摘要
目的:观察藏药仁青常觉的临床安全性。方法:患者服药15d,于服药前、服药15d和停药15d分别收集血样、尿样、粪便,检测血常规、尿常规、肝肾功能,以及血尿便中铅、砷、汞的含量。结果:与服药前比较,服药15d总蛋白、白蛋白水平显著降低(P<0.05),血肌酐水平、尿液pH值显著升高(P<0.05,P<0.01),血、尿、便的汞、铅、砷含量显著升高(P<0.01);与服药15d比较,停药15d总蛋白、白蛋白、球蛋白和总胆红素水平显著升高(P<0.05),尿素氮水平、尿液pH值显著降低(P<0.05),血汞、血铅、血砷、尿砷、便汞和便砷含量显著降低(P<0.01)。结论:按藏医理论服用仁青常觉,短期内对肝脏和肾脏部分指标有一定影响,但停药后均有恢复趋势,显示仁青常觉临床用药的安全性。
Objective: To observe the clinical safety of Tibetan medicine Renqingchangjue(RQCJ). Methods: The cases of taking the medicine for 15 days, at the time of before, 15 th days of taking the medicine, and 15 th days after taking the medicine, collect blood, urine and faeces to test blood routine, liver and kidney function, urines routine and the content of mercury, plumbum and arsenic in the blood, urine and faeces sample. Results: At the time of 15 th days of taking RQCJ,compared to the before period, the level of total protein and albumin decreased significantly(P<0.05), blood creatinine level,urine pH significantly increased(P<0.05, P<0.01), the content of mercury, plumbum and arsenic in the blood, urine and faeces sample all increased significantly(P<0.01); Compared to the 15 th days of taking RQCJ, at the 15 th days of stop taking RQCJ,the levels of total protein, albumin, globulin, and total bilirubin were significantly increased(P<0.05), urea nitrogen level,urine pH value significantly reduced(P<0.05), blood mercury, blood plumbum, blood arsenic, urine arsenic, fecal mercury and fecal arsenic content significantly decreased(P<0.01). Conclusion: According to the Tibetan theory to take RQCJ have effect on the liver and kidney function index, but they all could recover to the level of before period, these showed the safety of RQCJ clinical medication.
引文
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