值得注意的猪的潜在病原塞内卡病毒
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摘要
自2015年起我国广东、福建、湖北、河南、黑龙江等省份出现了塞内卡病疫情,虽未给养猪业造成较大的经济损失,但该病的潜在危害引起了人们重视。本文介绍了塞内卡病毒的病原学特征、临床症状及病理变化,重点阐述了塞内卡病毒的流行病学、诊断方法及防治措施等方面取得的最新进展。
There have been reports describing the outbreaks of SVA infection in pigs in Guangdong,Fujian,Hubei,Henan and Heilongjiang Province,China,since 2015.Although they did not caused large economic loss in swine industry,they have raised awareness and drawn attention to the disease.The pathogenic features and clinical of Senecavirus A were introduced in the present paper,and the research progress for the epidemiology,diagnosis,prevention and control of the disease would be summarized in the review.
There have been reports describing the outbreaks of SVA infection in pigs in Guangdong,Fujian,Hubei,Henan and Heilongjiang Province,China,since 2015.Although they did not caused large economic loss in swine industry,they have raised awareness and drawn attention to the disease.The pathogenic features and clinical of Senecavirus A were introduced in the present paper,and the research progress for the epidemiology,diagnosis,prevention and control of the disease would be summarized in the review.
引文
[1] HALES L M, KNOWLES N J, REDDY P S, et al.Complete genome sequence analysis of Seneca Valley virus-001,a novel oncolytic picornavirus[J].Journal of General Virology,2008,89(Pt5):1265-1275.
[2] SEGALES J,BRRCELLOS D,ALFOERI A,et al.Senecavirus A[J].Veterinary Pathology,2017,54(1):11-21.
[3] ZHANG J,PINEYRO P,CHEN Q,et al.Full-length genome sequences of Senecavirus A from recent idiopathic vesicular disease outbreak in U.S.swine[J].Genome Announcement,2015,3(6):e01270-15.
[4] LEME R A,ZOTTI E,ALCANTARA B K,et al.Senecavirus A:an emerging vesicular infection in Brazilian pig herds[J].Transboundary and Emerging Diseases,2015,62(2):603-611.
[5] SAENG-CHUTO K, RODTIAN P, TEMEEYASEN G, et al.The first detection of Senecavirus A in pig in Thailand,2016[J].Transboundary and Emerging Diseases,2018,65(1):285-288.
[6] WU Q,ZHAO X,CHEN Y,et al.Complete genome sequence of Seneca Valley virus CH-01-2015 identified in China[J].Genome Announcement,2016,4(1):e01509-15.
[7] WILLCOCKS MM, ZAINI S, CHAMOND N, et al.Distinct roles for theⅢd2 sub-domain in pestivirus and picornavirus internal ribosome entry sites[J].Nucleic Acids Research,2017,45(22):13016-13028.
[8] WILLCOCKS M M,LOCKER N,GOMWALK Z,et al.Structural features of the Seneca Valley virus internal ribosome site(IRES)element:a picornavirus with a pestivirus-like IRES[J].Journal of Virology,2011,85(9):4452-4461.
[9] ZHANG X,XIAO J,BA L,et al.Identification and genomic characterization of the emerging Senecavirus A in southeast China,2017[J].Transboundary and Emerging Diseases,2017,doi:10.1111.
[10] XU W,HOLE K,GOOLIA M,et al.Genome wide analysis of the evolution of Senecavirus A from swine clinical material and assembly yard environmental sample[J].PLoS One,2017,12(5):e0176964.
[11] LEME R A,ALFIERI A F,ALFIERI A A.Update on Seneavirus infection in pigs[J].Viruses,2017,9(7):E170.
[12] VENKATARAMAN S,REDDY S P,LOO J,et al.Structure of Seneca Valley virus-001:an oncolytic picornavirus representing a new genus[J].Structure,2008,16(10):1555-1561.
[13] MILES L A, BURGA L N, GARDNER E E, et al.Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus[J].Journal of Clinical Investigation,2017,127(8):2957-2967.
[14] LEME R A,OLIVEIRA T E,ALCANTARA B K,et al.Clinical manifestations of Senecavirus A infection in neonatal pigs,Brazil,2015[J].Emerging Infectious Diseases,2016,22(7):1238-1241.
[15] JOSHI L R,FERNANDES M H,CLEMENT T,et al.Pathogenesis of Senecavirus A infection in finishing pigs[J].Journal of General Virology,2016,97(12):3267-3279.
