保留乳头乳晕的乳房切除术肿瘤学安全性
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摘要
随着乳腺癌患者对形态要求增高及外科技术的发展,保留乳头乳晕的乳房切除术联合Ⅰ期或Ⅱ期乳房重建,可最大限度地切除肿瘤并维持乳房外观。但是,其安全性一直广受争议,手术适应证也未完全明确,亟须进一步探讨。
Nipple-areola complex sparing mastectomy combined with stage Ⅰ or Ⅱ breast reconstruction can maximize the resection of the breast tumor and maintain the breast appearance. To meet patients' higher expectation and with the development of surgical technique,this form of surgery has been increasingly applied. However,its safety has been widely disputed,and the indications have not been fully defined,so it is need to be further studied.
Nipple-areola complex sparing mastectomy combined with stage Ⅰ or Ⅱ breast reconstruction can maximize the resection of the breast tumor and maintain the breast appearance. To meet patients' higher expectation and with the development of surgical technique,this form of surgery has been increasingly applied. However,its safety has been widely disputed,and the indications have not been fully defined,so it is need to be further studied.
引文
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[2]Chen WQ,Zheng RS.Incidence,mortality and survival analysis of breast cancer in China[J].Chinese Journal of Clinical Oncology,2015,42(13):668-674.[陈万青,郑荣寿.中国女性乳腺癌发病死亡和生存状况[J].中国肿瘤临床,2015,42(13):668-674.]
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[6]Wang J,Xiao X,Wang J,et al.Predictors of nipple-areolar complex involvement by breast carcinoma:histopathologic analysis of 787 consecutive therapeutic mastectomy specimens[J].Annals of Surgical Oncology,2012,19(4):1174-1180.
[7]Hu Z,Wu J.Expert consensus and controversies of nipple-areolar complex sparing mastectomy[J].China Oncology,2016,26(6):476-480.[胡震,吴炅.保留乳头乳晕复合体乳房切除术的专家共识与争议(2015年版)[J].中国癌症杂志,2016,26(6):476-480.]
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[10]Ponzone R,Maggiorotto F,Carabalona S,et al.MRI and intraoperative pathology to predict nipple-areola complex(NAC)involvement in patients undergoing NAC-sparing mastectomy[J].European Journal of Cancer,2015,51(14):1882-1889.
[11]Mallon P,Feron J,Couturaud B,et al.The role of nipplesparing mastectomy in breast cancer[J].Plastic and Reconstructive Surgery,2013,131(5):969-984.
[12]Regolo L,Ballardini B,Gallarotti E,et al.Nipple sparing mastectomy:an innovative skin incision for an alternative approach[J].The Breast,2008,17(1):8-11.
[13]Krajewski AC,Boughey JC,Degnim AC,et al.Expanded indications and improved outcomes for nipple-sparing mastectomy over time[J].Annals of Surgical Oncology,2015,22(10):3317-3323.
[14]Schecter AK,Freeman MB,Giri D,et al.Applicability of the nipple-areola complex-sparing mastectomy[J].Annals of Plastic Surgery,2006,56(5):498-504.
[15]Elena F,Brachtel JERJ,Koerner AFC.Occult nipple involvement in breast cancer:clinicopathologic findings in316 consecutive mastectomy specimens[J].Journal of Clinical Oncology,2009,30(27):4948-4954.
[16]Joseph P,Crowe MRJP.Nipple-sparing mastectomy updateone hundred forty-nine procedures and clinical outcomes[J].Arch Surg,2008,11(143):1106-1110.
[17]Stolier AJ,Sullivan SK,Dellacroce FJ.Technical considerations in nipple-sparing mastectomy:82 consecutive cases without necrosis[J].Annals of Surgical Oncology,2008,15(5):1341-1347.
[18]de Alcantara Filho P,Capko D,Barry JM,et al.Nipplesparing mastectomy for breast cancer and risk-reducing surgery:the memorial sloan-kettering cancer center experience[J].Annals of Surgical Oncology,2011,18(11):3117-3122.
[19]Coopey SB,Tang R,Lei L,et al.Increasing eligibility for nipple-sparing mastectomy[J].Annals of Surgical Oncology,2013,20(10):3218-3222.
