医院放射人员染色体畸变与累积辐射剂量的关系研究
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摘要
目的探讨医院放射人员染色体畸变与累积辐射剂量的关系。方法选取唐山市各级医院放射人员1 217例,行染色体检查和累积辐射剂量监测,根据工种、工龄、医院级别进行分组。选取具有可比性的非放射人员170例为对照组,行染色体检查。分析染色体畸变与累积辐射剂量的关系。结果工种间比较,依对照组、放射诊断组、介入治疗组、放射治疗组、核医学组顺序,染色体畸变率(dic畸变率、ace畸变率、染色单体型畸变率、合计)呈增长趋势;依放射诊断组、介入治疗组、放射治疗组、核医学组顺序,累积辐射剂量呈增长趋势(P<0.05)。工龄间比较,依对照组、≤10年、10<~≤20年、20<~≤30年、30<年顺序,染色体畸变率(dic畸变率、ace畸变率、染色单体型畸变率、合计)呈增长趋势;依≤10年、10<~≤20年、20<~≤30年、30<年顺序,累积辐射剂量呈增长趋势(P<0.05)。医院级别间比较,依对照组、二甲以下、三甲、二甲顺序,染色体畸变率(dic畸变率、ace畸变率、染色单体型畸变率、合计)呈增长趋势;依二甲以下、三甲、二甲顺序,累积辐射剂量呈增长趋势(P<0.05)。染色体畸变与累积辐射剂量呈明显正相关性。结论工龄越长,累积辐射剂量越大,染色体畸变率越高。医院放射人员应该注重防护工作。
Objective To investigate the correlation between chromosome aberration and cumulative radiation dose in hospital radiation personnel.Methods The 1217 hospital radiation personnel who were selected from Tangshan hospitals and received chromosome examination and cumulative radiation dose monitoring,were divided into groups according to work type,working years,hospital level.Moreover 170 comparable non radiation workers were enrolled as control group,who received chromosome examination.The correlation between chromosome aberration and cumulative radiation dose was analyzed.Results According to comparison among different work types,the chromosome aberration rates(dic aberration rate,ace aberration rate,chromatid aberration rate,total aberration rate) were increased in order of control group,radiation diagnosis group,interventional treatment group,radiotherapy group,nuclear medicine group,however,the cumulative radiation dose showed an increasing trend in order of radiation diagnosis group,interventional treatment group,-radiotherapy group,nuclear medicine group(P < 0.05).According to comparison among different working years,the chromosome aberration rates(dic aberration rate,ace aberration rate,chromatid aberration rate,total aberration rate) showed an increasing trend in order of control group,≤10 years group,10 < ~ ≤20 years group,20 < ~ ≤30 years group,30 < years group,while the cumulative radiation dose was increased in order of ≤10 years group,10 < ~ ≤20 years group,20 < ~ ≤30 years group,30 < years group(P <0.05).According to comparison among different hospital levels,the chromosome aberration rate(dic aberration rate,ace aberration rate,chromatid aberration rate,total) showed an increasing trend in order of control group,below the second-grade class-A hospitals,the third-grade class-A hospitals,the second-grade class-A hospitals,however,cumulative radiation dose showed an increasing trend in order of below the second-grade class-A hospitals,the third-grade class-A hospitals,the second-grade class-A hospitals(P < 0.05).Conclusion The longer working years,the bigger cumulative radiation dose,the higher chromosome aberration rate is,therefor,hospital radiation personnel should pay much attention to protective measure.
Objective To investigate the correlation between chromosome aberration and cumulative radiation dose in hospital radiation personnel.Methods The 1217 hospital radiation personnel who were selected from Tangshan hospitals and received chromosome examination and cumulative radiation dose monitoring,were divided into groups according to work type,working years,hospital level.Moreover 170 comparable non radiation workers were enrolled as control group,who received chromosome examination.The correlation between chromosome aberration and cumulative radiation dose was analyzed.Results According to comparison among different work types,the chromosome aberration rates(dic aberration rate,ace aberration rate,chromatid aberration rate,total aberration rate) were increased in order of control group,radiation diagnosis group,interventional treatment group,radiotherapy group,nuclear medicine group,however,the cumulative radiation dose showed an increasing trend in order of radiation diagnosis group,interventional treatment group,-radiotherapy group,nuclear medicine group(P < 0.05).According to comparison among different working years,the chromosome aberration rates(dic aberration rate,ace aberration rate,chromatid aberration rate,total aberration rate) showed an increasing trend in order of control group,≤10 years group,10 < ~ ≤20 years group,20 < ~ ≤30 years group,30 < years group,while the cumulative radiation dose was increased in order of ≤10 years group,10 < ~ ≤20 years group,20 < ~ ≤30 years group,30 < years group(P <0.05).According to comparison among different hospital levels,the chromosome aberration rate(dic aberration rate,ace aberration rate,chromatid aberration rate,total) showed an increasing trend in order of control group,below the second-grade class-A hospitals,the third-grade class-A hospitals,the second-grade class-A hospitals,however,cumulative radiation dose showed an increasing trend in order of below the second-grade class-A hospitals,the third-grade class-A hospitals,the second-grade class-A hospitals(P < 0.05).Conclusion The longer working years,the bigger cumulative radiation dose,the higher chromosome aberration rate is,therefor,hospital radiation personnel should pay much attention to protective measure.