[16] TOUSIGNANT SJP,BRUNER L,SCHWARTZ J,et al.Longi tudinal study of Senecavirus a shedding in sows and piglets on a single United States farm during an outbreak of vesicular disease[J].BMC Veterinary Research,2017,13(1):277.
[17] DALL AGNOL A M,MIYABE F M,LEME R A,et al.Quantitative analysis of Senecavirus A in tissue sample from naturally infected newborn piglets[J].Archives of Virology,2017.
[18] OLIVEIRA T E S,MICHELAZZO M M Z,FERNANDES T,et al.Histopathological,immunohistochemical,and ultrastructural evidence of spontaneous Senecavirus A-induced lesions at the choroid plexus of newborn piglets[J].Scientific Reports,2017,7(1):16555.
[19] CANNING P,CANON A,BATES J L,et al.Vesicular lesions and lameness associated with Senecavirus A in a U.S.sow farm[J].Transboundary and Emerging Diseases,2016 May 23.doi:10.1111/tbed.12516.[Epub ahead of print] PMID:27213868.
[20] SUN D,VANNUCCI F,KNUTSON T P,et al.Emergence and whole-genome sequence of Senecavirus A in Colombia[J]. Transboundary and Emerging Diseases,2017,64(5):1346-1349.
[21] QIAN S,FAN W,QIAN P,et al.Isolation and full-genome aequencing of Seneca Valley virus in piglets from China,2016[J].Virology Journal,2016,13(1):173.
[22] LUO T,XU S,XIONG J,et al.Complete genome sequence of Senecavirus A strain SVV HN16 identified in China[J].Genome Announcement,2017,5(44):e01168-17.
[23] WANG H,LI C,ZHAO B,et al.Complete genome sequence and phylogenetic analysis of Senecavirus A isolated in Northeast China in 2016[J].Archives of Virology,2017.
[24] ZHAO X,WU Q,BAI Y,et al.Phylogenetic and genome analysis of seven senecavirus A isolates in China[J].Transboundary and Emerging Diseases,2017,64(6):2075-2082.
[25] SEGALES J,BARCELLOS D,ALFIERI A,et al.Senecavirus A:an emerging pathogen causing vesicular disease and mortality in pigs[J].Veterinary Pathology,2016,54(1):11-21.
[26] JOSHI L R,MOHR K A,CLEMENT T,et al.Detection of the merging picornavirus Senecavirus A in pigs,mice,and houseflies[J].Journal of Clinical Microbiology,2016,54(6):1536-1545.
[27] BRACHT A J,O’HEARN E S,FABIAN A W,et al.Real-time reverse transcription PCR assay for detection of Senecavirus A in swine vesicular diagnostic specimens[J].PLoS One,2016,11(1):e0146211.
[28] FOWLER V L,RANSBURGH R H,POULSEN E G,et al.Development of a novel real-time RT-PCR assay to detect Seneca Valley virus-1 associated with emerging cases of vesicular disease in pigs[J].Journal of Virological Methods,2017,239:34-37.
[29] GIMENEZ-LIROLA L G,RADEMACHER C,LINHARES D,et al.Serological and molecular detection of Senecavirus A associated with an outbreak of swine idiopathic vesicular disease and neonatal mortality[J].Journal of Clinical Microbiology,2016,54(8):2082-2089.
[30] DALL AGNOL A M,OTONEL R A A,LEME R A,et al.A TaqMan-based qRT-PCR assay for Senecavirus A detection in tissue samples of neonatal piglets[J].Molecular and Cellular Probes,2017,33:28-31.
[31] YANG M,VAN BRUGGEN R,XU W.Generation and diagnostic application of monoclonal antibodies against Seneca Valley virus[J].Journal of Veterinary Diagnostic Investigation,2012,24(1):42-50.
[32] DVORAK C M,AKKUTAY-YOLDAR Z,STONE S R,et al.An indirect enzyme-linked immunosorbent assay for the identification of antibodies to Senecavirus A in swine[J].BMC Veterinary Research,2017,13(1):50.
[33] GOOLIA M,VANNUCCI F,YANG M,et al.Validation of a competitive ELISA and a virus neutralization test for the detection and confirmation of antibodies to Senecavriu A in swine sera[J].Journal of Veterinary Diagnostic Investigation,2017,29(2):250-253.
[34] RESENDE T P,MARTHALER D G,VANNUCCI F A.A novel RNA-based in situ hybridization to detect Seneca Valley virus in neonatal piglets and sows affected with vesicular disease[J].PLos One,2017,12(4):e0173190.
