3D打印技术在结构性心脏病中的应用
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摘要
目的:探讨3D打印技术制作心脏三维模型在结构性心脏病诊疗中的应用价值。方法:将心脏增强CT图像导入Mimics软件进行三维重建,采用3D打印机打印出1∶1心脏模型。根据3D打印模型测量所需数据并制定手术方案。结果:4例心脏3D打印模型均制作成功,包括1例心肌梗死后室间隔穿孔合并心尖部室壁瘤、1例心肌梗死后室间隔穿孔、1例升主动脉瘤和1例法洛四联症。打印的模型能显示心脏各结构的空间位置及毗邻关系。结论:心脏增强CT图像可以打印出完整的心脏三维模型,为结构性心脏病提供术前模拟,对提高手术成功率有较大帮助。
Objective:To explore the value of three-dimensional heart model made by 3 D printing technology in the diagnosis and treatment of structural heart disease. Methods:The data of the series of heart sections scanned by CT were imported to Mimics soft for the 3 D reconstruction.Then the formation of 1∶1 model of heart was printed.Data was collected and surgical plan was made according to the heart models. Results:We successfully made four cardiac 3 D printing models,including one case of ventricular septal perforation with apical ventricular aneurysm after myocardial infarction,one case of ventricular septal perforation after myocardial infarction,one case of ascending aortic aneurysm and one case of tetralogy of Fallot.The printed model can show the spatial location and adjacent relationship of the structures of heart. Conclusions:CT pictures can be converted into a 3 D heart model.3 D heart models can provide simulating intervention therapy on the models and improve operation successful rate.
Objective:To explore the value of three-dimensional heart model made by 3 D printing technology in the diagnosis and treatment of structural heart disease. Methods:The data of the series of heart sections scanned by CT were imported to Mimics soft for the 3 D reconstruction.Then the formation of 1∶1 model of heart was printed.Data was collected and surgical plan was made according to the heart models. Results:We successfully made four cardiac 3 D printing models,including one case of ventricular septal perforation with apical ventricular aneurysm after myocardial infarction,one case of ventricular septal perforation after myocardial infarction,one case of ascending aortic aneurysm and one case of tetralogy of Fallot.The printed model can show the spatial location and adjacent relationship of the structures of heart. Conclusions:CT pictures can be converted into a 3 D heart model.3 D heart models can provide simulating intervention therapy on the models and improve operation successful rate.
引文
[1]刘金龙,刘锦纷.3D打印技术在小儿心脏外科中的应用[J].临床小儿外科,2016,15(3):212-214.
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[3]刘坤,吕滨,任心爽,等.3D打印技术应用于经导管主动脉瓣置人术前评估一例[J].中华心血管病杂志,2015,7(43):634-635.
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[6] Kim MS,Hansgen AR,Carroll JD.Use of rapid prototyping in the care of patients with structural heart disease[J].Trends Cardiovasc Med,2008,18(6):210-216.
[7] Riesenkampff E,Rietdorf U,Wolf I,et al.The practical clinical value of three-dimensional models of complex congenitally malformed hearts[J].J Thorac Cardiovasc Surg,2009,138(3):571-580.
[8] Schievano S,Migliavacca F,Coats LA,et al.Percutaneous pulmonary valve implantation based on rapid prototyping of right ventricular outflow tract and pulmonary trunk from MR data[J].Radiology,2007,242(2):490-497.
[9]潘湘斌.3D打印技术在心脏领域的应用前景和挑战[J].中华医学杂志,2017,97(16):1201-1203.
[10] Hockaday LA,Kang KH,Colangelo NW,et al.Rapid 3D printingofanatomicallyaccurateandmechanically heterogeneous aorticvalvehydrogelscaffolds[J].Biofabrication,2012,4(3):035005.
[11] Duan B, Kapetanovic E, Hockaday LA,et al.Threedimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells[J]. Acta Biomater,2014,10(5):1836-1846.
[2]庞英,梁明亭,杨帆,等.应用3D打印技术实施下腔型房间隔缺损封堵术1例[J].临床心血管病杂志,2016,32(1):97-98.
[3]刘坤,吕滨,任心爽,等.3D打印技术应用于经导管主动脉瓣置人术前评估一例[J].中华心血管病杂志,2015,7(43):634-635.
[4] Kim MS,Hansgen AR,Wink O,et al.Rapid prototyping:a new tool in understanding and treating structural heart disease[J].Circulation,2008,117(18):2388-2394.
[5] Jacobs S,Grunert R,Mohr FW,et al.3D-imaging of cardiac structures using 3D heart models for planning in heart surgery:apreliminary study[J].Interact Cardiovasc Thorac Surg,2008,7(1):6-9.
[6] Kim MS,Hansgen AR,Carroll JD.Use of rapid prototyping in the care of patients with structural heart disease[J].Trends Cardiovasc Med,2008,18(6):210-216.
[7] Riesenkampff E,Rietdorf U,Wolf I,et al.The practical clinical value of three-dimensional models of complex congenitally malformed hearts[J].J Thorac Cardiovasc Surg,2009,138(3):571-580.
[8] Schievano S,Migliavacca F,Coats LA,et al.Percutaneous pulmonary valve implantation based on rapid prototyping of right ventricular outflow tract and pulmonary trunk from MR data[J].Radiology,2007,242(2):490-497.
[9]潘湘斌.3D打印技术在心脏领域的应用前景和挑战[J].中华医学杂志,2017,97(16):1201-1203.
[10] Hockaday LA,Kang KH,Colangelo NW,et al.Rapid 3D printingofanatomicallyaccurateandmechanically heterogeneous aorticvalvehydrogelscaffolds[J].Biofabrication,2012,4(3):035005.
[11] Duan B, Kapetanovic E, Hockaday LA,et al.Threedimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells[J]. Acta Biomater,2014,10(5):1836-1846.