微针导入氨甲环酸联合疏肝活血汤治疗黄褐斑临床观察
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摘要
目的观察微针导入氨甲环酸联合疏肝活血汤治疗黄褐斑的临床疗效。方法将60例黄褐斑患者随机分为两组,每组30例。对照组单纯采用疏肝活血汤口服,观察组加用微针导入氨甲环酸治疗。两组均以4周为1个疗程,3个疗程后,观察临床疗效,同时记录不良反应。结果两组临床疗效分布比较,差异有统计学意义(P<0.05),观察组临床疗效显著优于对照组。与治疗前比较,两组患者治疗后皮损总积分显著降低(P<0.05),且观察组皮损积分降低值显著大于对照组(P<0.05)。结论微针导入氨甲环酸联合疏肝活血汤是治疗黄褐斑的有效方法之一。
Objective To investigate clinical effect of microneedle for importing tranexamic acid combined with Shugan Huoxue Decoction in the treatment of chloasma.Methods A total of 60 patients with chloasma were randomly divided into observation group and control group,with 30 patients in each group.The patient in the control group were given oral Shugan Huoxue Decoction alone,and those in the observation group were treated with the microneedle for importing tranexamic acid in addition to the treatment in the control group.Each course of treatment was four weeks,and after three courses of treatment,clinical outcome was observed and adverse events were recorded.Results There was a significant difference in the distribution of clinical outcomes between the two groups(P<0.05),and the observation group had a significantly better clinical outcome than the control group.Both groups had a significant reduction in total score of skin lesions after treatment(P<0.05),and the observation group had a significantly greater reduction than the control group(P<0.05).Conclusion Microneedle for importing tranexamic acid combined with Shugan Huoxue Decoction is an effective method for the treatment of chloasma.
Objective To investigate clinical effect of microneedle for importing tranexamic acid combined with Shugan Huoxue Decoction in the treatment of chloasma.Methods A total of 60 patients with chloasma were randomly divided into observation group and control group,with 30 patients in each group.The patient in the control group were given oral Shugan Huoxue Decoction alone,and those in the observation group were treated with the microneedle for importing tranexamic acid in addition to the treatment in the control group.Each course of treatment was four weeks,and after three courses of treatment,clinical outcome was observed and adverse events were recorded.Results There was a significant difference in the distribution of clinical outcomes between the two groups(P<0.05),and the observation group had a significantly better clinical outcome than the control group.Both groups had a significant reduction in total score of skin lesions after treatment(P<0.05),and the observation group had a significantly greater reduction than the control group(P<0.05).Conclusion Microneedle for importing tranexamic acid combined with Shugan Huoxue Decoction is an effective method for the treatment of chloasma.
引文
[1]周娜娜,景伟芳,刘雪,等.河北廊坊地区黄褐斑流行病学调查[J].中国公共卫生,2017,33(2):229-232.
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[7]刘丽琴,杨晓红,王全燕,等.祛斑汤治疗气滞血瘀型黄褐斑疗效及对外周血中血管内皮生长因子的影响[J].中国中西医结合皮肤性病学杂志,2015,14(6):374-376.
[8]何微,王建芬,杜玉菲,等.基于酪氨酸酶抑制活性的八白散组方研究[J].湖南中医药大学学报,2018,38(9):1009-1011.
[9]陈荣,许爱娥.黄褐斑发病机制研究进展[J].中国中西医结合皮肤性病学杂志,2019,18(2):189-191.
[10]KANG H Y,SUZUKI I,LEE D J,et al.Transcriptional profiling shows altered expression of wnt pathway-and lipid metabolism-related genes as well as melanogenesis-related genes in melasma[J].J Invest Dermatol,2011,131(8):1692-1700.
[11]孙慧,吴志波,倪小丽,等.微针导入氨甲环酸联合Q开关1 064nm激光治疗黄褐斑疗效观察[J].中国美容医学,2018,27(5):26-29.
[12]时悦,宋婷,单敏洁,等.扶正化瘀胶囊联合氨甲环酸治疗黄褐斑的临床观察[J].中国中西医结合皮肤性病学杂志,2016,15(4):239-240.
[13]HENRY S,MCALLISTER D V,ALLEN M G,et al.Microfabricated microneedles:a novel approach to transdermal drug delivery[J].J Pharm Sci,1998,87(8):922-925.
