胃上皮内瘤变的研究进展
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摘要
胃癌是一种常见的癌症,且是癌症相关死亡的常见原因。胃上皮内瘤变(GIN)作为胃癌的癌前病变始终是国内外研究的热点,其对早期发现、干预并防控胃癌发生有重要意义。近年在GIN的概念演变、发病机制、生物学特征、治疗策略如根除幽门螺杆菌、定期随访、内镜治疗等领域有较多研究。本文就GIN的研究进展作一综述。
Gastric cancer is a commonly seen cancer and a usual cause of cancer-related death. As a form of precancerous lesion of gastric cancer,gastric intraepithelial neoplasia( GIN) is always a hot research topic,and plays a very important role in the detection,intervention,prevention and control of development of gastric cancer. Recently,there has been great progress in research on GIN,including the evolution of concept,pathogenesis,biological features,therapeutic strategy such as eradication of Helicobacter pylori,regular follow-up and endoscopic therapy. This article reviewed the advances in study on GIN.
Gastric cancer is a commonly seen cancer and a usual cause of cancer-related death. As a form of precancerous lesion of gastric cancer,gastric intraepithelial neoplasia( GIN) is always a hot research topic,and plays a very important role in the detection,intervention,prevention and control of development of gastric cancer. Recently,there has been great progress in research on GIN,including the evolution of concept,pathogenesis,biological features,therapeutic strategy such as eradication of Helicobacter pylori,regular follow-up and endoscopic therapy. This article reviewed the advances in study on GIN.
引文
1 Ferlay J,Soerjomataram I,Dikshit R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J].Int J Cancer,2015,136(5):E359-E386.
2 Bosman FT,Carneiro F,Hruban RH,et al.WHO Classification of Tumours of the Digestive System[M].4th ed.Lyon:IARC press,2010.
3 Colle R,Cohen R,Cochereau D,et al.Immunotherapy and patients treated for cancer with microsatellite instability[J].Bull Cancer,2017,104(1):42-51.
4 Li B,Liu HY,Guo SH,et al.Microsatellite instability of gastric cancer and precancerous lesions[J].Int J Clin Exp Med,2015,8(11):21138-21144.
5 刘丽华,张方信.胃癌前病变中DNA甲基化状态与叶酸[J].世界华人消化杂志,2005,13(23):2770-2772.
6 Liu L,Yang X.Implication of Reprimo and h MLH1 gene methylation in early diagnosis of gastric carcinoma[J].Int J Clin Exp Pathol,2015,8(11):14977-14982.
7 Lu XX,Yu JL,Ying LS,et al.Stepwise cumulation of RUNX3 methylation mediated by Helicobacter pylori infection contributes to gastric carcinoma progression[J].Cancer,2012,118(22):5507-5517.
8 戚红霞,潘晓燕.CD133、β-catenin和h TERT在胃癌及癌前病变中的表达及相关性研究[J].胃肠病学和肝病学杂志,2017,26(9):981-985.
9 贾振军,李其海,曲勇,等.Ki-67在癌前病变及胃腺癌中的表达及意义[J].河北医科大学学报,2015,36(8):915-917,925.
10 肖艳景,张全武,赵红梅,等.C-myc、hnRNP K在胃上皮内瘤变组织中的表达[J].肿瘤基础与临床,2010,23(6):478-479.
11 Zhang L,Hou Y,Ashktorab H,et al.The impact of CMYC gene expression on gastric cancer cell[J].Mol Cell Biochem,2010,344(1-2):125-135.
12 Anagnostopoulos GK,Stefanou D,Arkoumani E,et al.Bax and Bcl-2 protein expression in gastric precancerous lesions:immunohistochemical study[J].J Gastroenterol Hepatol,2005,20(11):1674-1678.
13 Fischer M.Census and evaluation of p53 target genes[J].Oncogene,2017,36(28):3943-3956.
14 朱薇,史平,张煦,等.凋亡诱导因子和突变型p53在胃癌前病变组织及胃癌组织中的表达及其相关性研究[J].兰州大学学报(医学版),2015,41(2):41-45.
15 Saf C,Gulcan EM,Ozkan F,et al.Assessment of p21,p53expression,and Ki-67 proliferative activities in the gastric mucosa of children with Helicobacter pylori gastritis[J].Eur J Gastroenterol Hepatol,2015,27(2):155-161.
16 孙桂彬,杨景国,李永华,等.PTEN、p16和Cyclin D1在胃癌及癌前病变中表达的研究[J].现代中西医结合杂志,2012,21(15):1614-1616.
17 朱燕华,吴云林,吴巍,等.胃黏膜上皮内瘤变370例转归及胃癌筛查的研究[J].中华消化内镜杂志,2013,30(1):18-24.
18 朱燕华,吴云林,吴巍,等.胃黏膜低级别上皮内瘤变诊断及治疗探讨[J].中华消化病与影像杂志(电子版),2015,5(4):8-12.
19 肖强,宋育林.胃黏膜低级别上皮内瘤变随访研究[J].中华疾病控制杂志,2014,18(2):147-150.
20 Lamb A,Chen LF.Role of the Helicobacter pylori-induced inflammatory response in the development of gastric cancer[J].J Cell Biochem,2013,114(3):491-497.
21 Sun SB,Chen ZT,Zheng D,et al.Clinical pathology and recent follow-up study on gastric intraepithelial neoplasia and gastric mucosal lesions[J].Hepatogastroenterology,2013,60(127):1597-1601.
