独脚金的化学成分研究
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摘要
为研究玄参科植物独脚金(Striga asiatica(L.)O.K.)全草的化学成分,采用硅胶柱色谱、凝胶色谱等方法进行化学成分的分离纯化,通过理化性质和波谱数据(如核磁共振、红外光谱、质谱等)进行结构鉴定。结果表明:分离鉴定了到19个化合物,分别为(-)-threo-guaiacyl-glycerol-8-O-4'-(coniferyl alcohol) ether(1),3β-hydroxyolean-12-en-11-one acetate(2),2α, 3α, 19α, 23-四羟基-乌索烷-12-烯-28-O-β-D-葡萄糖苷(3),olean-12-ene-3β,7β,15α,28-tetraol(4),黄芩素6,4'-二甲醚(5),金圣草黄素(6),金圣草黄素-7-O-葡萄糖苷(7),rhamnopyranosyl vanilloyl(8),5, 3', 4'-三羟基-3,7-二甲氧基黄酮(9),5,7,3',4',5'-五甲氧基黄酮(10),木犀草素-7, 3', 4'-三甲醚(11),芹菜素(12),芹菜素-7-O-β-D-葡萄糖醛酸甲酯(13),芹菜素-7-O-β-D-葡萄糖醛酸苷(14),3-O-(6'-O-palmitoy-β-D-glucosyl)-spinasta-7,22-diene(15),木犀草素-7-O-β-D-葡萄糖苷(16),槲皮素-3-O-β-D-吡喃葡萄糖苷(17),withagulatin A(18),(6S,9R)-roseoside(19),其中化合物1,2,3,4和19是首次从该属植物中分离得到。
To study the chemical constituents of Striga asiatica(L.)O.K.,the chemical constituents were isolated and purified with silica column chromato-graphy and gel chromatography,and their structures were identified by physicochemical properties and various spectroscopic methods including NMR spectrum,MS,UV,etc. The results showed,19 compounds were isolated and elucidated as(-)-threo-guaiacyl-glycerol-8-O-4'-(coniferyl alcohol) ether(1),3β-hydroxyolean-12-en-11-one acetate(2),2α,3α,19α,23-tetrahydroxy-ursa-12-en-28-oicacid-28-O-β-Dglucopyranosylester(3),olean-12-ene-3β,7β,15α,28-tetraol(4),scutellain-6,4'-dimethy ether(5),chrysoeriol(6),chrysoeriol-7-O-glucoside(7),rhamnopyranosyl vanilloyl(8),5,3',4'-trihydroxy-3,7-dimethoxyflavone(9),5,7,3',4',5'-pentamethoxyflavone(10),luteolin-7,3',4'-trimethyl ether(11),apigenin(12),apigenin-7-O-β-D-glucuronide methyl ester(13),apigenin-7-O-β-D-glucopyranuro-nide(14),3-O-(6'-O-palmitoy-β-D-glucosyl)-spinasta-7,22-diene(15),luteolin-7-O-β-D-glucoside(16),quercetin-3-O-β-D-glucopyr-anoside(17),withagulatinA(18),(6 S,9 R)-roseoside(19).The compound 1,2,3,4 and 19 are isolated from the plant of genus for the first time.
To study the chemical constituents of Striga asiatica(L.)O.K.,the chemical constituents were isolated and purified with silica column chromato-graphy and gel chromatography,and their structures were identified by physicochemical properties and various spectroscopic methods including NMR spectrum,MS,UV,etc. The results showed,19 compounds were isolated and elucidated as(-)-threo-guaiacyl-glycerol-8-O-4'-(coniferyl alcohol) ether(1),3β-hydroxyolean-12-en-11-one acetate(2),2α,3α,19α,23-tetrahydroxy-ursa-12-en-28-oicacid-28-O-β-Dglucopyranosylester(3),olean-12-ene-3β,7β,15α,28-tetraol(4),scutellain-6,4'-dimethy ether(5),chrysoeriol(6),chrysoeriol-7-O-glucoside(7),rhamnopyranosyl vanilloyl(8),5,3',4'-trihydroxy-3,7-dimethoxyflavone(9),5,7,3',4',5'-pentamethoxyflavone(10),luteolin-7,3',4'-trimethyl ether(11),apigenin(12),apigenin-7-O-β-D-glucuronide methyl ester(13),apigenin-7-O-β-D-glucopyranuro-nide(14),3-O-(6'-O-palmitoy-β-D-glucosyl)-spinasta-7,22-diene(15),luteolin-7-O-β-D-glucoside(16),quercetin-3-O-β-D-glucopyr-anoside(17),withagulatinA(18),(6 S,9 R)-roseoside(19).The compound 1,2,3,4 and 19 are isolated from the plant of genus for the first time.
引文
[1]广西壮族自治区革委会卫生局主编.广西本草选编[M].南宁:广西人民出版社,1974:1631.
[2]姜海,杨柳,邢绪东,等.苍耳子的化学成分研究[J].中草药,2017,48(1):47-51.
[3]侯晶,艾瑞婷,周凌艳,等.苦碟子化学成分的分离与鉴定[J].沈阳药科大学学报,2011,28(11):879-881.
[4]张洁,李宝泉,冯锋,等.裸花紫珠的化学成分及其止血活性研究[J].中国中药杂志,2010,34(25):3297-3301.
