用于检测皮瓣移植术后血红蛋白浓度的多方位反射式无创测试系统
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摘要
血红蛋白浓度作为衡量皮瓣移植手术部位恢复状况的重要指标,能较好地反映血液流通状态。目前常见的术后血运监测方法限于对皮肤温度、颜色和肿胀程度等物理观察和经验诊断,或仅通过血氧饱和度粗略判断,未见对血红蛋白浓度的实时监测。本文设计并搭建了一种用于检测皮瓣移植术后血红蛋白浓度的多方位反射式无创测试系统,通过对样本数据的采集分析引入修正系数,实现了血红蛋白浓度的无创检测。实验结果表明,6名志愿者连续10次测量结果的标准偏差较小;40组测量值与真值的相关性良好;皮肤加热后采集的血红蛋白浓度对温度变化灵敏,说明系统具有较好的稳定性、精确性和有效性。项目组将与河南大学淮河医院合作,对皮瓣移植术后患者的血红蛋白浓度进行临床检测,进一步校准数据并研发小型化便携式测量仪器,为术后护理提供更加可靠的依据。
Hemoglobin concentration,as an important indicator of the recovery of the surgical site of the flap graft,can reflect the state of blood circulation.Current methods for monitoring blood flow after surgery are limited to physical observations and empirical diagnosis of skin temperature,color and swelling,or only rough determination of oxygen saturation,and less to real-time monitoring of hemoglobin concentration.In this paper,a multi-directional reflective non-invasive test system for detecting hemoglobin concentration after skin flap transplantation is designed and constructed.Through the collection and analysis of sample data,a correction factor is introduced to achieve non-invasive detection of hemoglobin concentration.The experimental results show that the standard deviation of 10 consecutive measurements of 6 volunteers is relatively small;the correlation between 40 measurement values and true values is relatively strong;the concentration of hemoglobin collected after skin heating is sensitive to temperature changes,indicating that the system has good stability,accuracy and effectiveness.The project team will cooperate with the Huaihe Hospital of Henan University to conduct clinical testing of hemoglobin concentration in patients after flap transplantation,further calibrate the data and develop miniaturized portable measuring instruments to provide more reliable basis for postoperative care.
Hemoglobin concentration,as an important indicator of the recovery of the surgical site of the flap graft,can reflect the state of blood circulation.Current methods for monitoring blood flow after surgery are limited to physical observations and empirical diagnosis of skin temperature,color and swelling,or only rough determination of oxygen saturation,and less to real-time monitoring of hemoglobin concentration.In this paper,a multi-directional reflective non-invasive test system for detecting hemoglobin concentration after skin flap transplantation is designed and constructed.Through the collection and analysis of sample data,a correction factor is introduced to achieve non-invasive detection of hemoglobin concentration.The experimental results show that the standard deviation of 10 consecutive measurements of 6 volunteers is relatively small;the correlation between 40 measurement values and true values is relatively strong;the concentration of hemoglobin collected after skin heating is sensitive to temperature changes,indicating that the system has good stability,accuracy and effectiveness.The project team will cooperate with the Huaihe Hospital of Henan University to conduct clinical testing of hemoglobin concentration in patients after flap transplantation,further calibrate the data and develop miniaturized portable measuring instruments to provide more reliable basis for postoperative care.
引文
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[11] YUAN Jing-ze.Non-invasive analysis method of human hemoglobin near-infrared spectroscopy[D].Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences,2017.
[12] CHEN Zi-jin,HAN Yu-long,XU Xin,et al.Dynamic heart rate and blood oxygen monitor based on AFE4400[J].China Science and Technology Information,2018,(5):62-63.
[13] HAN Huai-xiao,ZHANG Yan,WU Hua-wei,et al.Development of cerebral blood oxygen monitor based on near-infrared spectroscopy[J].China Medical Device Magazine,2017,41(6):407-411.
[14] HUANG Bo,YAO Yu-feng,JIANG Rui-ju.Optical measurement method and device for hemoglobin concentration[J].Optics and Precision Engineering,2009,17(12):2893-2898.
[15] FANG Lei.Design and implementation of non-invasive blood oxygen saturation measurement system[D].Huazhong University of Science and Technology,2012.
[16] WANG Xiao-fei,ZHAO Wen-jun.Measurement of multi-wavelength pulse oximetry based on dynamic spectroscopy[J].Spectroscopy and Spectral Analysis,2014,34(5):1323-1326.
[2] ZHANG Juan,SONG Bao-qiang.Research progress of blood supply monitoring after free flap transplantation[J].Modern Biomedicine,2014,14(18):3589-3592.
[3] XIE Yu-zhen.Observation and nursing of vascular crisis after free flap transplantation[J].World Medical Information Digest,2017,17(81):201.
[4] HAN Dong,CHEN Chuan-jun.Experimental study on the dynamic monitoring of vascular crisis after free flap transplantation by percutaneous oxygen saturation measurement[J].Chinese Journal of Clinical Healthcare,2007,(6):611-613.
[5] JIANG Wen-feng,LIU Li,FAN Gui-lian.Clinical observation and nursing of skin flap transplantation[J].Nursing practice and research,2010,7(2):62-63.
[6] GAN Yong-jin,LI Qiong,ZHENG Jin-cun,et al.Study on blood oxygen measurement based on reflective detection method[J].Biomedical Engineering Research,2018,37(2):138-141+158.
[7] LIU Guang-wei,MAO Lu-hong,XIE Sheng,et al.A photoelectric reflection pulse oximetry method[J].Optoelectronics·Laser,2014,25(3):620-624.
[8] DONG Qin,GUO Qing,YUAN Zhen-ming.A sensor design and verification for improving the oxygen measurement accuracy of wearable devices[J].Journal of Transduction Technology,2018,31(5):815-820.
[9] WU You,PANG Yu,HUANG Bo-qiang,et al.Design of wearable anti-interference blood oxygen saturation acquisition device[J].Electronic World,2017,(21):132-134.
[10] BAI Peng-fei,LIU Qiang,DUAN Fei-bo,et al.Wearable oxygen saturation detection system based on MAX30102[J].Laser & Infrared,2017,47(10):1276-1280.
[11] YUAN Jing-ze.Non-invasive analysis method of human hemoglobin near-infrared spectroscopy[D].Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences,2017.
[12] CHEN Zi-jin,HAN Yu-long,XU Xin,et al.Dynamic heart rate and blood oxygen monitor based on AFE4400[J].China Science and Technology Information,2018,(5):62-63.
[13] HAN Huai-xiao,ZHANG Yan,WU Hua-wei,et al.Development of cerebral blood oxygen monitor based on near-infrared spectroscopy[J].China Medical Device Magazine,2017,41(6):407-411.
[14] HUANG Bo,YAO Yu-feng,JIANG Rui-ju.Optical measurement method and device for hemoglobin concentration[J].Optics and Precision Engineering,2009,17(12):2893-2898.
[15] FANG Lei.Design and implementation of non-invasive blood oxygen saturation measurement system[D].Huazhong University of Science and Technology,2012.
[16] WANG Xiao-fei,ZHAO Wen-jun.Measurement of multi-wavelength pulse oximetry based on dynamic spectroscopy[J].Spectroscopy and Spectral Analysis,2014,34(5):1323-1326.