外周血高密度脂蛋白对乳腺癌术后切口愈合的影响
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摘要
目的:通过分析外周血高密度脂蛋白(high density lipoprotein,HDL)与乳腺癌患者术后切口愈合情况的相关性,探讨HDL对切口愈合的影响。方法:收集在汕头大学医学院第二附属医院行乳腺癌手术的住院患者132例;于术前进行HDL检测,术后统计引流管留置天数、引流量、换药次数及拆线时间作为切口愈合指标,并进行相关性分析。结果:HDL高于正常组引流管留置天数、引流量、换药次数及拆线时间等指标与HDL正常组、HDL低于正常组相比差异有统计学意义(均P <0.01);HDL水平与各愈合指标均呈显著负相关,其中与引流量相关性最高(r=-0.36,P <0.01)。结论:高水平的HDL对促进乳腺癌切口愈合或起到重要作用。
Objective: To investigate the effect of HDL on wound healing by analyzing the correlation between peripheral blood HDL and postoperative incision healing in patients with breast cancer. Methods: A total of 132 inpatients who underwent breast cancer surgery in the Second Affiliated Hospital of Shantou University Medical College were enrolled. HDL was detected before surgery. Drainage tube retention time, drainage volume,number of dressings and time of suture removal were counted and as an indicator of wound healing and conduct correlation analysis. Results: The group which have a higher HDL have a lower drainage tube retention time(P < 0.01), drainage volume(P < 0.01), dressing frequency(P < 0.01) and suture removal time(P < 0.01) than the normal or lower HDL level group; HDL levels were significantly negatively correlated with each healing index, and the correlation with drainage was the highest(r =-0.36, P < 0.01). Conclusion: High level of HDL plays an important role in promoting breast cancer incision healing.
Objective: To investigate the effect of HDL on wound healing by analyzing the correlation between peripheral blood HDL and postoperative incision healing in patients with breast cancer. Methods: A total of 132 inpatients who underwent breast cancer surgery in the Second Affiliated Hospital of Shantou University Medical College were enrolled. HDL was detected before surgery. Drainage tube retention time, drainage volume,number of dressings and time of suture removal were counted and as an indicator of wound healing and conduct correlation analysis. Results: The group which have a higher HDL have a lower drainage tube retention time(P < 0.01), drainage volume(P < 0.01), dressing frequency(P < 0.01) and suture removal time(P < 0.01) than the normal or lower HDL level group; HDL levels were significantly negatively correlated with each healing index, and the correlation with drainage was the highest(r =-0.36, P < 0.01). Conclusion: High level of HDL plays an important role in promoting breast cancer incision healing.
引文
[1] TORRE L A, BRAY F, SIEGEL R L, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65(2):87-108.
[2]马丽.皮肤创面无机诱导活性敷料联合高压氧治疗糖尿病足慢性溃疡效果[J].当代医学, 2015,21(7):44-45.
[3]谭翠莲,汪德清,邱丽,等.乳腺癌患者术后切口感染危险因素及不同敷贴对其愈合效果评价[J].中华医院感染学杂志, 2017, 27(14):3263-3266.
[4]张妮,胡敏,王颖.手术室优质护理对胃肠道手术患者切口愈合及预后的影响[J].实用临床医药杂志, 2017,21(6):114-117.
[5]曾庆华,王春晖,魏爽.血脂异常对小鼠视网膜色素上皮-玻璃膜-脉络膜毛细血管复合体影响的研究[J].中国中医眼科杂志, 2006, 16(2):90-94.
[6]姚俊成,牟艳,窦科.高血脂对单肾和双肾大鼠肾功能影响分析[J].实用医院临床杂志, 2018, 15(1):4-6.
[7]吴晓山,丁敏,张仁,等.高血脂对家兔伤口愈合的影响[J].浙江医学, 1996, 18(2):81-82.
[8] SOYAMA Y, MIURA K, MORIKAWA Y, et al. Highdensity lipoprotein cholesterol and risk of stroke in Japanese men and women:the Oyabe study[J]. Stroke,2003, 34(4):863-868.
