质量常数评价方法应用于玄参饮片等级评价研究
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摘要
将顺刀片模型质量常数等级评价方法应用于玄参饮片的等级评价。将收集到的19批玄参饮片进行外观形态指标测量,并以哈巴苷、哈巴俄苷为指标成分,进行含量测定,将传统分级标准与现代质控指标有机结合,进行质量常数计算,对该玄参饮片进行等级划分。结果显示所收集的19批玄参样品的质量常数为156. 75～491. 65;若规定百分质量常数≥80%为一等饮片,50%～80%为二等饮片,剩余为三等饮片,则一等玄参饮片质量常数≥393. 32,二等玄参饮片质量常数为245. 83～393. 32,三等玄参饮片质量常数<245. 83。该研究在合理科学的基础上体现其"个性化",将适用于顺刀片饮片质量常数等级划分模型进一步应用,在质量常数等级划分方法的研究基础上,结合了饮片的自然形态及切制特点。将该模型方法应用于玄参饮片的等级划分当中,阐述其分级方式,研究结果表明质量常数等级评价方法能够客观、合理、有效地将玄参饮片进行等级划分,进一步将玄参饮片等级评价的研究数据进行丰富,为玄参饮片等级评价提供了有益的参考。同时将质量常数等级划分方法进一步应用、推广,以证明该方法的合理性、科学性、实用性。
The quality constant evaluation method was applied in the grade evaluation of Scrophulariae Radix pieces. Nineteen batches of Scrophulariae Radix were measured for the appearance index. Harpagide and harpagoside were taken as index components for the content determination. The traditional grading standard and the modern quality control index were combined to calculate the quality constant and grade Scrophulariae Radix pieces. The results showed that the quality constants ranged between 156. 75 and 491. 65; according to the percentage mass constants,more than 80% were graded as first-class pieces,50%-80% were graded as second-class pieces,and the rest were graded as third-class pieces. The quality constants of first-class Scrophulariae Radix were >393. 32,that of second-class Scrophulariae Radix was between 245. 83 and 393. 32,and that of third-class Scrophulariae Radix was < 245. 83. The study shows that this method can objectively,reasonably and effectively classify Scrophulariae Radix pieces,and further promote and apply the evaluation method of slice model quality constant to prove the rationality,scientificity and practicability.
The quality constant evaluation method was applied in the grade evaluation of Scrophulariae Radix pieces. Nineteen batches of Scrophulariae Radix were measured for the appearance index. Harpagide and harpagoside were taken as index components for the content determination. The traditional grading standard and the modern quality control index were combined to calculate the quality constant and grade Scrophulariae Radix pieces. The results showed that the quality constants ranged between 156. 75 and 491. 65; according to the percentage mass constants,more than 80% were graded as first-class pieces,50%-80% were graded as second-class pieces,and the rest were graded as third-class pieces. The quality constants of first-class Scrophulariae Radix were >393. 32,that of second-class Scrophulariae Radix was between 245. 83 and 393. 32,and that of third-class Scrophulariae Radix was < 245. 83. The study shows that this method can objectively,reasonably and effectively classify Scrophulariae Radix pieces,and further promote and apply the evaluation method of slice model quality constant to prove the rationality,scientificity and practicability.
引文
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[2]马广恩,申雅维.玄参的化学和药理研究概况[J].国外国药·植物药分册,1997,12(6):251.
[3]贾成友,张传辉,赵凤平,等.玄参饮片质量控制方法研究[J].天然产物研究与开发,2015,71(5):1385.
[4]邓哲,焦梦姣,章军,等.相对质量常数用于甘草饮片等级评价研究[J].中国中药杂志,2017,42(13):2492.
[5]邓哲,章军,焦梦姣,等.以质量常数为核心的黄芩饮片等级评价研究[J].中国中药杂志,2017,42(9):1673.
[6]邓哲,焦梦姣,章军,等.基于质量常数评价方法划分黄柏饮片等级研究[J].中国中药杂志,2017,42(17):3356.
[7]夏成凯,胡云飞,陈思宇,等.基于中药质量常数的牡丹皮饮片等级划分[J].中国中药杂志,2018,43(3):647.
[8]邹宗成,向开栋,黄鹤,等.玄参规范化生产标准操作规程[J].中国现代中药,2007,9(6):30.
[9]刘芳,周小江,袁志鹰,等.玄参药材等级质量标准研究(Ⅰ)——基于肉桂酸含量的差异性[J].湖南中医杂志,2018,34(7):181.
[10]白志川.玄参药材HPLC指纹图谱的研究[J].中药材,2006,29(12):1295.
[11]王胜男,华愉教,邹立思,等.QTRAP-UPLC-MS/MS同时测定玄参不同产地及商品药材中10种核苷类成分的含量[J].中国新药杂志,2016,25(2):232.