溪黄草的化学成分研究
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摘要
目的对溪黄草Isodon serra(Maxim.)Hara的化学成分进行研究。方法采用柱层析方法进行分离、纯化,经现代波谱技术对化合物进行结构鉴定。结果从溪黄草中分离得到14个化合物,分别鉴定为诺多星(1)、毛果青茶菜素(2)、β-香树脂醇棕榈酸酯(3)、2-三十三酮(4)、三十烷酸对羟基苯乙酯(5)、腺苷(6)、丹酚酸B(7)、7-甲氧基香豆素(8)、伞形花内酯(9)、香草醛(10)、丁香酸(11)、香草酸(12)、绿原酸(13)、槲皮素-3,3′-二甲醚(14)。结论化合物3、4、5、6、7、8、9、12、13、14均为首次从溪黄草属中分离得到,化合物10、11为首次从该植物中分离得到。
Objective To study the chemical constituents of Isodon serra(Maxim.)Hara. Methods The chemical constituents of Isodon serra(Maxim.) Hara were isolated and purified by chromatographic methods,and their structure was elucidated by spectral analysis. Results Fourteen compounds were obtained and identified as nodosin(1),isodocarpin(2),β- amyrin palmitate(3),qritriacontan- 2- one(4),triacontanoic acid,2-(4- hydroxyphenyl)ether ester(5),adenosine(6),salvianolic acid B(7),7- methoxy coumarin(8),umbelliferone(9),vanillin(10),syringic acid(11),vanillic acid(12),chlorogenic acid(13),quercetin- 3,3′- dimethylether(14). Conclusion Compounds3- 9,12- 14 has been isolated from genus Isodon for the first time.
Objective To study the chemical constituents of Isodon serra(Maxim.)Hara. Methods The chemical constituents of Isodon serra(Maxim.) Hara were isolated and purified by chromatographic methods,and their structure was elucidated by spectral analysis. Results Fourteen compounds were obtained and identified as nodosin(1),isodocarpin(2),β- amyrin palmitate(3),qritriacontan- 2- one(4),triacontanoic acid,2-(4- hydroxyphenyl)ether ester(5),adenosine(6),salvianolic acid B(7),7- methoxy coumarin(8),umbelliferone(9),vanillin(10),syringic acid(11),vanillic acid(12),chlorogenic acid(13),quercetin- 3,3′- dimethylether(14). Conclusion Compounds3- 9,12- 14 has been isolated from genus Isodon for the first time.
引文
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[4]Pengwei Liu,Yingfeng Du,Xiaowei Zhang,et al.Rapid Analysis of27 Components of Isodon serra by LC ESI-MS MS[J].Chromatographia,2010,72,265.
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[6]韦建华,陈君,蔡少芳,等.倒地铃化学成分研究(I)[J].中草药,2011,42(8):1509-1511.
[7]许文清,龚小见,周欣,等.马兰化学成分的研究[J].中草药,2010,47(1):1056-1060.
[8]冯卫生,王彦志,郑晓珂.中药化学成分结构解析[M].北京:科学出版社,2008:551-554.
[9]谢婷婷.白花丹参的化学成分研究[D].济南:山东大学,2010.
[10]裴香萍,裴妙,丁海琪.葛花化学成分的研究[J].山西大学学报,2010,33(3):423-424.
[11]阎乾顺,张森,王延俊,等.滇西前胡的化学成分研究[J].中药材,2008,31(8):1157-1160.
[12]王刚,王国凯,刘劲松,等.马兰化学成分研究[J].中药材,2010,33(4):551-554.
[13]龚婧如,王书芳.刺五加的化学成分研究[J].中草药,2012,43(12):2337-2340.
[14]陶华明,王隶书,赵大庆,等.羊齿天门冬根中酚酸类化学成分研究[J].中草药,2011,42(11):2181-2184.
[15]吕小兰,麦曦,郭惠,等.乌饭树根化学成分研究[J].中药材,2012,35(6):917-920.
[16]梁晶晶,孙连娜,陶朝阳,等.水烛香蒲叶的化学成分研究[J].药学实践杂志,2007,25(3):150-151.
[17]国家药典委员会.中国药典(附录Ⅲ)[M].北京:中国医药科技出版社,2010:26.
[18]邓乔华,张为亮,王德勤,等.对新版药典溪黄草两种基原的研讨[J].现代中药研究与实践,2012,26(4):21-23.
[19]Zhou Wenting,Xie Haihui,Wu Ping,et al.Abietane diterpenoids from Isodon lophanthoides var.graciliflorus and their cytotoxicity[J].Food Chemistry,2013,(136):1110-1116.