[20]Billar JA,Dueck AC,Gray RJ,et al.Preoperative predictors of nipple-areola complex involvement for patients undergoing mastectomy for breast cancer[J].Annals of Surgical Oncology,2011,18(11):3123-3128.
[21]Weidong Li MSWM.Nipple involvement in breast cancer:retrospective analysis of 2323 consecutive mastectomy specimens[J].International Journal of Surgical Pathology,2011,3(19):328-334.
[22]Vlajcic Z,Zic R,Stanec S,et al.Nipple-areola complex preservation predictive factors of neoplastic nipple-areola complex invasion[J].Annals of Plastic Surgery,2005,55(3):240-244.
[23]Petit JY,Veronesi U,Orecchia R,et al.Risk factors associated with recurrence after nipple-sparing mastectomy for invasive and intraepithelial neoplasia[J].Annals of Oncology,2012,23(8):2053-2058.
[24]Headon HL,Kasem A,Mokbel K.The oncological safety of nipple-sparing mastectomy:a systematic review of the literature with a pooled analysis of 12358 procedures[J].Arch Plast Surg,2016,43(4):328-338.
[25]Karian LS,Therattil PJ,Wey PD,et al.Delay techniques for nipple-sparing mastectomy:a systematic review[J].Journal of Plastic,Reconstructive&Aesthetic Surgery,2017,70(2):236-242.
[26]Seki T,Jinno H,Okabayashi K,et al.Comparison of oncological safety between nipple sparing mastectomy and total mastectomy using propensity score matching[J].The Annals of The Royal College of Surgeons of England,2015,97(4):291-297.
[27]Adam H,Bygdeson M,de Boniface J.The oncological safety of nipple-sparing mastectomy-a Swedish matched cohort study[J].European Journal of Surgical Oncology(EJSO),2014,40(10):1209-1215.
[28]Kurian AW,Canchola AJ,Gomez SL,et al.Equivalent survival after nipple-sparing compared to non-nipple-sparing mastectomy:data from California,1988-2013[J].Breast Cancer Research and Treatment,2016,160(2):333-338.
[29]Li M,Chen K,Liu F,et al.Nipple sparing mastectomy in breast cancer patients and long-term survival outcomes:an analysis of the SEER database[J].PLoS One,2017,12(8):e183448.
[30]Murphy BL,Boughey JC,Hieken TJ.Nipple-sparing mastectomy for the management of recurrent breast cancer[J].Clinical Breast Cancer,2017,17(4):e209-e213.
[31]Ueda S,Tamaki Y,Yano K,et al.Cosmetic outcome and patient satisfaction after skin-sparing mastectomy for breast cancer with immediate reconstruction of the breast[J].Surgery,2008,143(3):414-425.
[32]Petit JY,Veronesi U,Orecchia R,et al.Nipple-sparing mastectomy in association with intra operative radiotherapy(ELIOT):a new type of mastectomy for breast cancer treatment[J].Breast Cancer Research and Treatment,2006,96(1):47-51.
[33]Metcalfe KA,Cil TD,Semple JL,et al.Long-term psychosocial functioning in women with bilateral prophylactic mastectomy:does preservation of the nipple-areolar complex make a difference?[J].Annals of Surgical Oncology,2015,22(10):3324-3330.
[34]Richard G Reish,Alex Lin BS,Nicole A Phillips MD,et al.Breast reconstruction outcomes after nipple-sparing mastectomy and radiation therapy[J].Plastic and Reconstructive Surgery,2014,135(4):959-966.
[35]Michael J Frederick,Alex M Lin,Robert Neuman,et al.Nipple-sparing mastectomy in patients with previous breast surgery:comparative analysis of 775 immediate breast reconstructions[J].Plastic and Reconstructive Surgery,2015,135(6):954-962.
[36]Chen Y,Chen JJ,Chen JY,et al.Currrent trends of breast reconstruction after mastectomy for breast cancer patients in China:a survey report[J].Chin J Oncol,2014,36(11):851-857.[陈颖,陈嘉健,陈嘉莹,等.中国乳腺癌术后乳房重建现况调查报告[J].中华肿瘤杂志,2014,36(11):851-857.]