[35] CHEN Z,YUAN F,LI Y,et al.Construction and characterization of a full-length cDNA infectious clone of emerging porcine Senecavirus A[J].Virology,2016,497:111-124.
[36] YANG F,ZHU Z,CAO W,et al.Immunogenicity and protective efficacy of an inactivated cell culture-derived Seneca Valley virus vaccine in pigs[J].Vaccine,2018,36(6).DOI:10.1016/j.vaccine.2017.12.055.
[37] HOLE K,AHMADPOUR F,KRISHNAN J,et al.Efficacy of accelerated hydrogen peroxide disinfectant on foot-and-mouth disease virus,swine vesicular disease virus and Senecavirus A[J].Journal of Applied Microbiology,2017,122(3):634-639.
[2] SEGALES J,BRRCELLOS D,ALFOERI A,et al.Senecavirus A[J].Veterinary Pathology,2017,54(1):11-21.
[3] ZHANG J,PINEYRO P,CHEN Q,et al.Full-length genome sequences of Senecavirus A from recent idiopathic vesicular disease outbreak in U.S.swine[J].Genome Announcement,2015,3(6):e01270-15.
[4] LEME R A,ZOTTI E,ALCANTARA B K,et al.Senecavirus A:an emerging vesicular infection in Brazilian pig herds[J].Transboundary and Emerging Diseases,2015,62(2):603-611.
[5] SAENG-CHUTO K, RODTIAN P, TEMEEYASEN G, et al.The first detection of Senecavirus A in pig in Thailand,2016[J].Transboundary and Emerging Diseases,2018,65(1):285-288.
[6] WU Q,ZHAO X,CHEN Y,et al.Complete genome sequence of Seneca Valley virus CH-01-2015 identified in China[J].Genome Announcement,2016,4(1):e01509-15.
[7] WILLCOCKS MM, ZAINI S, CHAMOND N, et al.Distinct roles for theⅢd2 sub-domain in pestivirus and picornavirus internal ribosome entry sites[J].Nucleic Acids Research,2017,45(22):13016-13028.
[8] WILLCOCKS M M,LOCKER N,GOMWALK Z,et al.Structural features of the Seneca Valley virus internal ribosome site(IRES)element:a picornavirus with a pestivirus-like IRES[J].Journal of Virology,2011,85(9):4452-4461.
[9] ZHANG X,XIAO J,BA L,et al.Identification and genomic characterization of the emerging Senecavirus A in southeast China,2017[J].Transboundary and Emerging Diseases,2017,doi:10.1111.
[10] XU W,HOLE K,GOOLIA M,et al.Genome wide analysis of the evolution of Senecavirus A from swine clinical material and assembly yard environmental sample[J].PLoS One,2017,12(5):e0176964.
[11] LEME R A,ALFIERI A F,ALFIERI A A.Update on Seneavirus infection in pigs[J].Viruses,2017,9(7):E170.
[12] VENKATARAMAN S,REDDY S P,LOO J,et al.Structure of Seneca Valley virus-001:an oncolytic picornavirus representing a new genus[J].Structure,2008,16(10):1555-1561.
[13] MILES L A, BURGA L N, GARDNER E E, et al.Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus[J].Journal of Clinical Investigation,2017,127(8):2957-2967.
[14] LEME R A,OLIVEIRA T E,ALCANTARA B K,et al.Clinical manifestations of Senecavirus A infection in neonatal pigs,Brazil,2015[J].Emerging Infectious Diseases,2016,22(7):1238-1241.
[15] JOSHI L R,FERNANDES M H,CLEMENT T,et al.Pathogenesis of Senecavirus A infection in finishing pigs[J].Journal of General Virology,2016,97(12):3267-3279.
[16] TOUSIGNANT SJP,BRUNER L,SCHWARTZ J,et al.Longi tudinal study of Senecavirus a shedding in sows and piglets on a single United States farm during an outbreak of vesicular disease[J].BMC Veterinary Research,2017,13(1):277.
[17] DALL AGNOL A M,MIYABE F M,LEME R A,et al.Quantitative analysis of Senecavirus A in tissue sample from naturally infected newborn piglets[J].Archives of Virology,2017.
[18] OLIVEIRA T E S,MICHELAZZO M M Z,FERNANDES T,et al.Histopathological,immunohistochemical,and ultrastructural evidence of spontaneous Senecavirus A-induced lesions at the choroid plexus of newborn piglets[J].Scientific Reports,2017,7(1):16555.