引文
1郭晓鹏,张苗苗,缪建顺,等.重离子束辐射生物学效应研究热点及其进展.辐射研究与辐射工艺学报,2015,33:7-12.
2 王玉珏,岳敏,林继红,等.不同剂量X射线辐射对睾丸生物学效应的影响.实用医学杂志,2015,31:17-20.
3 Katsube T,Wang B,Tanaka K,et al.Effects of chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes.Mutat Res,2017,813:18-26.
4 Jacquet P,van Buul P,van Duijn-Goedhart A,et al.Radiation sensitivity of the gastrula-stage embryo:Chromosome aberrations and mutation induction in lac Z transgenic mice:The roles of DNA double-strand break repair systems.Mutat Res Genet Toxicol Environ Mutagen,2015,792:26-34.
5 周鑫,王振华,张红,等.电离辐射引起的线粒体DNA损伤及突变研究进展.原子核物理评论,2012,29:399-405.
6 贺许良,卢先州,陈枚,等.免疫器官辐射损伤与防护的研究进展.现代生物医学进展,2014,14:997-1000.
7 康红,杨慧,柯少波,等.电离辐射对不同放射敏感性细胞中高迁移率簇蛋白B1的诱导表达作用.中华放射医学与防护杂志,2016,36:486-490.
8 宋梦姣,张继青.电离辐射对细胞应激反应相关信号转导的影响.国际医学放射学杂志,2012,35:566-569.
9 张素英,李全开.低剂量电离辐射对放射工作人员细胞遗传学影响.中国公共卫生,2011,27:48-50.
10 周齐红,俞慧娟,付风云,等.放射工作人员外周血淋巴细胞染色体畸变和微核率分析.中华劳动卫生职业病杂志,2016,34:275-277.
11 马娅,刘伟,信亚周,等.不同剂量率的低剂量X射线诱导早熟染色体断片的剂量效应关系.辐射防护,2015,35:209-213.
12 王春燕,佟鹏,苟巧,等.用早熟凝集染色体环法研究中子诱发染色体畸变的剂量效应关系.癌变·畸变·突变,2011,23:449-451.
13 李崇尚.濮阳市放射工作人员淋巴细胞染色体畸变情况分析.河南预防医学杂志,2016,27:565-566,579.
14 刘征宇,杨学琴,惠长野,等.深圳市放射工作人员周围血淋巴细胞染色体畸变分析.职业与健康,2013,29:1549-1551.
15 赖专华,张克俭,杨海峰,等.医用射线放射工作人员染色体畸变-剂量分析.职业与健康,2015,31:2911-2913.
16 包天宇,钱斌.无锡市医院放射工作人员所受放射电离辐射现状分析.职业与健康,2012,28:2095-2096,2099.
2 王玉珏,岳敏,林继红,等.不同剂量X射线辐射对睾丸生物学效应的影响.实用医学杂志,2015,31:17-20.
3 Katsube T,Wang B,Tanaka K,et al.Effects of chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes.Mutat Res,2017,813:18-26.
4 Jacquet P,van Buul P,van Duijn-Goedhart A,et al.Radiation sensitivity of the gastrula-stage embryo:Chromosome aberrations and mutation induction in lac Z transgenic mice:The roles of DNA double-strand break repair systems.Mutat Res Genet Toxicol Environ Mutagen,2015,792:26-34.
5 周鑫,王振华,张红,等.电离辐射引起的线粒体DNA损伤及突变研究进展.原子核物理评论,2012,29:399-405.
6 贺许良,卢先州,陈枚,等.免疫器官辐射损伤与防护的研究进展.现代生物医学进展,2014,14:997-1000.
7 康红,杨慧,柯少波,等.电离辐射对不同放射敏感性细胞中高迁移率簇蛋白B1的诱导表达作用.中华放射医学与防护杂志,2016,36:486-490.
8 宋梦姣,张继青.电离辐射对细胞应激反应相关信号转导的影响.国际医学放射学杂志,2012,35:566-569.
9 张素英,李全开.低剂量电离辐射对放射工作人员细胞遗传学影响.中国公共卫生,2011,27:48-50.
10 周齐红,俞慧娟,付风云,等.放射工作人员外周血淋巴细胞染色体畸变和微核率分析.中华劳动卫生职业病杂志,2016,34:275-277.
11 马娅,刘伟,信亚周,等.不同剂量率的低剂量X射线诱导早熟染色体断片的剂量效应关系.辐射防护,2015,35:209-213.
12 王春燕,佟鹏,苟巧,等.用早熟凝集染色体环法研究中子诱发染色体畸变的剂量效应关系.癌变·畸变·突变,2011,23:449-451.
13 李崇尚.濮阳市放射工作人员淋巴细胞染色体畸变情况分析.河南预防医学杂志,2016,27:565-566,579.
14 刘征宇,杨学琴,惠长野,等.深圳市放射工作人员周围血淋巴细胞染色体畸变分析.职业与健康,2013,29:1549-1551.
15 赖专华,张克俭,杨海峰,等.医用射线放射工作人员染色体畸变-剂量分析.职业与健康,2015,31:2911-2913.
16 包天宇,钱斌.无锡市医院放射工作人员所受放射电离辐射现状分析.职业与健康,2012,28:2095-2096,2099.