[2]Chen WQ,Zheng RS.Incidence,mortality and survival analysis of breast cancer in China[J].Chinese Journal of Clinical Oncology,2015,42(13):668-674.[陈万青,郑荣寿.中国女性乳腺癌发病死亡和生存状况[J].中国肿瘤临床,2015,42(13):668-674.]
[3]Kaufmann M,Morrow M,von Minckwitz G,et al.Locoregional treatment of primary breast cancer[J].Cancer,2010,116(5):1184-1191.
[4]Wei CH,Scott AM,Price AN,et al.Psychosocial and sexual well-being following nipple-sparing mastectomy and reconstruction[J].The Breast Journal,2016,22(1):10-17.
[5]Yang HP,Wang WQ,Wang S,et al.Nipple involvement in early breast cancer:retrospective analysis of 1190 consecutive mastectomy specimens[J].Chinese Journal of Clinical Oncology,2016,43(2):67-71.[杨后圃,王伟琦,王殊,等.1190例乳腺癌患者乳头浸润相关因素分析[J].中国肿瘤临床,2016,43(2):67-71.]
[6]Wang J,Xiao X,Wang J,et al.Predictors of nipple-areolar complex involvement by breast carcinoma:histopathologic analysis of 787 consecutive therapeutic mastectomy specimens[J].Annals of Surgical Oncology,2012,19(4):1174-1180.
[7]Hu Z,Wu J.Expert consensus and controversies of nipple-areolar complex sparing mastectomy[J].China Oncology,2016,26(6):476-480.[胡震,吴炅.保留乳头乳晕复合体乳房切除术的专家共识与争议(2015年版)[J].中国癌症杂志,2016,26(6):476-480.]
[8]Neslihan Cabioglu,Savitri Krishnamurthy,Henry M Kuerer,et al.Feasibility of breast-conserving surgery for patients with breast carcinoma associated with nipple discharge[J].Cancer,2004,101(3):508-517.
[9]Chang RY,Cheung PS.Nipple preservation in breast cancer associated with nipple discharge[J].World Journal of Surgery,2017,41(1):176-183.
[10]Ponzone R,Maggiorotto F,Carabalona S,et al.MRI and intraoperative pathology to predict nipple-areola complex(NAC)involvement in patients undergoing NAC-sparing mastectomy[J].European Journal of Cancer,2015,51(14):1882-1889.
[11]Mallon P,Feron J,Couturaud B,et al.The role of nipplesparing mastectomy in breast cancer[J].Plastic and Reconstructive Surgery,2013,131(5):969-984.
[12]Regolo L,Ballardini B,Gallarotti E,et al.Nipple sparing mastectomy:an innovative skin incision for an alternative approach[J].The Breast,2008,17(1):8-11.
[13]Krajewski AC,Boughey JC,Degnim AC,et al.Expanded indications and improved outcomes for nipple-sparing mastectomy over time[J].Annals of Surgical Oncology,2015,22(10):3317-3323.
[14]Schecter AK,Freeman MB,Giri D,et al.Applicability of the nipple-areola complex-sparing mastectomy[J].Annals of Plastic Surgery,2006,56(5):498-504.
[15]Elena F,Brachtel JERJ,Koerner AFC.Occult nipple involvement in breast cancer:clinicopathologic findings in316 consecutive mastectomy specimens[J].Journal of Clinical Oncology,2009,30(27):4948-4954.
[16]Joseph P,Crowe MRJP.Nipple-sparing mastectomy updateone hundred forty-nine procedures and clinical outcomes[J].Arch Surg,2008,11(143):1106-1110.
[17]Stolier AJ,Sullivan SK,Dellacroce FJ.Technical considerations in nipple-sparing mastectomy:82 consecutive cases without necrosis[J].Annals of Surgical Oncology,2008,15(5):1341-1347.
[18]de Alcantara Filho P,Capko D,Barry JM,et al.Nipplesparing mastectomy for breast cancer and risk-reducing surgery:the memorial sloan-kettering cancer center experience[J].Annals of Surgical Oncology,2011,18(11):3117-3122.
[19]Coopey SB,Tang R,Lei L,et al.Increasing eligibility for nipple-sparing mastectomy[J].Annals of Surgical Oncology,2013,20(10):3218-3222.
