%高效氟氯氰菊酯的最佳纳米乳液配方(表面活性剂6.6%,液体白蜡10%,水83.4%)。[结论]采用三角坐标图法能快速筛选出农药纳米乳液的最佳配方,该方法简便、高效,具有良好的实用性与经济性。
[Aims] The aims were to establish a simple method to efficiently screen the optimal formula of beta-cyfluthrin nano-emulsion. [Methods] The nano-emulsion formula of 2.5% beta-cyfluthrin was optimized by single factor method and triangular diagram method with particle size of emulsion, polydispersity index(PDI), heat stability and surface tension as evaluation indexes. [Results] The compound formula of surfactant(Span80 ∶Tween80)with hydrophile-lipophile balance(HLB) value of 11.0 was screened by single factor method. The optimal formula of beta-cyfluthrin 2.5% emulsion(surfactant 6.6%, liquid wax 10%, water 83.4%) was screened by triangular diagram method. [Conclusions] Application of triangular diagram method can rapidly screen the optimal formula of pesticide nano-emulsion. This method is simple, efficient, practical and economical.
[Aims] The aims were to establish a simple method to efficiently screen the optimal formula of beta-cyfluthrin nano-emulsion. [Methods] The nano-emulsion formula of 2.5% beta-cyfluthrin was optimized by single factor method and triangular diagram method with particle size of emulsion, polydispersity index(PDI), heat stability and surface tension as evaluation indexes. [Results] The compound formula of surfactant(Span80 ∶Tween80)with hydrophile-lipophile balance(HLB) value of 11.0 was screened by single factor method. The optimal formula of beta-cyfluthrin 2.5% emulsion(surfactant 6.6%, liquid wax 10%, water 83.4%) was screened by triangular diagram method. [Conclusions] Application of triangular diagram method can rapidly screen the optimal formula of pesticide nano-emulsion. This method is simple, efficient, practical and economical.
引文
[1]张鹏九,高越,史高川,等.含不同表面活性剂的高效氟氯氰菊酯水乳剂对桃小食心虫的防治效果[J].应用昆虫学报,2015,52(5):1154-1160.
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[19]唐仕,李嘉诚,张学良,等.恒温低能量乳化法制备水包油纳米乳液及其稳定性研究[J].日用化学工业,2010,40(5):346-349.
[20]ORAFIDIYA L O,OLADIMEJI F A.Determination of the Required HLB Values of Some Essential Oils[J].International Journal of Pharamaceutics,2002,237(1):241-249.
[21]张龙,李佳佳,刘天晴.水基型氯氰菊酯微乳剂的稳定性及润湿展布性研究[J].中国农学通报,2011,27(30):227-232.
[22]LIM C J,BASRI M,OMAR D,et al.Physicochemical Characterization and Formation of Glyphosate-laden Nano-emulsion for Herbicide Formulation[J].Industrial Crops and Products,2012,36(1):607-613.
[23]刘钰,路福绥,高翠丽,等.高效氟氯氰菊酯微乳剂形成规律探索[J].农药,2007,46(2):100-102.
[24]陈福良,张磊,贾伟娜,等.高分子表面活性剂在高效氟氯氰菊酯水乳剂中的应用[J].农药,2015,54(3):188-190.
[2]王振,高越,李光玉,等.高效氟氯氰菊酯水乳剂配方及其润湿性能研究[J].中国农学通报,2012,28(27):250-254.
[3]ANJALI C H,SHARMA Y,MUKHERJEE A,et al.Neem Oil(Azadirachta indica)Nanoemulsion—A Potent Larvicidal Agent against Culex quinquefasciatu s[J].Pest Management Science,2012,68(2):158-163.
[4]蓝强,李公让,张敬辉,等.石蜡纳米乳液的性能影响因素及低能乳化法制备[J].石油钻探技术,2012,40(1):58-63.
[5]黄啟良,李干佐,张文吉,等.高效氯氰菊酯微乳化复合表面活性剂体系的相行为及增溶[J].中国农业科学,2006,39(6):1173-1178.
[6]邓伶俐,余立意,买尔哈巴·塔西帕拉提,等.纳米乳液与微乳液的研究进展[J].中国食品学报,2013,13(8):173-180.
[7]夏茹,吴彬,张岭.三氟氯氰菊酯微乳剂的相图研究[J].农药,2005,44(2):56-58.
[8]白玮,沈青.结构化乳液的理论\制备与应用Ⅲ,结构化纳米乳液[J].高分子通报,2010(1):56-62.
[9]于丽杰.升温相转变组分法制备的纳米乳液(博士论文)[D].济南:山东大学,2013.
[10]宋世理,刘兴华,张楠,等.三唑磷纳米乳液制剂[J].农药,2009,48(9):650-653.
[11]李北兴,王伟昌,张大侠,等.正交设计和均匀设计在优化噻虫胺悬浮剂物理稳定性上的应用[J].中国农业科学,2015,48(2):280-292.
[12]张大侠,刘峰,张贵森,等.采用三角坐标图法快速筛选5%己唑醇悬浮剂配方[J].中国农业科学,2011,44(12):2469-2475.
[13]陶冉,王成章,张宇思,等.银杏叶聚戊烯醇纳米乳液的制备研究[J].生物质化学工程,2015,49(1):7-12.
[14]PER C M,MAESTRO A,GONZALEZ C,et al.Optimization of Nano-emulsions Prepared by Low-energy Emulsification Methods at Constant Temperature Using a Factorial Design Study[J].Colloids and Surfaces A,2006,288:144-150.
[15]HESSIEN M,SINGH N,KIM C,et al.Stability and Tunability of O/W Nanoemulsions Prepared by Phase Inversion Composition[J].Langmuir,2011,27:2299-2307.
[16]PENG Li-ching,LIU Chi-hsien,KWAN C C,et al.Optimization of Water-in-oil of Water-in-oil Nanoemulsions by Mixed Surfactants[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2010,370(1):136-142.
[17]BAZYLINSKA U,KULBACKA J,WILK K A.Dicephalic Ionic Surfactants in Fabrication of Biocompatible Nanoemulsion:Factors Influencing Droplet Size and Stability[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2014,460:312-320.
[18]冯建国,项盛,钱坤,等.乳状液稳定性表征方法及其在农药水乳剂研发中的应用[J].农药学学报,2015,17(1):15-26.
[19]唐仕,李嘉诚,张学良,等.恒温低能量乳化法制备水包油纳米乳液及其稳定性研究[J].日用化学工业,2010,40(5):346-349.
[20]ORAFIDIYA L O,OLADIMEJI F A.Determination of the Required HLB Values of Some Essential Oils[J].International Journal of Pharamaceutics,2002,237(1):241-249.
[21]张龙,李佳佳,刘天晴.水基型氯氰菊酯微乳剂的稳定性及润湿展布性研究[J].中国农学通报,2011,27(30):227-232.
[22]LIM C J,BASRI M,OMAR D,et al.Physicochemical Characterization and Formation of Glyphosate-laden Nano-emulsion for Herbicide Formulation[J].Industrial Crops and Products,2012,36(1):607-613.
[23]刘钰,路福绥,高翠丽,等.高效氟氯氰菊酯微乳剂形成规律探索[J].农药,2007,46(2):100-102.
[24]陈福良,张磊,贾伟娜,等.高分子表面活性剂在高效氟氯氰菊酯水乳剂中的应用[J].农药,2015,54(3):188-190.