行为药理学虚拟实验软件的设计与应用探索
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摘要
行为药理学实验是医学热点研究领域中抗老年痴呆药物研究的重要环节。为了使大学生了解学习抗老年痴呆药物药效学实验方法,文章采用多媒体网络技术设计了抗老年痴呆药物药效研究虚拟实验软件:以石杉碱甲为模型药物,多奈哌齐为阳性对照,采用Morris水迷宫实验测定大鼠的空间记忆功能,根据实验过程中产生的真实数据,运用软件工具,建立网络化虚拟实验软件。该软件经学生使用证明,在避免大量动物损失的条件下,有助于在大范围学生中开展科研性质的实验训练,以有效拓展学生知识领域。
Behavioral pharmacology experiment is an important part of research on medicine for Alzheimer's disease.In order to help undergraduates master the methods for researching nootropic drugs for the disease,a virtual experiment software is designed by using multimedia and network technology.Taking huperzine A as a model drug and donepezil as a positive control,spatial learning and memory functions of rats were measured by Morris water maze test.Based on the real data generated from the experiment,the network-based virtual experiment software was designed.The software contributes to strengthening the students' scientific research training and expanding their medical knowledge.
Behavioral pharmacology experiment is an important part of research on medicine for Alzheimer's disease.In order to help undergraduates master the methods for researching nootropic drugs for the disease,a virtual experiment software is designed by using multimedia and network technology.Taking huperzine A as a model drug and donepezil as a positive control,spatial learning and memory functions of rats were measured by Morris water maze test.Based on the real data generated from the experiment,the network-based virtual experiment software was designed.The software contributes to strengthening the students' scientific research training and expanding their medical knowledge.
引文
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[2]杜一宁.虚拟实验的研究现状以及在教学中的意义[J].浙江海洋学院学报:自然科学版,2010,29(4):390-393
[3]王东玲,谢百治,冯潇.虚拟现实技术在组胚学教学中的应用[J].中国医学教育技术,2010,24(2):58-60
[4]高航,陈霞,程丕显,等.病理学虚拟实验教学系统的建设与应用[J].中国高等医学教育,2013(4):65,68
[5]杨致邦,徐晨,王毅,等.医学微生物学虚拟试验在实验教学中的应用[J].实验室研究与探索,2014,33(10):46-49
[6]王也飞,倪麟,丁磊,等.虚拟实验教学在临床血液学检验课程中的尝试[J].医学教育,2012,11(6):638-640
[7]徐岚,朱旻,高上上.虚拟实验在生物化学实验中的应用[J].基础医学教育,2017,19(11):866-868
[8]Conradi E,Kavia S,Burden D,et al.Virtual patients in a virtual world:Training paramedic students for practice[J].Med Teach,2009,31(8):713-720
[9]Ribeiro I B,Ngu J M C,Lam B K,et al.Simulation-Based Skill Training for Trainees in Cardiac Surgery:A Systematic Review[J].Ann Thorac Surg,2018,105(3):972-982
[10]李稻,丁文龙,沈国舜,等.功能学虚拟实验软件的开发与应用[J].中华医学教育杂志,2009,29(6):100-101,110
[11]吴健桦,吴琛耘,杨杨,等.医学寄生虫学虚拟实验软件的构建与应用探索[J].基础医学教育,2016,18(9):747-749
[12]Richard G,Morris M.Spatial localization does not require the presence of local cues[J].Learn Motiva,1981,12(2):239-260
[13]丁正明,宫斌,莫启忠.老年痴呆动物模型研究进展[J].浙江中西医结合杂志,2000,10(10):638-641
[14]Likert R.A Technique for the Measurement of Attitudes[J].Arch of Psychol,1932,22(140):1-5