[20]Billar JA,Dueck AC,Gray RJ,et al.Preoperative predictors of nipple-areola complex involvement for patients undergoing mastectomy for breast cancer[J].Annals of Surgical Oncology,2011,18(11):3123-3128.
[21]Weidong Li MSWM.Nipple involvement in breast cancer:retrospective analysis of 2323 consecutive mastectomy specimens[J].International Journal of Surgical Pathology,2011,3(19):328-334.
[22]Vlajcic Z,Zic R,Stanec S,et al.Nipple-areola complex preservation predictive factors of neoplastic nipple-areola complex invasion[J].Annals of Plastic Surgery,2005,55(3):240-244.
[23]Petit JY,Veronesi U,Orecchia R,et al.Risk factors associated with recurrence after nipple-sparing mastectomy for invasive and intraepithelial neoplasia[J].Annals of Oncology,2012,23(8):2053-2058.
[24]Headon HL,Kasem A,Mokbel K.The oncological safety of nipple-sparing mastectomy:a systematic review of the literature with a pooled analysis of 12358 procedures[J].Arch Plast Surg,2016,43(4):328-338.
[25]Karian LS,Therattil PJ,Wey PD,et al.Delay techniques for nipple-sparing mastectomy:a systematic review[J].Journal of Plastic,Reconstructive&Aesthetic Surgery,2017,70(2):236-242.
[26]Seki T,Jinno H,Okabayashi K,et al.Comparison of oncological safety between nipple sparing mastectomy and total mastectomy using propensity score matching[J].The Annals of The Royal College of Surgeons of England,2015,97(4):291-297.
[27]Adam H,Bygdeson M,de Boniface J.The oncological safety of nipple-sparing mastectomy-a Swedish matched cohort study[J].European Journal of Surgical Oncology(EJSO),2014,40(10):1209-1215.
[28]Kurian AW,Canchola AJ,Gomez SL,et al.Equivalent survival after nipple-sparing compared to non-nipple-sparing mastectomy:data from California,1988-2013[J].Breast Cancer Research and Treatment,2016,160(2):333-338.
[29]Li M,Chen K,Liu F,et al.Nipple sparing mastectomy in breast cancer patients and long-term survival outcomes:an analysis of the SEER database[J].PLoS One,2017,12(8):e183448.
[30]Murphy BL,Boughey JC,Hieken TJ.Nipple-sparing mastectomy for the management of recurrent breast cancer[J].Clinical Breast Cancer,2017,17(4):e209-e213.
[31]Ueda S,Tamaki Y,Yano K,et al.Cosmetic outcome and patient satisfaction after skin-sparing mastectomy for breast cancer with immediate reconstruction of the breast[J].Surgery,2008,143(3):414-425.
[32]Petit JY,Veronesi U,Orecchia R,et al.Nipple-sparing mastectomy in association with intra operative radiotherapy(ELIOT):a new type of mastectomy for breast cancer treatment[J].Breast Cancer Research and Treatment,2006,96(1):47-51.
[33]Metcalfe KA,Cil TD,Semple JL,et al.Long-term psychosocial functioning in women with bilateral prophylactic mastectomy:does preservation of the nipple-areolar complex make a difference?[J].Annals of Surgical Oncology,2015,22(10):3324-3330.
[34]Richard G Reish,Alex Lin BS,Nicole A Phillips MD,et al.Breast reconstruction outcomes after nipple-sparing mastectomy and radiation therapy[J].Plastic and Reconstructive Surgery,2014,135(4):959-966.
[35]Michael J Frederick,Alex M Lin,Robert Neuman,et al.Nipple-sparing mastectomy in patients with previous breast surgery:comparative analysis of 775 immediate breast reconstructions[J].Plastic and Reconstructive Surgery,2015,135(6):954-962.
[36]Chen Y,Chen JJ,Chen JY,et al.Currrent trends of breast reconstruction after mastectomy for breast cancer patients in China:a survey report[J].Chin J Oncol,2014,36(11):851-857.[陈颖,陈嘉健,陈嘉莹,等.中国乳腺癌术后乳房重建现况调查报告[J].中华肿瘤杂志,2014,36(11):851-857.]