葡萄胎恶变相关因素及MMP-9在妊娠滋养细胞疾病中表达的临床意义
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摘要
目的:分析葡萄胎恶变相关因素的探讨及基质金属蛋白酶-9(MMP-9)在妊娠滋养细胞疾病中表达的临床意义。方法:采取免疫组化法对比108例妊娠滋养细胞疾病组织和正常早孕绒毛的MMP-9阳性表达,并分析影响葡萄胎恶变的因素。结果:恶变葡萄胎、侵袭性葡萄胎和绒毛膜癌患者的MMP-9表达显著高于对照组(P<0.05),但未发生恶变葡萄胎与对照组的MMP-9表达相比无统计学意义(P>0.05);恶变葡萄胎、侵袭性葡萄胎和绒毛膜癌患者的MMP-9表达无统计学意义(P>0.05)。葡萄胎的恶变与年龄、妊娠次数、子宫大小和人绒毛膜促性腺激素(β-HCG)持续阳性因素相关(P<0.05),但与滋养细胞增生程度、阴道出血和口服避孕药无关(P>0.05)。结论:年龄、妊娠次数、子宫大小和β-HCG持续阳性是影响葡萄胎恶变的主要因素,通过对患者进行MMP-9表达的检测,可以有效实现对葡萄胎恶变的预测,对葡萄胎恶变的预防产生了积极的影响。
Objective:To investigate the related factors of hydatidiform mole malignant transformation and the clin-ical significance of the expression of matrix metalloproteinase-9(MMP-9)in gestational trophoblastic disease. Methods:Immunohistochemical method was used to compare the positive expression of MMP-9 in 108 gestational trophoblas-tic disease tissues and normal early pregnancy villi,and to analyze the factors affecting the hydatidiform mole malignanttransformation. Results:The expression of MMP-9 in malignant mole,invasive hydatidiform mole and choriocarcinomawas significantly higher than that in control group(P < 0.05),but there was no significant difference in the expressionof MMP-9 between malignant mole and control group P > 0.05). The expression of MMP-9 in malignant mole,invasivemole and choriocarcinoma had no statistical significance(P > 0.05). Malignant changes in hydatidiform moles were asso-ciated with age,number of pregnancies,uterine size,and persistent positive factors of human chorionic gonadotropin(β-HCG)(P<0.05),but not with trophoblastic hyperplasia,vaginal bleeding and oral contraceptives(P > 0.05). Conclusions:Age,gestational age,uterine size and persistent positive of β-HCG are the main factors that affect the malignantmole of hydatidiform mole. The detection of MMP-9 expression in patients can effectively predict the malignancy of hyda-tidiform mole,Prevention has had a positive impact of hydatidiform mole.
Objective:To investigate the related factors of hydatidiform mole malignant transformation and the clin-ical significance of the expression of matrix metalloproteinase-9(MMP-9)in gestational trophoblastic disease. Methods:Immunohistochemical method was used to compare the positive expression of MMP-9 in 108 gestational trophoblas-tic disease tissues and normal early pregnancy villi,and to analyze the factors affecting the hydatidiform mole malignanttransformation. Results:The expression of MMP-9 in malignant mole,invasive hydatidiform mole and choriocarcinomawas significantly higher than that in control group(P < 0.05),but there was no significant difference in the expressionof MMP-9 between malignant mole and control group P > 0.05). The expression of MMP-9 in malignant mole,invasivemole and choriocarcinoma had no statistical significance(P > 0.05). Malignant changes in hydatidiform moles were asso-ciated with age,number of pregnancies,uterine size,and persistent positive factors of human chorionic gonadotropin(β-HCG)(P<0.05),but not with trophoblastic hyperplasia,vaginal bleeding and oral contraceptives(P > 0.05). Conclusions:Age,gestational age,uterine size and persistent positive of β-HCG are the main factors that affect the malignantmole of hydatidiform mole. The detection of MMP-9 expression in patients can effectively predict the malignancy of hyda-tidiform mole,Prevention has had a positive impact of hydatidiform mole.
引文
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[7]张苗苗,王才智.半乳糖凝集素-3和基质金属蛋白酶-9在宫颈癌组织中的表达及其临床意义[J].中华全科医学,2016,14(12):1994.
[8]何影娟,江翔,韩舒卿,等.埃兹蛋白和基质金属蛋白酶-9在子宫内膜癌中的表达及其临床意义[J].中国妇幼保健,2016,31(20):4287.
[2]吴齐斌,郑秀,吴荔香,等.maspin和p53在妊娠滋养细胞疾病中的表达及临床意义[J].国际妇产科学杂志,2015,42(6):630.
[3]陈应超,李泽文,周洁,等.转移抑制基因1和基质金属蛋白酶-9在鼻咽癌中表达的相关性及临床意义[J].安徽医药,2016,20(2):304.
[4]韩淑珍,王杜鹃,曾丽华,等.p57、p53和p63蛋白对葡萄胎和水肿性流产的鉴别诊断价值[J].岭南急诊医学杂志,2015,12(4):327.
[5]杨小梅,高媛,王春晖,等.正常妊娠滋养层组织中Lin28B表达变化的研究[J].生殖与避孕,2016,36(6):446.
[6]刘丽君,王艳军,宋涛,等.基质金属蛋白酶环氧合酶-2在葡萄胎组织的表达水平及临床意义[J].河北医学,2016,22(10):1657.
[7]张苗苗,王才智.半乳糖凝集素-3和基质金属蛋白酶-9在宫颈癌组织中的表达及其临床意义[J].中华全科医学,2016,14(12):1994.
[8]何影娟,江翔,韩舒卿,等.埃兹蛋白和基质金属蛋白酶-9在子宫内膜癌中的表达及其临床意义[J].中国妇幼保健,2016,31(20):4287.