MRISim:磁共振成像仿真实验软件包（英文）
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摘要
本文基于数值计算模拟技术,开发了模拟磁共振成像(MRI)数据采集与图像重建的仿真软件包——MRISim.虚拟数据采集部分通过对设备硬件、样品(标样或人体部位)进行物理数学建模后,构建原始模拟信号,并填充k空间,然后再基于k空间数据实现磁共振图像重建.该软件可以通过参数的任意调节对影响磁共振图像质量的因素进行可视化分析,包括11种常见伪影的特征和成因分析.我们的研究表明应用该仿真软件可以弥补台式MRI扫描仪价格昂贵、实验时间长等不足之处,实现对相关科技人员的批量化、规模化的实践操作培训.
A software package, MRISim, for virtual magnetic resonance imaging(MRI) data acquisition and image reconstruction was developed based on numerical simulation techniques. Virtual MRI data acquisition could be achieved through physical-mathematical modeling of the equipment and samples(i.e., phantom or human body). Image reconstruction of the virtual data was performed in the same manner as that in a real desktop MRI scanner. The software could also be applied for visualization of the features and causes of a variety of MRI artifacts, with the acquisition and processing parameters in the real experiments. MRISim was demonstrated as an efficient and reliable tool to conduct virtual MRI experiments, avoiding high expense of MRI training on real instruments.
A software package, MRISim, for virtual magnetic resonance imaging(MRI) data acquisition and image reconstruction was developed based on numerical simulation techniques. Virtual MRI data acquisition could be achieved through physical-mathematical modeling of the equipment and samples(i.e., phantom or human body). Image reconstruction of the virtual data was performed in the same manner as that in a real desktop MRI scanner. The software could also be applied for visualization of the features and causes of a variety of MRI artifacts, with the acquisition and processing parameters in the real experiments. MRISim was demonstrated as an efficient and reliable tool to conduct virtual MRI experiments, avoiding high expense of MRI training on real instruments.
引文
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[3]KUANG B,HE C M.A perception on the development of the virtual scan technology for the magnetic resonance imaging[J].Chinese J Magn Reson Imaging,2011,2(3):218-224.匡斌,何超明.磁共振成像虚拟扫描技术的发展及趋势浅淡[J].磁共振成像,2011,2(3):218-224.
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[5]HANSON L.A graphical simulator for teaching basic and advanced MR imaging techniques[J].Radiographics,2007,27(6):e27.
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[8]YODERD,ZHAO Y,PASCHAL C,et al.MRI simulator with object-specific field map calculations[J].Magn Reson Imaging,2004,22(3):315-328.
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[10]CAO Z,OH S,SICA C,et al.Bloch-based MRI system simulator considering realistic electromagnetic fields for calculation of signal,noise,and specific absorption rate[J].Magn Reson Med,2014,72(1):237-247.
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[12]BENOIT-CATTIN H,COLLEWET G,BELAROUSSI B.The SIMRI project:a versatile and interactive MRI simulator[J].J Magn Reson,2005,173(1):97-115.
[13]HACKLANDER T,METENS H.Virtual MRI:a PC-based simulation of a clinical MR scanner[J].Acad Radiol,2005,12(1):85-96.
[14]陈武凡,康立丽.MRI原理与技术[M].北京:科学出版社,2012.
[15]张学龙.医学影像物理学教程[M].北京:科学出版社,2013.
[16]WANG J,WANG X.The MATLAB-based rapid method of three-dimensional reconstruction of MRI images[J].Journal of Taishan Medical College,2012,3(7):515-517.王军,王昕.一种基于MATLAB的快速MRI图像三准重建方法[J].泰山医学院学报,2012,3(7):515-517.
[17]MATT A,BERNSTEIN B,KEVIN F,et al.Handbook of MRI pulse sequences[M].USA:Elsevier Academic Press,2004.
[18]XIAO P F,SHEN J,JIANG Y,et al.Bench-top magnetic resonance imaging system[J].Chinese J Magn Reson,2002,19(4):345-352.肖鹏飞,沈杰,蒋赟,等.台式磁共振成像系统的研制[J].波谱学杂志,2002,19(4):345-352.
[2]STOCKER T,VAHEDIPOUR K,PFLUGFELDER D,et al.A high performance computing MRI simulations[J].Magn Reson Med,2010,64(1):186-193.
[3]KUANG B,HE C M.A perception on the development of the virtual scan technology for the magnetic resonance imaging[J].Chinese J Magn Reson Imaging,2011,2(3):218-224.匡斌,何超明.磁共振成像虚拟扫描技术的发展及趋势浅淡[J].磁共振成像,2011,2(3):218-224.
[4]SHUI L.The design and realization of platform of magnetic resonance imaging[J].Software Guide,2014,13(6):147-150.
[5]HANSON L.A graphical simulator for teaching basic and advanced MR imaging techniques[J].Radiographics,2007,27(6):e27.
[6]NICHOLAS P,FUSHMAN D,RUCHINSKY V,et al.The virtual NMR spectrometer:a computer program for efficient simulation of NMRexperiments involving pulsed field gradients[J].J Magn Reson,2000,145(2):262-275.
[7]FORTIN A,SALMON A,BARUTHIO J,et al.High performance MRI simulation of arbitrarily complex flow:A versatile framework[J].HAL,2016,https://hal.archives-ouvertes.fr/hal-01326698.
[8]YODERD,ZHAO Y,PASCHAL C,et al.MRI simulator with object-specific field map calculations[J].Magn Reson Imaging,2004,22(3):315-328.
[9]KWAN R K,EVANS A C,PIKE G B.MRI simulation-based evaluation of image-processing and classification methods[J].IEEE T Med Imaging,1999,18(11):1085-1097.
[10]CAO Z,OH S,SICA C,et al.Bloch-based MRI system simulator considering realistic electromagnetic fields for calculation of signal,noise,and specific absorption rate[J].Magn Reson Med,2014,72(1):237-247.
[11]LIU F,KIJOWSKI R,BLOCK W.Performance of multiple types of numerical MR simulation using MRiLab[C].ISMRM,2014:5244.
[12]BENOIT-CATTIN H,COLLEWET G,BELAROUSSI B.The SIMRI project:a versatile and interactive MRI simulator[J].J Magn Reson,2005,173(1):97-115.
[13]HACKLANDER T,METENS H.Virtual MRI:a PC-based simulation of a clinical MR scanner[J].Acad Radiol,2005,12(1):85-96.
[14]陈武凡,康立丽.MRI原理与技术[M].北京:科学出版社,2012.
[15]张学龙.医学影像物理学教程[M].北京:科学出版社,2013.
[16]WANG J,WANG X.The MATLAB-based rapid method of three-dimensional reconstruction of MRI images[J].Journal of Taishan Medical College,2012,3(7):515-517.王军,王昕.一种基于MATLAB的快速MRI图像三准重建方法[J].泰山医学院学报,2012,3(7):515-517.
[17]MATT A,BERNSTEIN B,KEVIN F,et al.Handbook of MRI pulse sequences[M].USA:Elsevier Academic Press,2004.
[18]XIAO P F,SHEN J,JIANG Y,et al.Bench-top magnetic resonance imaging system[J].Chinese J Magn Reson,2002,19(4):345-352.肖鹏飞,沈杰,蒋赟,等.台式磁共振成像系统的研制[J].波谱学杂志,2002,19(4):345-352.