[5]张京,况燚,刘力,等.金荞麦块根化学成分的研究[J].中草药,2016,47(5):722-725.
[6]李光耀.几种苔藓植物化学成分及生物活性的研究[D].济南:山东大学,2000,34.
[7]韦建华,陈君,蔡少芳,等.倒地铃化学成分研究(I)[J].中草药,2011,42(8):1509-1511.
[8]杨念云,任爱农,胡万春,等.菊花脑嫩茎叶的化学成分[J].中国药科大学学报,2005,36(5):402-404.
[9]薛刚强,杜婧,潘新艳,等.玄参化学成分研究[J].中药材,2014,37(9):1597-1599.
[10]轧霁,张晓琦,王英,等.五指毛桃黄酮和香豆素类成分研究[J].林产化学与工业,2008,28(6):49-51.
[11]陈秋虹,黄艳,周洁洁,等.长柱金花茶叶的化学成分研究(II)[J].中草药,2017,48(23):4845-4849.
[12]Ampofo S.A.,Roussis V,Wiemer D.F..New prenylated phenolics from Piper auritum[J].Phytochemistry,1987,26(8):2367-2370.
[13]靳鑫时,圣明,张东方,等.穿心莲化学成分的研究[J].中草药,2012,43(1):47-50.
[14]晏小云,殷晓静,王国凯,等.南苜蓿的化学成分研究[J].中国药学杂志,2012,47(6):415-417.
[15]邹懿,洪敏,杨笑芳.百蕊草化学成分分离[J].中国实验方剂学杂志,2016,22(7):74-77.
[16]李媛,宋宝安,杨松,等.中草药玄参化学成分的研究[J].天然产物研究与开发,2012,24(1):47-51.
[17]Ma B,Liu S K,Xie YY,et al.Flavonol glycosides and triterpenes from the leaves of Uncaria rhynchophylla(Miq.)Jacks[J].Asia J Tradit Med,2009,4(3):85-91.
[18]李慧,杨宝,黄芬,等.半边旗化学成分研究[J].中草药,2018,49(1):95-99.
[19]Chen CM,Chen ZT,Hsieh CH,et al.Withangulatin A,a new withanolide from Physalis angulata[J].Heterocycles,1990,31(7):1371-1375.
[20]潘其明,黄日镇,潘英明,等.山豆根的化学成分研究[J].中国中药杂志,2016,41(1):96-100.
[2]姜海,杨柳,邢绪东,等.苍耳子的化学成分研究[J].中草药,2017,48(1):47-51.
[3]侯晶,艾瑞婷,周凌艳,等.苦碟子化学成分的分离与鉴定[J].沈阳药科大学学报,2011,28(11):879-881.
[4]张洁,李宝泉,冯锋,等.裸花紫珠的化学成分及其止血活性研究[J].中国中药杂志,2010,34(25):3297-3301.
[5]张京,况燚,刘力,等.金荞麦块根化学成分的研究[J].中草药,2016,47(5):722-725.
[6]李光耀.几种苔藓植物化学成分及生物活性的研究[D].济南:山东大学,2000,34.
[7]韦建华,陈君,蔡少芳,等.倒地铃化学成分研究(I)[J].中草药,2011,42(8):1509-1511.
[8]杨念云,任爱农,胡万春,等.菊花脑嫩茎叶的化学成分[J].中国药科大学学报,2005,36(5):402-404.
[9]薛刚强,杜婧,潘新艳,等.玄参化学成分研究[J].中药材,2014,37(9):1597-1599.
[10]轧霁,张晓琦,王英,等.五指毛桃黄酮和香豆素类成分研究[J].林产化学与工业,2008,28(6):49-51.
[11]陈秋虹,黄艳,周洁洁,等.长柱金花茶叶的化学成分研究(II)[J].中草药,2017,48(23):4845-4849.
[12]Ampofo S.A.,Roussis V,Wiemer D.F..New prenylated phenolics from Piper auritum[J].Phytochemistry,1987,26(8):2367-2370.
[13]靳鑫时,圣明,张东方,等.穿心莲化学成分的研究[J].中草药,2012,43(1):47-50.
[14]晏小云,殷晓静,王国凯,等.南苜蓿的化学成分研究[J].中国药学杂志,2012,47(6):415-417.
[15]邹懿,洪敏,杨笑芳.百蕊草化学成分分离[J].中国实验方剂学杂志,2016,22(7):74-77.
[16]李媛,宋宝安,杨松,等.中草药玄参化学成分的研究[J].天然产物研究与开发,2012,24(1):47-51.
[17]Ma B,Liu S K,Xie YY,et al.Flavonol glycosides and triterpenes from the leaves of Uncaria rhynchophylla(Miq.)Jacks[J].Asia J Tradit Med,2009,4(3):85-91.
[18]李慧,杨宝,黄芬,等.半边旗化学成分研究[J].中草药,2018,49(1):95-99.
[19]Chen CM,Chen ZT,Hsieh CH,et al.Withangulatin A,a new withanolide from Physalis angulata[J].Heterocycles,1990,31(7):1371-1375.
[20]潘其明,黄日镇,潘英明,等.山豆根的化学成分研究[J].中国中药杂志,2016,41(1):96-100.