22 Liu KS,Wong IO,Leung WK.Helicobacter pylori associated gastric intestinal metaplasia:Treatment and surveillance[J].World J Gastroenterol,2016,22(3):1311-1320.
23 Chen HN,Wang Z,Li X,et al.Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia:evidence from a meta-analysis[J].Gastric Cancer,2016,19(1):166-175.
24 Kim SI,Han HS,Kim JH,et al.What is the next step for gastric atypical epithelium on histological findings of endoscopic forceps biopsy?[J].Dig Liver Dis,2013,45(7):573-577.
25 崔建芳,杨爱明,姚芳,等.胃上皮内瘤变内镜活组织检查与内镜切除标本病理结果差异分析[J].中华消化内镜杂志,2017,34(1):30-33.
26 Sung JK.Diagnosis and management of gastric dysplasia[J].Korean J Intern Med,2016,31(2):201-209.
2 Bosman FT,Carneiro F,Hruban RH,et al.WHO Classification of Tumours of the Digestive System[M].4th ed.Lyon:IARC press,2010.
3 Colle R,Cohen R,Cochereau D,et al.Immunotherapy and patients treated for cancer with microsatellite instability[J].Bull Cancer,2017,104(1):42-51.
4 Li B,Liu HY,Guo SH,et al.Microsatellite instability of gastric cancer and precancerous lesions[J].Int J Clin Exp Med,2015,8(11):21138-21144.
5 刘丽华,张方信.胃癌前病变中DNA甲基化状态与叶酸[J].世界华人消化杂志,2005,13(23):2770-2772.
6 Liu L,Yang X.Implication of Reprimo and h MLH1 gene methylation in early diagnosis of gastric carcinoma[J].Int J Clin Exp Pathol,2015,8(11):14977-14982.
7 Lu XX,Yu JL,Ying LS,et al.Stepwise cumulation of RUNX3 methylation mediated by Helicobacter pylori infection contributes to gastric carcinoma progression[J].Cancer,2012,118(22):5507-5517.
8 戚红霞,潘晓燕.CD133、β-catenin和h TERT在胃癌及癌前病变中的表达及相关性研究[J].胃肠病学和肝病学杂志,2017,26(9):981-985.
9 贾振军,李其海,曲勇,等.Ki-67在癌前病变及胃腺癌中的表达及意义[J].河北医科大学学报,2015,36(8):915-917,925.
10 肖艳景,张全武,赵红梅,等.C-myc、hnRNP K在胃上皮内瘤变组织中的表达[J].肿瘤基础与临床,2010,23(6):478-479.
11 Zhang L,Hou Y,Ashktorab H,et al.The impact of CMYC gene expression on gastric cancer cell[J].Mol Cell Biochem,2010,344(1-2):125-135.
12 Anagnostopoulos GK,Stefanou D,Arkoumani E,et al.Bax and Bcl-2 protein expression in gastric precancerous lesions:immunohistochemical study[J].J Gastroenterol Hepatol,2005,20(11):1674-1678.
13 Fischer M.Census and evaluation of p53 target genes[J].Oncogene,2017,36(28):3943-3956.
14 朱薇,史平,张煦,等.凋亡诱导因子和突变型p53在胃癌前病变组织及胃癌组织中的表达及其相关性研究[J].兰州大学学报(医学版),2015,41(2):41-45.
15 Saf C,Gulcan EM,Ozkan F,et al.Assessment of p21,p53expression,and Ki-67 proliferative activities in the gastric mucosa of children with Helicobacter pylori gastritis[J].Eur J Gastroenterol Hepatol,2015,27(2):155-161.
16 孙桂彬,杨景国,李永华,等.PTEN、p16和Cyclin D1在胃癌及癌前病变中表达的研究[J].现代中西医结合杂志,2012,21(15):1614-1616.
17 朱燕华,吴云林,吴巍,等.胃黏膜上皮内瘤变370例转归及胃癌筛查的研究[J].中华消化内镜杂志,2013,30(1):18-24.
18 朱燕华,吴云林,吴巍,等.胃黏膜低级别上皮内瘤变诊断及治疗探讨[J].中华消化病与影像杂志(电子版),2015,5(4):8-12.
19 肖强,宋育林.胃黏膜低级别上皮内瘤变随访研究[J].中华疾病控制杂志,2014,18(2):147-150.
20 Lamb A,Chen LF.Role of the Helicobacter pylori-induced inflammatory response in the development of gastric cancer[J].J Cell Biochem,2013,114(3):491-497.
21 Sun SB,Chen ZT,Zheng D,et al.Clinical pathology and recent follow-up study on gastric intraepithelial neoplasia and gastric mucosal lesions[J].Hepatogastroenterology,2013,60(127):1597-1601.
22 Liu KS,Wong IO,Leung WK.Helicobacter pylori associated gastric intestinal metaplasia:Treatment and surveillance[J].World J Gastroenterol,2016,22(3):1311-1320.
23 Chen HN,Wang Z,Li X,et al.Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia:evidence from a meta-analysis[J].Gastric Cancer,2016,19(1):166-175.
24 Kim SI,Han HS,Kim JH,et al.What is the next step for gastric atypical epithelium on histological findings of endoscopic forceps biopsy?[J].Dig Liver Dis,2013,45(7):573-577.
25 崔建芳,杨爱明,姚芳,等.胃上皮内瘤变内镜活组织检查与内镜切除标本病理结果差异分析[J].中华消化内镜杂志,2017,34(1):30-33.
26 Sung JK.Diagnosis and management of gastric dysplasia[J].Korean J Intern Med,2016,31(2):201-209.