[9]吴为明,陈凤娜.高脂血症对直肠癌开腹及腹腔镜手术合并症的影响[J].中国医药导报, 2014, 11(13):51-54.
[10] YVAN-CHARVET L, WANG N, TALL A R. Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses[J]. Arterioscler Thromb Vasc Biol, 2010,30(2):139-143.
[11] MILLAR C L, DUCLOS Q, BLESSO C N. Effects of dietary flavonoids on reverse cholesterol transport,HDL metabolism, and HDL function[J]. Adv Nutr,2017, 8(2):226-239.
[12] DIEGELMANN R, EVANS M. Wound healing:an overview of acute, fibrotic and delayed healing[J].Front Biosc, 2003, 9(71):283-289.
[13] FENG Y, VAN ECK M, VAN CRAEYVELD E, et al.Critical role of scavenger receptor-BI-expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo AI transfer[J]. Blood, 2009, 113(3):755-764.
[14] GORDTS S, MUTHURAMU I, AMIN R, et al. The impact of lipoproteins on wound healing:topical HDL therapy corrects delayed wound healing in apolipoprotein E deficient mice[J]. Pharmaceuticals,2014, 7(4):419-432.
[15] AYAORI M. Role of HDL in cholesterol efflux and reverse cholesterol transport[J]. Rinsho Byori, 2016, 64(1):57-65.
[2]马丽.皮肤创面无机诱导活性敷料联合高压氧治疗糖尿病足慢性溃疡效果[J].当代医学, 2015,21(7):44-45.
[3]谭翠莲,汪德清,邱丽,等.乳腺癌患者术后切口感染危险因素及不同敷贴对其愈合效果评价[J].中华医院感染学杂志, 2017, 27(14):3263-3266.
[4]张妮,胡敏,王颖.手术室优质护理对胃肠道手术患者切口愈合及预后的影响[J].实用临床医药杂志, 2017,21(6):114-117.
[5]曾庆华,王春晖,魏爽.血脂异常对小鼠视网膜色素上皮-玻璃膜-脉络膜毛细血管复合体影响的研究[J].中国中医眼科杂志, 2006, 16(2):90-94.
[6]姚俊成,牟艳,窦科.高血脂对单肾和双肾大鼠肾功能影响分析[J].实用医院临床杂志, 2018, 15(1):4-6.
[7]吴晓山,丁敏,张仁,等.高血脂对家兔伤口愈合的影响[J].浙江医学, 1996, 18(2):81-82.
[8] SOYAMA Y, MIURA K, MORIKAWA Y, et al. Highdensity lipoprotein cholesterol and risk of stroke in Japanese men and women:the Oyabe study[J]. Stroke,2003, 34(4):863-868.
[9]吴为明,陈凤娜.高脂血症对直肠癌开腹及腹腔镜手术合并症的影响[J].中国医药导报, 2014, 11(13):51-54.
[10] YVAN-CHARVET L, WANG N, TALL A R. Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses[J]. Arterioscler Thromb Vasc Biol, 2010,30(2):139-143.
[11] MILLAR C L, DUCLOS Q, BLESSO C N. Effects of dietary flavonoids on reverse cholesterol transport,HDL metabolism, and HDL function[J]. Adv Nutr,2017, 8(2):226-239.
[12] DIEGELMANN R, EVANS M. Wound healing:an overview of acute, fibrotic and delayed healing[J].Front Biosc, 2003, 9(71):283-289.
[13] FENG Y, VAN ECK M, VAN CRAEYVELD E, et al.Critical role of scavenger receptor-BI-expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo AI transfer[J]. Blood, 2009, 113(3):755-764.
[14] GORDTS S, MUTHURAMU I, AMIN R, et al. The impact of lipoproteins on wound healing:topical HDL therapy corrects delayed wound healing in apolipoprotein E deficient mice[J]. Pharmaceuticals,2014, 7(4):419-432.
[15] AYAORI M. Role of HDL in cholesterol efflux and reverse cholesterol transport[J]. Rinsho Byori, 2016, 64(1):57-65.