[14]YOON J,PARK D,SON T,et al.Enhancement of transdermal delivery of glycerol by micro-needling method combined with sonophoresis[J].Proc SPIE Int Soc Opt Eng,2009,7161:716109[2009-02-01].https://www.researchgate.net/publication/253292125_Enhancement_of_transdermal_delivery_of_glycerol_by_micro-needling_method_combined_with_sonophoresis.DOI:10.1117/12.809866.
[15]孟宪芙,王祎琳,胡晓春,等.光动力联合胶原贴敷料治疗中重度痤疮疗效观察[J].临床皮肤科杂志,2015,44(1):43-45.
[16]陈晓洁,吕爱凤,高晶,等.功能敷料的“伤口湿润环境愈合”理论与实践[J].生物医学工程学进展,2013,34(1):31-34.
[17]郑建辉.点阵激光联合胶原贴敷料治疗面部痤疮凹陷性瘢痕20例临床观察[J].皮肤病与性病,2018,40(2):232-233.
[2]NA J I,CHOI S Y,YANG S H,et al.Effect of tranexamic acid on melasma:a clinical trial with histological evaluation[J].J Eur Acad Dermatol Venereol,2013,27(8):1035-1039.
[3]中国中西医结合学会皮肤性病专业委员会色素病学组.黄褐斑的临床诊断和疗效标准(2003年修订稿)[J].中华皮肤科杂志,2004,37(7):440.
[4]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:280.
[5]李燕芳.喻文球教授从肝论治黄褐斑经验[J].中国民间疗法,2014,22(4):12-13.
[6]俞若熙,张惠敏,郑燕飞,等.浅谈王琦治疗黄褐斑经验与思路[J].辽宁中医杂志,2013,40(9):1781-1783.
[7]刘丽琴,杨晓红,王全燕,等.祛斑汤治疗气滞血瘀型黄褐斑疗效及对外周血中血管内皮生长因子的影响[J].中国中西医结合皮肤性病学杂志,2015,14(6):374-376.
[8]何微,王建芬,杜玉菲,等.基于酪氨酸酶抑制活性的八白散组方研究[J].湖南中医药大学学报,2018,38(9):1009-1011.
[9]陈荣,许爱娥.黄褐斑发病机制研究进展[J].中国中西医结合皮肤性病学杂志,2019,18(2):189-191.
[10]KANG H Y,SUZUKI I,LEE D J,et al.Transcriptional profiling shows altered expression of wnt pathway-and lipid metabolism-related genes as well as melanogenesis-related genes in melasma[J].J Invest Dermatol,2011,131(8):1692-1700.
[11]孙慧,吴志波,倪小丽,等.微针导入氨甲环酸联合Q开关1 064nm激光治疗黄褐斑疗效观察[J].中国美容医学,2018,27(5):26-29.
[12]时悦,宋婷,单敏洁,等.扶正化瘀胶囊联合氨甲环酸治疗黄褐斑的临床观察[J].中国中西医结合皮肤性病学杂志,2016,15(4):239-240.
[13]HENRY S,MCALLISTER D V,ALLEN M G,et al.Microfabricated microneedles:a novel approach to transdermal drug delivery[J].J Pharm Sci,1998,87(8):922-925.
[14]YOON J,PARK D,SON T,et al.Enhancement of transdermal delivery of glycerol by micro-needling method combined with sonophoresis[J].Proc SPIE Int Soc Opt Eng,2009,7161:716109[2009-02-01].https://www.researchgate.net/publication/253292125_Enhancement_of_transdermal_delivery_of_glycerol_by_micro-needling_method_combined_with_sonophoresis.DOI:10.1117/12.809866.
[15]孟宪芙,王祎琳,胡晓春,等.光动力联合胶原贴敷料治疗中重度痤疮疗效观察[J].临床皮肤科杂志,2015,44(1):43-45.
[16]陈晓洁,吕爱凤,高晶,等.功能敷料的“伤口湿润环境愈合”理论与实践[J].生物医学工程学进展,2013,34(1):31-34.
[17]郑建辉.点阵激光联合胶原贴敷料治疗面部痤疮凹陷性瘢痕20例临床观察[J].皮肤病与性病,2018,40(2):232-233.