四君子汤加减治疗老年胃癌术后化疗患者消化道毒副反应临床观察
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摘要
目的观察中西医结合治疗老年胃癌术后化疗患者消化道毒副反应的临床效果。方法选择我院老年胃癌术后化疗患者60例,随机分为恩丹西酮治疗组(西药组)和恩丹西酮治疗基础上采用四君子汤加减治疗组(中西医结合组),统计分析两组患者的临床疗效、消化道毒副反应发生情况。结果中西医结合组患者治疗的总有效率显著高于西药组(P<0.05);恶心呕吐、口腔溃疡、腹泻、便秘发生率均显著低于西药组(P<0.05)。结论中西医结合治疗老年胃癌术后化疗患者消化道毒副反应的临床效果优于单独西医治疗。
Objective To investigate the clinical effect of integrated Chinese-western therapy on gastrointestinal toxicity and side effects of elderly patients with gastric cancer after chemotherapy. Methods 60 cases of elderly patients with gastric cancer undergoing postoperative chemotherapy were randomly divided into two groups,30 cases in each group. Western medicine group was treated with ondansetron alone,integrated Chinese-western therapy group was treated with modified Sijunzi decoction on the basis of western medicine group,the clinical efficacy,gastrointestinal toxicity and side effects of the two groups were statistically analyzed. Results The total effective rate of integrated Chinese-western therapy group was significantly higher than that of western medicine group(P<0.05). The incidence of nausea,vomiting,oral ulcer,diarrhea and constipation of integrated Chinese-western therapy group were significantly lower than those of western medicine group(P<0.05). Conclusion The clinical effect of integrated Chinese-western therapy on gastrointestinal toxicity and side effects of elderly patients with gastric cancer after chemotherapy is superior to western medicine alone.
Objective To investigate the clinical effect of integrated Chinese-western therapy on gastrointestinal toxicity and side effects of elderly patients with gastric cancer after chemotherapy. Methods 60 cases of elderly patients with gastric cancer undergoing postoperative chemotherapy were randomly divided into two groups,30 cases in each group. Western medicine group was treated with ondansetron alone,integrated Chinese-western therapy group was treated with modified Sijunzi decoction on the basis of western medicine group,the clinical efficacy,gastrointestinal toxicity and side effects of the two groups were statistically analyzed. Results The total effective rate of integrated Chinese-western therapy group was significantly higher than that of western medicine group(P<0.05). The incidence of nausea,vomiting,oral ulcer,diarrhea and constipation of integrated Chinese-western therapy group were significantly lower than those of western medicine group(P<0.05). Conclusion The clinical effect of integrated Chinese-western therapy on gastrointestinal toxicity and side effects of elderly patients with gastric cancer after chemotherapy is superior to western medicine alone.
引文
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[10]熊轩伟,夏联义,吴飞马,等.中药辅助常规肠内营养对胃癌术后营养状况的影响[J].湖北中医药大学学报,2018,20(2):67-69.
[2]李惠惠,李全富.扶正解毒方对小鼠前胃癌诱导肿瘤相关巨噬细胞的影响[J].吉林中医药,2016,36(9):922-924,925.
[3]冯福明,吕建林,冉思邈,等.中西医结合治疗胃癌的研究进展[J].大众科技,2018,20(5):74-76.
[4]国家“863”重大项目“胃癌分子分型与个体化诊疗”课题组.胃癌病理分型和诊断标准的建议[J].中华病理学杂志,2010,39(4):266-269.
[5]中华人民共和国卫生部医政司.胃癌诊疗规范(2011年版)[J].中国医学前沿杂志(电子版),2012,4(5):62-71.
[6]吴舟桥,王琦,石晋瑶等.欧美国家胃癌手术并发症的诊断标准及风险评估[J].中华胃肠外科杂志,2017,20(2):135-139.
[7]罗冠琴.中西医结合临床路径方案治疗胃癌的疗效观察[J].中西医结合心血管病电子杂志,2016,20(4):165.
[8]王艳霞.中西医结合临床路径方案治疗胃癌患者临床效果观察[J].河南医学研究,2016,25(6):1124-1125.
[9]肖霞.扶正化瘀经验方联合化疗辨治胃癌临床观察[J].湖北中医药大学学报,2015,17(4):65-67.
[10]熊轩伟,夏联义,吴飞马,等.中药辅助常规肠内营养对胃癌术后营养状况的影响[J].湖北中医药大学学报,2018,20(2):67-69.