7-溴异喹啉-1-醇的合成
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摘要
以3-溴苯甲醛和氨基乙醛缩二甲醇起始原料,经Pictet-Gams反应、过氧化反应以及自由基反应得到7-溴异喹啉-1-醇,总收率35%。由核磁共振和质谱对产物进行结构表征。本方法具有反应条件温和、收率高、易于纯化的特点,为7-溴异喹啉-1-醇的合成提供了新途径。
The titled compound was synthesized using 3-bromobenzaldehyde and 2,2-dimeth-oxyethan-1-amine as the starting materials via Pictet-Gams, peroxidation and radical reaction. The total yield was 35%.The products were characterized using1 H NMR and MS. This synthetic route had the advantages including mild conditions, high yield and easy purification.
The titled compound was synthesized using 3-bromobenzaldehyde and 2,2-dimeth-oxyethan-1-amine as the starting materials via Pictet-Gams, peroxidation and radical reaction. The total yield was 35%.The products were characterized using1 H NMR and MS. This synthetic route had the advantages including mild conditions, high yield and easy purification.
引文
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