壮药三角泡黄酮类化学成分研究
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摘要
目的研究壮药三角泡(倒地铃Cardiospermum halicacabum干燥全草)的化学成分。方法通过硅胶、聚酰胺、凝胶等柱色谱及重结晶方法进行分离和纯化,根据理化性质和波谱数据对化合物结构进行鉴定。结果从三角泡正丁醇部位分离13个化合物,分别鉴定为金圣草黄素-7-O-β-D-葡萄糖醛酸苷丁酯(1)、金圣草黄素-7-O-β-D-葡萄糖醛酸苷乙酯(2)、金圣草黄素-7-O-β-D-葡萄糖醛酸苷甲酯(3)、金圣草黄素(4)、芹菜素-7-O-β-D-葡萄糖醛酸苷丁酯(5)、芹菜素-7-O-β-D-葡萄糖醛酸苷乙酯(6)、芹菜素-7-O-β-D-葡萄糖醛酸苷甲酯(7)、芹菜素-7-O-β-D-葡萄糖苷(8)、芹菜素(9)、木犀草素-7-O-β-D-葡萄糖醛酸苷甲酯(10)、木犀草素-7-O-β-D-葡萄糖醛酸苷(11)、木犀草素(12)、槲皮素(13)。结论化合物1~3为新的黄酮类化合物,分别命名为倒地铃苷D、倒地铃苷B和倒地铃苷A;化合物5~8、10、11为首次从该属植物中分离得到。
Objective To study the chemical constituents of Zhuang medicine Cardiospermum halicacabum. Methods The compounds were isolated and purified by silica gel, polyamide gel, and Sephadex LH-20 chromatography. The structures of the compounds were identified on the basis of chemical and spectral methods. Results Thirteen compounds were isolated from the butanol extracts of C. halicacabum and identified as chrysoeriol-7-O-β-D-glucuronide butyl ester(1), chrysoeriol-7-O-β-Dglucuronide ethyl ester(2), chrysoeriol-7-O-β-D-glucuronide methyl ester(3), chrysoeriol(4), apigenin-7-O-β-D-glucuronide butyl ester(5), apigenin-7-O-β-D-glucuronide ethyl ester(6), apigenin-7-O-β-D-glucuronide methyl ester(7), apigenin-7-O-β-Dglucuronide(8), apigenin(9), luteolin-7-O-β-D-glucuronide methyl ester(10), luteolin-7-O-β-D-glucuronide(11), luteolin(12), and quercetin(13). Conclusion Compounds 1, 2, and 3 are new flavonoiels named as cardiosperoside D, cardiosperoside B, and cardiosperoside A. Compounds 5—8, 10, and 11 are isolated from this genus for the first time.
Objective To study the chemical constituents of Zhuang medicine Cardiospermum halicacabum. Methods The compounds were isolated and purified by silica gel, polyamide gel, and Sephadex LH-20 chromatography. The structures of the compounds were identified on the basis of chemical and spectral methods. Results Thirteen compounds were isolated from the butanol extracts of C. halicacabum and identified as chrysoeriol-7-O-β-D-glucuronide butyl ester(1), chrysoeriol-7-O-β-Dglucuronide ethyl ester(2), chrysoeriol-7-O-β-D-glucuronide methyl ester(3), chrysoeriol(4), apigenin-7-O-β-D-glucuronide butyl ester(5), apigenin-7-O-β-D-glucuronide ethyl ester(6), apigenin-7-O-β-D-glucuronide methyl ester(7), apigenin-7-O-β-Dglucuronide(8), apigenin(9), luteolin-7-O-β-D-glucuronide methyl ester(10), luteolin-7-O-β-D-glucuronide(11), luteolin(12), and quercetin(13). Conclusion Compounds 1, 2, and 3 are new flavonoiels named as cardiosperoside D, cardiosperoside B, and cardiosperoside A. Compounds 5—8, 10, and 11 are isolated from this genus for the first time.
引文
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[13]黄婕,王国才,李桃,等.黄荆的化学成分研究[J].中草药,2013,44(10):1237-1240.
[14]冯卫生,陈文静,郑晓珂,等.怀菊花中黄酮类化学成分研究[J].中国药学杂志,2017,52(17):1497-1502.
[15]Feng X Z,Xu S X,Dong M.Two novel flavonoids from Ixeris sonchifolia[J].J Chin Pharm Sci,2000,9(3):134-136.
[16]石萍萍,李晓霞,韩丽雯,等.北葶苈子中黄酮苷类成分的分离与鉴定[J].沈阳药科大学学报,2015,32(10):767-771.
[17]舒任庚,蔡慧,王晓敏,等.连钱草化学成分研究[J].中草药,2017,48(20):4215-4218.
[2]中华本草编委会.中华本草[M].上海:上海科学技术出版社,1999.
[3]Govindarajan M,Sivakumar R.Adulticidal properties of Cardiospermum halicacabum plant extracts against three important vector mosquitoes[J].Eur Rev Med Pharmaco,2012,16(3):95-104.
[4]Parameshappa B,Basha M S A,Sen S,et al.AcetaminoPhen-induced nephrotoxicity in rats:Protective role of Cardiospermum halicacabum[J].PharmaceuticalBiology,2012,50(2):247-253.
[5]Sadique J,Chandra T,Thenmozhi V,et al.Biochemical modes of action of Cassia occidentalis and Cardiospermum halicacabum in inflammation[J].JEthnopharmacol,1987,19(2):201-212.
[6]Kasi M,Venkatesh P R,Shanmugasamy S,et al.Antiviral activity of Cardiospermum halicacabum L.extract against coinfecting agents HIV and HBV[J].J Herbs,2011,17(4):403-418.
[7]广西植物研究所.广西植物志[M].南宁:广西科学技术出版社,1991.
[8]陈君,韦建华,苗伟生,等.倒地铃急性毒性及降血糖作用的初步研究[J].时珍国医国药,2012,23(5):1083-1085
[9]韦建华,陈君,蔡少芳,等.倒地铃化学成分研究(I)[J].中草药,2011,40(8):1509-1511.
[10]靳鑫,时圣明,张东方,等.穿心莲化学成分的研究[J].中草药,2012,43(1):47-50.
[11]徐燕,梁敬钰.苦苣菜的化学成分[J].中国药科大学学报,2005,36(5):411-413.
[12]吴娟,周先礼,周小丽,等.藏角蒿花的化学成分研究[J].中草药,2012,43(1):55-59.
[13]黄婕,王国才,李桃,等.黄荆的化学成分研究[J].中草药,2013,44(10):1237-1240.
[14]冯卫生,陈文静,郑晓珂,等.怀菊花中黄酮类化学成分研究[J].中国药学杂志,2017,52(17):1497-1502.
[15]Feng X Z,Xu S X,Dong M.Two novel flavonoids from Ixeris sonchifolia[J].J Chin Pharm Sci,2000,9(3):134-136.
[16]石萍萍,李晓霞,韩丽雯,等.北葶苈子中黄酮苷类成分的分离与鉴定[J].沈阳药科大学学报,2015,32(10):767-771.
[17]舒任庚,蔡慧,王晓敏,等.连钱草化学成分研究[J].中草药,2017,48(20):4215-4218.