[19] CANNING P,CANON A,BATES J L,et al.Vesicular lesions and lameness associated with Senecavirus A in a U.S.sow farm[J].Transboundary and Emerging Diseases,2016 May 23.doi:10.1111/tbed.12516.[Epub ahead of print] PMID:27213868.
[20] SUN D,VANNUCCI F,KNUTSON T P,et al.Emergence and whole-genome sequence of Senecavirus A in Colombia[J]. Transboundary and Emerging Diseases,2017,64(5):1346-1349.
[21] QIAN S,FAN W,QIAN P,et al.Isolation and full-genome aequencing of Seneca Valley virus in piglets from China,2016[J].Virology Journal,2016,13(1):173.
[22] LUO T,XU S,XIONG J,et al.Complete genome sequence of Senecavirus A strain SVV HN16 identified in China[J].Genome Announcement,2017,5(44):e01168-17.
[23] WANG H,LI C,ZHAO B,et al.Complete genome sequence and phylogenetic analysis of Senecavirus A isolated in Northeast China in 2016[J].Archives of Virology,2017.
[24] ZHAO X,WU Q,BAI Y,et al.Phylogenetic and genome analysis of seven senecavirus A isolates in China[J].Transboundary and Emerging Diseases,2017,64(6):2075-2082.
[25] SEGALES J,BARCELLOS D,ALFIERI A,et al.Senecavirus A:an emerging pathogen causing vesicular disease and mortality in pigs[J].Veterinary Pathology,2016,54(1):11-21.
[26] JOSHI L R,MOHR K A,CLEMENT T,et al.Detection of the merging picornavirus Senecavirus A in pigs,mice,and houseflies[J].Journal of Clinical Microbiology,2016,54(6):1536-1545.
[27] BRACHT A J,O’HEARN E S,FABIAN A W,et al.Real-time reverse transcription PCR assay for detection of Senecavirus A in swine vesicular diagnostic specimens[J].PLoS One,2016,11(1):e0146211.
[28] FOWLER V L,RANSBURGH R H,POULSEN E G,et al.Development of a novel real-time RT-PCR assay to detect Seneca Valley virus-1 associated with emerging cases of vesicular disease in pigs[J].Journal of Virological Methods,2017,239:34-37.
[29] GIMENEZ-LIROLA L G,RADEMACHER C,LINHARES D,et al.Serological and molecular detection of Senecavirus A associated with an outbreak of swine idiopathic vesicular disease and neonatal mortality[J].Journal of Clinical Microbiology,2016,54(8):2082-2089.
[30] DALL AGNOL A M,OTONEL R A A,LEME R A,et al.A TaqMan-based qRT-PCR assay for Senecavirus A detection in tissue samples of neonatal piglets[J].Molecular and Cellular Probes,2017,33:28-31.
[31] YANG M,VAN BRUGGEN R,XU W.Generation and diagnostic application of monoclonal antibodies against Seneca Valley virus[J].Journal of Veterinary Diagnostic Investigation,2012,24(1):42-50.
[32] DVORAK C M,AKKUTAY-YOLDAR Z,STONE S R,et al.An indirect enzyme-linked immunosorbent assay for the identification of antibodies to Senecavirus A in swine[J].BMC Veterinary Research,2017,13(1):50.
[33] GOOLIA M,VANNUCCI F,YANG M,et al.Validation of a competitive ELISA and a virus neutralization test for the detection and confirmation of antibodies to Senecavriu A in swine sera[J].Journal of Veterinary Diagnostic Investigation,2017,29(2):250-253.
[34] RESENDE T P,MARTHALER D G,VANNUCCI F A.A novel RNA-based in situ hybridization to detect Seneca Valley virus in neonatal piglets and sows affected with vesicular disease[J].PLos One,2017,12(4):e0173190.
[35] CHEN Z,YUAN F,LI Y,et al.Construction and characterization of a full-length cDNA infectious clone of emerging porcine Senecavirus A[J].Virology,2016,497:111-124.
[36] YANG F,ZHU Z,CAO W,et al.Immunogenicity and protective efficacy of an inactivated cell culture-derived Seneca Valley virus vaccine in pigs[J].Vaccine,2018,36(6).DOI:10.1016/j.vaccine.2017.12.055.
[37] HOLE K,AHMADPOUR F,KRISHNAN J,et al.Efficacy of accelerated hydrogen peroxide disinfectant on foot-and-mouth disease virus,swine vesicular disease virus and Senecavirus A[J].Journal of Applied Microbiology,2017,122(3):634-639.